A basic research for phosphatidylinositol 3-kinase inhibitor utilization in lymphoma

• Project/Area Number: 19790273
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: TAKEUCHI Kengo Japanese Foundation For Cancer Research, 癌研究所病理部, 研究員 (40323612)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: リンパ腫 / PI3K / lymphoma

Research Abstract

of the cases are accompanied by clinical information. In order to develop a biomarker analysis for PI3K pathway activation, we tried to immunostain the TMA slides for a phosphorylated substance X using various enhancement techniques. However, we failed to obtain a positive result. We also analyzed the methylation status of PTEN, which suppresses the PI3K pathway. Methylation-specific PCR revealed that the gene was methylated in 4 of 15 cases.

Research Products

• [Journal Article] Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations (2010)
  • Author(s): Hiramatsu M, Ninomiya H, Inamura K, Nomura K, Takeuchi K, Satoh Y, Okumura S, Nakagawa K, Yamori T, Matsuura M, Morikawa T, Ishikawa Y.
  • Journal Title: Lung Cancer
• [Journal Article] Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy (2010)
  • Author(s): Ennishi D, Asai H, Maeda Y, Shinagawa K, Ikeda K, Yokoyama M, Terui Y, Takeuchi K, Yoshino T, Matsuo K, Hatake K, Tanimoto M.
  • Journal Title: Ann Oncol. 21 Pages: 1217-1221
• [Journal Article] Is Statin Use Really Associated With Efficacy of Rituximab? (2010)
  • Author(s): Asai H, Yokoyama M, Terui Y, Ennishi D, Takeuchi K, Hatake K.
  • Journal Title: J Clin Oncol.
• [Journal Article] Identification of CD20 C-Terminal Deletion Mutations Associated with Loss of CD20 Expression in Non-Hodgkin's Lymphoma (2009)
  • Author(s): Terui Y, Mishima Y, Sugimura N, Kojima K, Sakurai T, Kuniyoshi R, Taniyama A, Yokoyama M, Sakajiri S, Takeuchi K, Watanabe C, Takahashi S, Ito Y, Hatake K.
  • Journal Title: Clin Cancer Res. 15 Pages: 2523-2530
• [Journal Article] KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer (2009)
  • Author(s): Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
  • Journal Title: Clin Cancer Res. 15 Pages: 3143-3149
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas (2009)
  • Author(s): Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S.
  • Journal Title: Nature 459 Pages: 712-716
• [Journal Article] Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP (RCHOP) therapy (2009)
  • Author(s): Ennishi D, Yokoyama M, Terui Y, Asai H, Sakajiri S, Mishima Y, Takahashi S, Komatsu H, Ikeda K, Takeuchi K, Tanimoto M, Hatake K.
  • Journal Title: Ann Oncol. 20 Pages: 526-533
• [Journal Article] Prognostic value of matrix G1a protein in breast cancer (2009)
  • Author(s): Yoshimura K, Takeuchi K, et al.
  • Journal Title: Molecular Medicine Reports 2 Pages: 549-553
  • Peer Reviewed
• [Journal Article] A case of primary esophageal mucosa-associated lymphoid tissue lymphoma with a numerical abnormality of 18q21 detected by fluorescence in situ hybridization (2009)
  • Author(s): Yano S, et al., 13人中12番目
  • Journal Title: Ann Hematol. 88 Pages: 703-704
  • Peer Reviewed
• [Journal Article] Clinicopathological features of lymphoma/leukemia patients carrying both BCL2 and MYC translocations (2009)
  • Author(s): Tomita N, et al., 15人中4番目
  • Journal Title: Haematologica. 94 Pages: 935-943
  • Peer Reviewed
• [Journal Article] Diffuse large B cell lymphoma without immunoglobulin light chain restriction by flow cytometry (2009)
  • Author(s): Tomita N, Takeuchi K, et al.
  • Journal Title: Acta Haematol. 121 Pages: 196-201
  • Peer Reviewed
• [Journal Article] Identification of CD20 C-Terminal Deletion Mutations Associated with Loss of CD20 Expression in Non-Hodgkin's Lymphoma (2009)
  • Author(s): Terui Y, et al., 14人中10番目
  • Journal Title: Clin Cancer Res. 15 Pages: 2523-2530
  • Peer Reviewed
• [Journal Article] ERas Is Expressed in Primate Embryonic Stem Cells But Not Related to Tumorigenesis (2009)
  • Author(s): Tanaka Y, et al., 13人中6番目
  • Journal Title: Cell Transplant. 18 Pages: 381-389
  • Peer Reviewed
• [Journal Article] KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistoc hemistry-based Diagnostic System for ALK-positive Lung Cancer (2009)
  • Author(s): Takeuchi K, et al.
  • Journal Title: Clin Cancer Res. 15 Pages: 3143-3149
  • Peer Reviewed
• [Journal Article] Kruppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression (2009)
  • Author(s): Nakamura Y, et al., 17人中10番目
  • Journal Title: Int J Cancer. 125 Pages: 1859-1867
  • Peer Reviewed
• [Journal Article] An imaging- based rapid evaluation method for complement- dependent cytotoxicity discriminated clinical response to rituximab-containing chemotherapy (2009)
  • Author(s): Mishima Y, et al., 11人中5番目
  • Journal Title: Clin Cancer Res. 15 Pages: 3624-3632
  • Peer Reviewed
• [Journal Article] Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates (2009)
  • Author(s): Masuda S, et al., 9人中6番目
  • Journal Title: Exp Hematol. 37
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus-positive inflammatory pseudotumour and inflammatory pseudotumour-like follicular dendritic cell tumour (2009)
  • Author(s): Kiryu S, Takeuchi K, et al.
  • Journal Title: Br J Radiol. 82
  • Peer Reviewed
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas (2009)
  • Author(s): Kato M, et al., 29人中6番目
  • Journal Title: Nature. 459 Pages: 712-716
  • Peer Reviewed
• [Journal Article] EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset (2009)
  • Author(s): Inamura K, Takeuchi K, et al.
  • Journal Title: Mod Pathol. 22 Pages: 508-515
  • Peer Reviewed
• [Journal Article] Absence of tumor-specific over-expression of Polo-like kinase 1(Plk1)in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma (2009)
  • Author(s): Imai H, et al., 10人中6番目
  • Journal Title: Int J Hematol. 89 Pages: 673-678
  • Peer Reviewed
• [Journal Article] Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP(RCHOP)therapy (2009)
  • Author(s): Ennishi D, et al., 12人中10番目
  • Journal Title: Ann Oncol. 20 Pages: 526-533
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus-positive inflammatory pseudotumour and inflammatory pseeudotumour-like follicular dendritic cell tumour. (2009)
  • Author(s): Kiryu S, Takeuchi K, Shibahara J, et al.
  • Journal Title: Br J Radiol. 82 Pages: 67-71
  • Peer Reviewed
• [Journal Article] CD5 expression is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy. (2008)
  • Author(s): Ennishi D, Takeuchi K, Yokoyama M, Asai H, Mishima Y, Terui Y, Takahashi S, Komatsu H, Ikeda K, Yamaguchi M, Suzuki R, Tanimoto M, Hatake K.
  • Journal Title: Ann Oncol 19 Pages: 1921-1926
• [Journal Article] CD5 expressions is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy. (2008)
  • Author(s): Ennishi D, Takeuchi K, Yokoyama M, et al.
  • Journal Title: Ann Oncol. 19
  • Peer Reviewed
• [Journal Article] Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. (2008)
  • Author(s): Suzuki R, Takeuchi K, Oshima K, Nakamura S.
  • Journal Title: Hematol Oncol. 26 Pages: 66-72
  • Peer Reviewed
• [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients (2007)
  • Author(s): Oyama T, Yamamoto K, Asano N, Oshiro A, Suzuki R, Kagami Y, Morishima Y, Takeuchi K, Izumo T, Mori S, Ohshima K, Suzumiya J, Nakamura N, Abe M, Ichimura K, Sato Y, Yoshino T, Naoe T, Shimoyama Y, Kamiya Y, Kinoshita T, Nakamura S.
  • Journal Title: Clin Cancer Res. 13 Pages: 5124-5132
• [Journal Article] Rituximab plus CHOP as an initial chemotherapy for patients with disseminated MALT lymphoma (2007)
  • Author(s): Ennishi D, Yokoyama M, Mishima Y, Watanabe C, Terui Y, Takahashi S, Takeuchi K, Ikeda K, Tanimoto M, Hatake K.
  • Journal Title: Leuk Lymphoma 48 Pages: 2241-2243
• [Presentation] Lymphomatoid gastropathy:本邦発の新しいNK細胞増殖症 (2009)
  • Author(s): 竹内賢吾
  • Organizer: 第55回日本病理学会秋季特別総会
  • Place of Presentation: 九段会館
  • Year and Date: 2009-11-19
• [Presentation] ALK融合遺伝子陽性腫瘍の病理学的スペクトラム (2009)
  • Author(s): 竹内賢吾
  • Organizer: 第55回日本病理学会秋季特別総会
  • Place of Presentation: 九段会館
  • Year and Date: 2009-11-19
• [Presentation] ALK肺がんの診断:理論, 実践, 実績 (2009)
  • Author(s): 竹内賢吾
  • Organizer: 第50回日本肺癌学会総会 サテライトシンポジウムALK肺がんの診断と治療
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2009-11-13
• [Presentation] ALK陽性肺癌の統合的診断法の開発とその応用 (2009)
  • Author(s): 竹内賢吾
  • Organizer: 第68回日本癌学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] T/NK細胞リンパ腫 (2009)
  • Author(s): 竹内賢吾
  • Organizer: 第49回日本リンパ網内系学会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2009-07-10