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Preventive effects of green tea catechin on hematogenous metastasis of colon cancer cells

Research Project

Project/Area Number 19790419
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionToyama Prefectural Institute. for Pharmaceutical Research.

Principal Investigator

OGASAWARA Masaru  Toyama Prefectural Institute. for Pharmaceutical Research., バイオテクノロジー・和漢薬研究課, 主任研究員 (30443427)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥1,940,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Keywordsエピガロカテキンガレート / 大腸がん / 転移 / アシアロGM1陽性細胞 / 予防効果 / 予防 / ナチュラルキラー細胞
Research Abstract

本研究では,緑カテキンとして,エピガロカテキンガレート(EGCG),ガロカテキンガレート,エピカテキンガレート,エピガロカテキンのがん転移抑制活性を,マウスcolon26-L5結腸がん細胞の実験的肺転移モデルを用いて比較検討した.その結果,EGCGが最も強力な抑制効果を示すことを明らかにした.さらに作用メカニズムについて検討を行ったところ, アシアロGM1陽性細胞が極めて重要であることを明らかにした.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All 2008

All Presentation (2 results)

  • [Presentation] Screening of Antioxidants for Inhibitory Activity against Lung Metastasis of Murine Colon Cancer Cells in Mice2008

    • Author(s)
      OGASAWARA M, MATSUNAGA T, NAGAI Y, TAKATSU K
    • Organizer
      2nd World Conference on Magic Bullets (EhrlichII)
    • Place of Presentation
      ドイツ,ニュルンベルク
    • Year and Date
      2008-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Screening of Antioxidants for Inhibitory Activity against Lung Metastasis of Murine Colon Cancer Cells in Mice2008

    • Author(s)
      小笠原勝
    • Organizer
      2nd World Conference on Magic Bullets(Ehrlich II)
    • Place of Presentation
      ドイツ,ニュルンベルク
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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