Antinociceptive effects of glycine-and GABA-transporter inhibitors in neuropathic pain models

Research Project

Project/Area Number	19791095
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	HARA Koji University of Occupational and Environmental Health, Japan, 医学部, 講師 (20331001)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000) Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords	神経障害性疼痛 / グリシントランスポーター阻害剤 / GABAトランスポーター阻害剤 / 疼痛行動実験 / 坐骨神経結紮モデル / 抗侵害作用 / 運動協調機能 / 神経因性疼痛 / 糖尿病性ニューロパチーモデル / グリシントランスポーター / GABAトランスポーター / 坐骨神経部分結紮モデル
Research Abstract	Inhibitory neurotransmitter transporters are promising targets for treatments of acute, inflammatory, and neuropathic pains, and glycinergic neurons may be key component of modulating nociceptive transmittion.

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