| Project/Area Number |
19791211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Ehime University |
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Principal Investigator |
TAGUCHI Aki Ehime University, 大学院・医学系研究科, 講師 (00380238)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,660,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
|
|---|
| Keywords | 下咽頭収縮筋 / 加齢 / 神経栄養因子 / 嚥下機能予防低下 / 嚥下機能低下予防 |
|---|
| Research Abstract |
We studied about the protection of functional deterioration of deglutition decline by IGF-1. In the present study, aging effects in the subneural apparatus (SNA) were histologically investigated in the inferior pharyngeal muscle of a rat using scanning electron microscopy. In the cricopharyngeal muscle, the depression type of the primary synaptic clefts were 63.4%, while the IGF-1 dosage group were 60%. There was more it than aging group, and an unripe nervous system bottom device appeared in the group of IGF-1 dosage aging in comparison with the aging group. In addition, about 27% were able to observe the nervous system bottom device that a secondary synapse was observed outward from the ditch of the primary synapse.
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