Genomic research for the receptive mechanism of mechanical stress andthe bone remodeling in the inner bone structure in residual ridge

• Project/Area Number: 19791421
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 補綴理工系歯学
• Research Institution: Tohoku University
• Principal Investigator: OKAYAMA Keisuke Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (30436092)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,570,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 義歯床 / 骨改造 / 圧縮力 / 義歯床圧 / サイトカイン / BMP / マイクロアレイ / ラット

Research Abstract

To examine mechanism of bone formation to biomechanical stress and bone resorption by inflammation, in vitro genomic investigation on the crosstalk mechanism between BMP signaling related to bone formation and TNF signalling related to inflammatory cytokine induced in over mechanical stress. The results in this study provide a genome-wide profile of the downstream genes of BMP signals that are regulated by TNF-a in a stable 293 cell line expressing BMPRII, which is useful for further analysis of the crosstalk mechanism between BMP signals and TNF signals.

Research Products

• [Journal Article] Regulation of bone morphogenetic protein-mediated signaling by tumor necrosis factor-α. (2010)
  • Author(s): K. Okayama, T.A. Kudo, Y. Shimizu, Y. Zhang, F. Zhao, M. Kano, H. Kanetaka, K. Sasaki
  • Journal Title: Interface Oral Health Science 2009 Pages: 202-204
• [Journal Article] Regulation of bone morphogenetic protein-mediated signaling by tumor necrosis factor-α (2010)
  • Author(s): Okayama K, Kudo T, Shimizu Y, Zhang Y, Zhao F, Kano M, Kanetaka H, Sasaki K
  • Journal Title: Interface Oral Health Science 2009 (in print) Pages: 202-203
• [Presentation] Genome-wide analysis of the regulation of BMP2-induced gene expression by inflammatory cytokine TNF-a in a stable 293 cell line expressing BMPRII. (2009)
  • Author(s): K. Okayama, T.A. Kudo, Y. Shimizu, Y. Zhang, F. Zhao, M. Kano, H. Kanetaka, K. Sasaki
  • Organizer: The 3rd International Symposium for Interface Oral Health Science in Sendai.
  • Place of Presentation: 仙台市
• [Presentation] Genome-wide analysis of the regulation of BMP2-induced gene expression by inflammatory cytokine TNF-α in a stable 293 cell line expressing BMPR II (2009)
  • Author(s): K. Okayama, T. A. Kudo, Y. Shimizu, F. Zhao, M. Kano, H. Kanetaka, K. Sasaki
  • Organizer: The 3^<rd> International Symposium for Interface Oral Health Science in Sendai
  • Place of Presentation: Sendai