A genome-wide association study of mandibular prognathism using pooled DNA typing

• Project/Area Number: 19791561
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: KAJII Takashi Hokkaido University, 大学院・歯学研究科, 助教 (60322822)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,910,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
• Keywords: 歯科矯正学 / 基礎ゲノム科学 / ヒトゲノムDNA / ゲノムワイド遺伝的相関解析 / pooled DNAタイピング / 骨格性下顎前突症 / pooled DNAタピング

Research Abstract

The pooled DNA of 140 of mandibular prognathism (case) group and that of 180 of healthy (control) group were prepared. We conducted a genome-wide association study of mandibular prognathism using micro-satellite markers and the pooled DNA. The first screening of genome-wide association study focused 750 of loci associated with mandibular prognathism from 30,000 of total loci.

Research Products

• [Journal Article] Relationship between degree of malocclusion and occlusal interference in mice that spontaneously develop anterior transverse crossbite. (2010)
  • Author(s): Tsukamoto Y, Kajii TS, Sugawara-Kato Y, Hirabayashi Y, Fujimori O, Iida J
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics 138(in press)
  • Peer Reviewed
• [Journal Article] Three-dimensional cranio-maxillary characteristics of the mouse with spontaneous malocclusion using micro-computed tomography. (2010)
  • Author(s): Saito F, Kajii TS, Sugawara-Kato Y, Tsukamoto Y, Arai Y, Hirabayashi Y, Fujimori O, Iida J
  • Journal Title: European Journal of Orthodontics 32(in press)
  • Peer Reviewed
• [Journal Article] Relationship between degree of malocclusion and occlusal interference in mice that spontaneously develop anterior transverse crossbite (2010)
  • Author(s): Tsukamoto Y, Kajii TS, Sugawara-Kato Y, Hirabayashi Y, Fujimori O, Iida J
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics 138(in press)
  • Peer Reviewed
• [Journal Article] Three-dimensional cranio-maxillary characteristics of the mouse with spontaneous malocclusion using micro-computed tomography (2010)
  • Author(s): Saito F, Kajii TS, Sugawara-Kato Y, Tsukamoto Y, Arai Y, Hirabayashi Y, Fujimori O, Iida J
  • Journal Title: European Journal of Orthodontics 32(in press)
  • Peer Reviewed
• [Journal Article] Growth and development of the cranial base of BALB/c-bm/bm mouse that spontaneously induces anterior transverse crossbite: Histological study. (2008)
  • Author(s): Tsukamoto Y, Kajii TS, Oonshi Y, Sugawara-Kato Y, Hirabayashi Y, Iida J
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics 134 Pages: 675-682
  • Peer Reviewed
• [Journal Article] Growth and development of the cranial base of BALB/c-bm/bm mouse that spontaneously induces anterior transverse crossbite : Histological study (2008)
  • Author(s): Tsukamoto Kajii TS, Oonshi Y, Sugawara-Kato Y, Hirabayashi Y, Iida J
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics 134 Pages: 676-83
  • Peer Reviewed
• [Journal Article] Growth and development of the cranial base of BALB/c-bm/bm mouse that spontaneously induces anterior transverse crossbite: Histological study (2008)
  • Author(s): Tsukamoto Y, Kajii TS, Oonshi Y, Sugawara-Kato Y, Hirabayashi Y, Iida J
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics 133(In press)
  • Peer Reviewed
• [Presentation] 不正咬合自然発症マウスの顎顔面形態-マイクロCT を用いて-. (2009)
  • Author(s): 梶井貴史
  • Organizer: 北海道歯学会9 月例会
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-24
• [Presentation] 不正咬合自然発症マウスの顎顔面形態-マイクロCTを用いて- (2009)
  • Author(s): 梶井貴史
  • Organizer: 北海道歯学会9月例会
  • Place of Presentation: 北海道大学歯学部講堂(札幌)
  • Year and Date: 2009-09-24
• [Presentation] ゲノムワイド関連解析を用いた顎顔面変形症の発症予測システム構築. (2009)
  • Author(s): 梶井貴史
  • Organizer: 北大若手研究者の会第2 回若手研究者交流会
  • Place of Presentation: 札幌
  • Year and Date: 2009-07-17
• [Presentation] Three-dimensional craniofacial measurements of the mice with induced spontaneous malocclusion using the micro computedtomography. (2008)
  • Author(s): Saito F, Kajii TS, Hirabayashi Y, Arai Y, Iida J
  • Organizer: 41st Annual Scientific Congress of Korean Association of Orthodontists (KAO) and 2nd Joint Meeting of KAO and JapaneseOrthodontic Society
  • Place of Presentation: Seoul
  • Year and Date: 2008-11-07
• [Presentation] Three-dimensional craniofacial measurements of the mice with induced spontaneous malocclusion using the micro computed tomography (2008)
  • Author(s): Saitb F, Kajii TS, Hirabayashi Y, Arai Y, Iida J
  • Organizer: 41st-Annual Scientific Congress of Korean Association of Orthodontists(KAO) and 2nd Joint Meeting of KAO and Japanese-Orthodontic Society
  • Place of Presentation: Seoul, COEX hall
• [Presentation] Chronological change in sizes of teeth-alveolar bone in Japanese orthodontic patients. (2007)
  • Author(s): Kajii TS, Alam MK, Iida J
  • Organizer: 83rd congress of European Orthodontic Society
  • Place of Presentation: Berlin
  • Year and Date: 2007-06-23
• [Presentation] Chronological change in sizes of teeth-alveolar bone in Japanese orthodontic patients (2007)
  • Author(s): Kajii TS, Alam MK, Iida J
  • Organizer: 83rd congress of European Orthodontic Society
  • Place of Presentation: Berlin, Philharmonic Hall