Exploration of Self-Assembling Bioactive Small Molecules

• Project/Area Number: 19H00922
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 37:Biomolecular chemistry and related fields
• Research Institution: Kyoto University
• Principal Investigator: Uesugi Motonari 京都大学, 化学研究所, 教授 (10402926)
• Co-Investigator(Kenkyū-buntansha): 山崎 晶 大阪大学, 微生物病研究所, 教授 (40312946) ; Packwood Daniel 京都大学, 高等研究院, 講師 (40640884) ; 倉田 博基 京都大学, 化学研究所, 教授 (50186491) ; 柴 祐司 信州大学, 学術研究院医学系, 教授 (70613503)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000); Fiscal Year 2021: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2020: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2019: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
• Keywords: 自己集合 / 生理活性小分子

Outline of Research at the Start

自己集合体とは分子が自律的に集合してできる物質のことである。核酸・脂質・タンパク質などの自己集合体は、生命現象を巧みに維持している。これを逆に考えれば、自己集合する人工化合物で、生命の営みを操作することが可能だと推測できる。本研究の目的は、そのような人工化合物を発見し、解析することである。免疫治療、細胞治療などの分野で、古典的な薬物の枠を超えた生理活性を実現できる可能性がある。

Outline of Final Research Achievements

This study pioneered the concept of "self-assembling bioactive small molecules.” Self-assemblies of nucleic acids, lipids, and proteins maintain biological events. We envisioned that self-assembling small molecules may mimic or modulate these biological assemblies to control cellular events. In this study, an interdisciplinary team was assembled to comprehensively discover, analyze, optimize, and utilize self-assembling molecules that manipulate the biological processes. Examples of such molecules include self-assembling molecules that improve cell transplantation, self-assembling adjuvants that activate vaccines, and self-assembling compounds that form tubulin concentrates.

Academic Significance and Societal Importance of the Research Achievements

本研究では生理活性化合物の新しいコンセプトを開拓した。これまでに使われてきた薬物とは生理活性を発揮するメカニズムが異なり、自発的に集合して巨大化する「自己集合」という材料化学の概念を利用している。特記すべきは、ワクチンアジュバント化合物コリカマイドの発見である。この化合物は自己集合して自然免疫を活性化し、動物でウイルスワクチンを活性化した。今後の実用化が期待される。

Research Products

• [Int'l Joint Research] Fudan University/Tsinghua University(中国)
• [Int'l Joint Research] Fudan University/Tsinghua University(中国)
• [Journal Article] Glucose as a Protein-Condensing Cellular Solute (2022)
  • Author(s): Noda, N., Jung, Y., Ado, G., Mizuhata, Y., Higuchi, M., Ogawa, T., Ishidate, F., Sato, S., Kurata, H., Tokitoh, N., Uesugi, M.
  • Journal Title: ACS Chem. Biol. Volume: 17 Issue: 3 Pages: 567-575
  • DOI: 10.1021/acschembio.1c00849
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe (2022)
  • Author(s): Jung, Y., Noda, N., Takaya, J., Abo, M., Toh, K., Tajiri, K., Cui, C., Zhou, L., Sato, S., Uesugi, M.
  • Journal Title: ACS Chem. Biol. Volume: 17 Issue: 2 Pages: 340-347
  • DOI: 10.1021/acschembio.1c00824
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite (2022)
  • Author(s): Mendoza, A., Takemoto, Y., Cruzado, KT., Masoud, SS., Nagata, A., Tantipanjaporn, A., Okuda, S., Kawagoe, F., Sakamoto, R., Odagi, M., Mototani, S., Togashi, M., Kawatani, M., Aono, H., Osada, H., Nakagawa, H., Higashi, T., Kittaka, A., Nagasawa, K., Uesugi, M.
  • Journal Title: Cell Chem Biol. Volume: 29 Issue: 4 Pages: 660-669
  • DOI: 10.1016/j.chembiol.2021.08.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis (2021)
  • Author(s): Takemoto Yasushi、Kadota Shin、Minami Itsunari、Otsuka Shinya、Okuda Satoshi、Abo Masahiro、Punzalan Louvy Lynn、Shen Yan、Shiba Yuji、Uesugi Motonari
  • Journal Title: Angewandte Chemie International Edition Volume: 60 Issue: 40 Pages: 21824-21831
  • DOI: 10.1002/anie.202100523
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo (2021)
  • Author(s): Kawagoe, F., Mendoza, A., Hayata, Y., Asano, L., Kotake, K., Mototani, S., Kawamura, S., Kurosaki, S., Akagi, Y., Takemoto, Y., Nagasawa, K., Nakagawa, H., Uesugi, M., Kittaka, A.
  • Journal Title: J Med Chem. Volume: 64 Issue: 9 Pages: 5689-5709
  • DOI: 10.1021/acs.jmedchem.0c02179
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Light‐Controlled Tyrosine Nitration of Proteins (2021)
  • Author(s): Long, T., Liu, L., Tao, Y., Zhang, W., Quan, J., Zheng, J., Hegemann, JD., Uesugi, M., Yao, W., Tian, H., Wang, H.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 60 Issue: 24 Pages: 13414-13422
  • DOI: 10.1002/anie.202102287
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differential diagnosis of vitamin D‐related hypercalcemia using serum vitamin D metabolite profiling (2021)
  • Author(s): Kaufmann, M., Schlingmann, K-P., Berezin, L., Molin, A., Sheftel, J., Vig, M., Gallagher, JC., Nagata, A., Masoud, SS., Sakamoto, R., Nagasawa, K., Uesugi, M., Kottler, ML., Konrad, M., Jones, G.
  • Journal Title: JBMR Volume: 36 Issue: 7 Pages: 1340-1350
  • DOI: 10.1002/jbmr.4306
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients (2021)
  • Author(s): Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.
  • Journal Title: J Exp Med. Volume: 218 Issue: 12
  • DOI: 10.1084/jem.20211327
  • Peer Reviewed / Open Access
• [Journal Article] TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation. (2021)
  • Author(s): Iizasa, E., Chuma, Y., Uematsu, T., Kubota, M., Kawaguchi, H., Umemura, M., Toyonaga, K., Kiyohara, H., Yano, I., Colonna, M., Sugita, M., Matsuzaki, G., Yamasaki, S., Yoshida, H., Hara, H.
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 2299-2314
  • DOI: 10.1038/s41467-021-22620-3
  • NAID: 120007170570
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner. (2021)
  • Author(s): Lynch, AT., Motozono, C., Foster, AJ., Kodar, K., Dangerfield, EM., Yamasaki, S., Wedlock, DN., Timmer, MSM., Stocker, BL.
  • Journal Title: Bioorg Chem. Volume: 110 Pages: 104747-104747
  • DOI: 10.1016/j.bioorg.2021.104747
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cholesteryl glucosides signal through the carbohydrate recognition domain of the macrophage inducible C-type lectin (mincle) (2021)
  • Author(s): Timmer Mattie S. M.、Teunissen Thomas J.、Kodar Kristel、Foster Amy J.、Yamasaki Sho、Stocker Bridget L.
  • Journal Title: Organic & Biomolecular Chemistry Volume: 19 Issue: 10 Pages: 2198-2202
  • DOI: 10.1039/d0ob02342f
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts (2021)
  • Author(s): Li, Q., Meissner, TB., Wang, F., Du, Z., Ma, S., Kshirsagar, S., Tilburgs, T., Buenrostro, JD., Uesugi, M., Strominger, JL.
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 118 Issue: 9
  • DOI: 10.1073/pnas.2025512118
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Non-genetic cell-surface modification with a self-assembling molecular glue (2021)
  • Author(s): Hakariya, H., Takashima, I., Takemoto, M., Noda, N., Sato, S., Uesugi, M.
  • Journal Title: Chem Commun. Volume: 57 Issue: 12 Pages: 1470-1473
  • DOI: 10.1039/d0cc07171d
  • NAID: 120007002689
  • Peer Reviewed
• [Journal Article] Helicobacter metabolites exacerbate gastritis through C-type lectin receptors. (2021)
  • Author(s): Nagata M, Toyonaga K, Ishikawa E, Haji S, Okahashi N, Takahashi M, Izumi Y, Imamura A, Takato K, Ishida H, Nagai S, Illarionov P, Stocker B L, Timmer M S M, Smith D G M, Williams S J, Bamba T, Miyamoto T, Arita M, Appelmelk B J, Yamasaki S*.
  • Journal Title: J. Exp. Med. Volume: 218(1) Issue: 1
  • DOI: 10.1084/jem.20200815
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pluripotent Stem Cells for Cardiac Regeneration ― Current Status, Challenges, and Future Perspectives ― (2020)
  • Author(s): Shiba Yuji
  • Journal Title: Circulation Journal Volume: 84 Issue: 12 Pages: 2129-2135
  • DOI: 10.1253/circj.CJ-20-0755
  • NAID: 130007942529
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-11-25
  • Peer Reviewed / Open Access
• [Journal Article] Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants (2020)
  • Author(s): Jin Shuyu、Vu Hue Thi、Hioki Kou、Noda Naotaka、Yoshida Hiroki、Shimane Toru、Ishizuka Shigenari、Takashima Ippei、Mizuhata Yoshiyuki、Beverly Pe Kathleen、Ogawa Tetsuya、Nishimura Naoya、Packwood Daniel、Tokitoh Norihiro、Kurata Hiroki、Yamasaki Sho、Ishii Ken J.、Uesugi Motonari
  • Journal Title: Angewandte Chemie International Edition Volume: 60 Issue: 2 Pages: 961-969
  • DOI: 10.1002/anie.202011604
  • NAID: 120006958092
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor (2020)
  • Author(s): Ito Daishi、Kawazoe Yoshinori、Sato Ayato、Uesugi Motonari、Hirata Hiromi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-8
  • DOI: 10.1038/s41598-020-70983-2
  • Peer Reviewed / Open Access
• [Journal Article] Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library (2020)
  • Author(s): Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi
  • Journal Title: Cell Chemical Biology Volume: 27 Issue: 6 Pages: 708-718
  • DOI: 10.1016/j.chembiol.2020.04.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Direct Binding Analysis Between C-Type Lectins and Glycans Using Immunoglobulin Receptor Fusion Proteins (2020)
  • Author(s): Watanabe Miyuki、Omahdi Zakaria、Yamasaki Sho
  • Journal Title: Methods Mol. Biol. Volume: 2132 Pages: 119-128
  • DOI: 10.1007/978-1-0716-0430-4_12
  • ISBN: 9781071604298, 9781071604304
  • Peer Reviewed
• [Journal Article] Recognition of Mycobacteria by Dendritic Cell Immunoactivating Receptor (2020)
  • Author(s): Toyonaga K, Yamasaki S.
  • Journal Title: Current topics in microbiology and immunology Volume: 429 Pages: 103-115
  • DOI: 10.1007/82_2020_203
  • ISBN: 9783030622367, 9783030622374
  • Peer Reviewed
• [Journal Article] Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo (2020)
  • Author(s): Ichimura Hajime、Kadota Shin、Kashihara Toshihide、Yamada Mitsuhiko、Ito Kuniaki、Kobayashi Hideki、Tanaka Yuki、Shiba Naoko、Chuma Shinichiro、Tohyama Shugo、Seto Tatsuichiro、Okada Kenji、Kuwahara Koichiro、Shiba Yuji
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 11883-11883
  • DOI: 10.1038/s41598-020-68373-9
  • NAID: 120007006223
  • Peer Reviewed / Open Access
• [Journal Article] Heart regeneration using pluripotent stem cells (2020)
  • Author(s): Kadota Shin、Tanaka Yuki、Shiba Yuji
  • Journal Title: Journal of Cardiology Volume: 76 Issue: 5 Pages: 459-463
  • DOI: 10.1016/j.jjcc.2020.03.013
  • Peer Reviewed / Open Access
• [Journal Article] Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule. (2020)
  • Author(s): Zhang, X., Jiang, L., Huang, K., Fang, C., Li, J., Yang, J., Li, H., Ruan, X., Wang, P., Mo, M., Wu, O., Xu, Y., Peng, C., Uesugi, M., Ye, D.*, Yu, FX.*, Zhou, L.*
  • Journal Title: ACS Chem. Biol. Volume: 15 Issue: 3 Pages: 632-639
  • DOI: 10.1021/acschembio.9b00962
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of a Small-Molecule-Dependent Photolytic Peptide (2020)
  • Author(s): Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Goetze, Shin-ichi Sato, Motonari Uesugi
  • Journal Title: Journal of the American Chemical Society Volume: 142 Issue: 3 Pages: 1142-1146
  • DOI: 10.1021/jacs.9b09178
  • NAID: 120006813278
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR (2020)
  • Author(s): Omahdi Zakaria、Horikawa Yuto、Nagae Masamichi、Toyonaga Kenji、Imamura Akihiro、Takato Koichi、Teramoto Takamasa、Ishida Hideharu、Kakuta Yoshimitsu、Yamasaki Sho
  • Journal Title: Journal of Biological Chemistry Volume: 295 Issue: 17 Pages: 5807-5817
  • DOI: 10.1074/jbc.ra120.012491
  • Peer Reviewed
• [Journal Article] Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators (2019)
  • Author(s): Furuta Tomoyuki、Mizukami Yuya、Asano Lisa、Kotake Kenjiro、Ziegler Slava、Yoshida Hiroki、Watanabe Mizuki、Sato Shin-ichi、Waldmann Herbert、Nishikawa Makiya、Uesugi Motonari
  • Journal Title: ACS Chemical Biology Volume: 14 Issue: 9 Pages: 1860-1865
  • DOI: 10.1021/acschembio.9b00444
  • NAID: 120006769193
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses (2019)
  • Author(s): Suematsu, R. Miyamoto, T. Saijo, S. Yamasaki, S. Tada, Y. Yoshida, H. Miyake, Y.
  • Journal Title: Int J Mol Sci Volume: 45 Issue: 45 Pages: 16776-16788
  • DOI: 10.1074/jbc.ra119.009835
  • Peer Reviewed / Open Access
• [Journal Article] The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species (2019)
  • Author(s): Haider Mohammed、Dambuza Ivy M.、Asamaphan Patawee、Stappers Mark、Reid Delyth、Yamasaki Sho、Brown Gordon D.、Gow Neil A. R.、Erwig Lars P.
  • Journal Title: PLOS ONE Volume: 14 Issue: 8 Pages: e0220867-e0220867
  • DOI: 10.1371/journal.pone.0220867
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Data-driven approaches for surface materials and beyond (2022)
  • Author(s): Daniel Packwood
  • Organizer: IMI Workshop for the Join Research Projects in Kyushu University: Perspectives on Artificial Intelligence and Machine Learning in Materials Science
  • Int'l Joint Research / Invited
• [Presentation] 栄養素結合体の化学コミュニケーション (2021)
  • Author(s): 上杉 志成
  • Organizer: 新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第8回公開シンポジウム
  • Invited
• [Presentation] 自己集合性ワクチンアジュバントの発見 (2021)
  • Author(s): 上杉 志成
  • Organizer: 第94回日本生化学会大会 創薬を志向したケミカルバイオロジー
  • Invited
• [Presentation] Self-Assembling Bioactive Small Molecules (2021)
  • Author(s): Motonari Uesugi
  • Organizer: Pacifichem2021: New Frontier of Chemical Probes Exploring Biology and Medicine
  • Int'l Joint Research / Invited
• [Presentation] Identification of Protein Targets of Lactone-Vitamin D3 (2021)
  • Author(s): Motonari Uesugi
  • Organizer: Pacifichem2021: Drug-Discovery Based on Natural Products Chemistry; Isolation, Synthesis, and Biosynthesis
  • Int'l Joint Research / Invited
• [Presentation] Kinetics of FcRγ signaling determines distinct cellular responses by altering chromatin status (2021)
  • Author(s): Miyuki Watanabe, Sho Yamasaki
  • Organizer: Cold Spring Harbor Asia Virtual meeting on Immunoreceptor Signalling: from Bench to Bed
  • Int'l Joint Research
• [Presentation] 感染に対する免疫応答と疾患 (2021)
  • Author(s): 山﨑 晶
  • Organizer: 【慶應医学部】第7回新次元開拓セミナー
  • Invited
• [Presentation] Learning from mycobacteria to tackle pandemic (2021)
  • Author(s): 山﨑 晶
  • Organizer: 第16回国際エンドトキシン・自然免疫学会
  • Int'l Joint Research / Invited
• [Presentation] スフィンゴ脂質蓄積による疾患と発症機構 (2021)
  • Author(s): 山﨑 晶
  • Organizer: 第94回日本生化学会
  • Invited
• [Presentation] 結核菌糖脂質アナログを活用する選択的T細胞活性化 (2021)
  • Author(s): 山﨑 晶
  • Organizer: 次世代アジュバント研究会
  • Invited
• [Presentation] Self-Assembling Bioactive Small Molecules (2021)
  • Author(s): Motonari Uesugi
  • Organizer: ACBI 2021 Online Meeting
  • Int'l Joint Research / Invited
• [Presentation] Cardiac Regeneration via Pluripotent Stem Cells. (2021)
  • Author(s): Yuji Shiba
  • Organizer: Myocardial Ischemia Symposium in Korea 2021
  • Int'l Joint Research / Invited
• [Presentation] 霊長類を用いた心筋再生治療の開発 (2021)
  • Author(s): 柴 祐司
  • Organizer: 第20回日本再生医療学会総会
  • Invited
• [Presentation] Primate model for allogeneic transplantation study of iPS cell-derived cardiomyocytes. (2021)
  • Author(s): 柴 祐司
  • Organizer: 第85回日本循環器学会学術集会
  • Invited
• [Presentation] 生理活性化合物の新しい世界 (2020)
  • Author(s): 上杉 志成
  • Organizer: 近畿化学協会合成部会 令和2年度第1回合成フォーラム（招待講演）
  • Invited
• [Presentation] Lipid Control by Vitamin D (2020)
  • Author(s): Motonari Uesugi
  • Organizer: The 8th Seoul Symposium on Bone Health (SSBH)
  • Int'l Joint Research / Invited
• [Presentation] 自己集合性ワクチンアジュバントの発見 (2020)
  • Author(s): 上杉 志成
  • Organizer: 化学コミュニ第2回領域リトリート
  • Invited
• [Presentation] New Directions of Chemical Biology: Self-Assembling Chemicals as New Vaccine Adjuvants (2020)
  • Author(s): Motonari Uesugi
  • Organizer: Fudan University International Academic Forum
  • Int'l Joint Research / Invited
• [Presentation] Self-Assembling Bioactive Small Molecules (2020)
  • Author(s): Motonari Uesugi
  • Organizer: Shanghai-Kyoto Chemistry Forum 2020
  • Int'l Joint Research / Invited
• [Presentation] iPS細胞を用いた心筋梗塞治療 (2020)
  • Author(s): 柴 祐司
  • Organizer: 第19回日本再生医療学会総会
  • Invited
• [Presentation] Preclinical transplantation studies of pluripotent stem cell-derived cardiomyocytes for cardiac repair. (2020)
  • Author(s): Yuji Shiba
  • Organizer: Myocardial Ischemia Symposium in Korea 2020
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2020)
  • Author(s): 上杉 志成
  • Organizer: 神奈川大学講演会
  • Invited
• [Presentation] New Opportunities of Synthetic Bioactive Molecules (2020)
  • Author(s): Motonari Uesugi
  • Organizer: IIT Bombay Research Seminar
  • Int'l Joint Research / Invited
• [Presentation] New Opportunities of Synthetic Bioactive Molecules (2020)
  • Author(s): Motonari Uesugi
  • Organizer: CSIR-Indian Institute of Chemical Biology
  • Int'l Joint Research / Invited
• [Presentation] Bioactive Self-Assembling Molecules (2019)
  • Author(s): Motonari Uesugi
  • Organizer: Gordon Research Conference: Self-Assembly and Supramolecular Chemistry
  • Int'l Joint Research
• [Presentation] Self-Assembling Bioactive Molecules (2019)
  • Author(s): Motonari Uesugi
  • Organizer: Academia Sinica / iCeMS Joint Symposium
  • Int'l Joint Research / Invited
• [Presentation] Self-Assembling Bioactive Small Molecules (2019)
  • Author(s): Motonari Uesugi
  • Organizer: 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] Synthetic Small Molecule Tools for Cell Biology (2019)
  • Author(s): Motonari Uesugi
  • Organizer: IUPAC International Symposium on Bioorganic Chemistry (ISBOC-12)
  • Int'l Joint Research / Invited
• [Presentation] 生理活性合成化合物の新しい世界 (2019)
  • Author(s): 上杉 志成
  • Organizer: 東京大学農学部講演会
  • Invited
• [Presentation] Sensing infectious and injurious stimuli by immune receptors for lipids (2019)
  • Author(s): Sho Yamasaki
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research / Invited
• [Presentation] Sensing environmental lipids and metabolites via immune receptors (2019)
  • Author(s): Sho Yamasaki
  • Organizer: The 1st UCL-OU Joint Symposium on Immunology
  • Int'l Joint Research / Invited
• [Presentation] Recognition of bacterial glycolipids via host immune receptors (2019)
  • Author(s): Sho Yamasaki
  • Organizer: 25th International symposium on glycoconjugates
  • Int'l Joint Research / Invited
• [Presentation] Lipid recognition through Immune receptors (2019)
  • Author(s): Sho Yamasaki
  • Organizer: International ITU Molecular Biology and Genetics Student Congress’19
  • Int'l Joint Research / Invited
• [Presentation] Regulation of immune responses via glycolipid sensors (2019)
  • Author(s): Sho Yamasaki
  • Organizer: KAI International Meeting 2019
  • Int'l Joint Research / Invited
• [Presentation] Sensing infectious and injurious stimuli by C-type lectin receptors (2019)
  • Author(s): Sho Yamasaki
  • Organizer: 11th ACGG (Asian Community of Glycoscience and Glycotechnology)
  • Int'l Joint Research / Invited
• [Book] Cell-Inspired Materials and Engineering: Machine Learning and Monte Carlo Methods for Surface-Assisted Molecular Self-Assembly (2021)
  • Author(s): Daniel Packwood
  • Publisher: Springer
• [Remarks] 京都大学化学研究所上杉研究室
  • URL: https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php
• [Remarks] 大阪大学微生物研究所山崎研究室
  • URL: http://molimm.biken.osaka-u.ac.jp
• [Remarks] 京都大学高等研究院物質-細胞統合システム拠点Packwood研究室
  • URL: http://www.packwood.icems.kyoto-u.ac.jp/
• [Remarks] 京都大学化学研究所倉田研究室
  • URL: https://eels.kuicr.kyoto-u.ac.jp/
• [Remarks] 信州大学バイオメディカル研究所・医学部再生医科学教室
  • URL: https://yshiba425.wixsite.com/regeneration
• [Remarks] 京都大学化学研究所倉田研究室
  • URL: http://eels.kuicr.kyoto-u.ac.jp/Root/