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Healthy Livestock Production Strategy by Enhancing Anti-Disease Synergy between Breeding and Feeding via the Endogenous Antimicrobial Factor PGRP

Research Project

Project/Area Number 19H00965
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Research InstitutionTohoku University

Principal Investigator

Kitazawa Haruki  東北大学, 農学研究科, 教授 (10204885)

Co-Investigator(Kenkyū-buntansha) 大坪 和香子  東北大学, 農学研究科, 助教 (00598203)
野地 智法  東北大学, 農学研究科, 教授 (10708001)
宗田 吉広  国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, 上級研究員 (20391451)
宮崎 綾子  国立研究開発法人農業・食品産業技術総合研究機構, 動物衛生研究部門, 上級研究員 (30355169)
麻生 久  東北大学, 農学研究科, 教授 (50241625)
上西 博英  国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, グループ長 (80391556)
須田 義人  宮城大学, 食産業学群, 教授 (90404847)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2022: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2021: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2020: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2019: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Keywords(ポスト)イムノバイオティクス / 抗病性育種 / 健全畜産 / ブタ / 抗菌因子 / イムノバイオティクス
Outline of Research at the Start

薬剤耐性菌感染症の世界的拡大を受け、耐性菌の出現と拡散を防ぐ人獣横断的な取組みが課題となっている。養豚では、下痢等常在疾病対策を目的とした抗菌剤の多用が懸案であり、抗菌剤に依存しない常在疾病対策法による家畜健全育成技術の向上が喫緊の課題である。本研究では、内在性抗菌因子(ペプチドグリカン認識タンパク質;PGRP)に着目し、抗病性分子遺伝育種と抗病性イムノバイオティクス飼養の融合によるシナジー強化から抗菌剤に依存しない新たな家畜の抗病性機能強化基盤を構築する。

Outline of Final Research Achievements

In response to the global spread of antimicrobial-resistant bacterial infections, there is an urgent need to improve livestock healthy growing techniques using endemic disease control methods without antimicrobials. In this study, we focused on endogenous antimicrobial factors (peptidoglycan recognition proteins; PGRPs) in pigs and aimed to establish a foundation for enhancing antimicrobial synergy in livestock as an alternative antimicrobial system by integrating genetic breeding and immunobiotic feeding techniques. We were able to elucidate part of the relationship between genetic polymorphisms of PGRP and disease-related traits in pigs and select candidate strains of immunobiotics with PGRP-enhancing activity and evaluate their mechanisms in vitro and in vivo. These results will contribute to the establishment of a new foundation for healthy livestock strategy as an alternative to antimicrobials.

Academic Significance and Societal Importance of the Research Achievements

抗菌薬が効かない薬剤耐性菌による感染症の世界的拡大の加速を受け、薬剤耐性菌の出現と拡散を防ぐ人獣横断的な取り組みが求められている。中でも養豚では、成長促進や下痢・肺炎等の常在疾病対策を目的とした抗菌剤使用が国内使用量の約7割を占めており、抗菌剤に依存しない常在疾病対策法による家畜健全育成技術の飛躍的向上が切望されている。本研究成果により、豚が本来有する内在性抗菌因子に着目し、遺伝育種学的手法とイムノバイオティクス飼養管理手法の技術を融合することで、抗菌剤のみに依存しない家畜の抗病性シナジー強化から、抗菌剤代替の新たな家畜健全育成基盤の確立に貢献することができ、学術および社会的意義は極めて高い。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (112 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (7 results) Journal Article (51 results) (of which Int'l Joint Research: 49 results,  Peer Reviewed: 50 results,  Open Access: 44 results) Presentation (43 results) (of which Int'l Joint Research: 12 results,  Invited: 12 results) Book (6 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] CERELA-CONICET(アルゼンチン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] コンセプシオン大学(チリ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] CERELA-CONICET(アルゼンチン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Concepcion(チリ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Bangladesh Agricultural University(バングラデシュ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] CERELA-CONICET(アルゼンチン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Utrecht University(オランダ)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] The Respiratory Commensal Bacterium Corynebacterium pseudodiphtheriticum as a Mucosal Adjuvant for Nasal Vaccines2023

    • Author(s)
      Ortiz Moyano Ramiro、Raya Tonetti Fernanda、Fukuyama Kohtaro、Elean Mariano、Tomokiyo Mikado、Suda Yoshihito、Melnikov Vyacheslav、Kitazawa Haruki、Villena Julio
    • Journal Title

      Vaccines

      Volume: 11:611 Issue: 3 Pages: 1-14

    • DOI

      10.3390/vaccines11030611

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 豚のオミクス解析と疾病に関する最近の話題と研究2023

    • Author(s)
      宗田吉広, 関山恭代, 須田智子, 宮崎綾子, 新開浩樹, 廣瀬健右, 上西博英, 北澤春樹
    • Journal Title

      豚病会報

      Volume: 81 Pages: 30-38

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lactiplantibacillus plantarum Strains Modulate Intestinal Innate Immune Response and Increase Resistance to Enterotoxigenic Escherichia coli Infection2022

    • Author(s)
      Baillo Ayelen、Villena Julio、Albarracin Leonardo、Tomokiyo Mikado、Elean Mariano、Fukuyama Kohtaro、Quilodran-Vega Sandra、Fadda Silvina、Kitazawa Haruki
    • Journal Title

      Microorganisms

      Volume: 11:63 Issue: 1 Pages: 1-17

    • DOI

      10.3390/microorganisms11010063

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Mucus Binding Factor Is Not Necessary for Lacticaseibacillus rhamnosus CRL1505 to Exert Its Immunomodulatory Activities in Local and Distal Mucosal Sites2022

    • Author(s)
      Tomotsune Kae、Raya Tonetti Fernanda、Mizuno Hiroya、Elean Mariano、Fukuyama Kohtaro、Zhou Binghui、Ikeda-Ohtsubo Wakako、Nishiyama Keita、Yamamura Akihiro、Karasawa Hideaki、Ohnuma Shinobu、Horii Akira、Saito Tadao、Kitazawa Haruki、Villena Julio
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23:14357 Issue: 22 Pages: 1-17

    • DOI

      10.3390/ijms232214357

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunomodulatory Effects of Probiotics: A Novel Preventive Approach for the Control of Bovine Mastitis2022

    • Author(s)
      Kober A. K. M. Humayun、Saha Sudeb、Islam Md. Aminul、Rajoka Muhammad Shahid Riaz、Fukuyama Kohtaro、Aso Hisashi、Villena Julio、Kitazawa Haruki
    • Journal Title

      Microorganisms

      Volume: 10:2255 Issue: 11 Pages: 1-17

    • DOI

      10.3390/microorganisms10112255

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Ability of Postimmunobiotics from L. rhamnosus CRL1505 to Protect against Respiratory Syncytial Virus and Pneumococcal Super-Infection Is a Strain-Dependent Characteristic2022

    • Author(s)
      Raya Tonetti Fernanda、Clua Patricia、Fukuyama Kohtaro、Marcial Guillermo、Sacur Jacinto、Marranzino Gabriela、Tomokiyo Mikado、Vizoso-Pinto Guadalupe、Garcia-Cancino Apolinaria、Kurata Shoichiro、Kitazawa Haruki、Villena Julio
    • Journal Title

      Microorganisms

      Volume: 10:2185 Issue: 11 Pages: 1-22

    • DOI

      10.3390/microorganisms10112185

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lactiplantibacillus plantarum LOC1 Isolated from Fresh Tea Leaves Modulates Macrophage Response to TLR4 Activation2022

    • Author(s)
      Suzuki Masahiko、Albarracin Leonardo、Tsujikawa Yuji、Fukuyama Kohtaro、Sakane Iwao、Villena Julio、Kitazawa Haruki
    • Journal Title

      Foods

      Volume: 11:3257 Issue: 20 Pages: 1-24

    • DOI

      10.3390/foods11203257

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of Alveolar Macrophages by Postimmunobiotics: Impact on TLR3-Mediated Antiviral Respiratory Immunity2022

    • Author(s)
      Tomokiyo Mikado、Tonetti Fernanda Raya、Yamamuro Hikari、Shibata Ryoko、Fukuyama Kohtaro、Gobbato Nadia、Albarracin Leonardo、Rajoka Muhammad Shahid Riaz、Kober A. K. M. Humayun、Ikeda-Ohtsubo Wakako、Villena Julio、Kitazawa Haruki
    • Journal Title

      Cells

      Volume: 11:2986 Issue: 19 Pages: 1-23

    • DOI

      10.3390/cells11192986

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Respiratory Commensal Bacteria Increase Protection against Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Infection2022

    • Author(s)
      Dentice Maidana Stefania、Ortiz Moyano Ramiro、Vargas Juan Martin、Fukuyama Kohtaro、Kurata Shoichiro、Melnikov Vyacheslav、Jure Maria Angela、Kitazawa Haruki、Villena Julio
    • Journal Title

      Pathogens

      Volume: 11:1063 Issue: 9 Pages: 1-11

    • DOI

      10.3390/pathogens11091063

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic Characterization of Lactiplantibacillus plantarum Strains Possessing Differential Antiviral Immunomodulatory Activities2022

    • Author(s)
      Albarracin Leonardo、Raya Tonetti Fernanda、Fukuyama Kohtaro、Suda Yoshihito、Zhou Binghui、Baillo Ayelen A.、Fadda Silvina、Saavedra Lucila、Kurata Shoichiro、Hebert Elvira M.、Kitazawa Haruki、Villena Julio
    • Journal Title

      Bacteria

      Volume: 1 Issue: 3 Pages: 136-160

    • DOI

      10.3390/bacteria1030012

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic and Immunological Characterization of Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Isolates from Northwest Argentina2022

    • Author(s)
      Albarracin Leonardo、Ortiz Moyano Ramiro、Vargas Juan Martin、Andrade Bruno G. N.、Cortez Zamar Juan、Dentice Maidana Stefania、Fukuyama Kohtaro、Kurata Shoichiro、Jure Maria Angela、Kitazawa Haruki、Villena Julio
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23:7361 Issue: 13 Pages: 1-20

    • DOI

      10.3390/ijms23137361

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Editorial: Malnutrition and Infections2022

    • Author(s)
      Villena Julio、Kitazawa Haruki、Al Kassaa Imad、Alvarez Susana
    • Journal Title

      Frontiers in Nutrition

      Volume: 9:897780 Pages: 1-2

    • DOI

      10.3389/fnut.2022.897780

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of respiratory microbiota in the protection against viral diseases: respiratory commensal bacteria as next-generation probiotics for COVID-192022

    • Author(s)
      ANDRADE Bruno G. N.、CUADRAT Rafael R. C.、TONETTI Fernanda Raya、KITAZAWA Haruki、VILLENA Julio
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 41 Issue: 3 Pages: 94-102

    • DOI

      10.12938/bmfh.2022-009

    • ISSN
      2186-3342
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunomodulation Potential of Probiotics: A Novel Strategy for Improving Livestock Health, Immunity, and Productivity2022

    • Author(s)
      Kober A. K. M. Humayun、Riaz Rajoka Muhammad Shahid、Mehwish Hafiza Mahreen、Villena Julio、Kitazawa Haruki
    • Journal Title

      Microorganisms

      Volume: 10:388 Issue: 2 Pages: 1-21

    • DOI

      10.3390/microorganisms10020388

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Soymilk-fermented with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L improves immune-health in pigs2022

    • Author(s)
      Suda Y.、Kagawa K.、Fukuyama K.、Elean M.、Zhou B.、Tomokiyo M.、Islam M. Aminul、Rajoka M.S.R.、Kober A.K.M. Humayun、Shimazu T.、Egusa S.、Terashima Y.、Aso H.、Ikeda-Ohtsubo W.、Villena J.、Kitazawa H.
    • Journal Title

      Beneficial Microbes

      Volume: 13(1) Issue: 1 Pages: 61-72

    • DOI

      10.3920/bm2021.0068

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lactobacillus delbrueckii CRL 581 Differentially Modulates TLR3-Triggered Antiviral Innate Immune Response in Intestinal Epithelial Cells and Macrophages2021

    • Author(s)
      Elean Mariano、Albarracin Leonardo、Fukuyama Kohtaro、Zhou Binghui、Tomokiyo Mikado、Kitahara Shugo、Araki Shota、Suda Yoshihito、Saavedra Lucila、Villena Julio、Hebert Elvira M.、Kitazawa Haruki
    • Journal Title

      Microorganisms

      Volume: 9:2449 Issue: 12 Pages: 1-18

    • DOI

      10.3390/microorganisms9122449

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunobiotic Lactobacilli Improve Resistance of Respiratory Epithelial Cells to SARS-CoV-2 Infection2021

    • Author(s)
      Islam Md. Aminul、Albarracin Leonardo、Tomokiyo Mikado、Valdez Juan Carlos、Sacur Jacinto、Vizoso-Pinto Maria Guadalupe、Andrade Bruno G. N.、Cuadrat Rafael R. C.、Kitazawa Haruki、Villena Julio
    • Journal Title

      Pathogens

      Volume: 10:1197 Issue: 9 Pages: 1-16

    • DOI

      10.3390/pathogens10091197

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris2021

    • Author(s)
      Espinoza-Monje Marcela、Campos Jorge、Alvarez Villamil Eduardo、Jerez Alonso、Dentice Maidana Stefania、Elean Mariano、Salva Susana、Kitazawa Haruki、Villena Julio、Garcia-Cancino Apolinaria
    • Journal Title

      Microorganisms

      Volume: 9:1486 Issue: 7 Pages: 1-24

    • DOI

      10.3390/microorganisms9071486

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Draft genome sequences of two hypermucoviscous carbapenem-resistant ST25 Klebsiella pneumoniae strains causing respiratory and systemic infections2021

    • Author(s)
      Jure Maria Angela、Albarracin Leonardo、Vargas Juan Martin、Maidana Stefania Dentice、Zamar Juan Cortez、Kitazawa Haruki、Villena Julio
    • Journal Title

      Journal of Global Antimicrobial Resistance

      Volume: 26 Pages: 174-176

    • DOI

      10.1016/j.jgar.2021.05.018

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae2021

    • Author(s)
      Raya Tonetti Fernanda、Tomokiyo Mikado、Ortiz Moyano Ramiro、Quilodran-Vega Sandra、Yamamuro Hikari、Kanmani Paulraj、Melnikov Vyacheslav、Kurata Shoichiro、Kitazawa Haruki、Villena Julio
    • Journal Title

      Microorganisms

      Volume: 9:1324 Issue: 6 Pages: 1-19

    • DOI

      10.3390/microorganisms9061324

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of Porcine Intestinal Epitheliocytes as an In vitro Immunoassay System for the Selection of Probiotic Bifidobacteria to Alleviate Inflammatory Bowel Disease2021

    • Author(s)
      Sato Nana、Yuzawa Mao、Aminul Md Islam、Tomokiyo Mikado、Albarracin Leonardo、Garcia-Castillo Valeria、Ideka-Ohtsubo Wakako、Iwabuchi Noriyuki、Xiao Jin-zhong、Garcia-Cancino Apolinaria、Villena Julio、Kitazawa Haruki
    • Journal Title

      Probiotics and Antimicrobial Proteins

      Volume: 13(3) Issue: 3 Pages: 824-836

    • DOI

      10.1007/s12602-020-09694-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dolosigranulum pigrum Modulates Immunity against SARS-CoV-2 in Respiratory Epithelial Cells2021

    • Author(s)
      Islam Md. Aminul、Albarracin Leonardo、Melnikov Vyacheslav、Andrade Bruno G. N.、Cuadrat Rafael R. C.、Kitazawa Haruki、Villena Julio
    • Journal Title

      Pathogens

      Volume: 10:634 Issue: 6 Pages: 1-11

    • DOI

      10.3390/pathogens10060634

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection2021

    • Author(s)
      Yuhki Indo, Shugo Kitahara, Mikado Tomokiyo, Shota Araki, Md Aminul Islam, Binghui Zhou, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa
    • Journal Title

      Front Immunol

      Volume: 12 Pages: 652923-652923

    • DOI

      10.3389/fimmu.2021.652923

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunobiotic Feed Developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the Soymilk By-Product Okara Improves Health and Growth Performance in Pigs2021

    • Author(s)
      Suda Yoshihito、Sasaki Nana、Kagawa Kyoma、Elean Mariano、Zhou Binghui、Tomokiyo Mikado、Islam Md. Aminul、Rajoka Muhammad Shahid Riaz、Kober A. K. M. Humayun、Shimazu Tomoyuki、Egusa Shintaro、Terashima Yuji、Aso Hisashi、Ikeda-Ohtsubo Wakako、Villena Julio、Kitazawa Haruki
    • Journal Title

      Microorganisms

      Volume: 9:921 Issue: 5 Pages: 1-18

    • DOI

      10.3390/microorganisms9050921

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Dietary Supplementation of Immunobiotic Lactiplantibacillusplantarum N14 Fermented Rakkyo (Allium chinense) Pickled Juice on the Immunocompetence and Production Performance of Pigs2021

    • Author(s)
      Islam Md. Aminul、Hashiguchi Kenji、Kober A.K.M. Humayun、Morie Kyoko、Zhou Binghui、Tomokiyo Mikado、Shimazu Tomoyuki、Aso Hisashi、Villena Julio、Suda Yoshihito、Kitazawa Haruki
    • Journal Title

      Animals

      Volume: 11 Issue: 3 Pages: 752-752

    • DOI

      10.3390/ani11030752

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lactiplantibacillus plantarum as a Potential Adjuvant and Delivery System for the Development of SARS-CoV-2 Oral Vaccines2021

    • Author(s)
      Villena Julio、Li Chang、Vizoso-Pinto Maria Guadalupe、Sacur Jacinto、Ren Linzhu、Kitazawa Haruki
    • Journal Title

      Microorganisms

      Volume: 9 Issue: 4 Pages: 683-683

    • DOI

      10.3390/microorganisms9040683

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Selection of Immunobiotic Ligilactobacillus salivarius Strains from the Intestinal Tract of Wakame-Fed Pigs: Functional and Genomic Studies2020

    • Author(s)
      Binghui Zhou, Leonardo Albarracin, Yuhki Indo, Lorena Arce, Yuki Masumizu, Mikado Tomokiyo, Md. Aminul Islam, Valeria Garcia-Castillo, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Hidetoshi Morita, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 11 Pages: 1659-1659

    • DOI

      10.3390/microorganisms8111659

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional and Genomic Characterization of Ligilactobacillus salivarius TUCO-L2 Isolated From Lama glama Milk: A Promising Immunobiotic Strain to Combat Infections2020

    • Author(s)
      Quilodran-Vega Sandra、Albarracin Leonardo、Mansilla Flavia、Arce Lorena、Zhou Binghui、Islam Md Aminul、Tomokiyo Mikado、Al Kassaa Imad、Suda Yoshihito、Kitazawa Haruki、Villena Julio
    • Journal Title

      Frontiers in Microbiology

      Volume: 11

    • DOI

      10.3389/fmicb.2020.608752

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Alveolar Macrophages Are Key Players in the Modulation of the Respiratory Antiviral Immunity Induced by Orally Administered Lacticaseibacillus rhamnosus CRL15052020

    • Author(s)
      Garcia-Castillo Valeria、Tomokiyo Mikado、Raya Tonetti Fernanda、Islam Md. Aminul、Takahashi Hideki、Kitazawa Haruki、Villena Julio
    • Journal Title

      Frontiers in Immunology

      Volume: 11

    • DOI

      10.3389/fimmu.2020.568636

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Draft Genome Sequence of Ligilactobacillus salivarius FFIG58, Isolated from the Intestinal Tract of Wakame-Fed Pig2020

    • Author(s)
      Zhou Binghui、Albarracin Leonardo、Masumizu Yuki、Indo Yuhki、Islam M. Aminul、Garcia-Castillo Valeria、Ikeda-Ohtsubo Wakako、Suda Yoshihito、Aso Hisashi、Villena Julio、Kitazawa Haruki
    • Journal Title

      Microbiology Resource Announcements

      Volume: 9 Issue: 34

    • DOI

      10.1128/mra.00839-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Draft Genome Sequence of Ligilactobacillus salivarius TUCO-L2, Isolated from Lama glama Milk2020

    • Author(s)
      Albarracin Leonardo、Quilodran-Vega Sandra、Fukuyama Kohtaro、Tomokiyo Mikado、Islam M. Aminul、Arce Lorena、Kitazawa Haruki、Villena Julio
    • Journal Title

      Microbiology Resource Announcements

      Volume: 9 Issue: 32

    • DOI

      10.1128/mra.00784-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunobiotic Lactobacillus jensenii TL2937 Alleviates Dextran Sodium Sulfate-Induced Colitis by Differentially Modulating the Transcriptomic Response of Intestinal Epithelial Cells2020

    • Author(s)
      Sato Nana、Garcia-Castillo Valeria、Yuzawa Mao、Islam Md. Aminul、Albarracin Leonardo、Tomokiyo Mikado、Ikeda-Ohtsubo Wakako、Garcia-Cancino Apolinaria、Takahashi Hideki、Villena Julio、Kitazawa Haruki
    • Journal Title

      Frontiers in Immunology

      Volume: 11

    • DOI

      10.3389/fimmu.2020.02174

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New immunobiotics from highly proteolytic Lactobacillus delbrueckii strains: their impact on intestinal antiviral innate immune response2020

    • Author(s)
      Elean M.、Albarracin L.、Cataldo P.G.、Londero A.、Kitazawa H.、Saavedra L.、Villena J.、Hebert E.M.
    • Journal Title

      Beneficial Microbes

      Volume: 11 Issue: 4 Pages: 375-390

    • DOI

      10.3920/bm2019.0198

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Role of Alveolar Macrophages in the Improved Protection against Respiratory Syncytial Virus and Pneumococcal Superinfection Induced by the Peptidoglycan of Lactobacillus rhamnosus CRL15052020

    • Author(s)
      Clua Patricia、Tomokiyo Mikado、Raya Tonetti Fernanda、Islam Md. Aminul、Garc?a Castillo Valeria、Marcial Guillermo、Salva Susana、Alvarez Susana、Takahashi Hideki、Kurata Shoichiro、Kitazawa Haruki、Villena Julio
    • Journal Title

      Cells

      Volume: 9 Issue: 7 Pages: 1653-1653

    • DOI

      10.3390/cells9071653

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic?2020

    • Author(s)
      Villena Julio、Kitazawa Haruki
    • Journal Title

      Frontiers in Physiology

      Volume: 11

    • DOI

      10.3389/fphys.2020.00699

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the Immunomodulatory Ability of Lactic Acid Bacteria Isolated from Feedlot Cattle Against Mastitis Using a Bovine Mammary Epithelial Cells In Vitro Assay2020

    • Author(s)
      Fukuyama Kohtaro、Islam Md. Aminul、Takagi Michihiro、Ikeda-Ohtsubo Wakako、Kurata Shoichiro、Aso Hisashi、Vignolo Graciela、Villena Julio、Kitazawa Haruki
    • Journal Title

      Pathogens

      Volume: 9 Issue: 5 Pages: 410-410

    • DOI

      10.3390/pathogens9050410

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exopolysaccharides from Streptococcus thermophilus ST538 modulate the antiviral innate immune response in porcine intestinal epitheliocytes.2020

    • Author(s)
      Mizuno H, Tomotsune K, Islam MA, Funabashi R, Albarracin L, Ikeda-Ohtsubo W, Aso H, Takahashi H, Kimura K, Villena J, Sasaki Y and Kitazawa H
    • Journal Title

      Frontiers in Microbiology

      Volume: 11 Pages: 894-894

    • DOI

      10.3389/fmicb.2020.00894

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic2020

    • Author(s)
      Ortiz Moyano Ramiro、Raya Tonetti Fernanda、Tomokiyo Mikado、Kanmani Paulraj、Vizoso-Pinto Maria Guadalupe、Kim Hojun、Quilodr?n-Vega Sandra、Melnikov Vyacheslav、Alvarez Susana、Takahashi Hideki、Kurata Shoichiro、Kitazawa Haruki、Villena Julio
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 5 Pages: 727-727

    • DOI

      10.3390/microorganisms8050727

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of Toll-like receptor-mediated innate immunity in bovine intestinal epithelial cells by lactic acid bacteria isolated from feedlot cattle2020

    • Author(s)
      Mansilla F.、Takagi M.、Garcia-Castillo V.、Aso H.、Nader-Macias M.E.、Vignolo G.、Kitazawa H.、Villena J.
    • Journal Title

      Beneficial Microbes

      Volume: 11 Issue: 3 Pages: 269-282

    • DOI

      10.3920/bm2019.0189

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lipoteichoic acid is involved in the ability of the immunobiotic strain Lactobacillus plantarum CRL1506 to modulate the intestinal antiviral innate immunity triggered by TLR3 activation.2020

    • Author(s)
      Hiroya Mizuno, Lorena Arce, Kae Tomotsune, Leonardo Albarracin, Ryutaro Funabashi, Daniela Vera, Md. Aminul Islam, Maria Guadalupe Vizoso-Pinto, Hideki Takahashi, Yasuko Sasaki, Haruki Kitazawa and Julio Villena
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 571-571

    • DOI

      10.3389/fimmu.2020.00571

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ブタ由来乳酸桿菌ライブラリーの構築とイムノバイオティック評価2020

    • Author(s)
      扇 隆介、北澤春樹
    • Journal Title

      日本食品免疫学会会報(学会創立15周年記念号)

      Volume: 15 Pages: 6-6

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes2020

    • Author(s)
      Leonardo, A., V. Garcia-Castillo, H. Kitazawa et al.
    • Journal Title

      Frontiers in Immunology

      Volume: 11:543 Pages: 1-16

    • DOI

      10.3389/fimmu.2020.00543

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Exopolysaccharide of Lactobacillus fermentum UCO-979C Is Partially Involved in Its Immunomodulatory Effect and Its Ability to Improve the Resistance against Helicobacter pylori Infection2020

    • Author(s)
      Garcia-Castillo, V., H. Kitazawa et al.
    • Journal Title

      Microorganisms

      Volume: 8:479 Issue: 4 Pages: 1-20

    • DOI

      10.3390/microorganisms8040479

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptome Analysis of The Inflammatory Responses of Bovine Mammary Epithelial Cells: Exploring Immunomodulatory Target Genes for Bovine Mastitis2020

    • Author(s)
      Islam, Md. A., T. Michihiro, K. Fukuyama, H. Kitazawa et al.
    • Journal Title

      Pathogens

      Volume: 9:200 Issue: 3 Pages: 1-18

    • DOI

      10.3390/pathogens9030200

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In-Vitro Cell Culture for Efficient Assessment of Mycotoxin Exposure, Toxicity and Risk Mitigation2020

    • Author(s)
      Xu, R., N. A. Karrow H. Kitazawa et al.
    • Journal Title

      Toxins

      Volume: 12:146 Issue: 3 Pages: 1-31

    • DOI

      10.3390/toxins12030146

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunomodulatory properties of bacterium-like particles obtained from immunobiotic lactobacilli: prospects for their use as mucosal adjuvants.2020

    • Author(s)
      Raya F, Arce L, Salva S, Alvarez S, Takahashi H, Kitazawa H, Villena J, Vizoso-Pinto, MG
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 1-13

    • DOI

      10.3389/fimmu.2020.00015

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nasal priming with immunobiotic lactobacilli improves the adaptive immune response against influenza virus.2020

    • Author(s)
      Raya F, Islam MA, Vizoso-Pinto MG, Takahashi H, Kitazawa H, Villena J
    • Journal Title

      International Immunopharmacology

      Volume: 78 Pages: 1-12

    • DOI

      10.1016/j.intimp.2019.106115

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A2019

    • Author(s)
      Garcia-Castillo, V., H. Kitazawa et al.
    • Journal Title

      Biofouling

      Volume: 35 Issue: 8 Pages: 922-937

    • DOI

      10.1080/08927014.2019.1675153

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Paraimmunobiotic Bifidobacteria Modulate the Expression Patterns of Peptidoglycan Recognition Proteins in Porcine Intestinal Epitheliocytes and Antigen Presenting Cells2019

    • Author(s)
      Iida, H., M. Tohno, Md. A. Islam, H. Kitazawa et al.
    • Journal Title

      Cells

      Volume: 8:891 Issue: 8 Pages: 1-22

    • DOI

      10.3390/cells8080891

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation and Immunocharacterization of Lactobacillus salivarius from the Intestine of Wakame-Fed Pigs to Develop Novel “Immunosynbiotics”2019

    • Author(s)
      Masumizu, Y., B. Zhou, H. Kitazawa et al.
    • Journal Title

      Microorganisms

      Volume: 7:167 Issue: 6 Pages: 1-17

    • DOI

      10.3390/microorganisms7060167

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptome Modifications in Porcine Adipocytes via Toll-Like Receptors Activation2019

    • Author(s)
      Igata Manami、Islam Md. Aminul、Tada Asuka、Takagi Michihiro、Kober A. K. M. Humayun、Albarracin Leonardo、Aso Hisashi、Ikeda-Ohtsubo Wakako、Miyazawa Kenji、Yoda Kazutoyo、He Fang、Takahashi Hideki、Villena Julio、Kitazawa Haruki
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 1-15

    • DOI

      10.3389/fimmu.2019.01180

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 緑茶葉より単離した乳酸菌のIL-12発現誘導の作用機序の解析2022

    • Author(s)
      鈴木 政彦、辻川 勇治、坂根 巌、Julio Villena、北澤春樹、薩 秀夫
    • Organizer
      日本食品免疫学会第18回学術大会(JAFI2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Lactobacillus delbrueckii TUA4408Lが生産する抗ウイルス性イムノジェニクスの解明2022

    • Author(s)
      今村圭哉、須田義人、北澤春樹(会員外:船橋龍太郎、荒木祥太、周冰 卉、大坪和香子、山下順弘、菅原 誠、Julio Villena、宮﨑綾子)
    • Organizer
      日本食品免疫学会第18回学術大会(JAFI2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Postimmunobiotics: promising alternatives to combat viral infectious diseases2022

    • Author(s)
      Haruki Kitazawa
    • Organizer
      The Special Seminar in INSIBIO
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Immunomodulatory potential of EPS produced by LAB for the dairy industry2022

    • Author(s)
      Hafiza Mahreen Mehwish, Md. Shahid Riaz Rajoka, KAKM Humayun Kober, Tomokiyo Mikado, Binghui Zhou, Wakako Ikeda-Ohtsubo, Haruki Kitazawa
    • Organizer
      日本畜産学会第130回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Evaluation of anti-inflammatory immunobiotics in bovine mammary epithelial cells2022

    • Author(s)
      福山 皓太朗, 高木 理宏, MD Aminul Islam、Muhammad, Shahid Riaz Rajoka, AKM, Humayun Kobe, 大坪 和香子, 野地 智, 麻生 久, Julio Villena, 北澤 春樹
    • Organizer
      日本畜産学会第130回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Advanced development of an in-vitro IBD model for the selection of immunobiotics2022

    • Author(s)
      笠原 日菜子, AKM Humayun Kober、Muhammad Shahid Riaz Rajoka, 周 冰卉, 大坪 和香子, Julio Villena, 北澤 春樹
    • Organizer
      日本畜産学会第130回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Basic research on growth improvement of immunosynbiotic2022

    • Author(s)
      周 冰卉, 劉 瑛琦, 櫻井 美月, AKM, Humayun Kober、Muhammad Shahid Riaz Rajoka, 大坪 和香子, Julio Villena, 北澤 春樹
    • Organizer
      日本畜産学会第130回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 「ポストイムノバイオティクス」の呼吸器モデル系による抗ウイルス免疫評価2022

    • Author(s)
      友清 帝, 山室 ひかり, 柴田 涼子, 福山 皓太朗, Leonardo Albarracin, 大坪 和香子, Julio Villena, 北澤 春樹
    • Organizer
      日本畜産学会第130回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ロタウイルス感染低減性イムノバイオティクスの選抜及び評価2022

    • Author(s)
      荒木祥多, 北原秀悟, 扇 隆介, 櫻井美月, 周 冰卉, 庄 涛, 宮﨑綾子, 宮澤光太郎, 大坪和香子, 麻生 久, 北澤春樹
    • Organizer
      酪農科学シンポジウム2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Survival of immunobiotics in the GI tract for immunosynbiotic development2022

    • Author(s)
      Binghui Zhou, AKM Humayun Kober, Muhammad Shahid Riaz Rajoka, Wakako Ikeda-Ohtsubo, Julio Villena, Haruki Kitazawa
    • Organizer
      酪農科学シンポジウム2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 乳酸桿菌表層タンパク由来イムノジェニクスの解明2022

    • Author(s)
      山室ひかり, 友清 帝, 柴田諒子, 周 冰卉, Julio Villena, Leonard Albarracin, 大坪和香子, 北澤春樹
    • Organizer
      酪農科学シンポジウム2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] (ポスト)イムノバイオティクス 免疫力を底上げする有用微生物の将来性2022

    • Author(s)
      北澤春樹
    • Organizer
      宮城県食品産業協議会 令和4年度記念講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 安全安心な持続的家畜生産に貢献するイムノバイオティクス ~モルッカの新たな一面~2022

    • Author(s)
      北澤春樹
    • Organizer
      国際養鶏養豚総合展(IPPS)2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 「次世代継承型イムノバイオティクス」の創成2022

    • Author(s)
      北澤春樹
    • Organizer
      第35回 秋田県 排尿・生殖研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 抗ウイルス性イムノバイオティクスの応用基盤研究2022

    • Author(s)
      北澤春樹
    • Organizer
      第55 回日本無菌生物ノートバイオロジー学会総会(シンポジウム1)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Antiviral immunobiotics and immunopostbiotics: promising alternatives to combat viral infectious diseases2021

    • Author(s)
      Haruki Kitazawa
    • Organizer
      The 11th Asian Conference for Lactic Acid Bacteria
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of in vitro evaluation system for immunobiotics and immunogenetics in swine2021

    • Author(s)
      Haruki Kitazawa
    • Organizer
      AGRITECH SEMINAR (Embassy of Belgium in Tokyo)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] イムノバオティクスの畜産応用基盤研究2021

    • Author(s)
      北澤春樹
    • Organizer
      日本乳酸菌学会設立30周年記念シンポジウム(多様な乳酸菌研究と乳酸菌利用の新たな潮流)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 健全畜産シナジー強化の創出2021

    • Author(s)
      北澤春樹
    • Organizer
      日本畜産学会第129回大会 メインシンポジウム「畜産学のレジリエンスと進化」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] (パラ)イムノバイオティクスの抗ウイルス食品・飼料免疫学的利用性2021

    • Author(s)
      北澤春樹
    • Organizer
      第25回 腸内細菌学会学術集会 シンポジウム2「感染症と腸内フローラ・腸管免疫」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Functional and genomic characterization of immunobiotic lactobacilli for immunosynbiotic development2021

    • Author(s)
      Binghui Zhou, Yuhki Indo, Leonardo Albarracin, Yuki Masumizu, Md Aminul Islam, Wakako Ikeda-Ohtsubo, Hisashi Aso, Julio Villena, Haruki Kitazawa
    • Organizer
      The 11th Asian Conference for Lactic Acid Bacteria
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ロタウイルス感染低減性イムノバイオティクスのインビトロ評価2021

    • Author(s)
      北原秀悟, 荒木祥多, 扇 隆介, 櫻井美月, 周 冰卉, 庄 涛, 宮崎綾子, 宮澤光太郎, 大坪和香子, 麻生 久, 北澤春樹
    • Organizer
      酪農科学シンポジウム2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Advanced in vitro evaluation to explore novel anti-rotavirus immunobiotics2021

    • Author(s)
      Shugo Kitahara, Shota Araki, Ryusuke Ogi, Mitsuki Sakurai, Binghui Zhou, Tao Zhuang, Ayako Miyazaki, Kohtaro Miyazawa, Wakako Ikeda-Ohtsubo, Hisashi Aso, Haruki Kitazawa
    • Organizer
      日本畜産学会第129回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of transgenerational immunobiotic library with innate immune activation2021

    • Author(s)
      Mitsuki Sakurai, Ryusuke Ohgi, Taiga Sakuma, Yuhka Nakano, Binghui Zhou, Yoshihito Suda, Md. Aminul Islam, Wakako Ikeda-Ohtsubo, Haruki Kitazawa
    • Organizer
      日本畜産学会第129回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 豚空腸オルガノイドを活用したイムノバイオティクス菌株のロタウイルス増殖抑制効果のex vivo評価2021

    • Author(s)
      宮﨑綾子, 宮澤光太郎, 西川明芳, 須田遊人, 岸田なつみ, 髙木道浩, 下地善弘, 鈴木香澄, 吉岡 豪, 北原秀悟, 荒木祥多, 扇 隆介, 友清 帝, 北澤 春樹
    • Organizer
      日本畜産学会第129回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Characterization of immunobiotics for survivability in the GI tract2021

    • Author(s)
      Binghui Zhou, Yuhki Indo, Leonardo Albarracin, Yuki Masumizu, Md Aminul Islam, Wakako Ikeda-Ohtsubo, Hisashi Aso, Julio Villena, Haruki Kitazawa
    • Organizer
      日本畜産学会第129回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Basic research on the development of immunosynbiotics2021

    • Author(s)
      Yingqi Liu, Binghui Zhou, Nozomi Oka, Kengo Matsuo, Hironori Takamori, Wakako Ikeda-Ohtsubo, Haruki Kitazawa
    • Organizer
      日本畜産学会第129回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Immunododulatory properties and the genomic studies of immunobiotics and immunosynbiotic characterization2021

    • Author(s)
      周 冰卉, 犬童 優樹, Leonardo Albarracin, 舛水 由季, Aminul Islam, 大坪 和香子, 麻生 久, Julio Villena, 北澤 春樹
    • Organizer
      日本畜産学会第128回大会(九大、オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Lactobacillus plantarum CRL1506における抗ウイルス性イムノジェニクスの解明2021

    • Author(s)
      舟橋 龍太郎, 水野 滉也, 友常 加恵, 友清 帝, Md. Aminul Islam, Leonardo Albarracin, 大坪 和香子, 麻生 久, Julio Villena, 北澤 春樹
    • Organizer
      日本畜産学会第128回大会(九大、オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ブタパターン認識受容体遺伝子型と抗病性関連形質との関連性2021

    • Author(s)
      一関 可純, 上西 博英, 松本 敏美, 岡 希, 高森 広典, 門脇 宏, 柴田 千尋, 鈴木 英作, 岡村 俊宏, 北澤 春樹, 麻生 久, 佐藤 正寛, 鈴木 啓一, 上本 吉伸
    • Organizer
      日本畜産学会第128回大会(九大、オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 植物性発酵乳における菌体外多糖の免疫活性2021

    • Author(s)
      仲田 創, 友清 帝, 北原 秀悟, 平光 正典, 井上 孝司, 北澤 春樹
    • Organizer
      日本農芸化学会2021年度大会(東北大、オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Role of lipoteichoic acid in the ability of Lactobacillus plantarum CRL1506 to modulate intestinal innate antiviral immune response2019

    • Author(s)
      Arce, L., Y. Suda, J. Villena, H. Kitazawa
    • Organizer
      日本食品免疫学会2019年度大会(JAFI 2019)設立15周年記念学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Selection of new immunobiotic strains with antiviral effect in local and distal mucosal sites by using porcine intestinal epitheliocytes2019

    • Author(s)
      Albarracin, L., Y. Suda, J. Villena, H. Kitazawa
    • Organizer
      日本食品免疫学会2019年度大会(JAFI 2019)設立15周年記念学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The molecular interaction of paraimmunobiotics and immunosynbiotics with intestinal epithelial cells and their influence in the resistance to infections2019

    • Author(s)
      Kitazawa, H., J. Villena
    • Organizer
      SYMPOSIUM I: INFECTION AND IMMUNITY, LXVII REUNION CIENTIFICA ANUAL de la Sociedad Argentina de Inmunologia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lactobacillus salivarius TUCO-L2 isolated from lama glama milk differentially modulate toll-like receptor 4-mediated innate immunity in porcine intestinal epithelial cells2019

    • Author(s)
      Mansilla, F., H. Kitazawa et al.
    • Organizer
      LXVII REUNION CIENTIFICA ANUAL de la Sociedad Argentina de Inmunologia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selection of porcine immunobiotics with the ability to improve innate antiviral immunity in porcine intestinal epithelial cells2019

    • Author(s)
      Indo, Y., H. Kitazawa et al.
    • Organizer
      LXVII REUNION CIENTIFICA ANUAL de la Sociedad Argentina de Inmunologia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of peptidoglycan recognition proteins-mediated porcine intestinal innate immunity by paraimmunobiotic bifidobacteria2019

    • Author(s)
      Islam, Md. A., H. Iida, M. Tohno, H. Kitazawa et al.
    • Organizer
      LXVII REUNION CIENTIFICA ANUAL de la Sociedad Argentina de Inmunologia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lipoteichoic acid is involved in the immunomodulatory activities of Lactobacillus plantarum CRL15062019

    • Author(s)
      Mizuno, H., L. Arce, H. Kitazawa et al.
    • Organizer
      LXVII REUNION CIENTIFICA ANUAL de la Sociedad Argentina de Inmunologia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adhesion to the intestinal mucosa is not necessary for Lactobacillus rhamnosus CRL1505 to exert its immunomodulatory activities in local and distal mucosal sites2019

    • Author(s)
      Tomotsune, K. F. R. Tonetti, H. Kitazawa et al.
    • Organizer
      LXVII REUNION CIENTIFICA ANUAL de la Sociedad Argentina de Inmunologia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-viral immunobiotics from porcine small intestine2019

    • Author(s)
      Indo, Y., B. Zhou, H. Kitazawa et al.
    • Organizer
      日本畜産学会第126回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] イムノバイオティクスからイムノシンバイオティクス-その開発と将来性-2019

    • Author(s)
      北澤春樹
    • Organizer
      動物用ワクチン-バイオ医薬品研究会シンポジウム「プロバイオティクスによる動物の疾病制御技術の基礎と応用」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Immunobiotic Lactobacillus jensenii TL2937 Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice2019

    • Author(s)
      Islam, Md. A, V. Garcia-Castillo, H. Kitazawa et al.
    • Organizer
      FEMS2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Selection of wakame assimilative Lactobacilli and in vitro evaluation of their immunomodulatory potentials2019

    • Author(s)
      Zhou, B, Y. Masumizu, H. Kitazawa et al.
    • Organizer
      FEMS2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] 腎と透析(増大号)特集 COVID-19と腎臓病 (総論)粘膜免疫防御機構:有用微生物によるCOVID-19感染・重症化の軽減ネットワーク)2022

    • Author(s)
      Julio Villena, 北澤春樹(分担執筆)
    • Total Pages
      364
    • Publisher
      東京医学社
    • Related Report
      2021 Annual Research Report
  • [Book] 食品免疫学事典(担当: 8章 食品機能の評価法 8-15 代替法の開発)2021

    • Author(s)
      北澤春樹(共編著者、分担執筆)
    • Total Pages
      496
    • Publisher
      朝倉書店
    • Related Report
      2021 Annual Research Report
  • [Book] 食品免疫学事典(担当: 6章 免疫調節食品 6-15 乳酸菌)2021

    • Author(s)
      北澤春樹(共編著者、分担執筆)
    • Total Pages
      496
    • Publisher
      朝倉書店
    • Related Report
      2021 Annual Research Report
  • [Book] 食品免疫学事典(担当: 3章 免疫の働き 3-30 トル様受容体(TLR))2021

    • Author(s)
      北澤春樹(共編著者、分担執筆)
    • Total Pages
      496
    • Publisher
      朝倉書店
    • Related Report
      2021 Annual Research Report
  • [Book] 食品免疫学事典(担当:3章 免疫の働き 3-3 自然免疫)2021

    • Author(s)
      北澤春樹(共編著者、分担執筆)
    • Total Pages
      496
    • Publisher
      朝倉書店
    • Related Report
      2021 Annual Research Report
  • [Book] 乳酸菌の機能と産業利用(監修:木下英樹、井越敬司)2021

    • Author(s)
      北澤春樹(分担執筆)4.イムノバイオティクスの畜産への応用(pp33-39)
    • Total Pages
      205
    • Publisher
      シーエムシー出版
    • ISBN
      9784781315942
    • Related Report
      2020 Annual Research Report
  • [Remarks] 食と農免疫国際教育研究センター

    • URL

      https://www.agri.tohoku.ac.jp/jp/center/agri_cfai/

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Remarks] 食と農免疫国際教育研究センター

    • URL

      http://www.agri.tohoku.ac.jp/cfai/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] JSPS研究拠点形成事業先端拠点形成「食の安全性の飛躍的向上を目指した農免疫国際共同研究拠点形成」

    • URL

      http://www.agri.tohoku.ac.jp/fain/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      https://tohokuagri.wixsite.com/lapc

    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗ウイルス剤2020

    • Inventor(s)
      北澤春樹ら
    • Industrial Property Rights Holder
      北澤春樹ら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

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