• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Human health promotion by inter-species symbiosis-Mental and physical health development of children by human-dog coexistent of microbiota

Research Project

Project/Area Number 19H00972
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Research InstitutionAzabu University

Principal Investigator

Kikusui Takefumi  麻布大学, 獣医学部, 教授 (90302596)

Co-Investigator(Kenkyū-buntansha) 西田 淳志  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, プロジェクトリーダー (20510598)
安藤 俊太郎  東京大学, 医学部附属病院, 准教授 (20616784)
野元 謙作  獨協医科大学, 医学部, 講師 (30786976)
茂木 一孝  麻布大学, 獣医学部, 教授 (50347308)
宮内 栄治  群馬大学, 生体調節研究所, 准教授 (60634706)
永澤 美保  麻布大学, 獣医学部, 准教授 (70533082)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2022: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2021: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2020: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords思春期コホート / 腸内細菌叢 / 向社会性 / 内分泌 / 心尺度 / イヌ飼育 / コホート研究 / ノトバイオートマウス / 社会性 / 思春期 / 問題行動 / 腸内細菌叢解析 / 無菌マウス / 思春期児童 / Well-Being / オキシトシン / イヌの飼育 / 心的尺度 / 細菌叢 / 心理アンケート / 行動 / 心理発達 / ペットの飼育 / マウスモデル / ペット飼育 / 心理スコア / ヒト発達 / 細菌叢解析 / 社会行動 / モデルマウス
Outline of Research at the Start

イヌと生活することでのヒトの心身における恩恵に関しては枚挙に暇がない。うつ病、自閉症児のケア、疼痛抑制や消化器疾患において、イヌとの生活が効果をもつことが報告されている。そのメカニズムとして、共有細菌叢に着目した。本研究では、イヌとの生活によってもたらさせる心身の健康に寄与する、イヌとの生活によって変化するヒト細菌叢(共生細菌叢)の機能を解明する。

Outline of Final Research Achievements

A life-log investigation was conducted to examine the long-term changes in human-dog coexistence. The results revealed various factors such as physical activity, endocrine responses, and gut microbiota, shedding light on the evolving dynamics and their impact on both humans and dogs. Particularly, correlations were found between the physical activity levels and oxytocin values of dogs and their owners, as well as their psychological measures. Furthermore, an examination of the effects of dog ownership on children demonstrated certain differences between the dog-owning group and the control group in the measured variables. It was also discovered that the gut microbiota could be involved in some of the effects of dog ownership on human well-being. While further research is needed, the potential benefits of dog ownership on human physical and mental health have been suggested.

Academic Significance and Societal Importance of the Research Achievements

本研究ではイヌの飼育によるヒトの心身の健康への影響を、運動、睡眠リズム、内分泌変化、腸内細菌叢と心尺度から調査した。その結果、思春期の飼育児童のWell-Beingが向上し、その背景にオキシトシンやコルチゾールの変化を伴っていることを見出した。またイヌ飼育の思春期児童の細菌叢を無菌マウスに投与しノトバイオートマウスを作成したところ、向社会行動の増加を認め、イヌ飼育の影響の一部は細菌叢の変化を介したものであることが示唆された。これらの結果は、先進国で最低に近い思春期児童のWell-Beingの向上に向けた科学的視点に資するものとなった。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (45 results)

All 2022 2021 2020 2019 Other

All Journal Article (23 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 22 results,  Open Access: 19 results) Presentation (18 results) (of which Int'l Joint Research: 3 results,  Invited: 13 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Sociality of Cats toward Humans Can Be Influenced by Hormonal and Socio-Environmental Factors: Pilot Study2022

    • Author(s)
      Koyasu Hikari、Takahashi Hironobu、Sasao Ikuto、Takagi Saho、Nagasawa Miho、Kikusui Takefumi
    • Journal Title

      Animals

      Volume: 13 Issue: 1 Pages: 146-146

    • DOI

      10.3390/ani13010146

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of genes associated with human-canine communication in canine evolution2022

    • Author(s)
      Tonoike Akiko、Otaki Ken-ichi、Terauchi Go、Ogawa Misato、Katayama Maki、Sakata Hikari、Miyasako Fumina、Mogi Kazutaka、Kikusui Takefumi、Nagasawa Miho
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 6950-6950

    • DOI

      10.1038/s41598-022-11130-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increase of tear volume in dogs after reunion with owners is mediated by oxytocin2022

    • Author(s)
      Murata Kaori、Nagasawa Miho、Onaka Tatsushi、Kanemaki Nobuyuki、Nakamura Shigeru、Tsubota Kazuo、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      Current Biology

      Volume: 32 Issue: 16 Pages: R869-R870

    • DOI

      10.1016/j.cub.2022.07.031

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlations between behavior and hormone concentrations or gut microbiome imply that domestic cats (Felis silvestris catus) living in a group are not like ‘groupmates’2022

    • Author(s)
      Koyasu Hikari、Takahashi Hironobu、Yoneda Moeka、Naba Syunpei、Sakawa Natsumi、Sasao Ikuto、Nagasawa Miho、Kikusui Takefumi
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 7 Pages: e0269589-e0269589

    • DOI

      10.1371/journal.pone.0269589

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autonomic nervous system responses of dogs to human-dog interaction videos2022

    • Author(s)
      Matsushita Shohei、Nagasawa Miho、Kikusui Takefumi
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 11 Pages: e0257788-e0257788

    • DOI

      10.1371/journal.pone.0257788

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroendocrine Mechanisms of Social Bonds and Separation Stress in Rodents, Dogs, and Other Species2021

    • Author(s)
      Nagasawa Miho、Kikusui Takefumi
    • Journal Title

      Current Topics in Behavioral Neurosciences

      Volume: 1 Pages: 1-20

    • DOI

      10.1007/7854_2021_257

    • ISBN
      9783031042553, 9783031042560
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin neurons enable social transmission of maternal behaviour2021

    • Author(s)
      Carcea I、Caraballo N、Marlin B、Ooyama R、Riceberg J、Mendoza N、Opendak M、Diaz V、Schuster L、Alvarado T、Lethin H、Ramos D、Minder J、Mendoza S、Bair-Marshall C、Samadjopoulos G、Hidema S、Falkner A、Lin D、Mar A、Wadghiri Y、Nishimori K、Kikusui T、Mogi K、Sullivan R、Froemke R.
    • Journal Title

      Nature

      Volume: 596 Issue: 7873 Pages: 553-557

    • DOI

      10.1038/s41586-021-03814-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aims of the special issue of “Neuro-Molecular Understanding for the Gut-Brain Axis”2021

    • Author(s)
      Kikusui Takefumi
    • Journal Title

      Neuroscience Research

      Volume: 168 Pages: 1-2

    • DOI

      10.1016/j.neures.2021.05.008

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] Validation of a newly generated oxytocin antibody for enzyme-linked immunosorbent assays2021

    • Author(s)
      MURATA Kaori、NAGASAWA Miho、ONAKA Tatsushi、TAKEYAMA Ken-ichi、KIKUSUI Takefumi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 3 Pages: 478-481

    • DOI

      10.1292/jvms.20-0723

    • NAID

      130008021179

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dog and Cat Ownership Predicts Adolescents’ Mental Well-Being: A Population-Based Longitudinal Study2020

    • Author(s)
      Endo Kaori、Yamasaki Syudo、Ando Shuntaro、Kikusui Takefumi、Mogi Kazutaka、Nagasawa Miho、Kamimura Itsuka、Ishihara Junko、Nakanishi Miharu、Usami Satoshi、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 3 Pages: 884-884

    • DOI

      10.3390/ijerph17030884

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microbial colonization history modulates anxiety-like and complex social behavior in mice2020

    • Author(s)
      Kamimura Itsuka、Kaneko Ryou、Morita Hidetoshi、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 64-75

    • DOI

      10.1016/j.neures.2020.01.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between Pet Ownership and Obesity: A Systematic Review and Meta-Analysis2020

    • Author(s)
      Miyake Kenta、Kito Kumiko、Kotemori Ayaka、Sasaki Kazuto、Yamamoto Junpei、Otagiri Yuko、Nagasawa Miho、Kuze-Arata Sayaka、Mogi Kazutaka、Kikusui Takefumi、Ishihara Junko
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 10 Pages: 3498-3498

    • DOI

      10.3390/ijerph17103498

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心拍変動を用いた運動中のイヌの情動評価の試み2020

    • Author(s)
      村山 未来, 永澤 美保, 片山 真希, 池田 和司, 久保 孝富, 山川 俊貴, 藤原 幸一, 菊水 健史
    • Journal Title

      動物心理学研究

      Volume: 70 Issue: 1 Pages: 15-18

    • DOI

      10.2502/janip.70.1.1

    • NAID

      130007884222

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Familiarity with humans affect dogs’ tendencies to follow human majority groups2020

    • Author(s)
      Nagasawa Miho、Mogi Kazutaka、Ohtsuki Hisashi、Kikusui Takefumi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 7119-7119

    • DOI

      10.1038/s41598-020-64058-5

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Breastfeeding dynamically changes endogenous oxytocin levels and emotion recognition in mothers2020

    • Author(s)
      Matsunaga Michiko, Kikusui Takefumi, Mogi Kazutaka, Nagasawa Miho, Ooyama Rumi, Myowa Masako
    • Journal Title

      Biology Letters

      Volume: 16 Issue: 6 Pages: 20200139-20200139

    • DOI

      10.1098/rsbl.2020.0139

    • NAID

      120006848369

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Gaze Communications Between Dogs/Cats and Humans: Recent Research Review and Future Directions2020

    • Author(s)
      Koyasu Hikari、Kikusui Takefumi、Takagi Saho、Nagasawa Miho
    • Journal Title

      Frontiers in Psychology

      Volume: 11 Pages: 613512-613512

    • DOI

      10.3389/fpsyg.2020.613512

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The blockade of oxytocin receptors in the paraventricular thalamus reduces maternal crouching behavior over pups in lactating mice.2020

    • Author(s)
      A. Watarai, S. Tsutaki, K. Nishimori, T. Okuyama, K. Mogi, T. Kikusui
    • Journal Title

      Neuroscience Letters

      Volume: 720 Pages: 134761-134761

    • DOI

      10.1016/j.neulet.2020.134761

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine Regulations in Human?Dog Coexistence through Domestication2019

    • Author(s)
      Kikusui Takefumi、Nagasawa Miho、Nomoto Kensaku、Kuse-Arata Sayaka、Mogi Kazutaka
    • Journal Title

      Trends in Endocrinology & Metabolism

      Volume: 30 Issue: 11 Pages: 793-806

    • DOI

      10.1016/j.tem.2019.09.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emotional Contagion From Humans to Dogs Is Facilitated by Duration of Ownership2019

    • Author(s)
      Katayama Maki、Kubo Takatomi、Yamakawa Toshitaka、Fujiwara Koichi、Nomoto Kensaku、Ikeda Kazushi、Mogi Kazutaka、Nagasawa Miho、Kikusui Takefumi
    • Journal Title

      Frontiers in Psychology

      Volume: 10 Pages: 1678-1678

    • DOI

      10.3389/fpsyg.2019.01678

    • NAID

      120006784467

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low maternal care enhances the skin barrier resistance of offspring in mice2019

    • Author(s)
      Sakamoto Takashi、Ishio Yukino、Ishida Yuiko、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 7 Pages: e0219674-e0219674

    • DOI

      10.1371/journal.pone.0219674

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex2019

    • Author(s)
      Kikusui Takefumi、Kanbara Natsumi、Ozaki Mariya、Hirayama Nozomi、Ida Kumiko、Tokita Mika、Tanabe Naho、Mitsuyama Kuriko、Abe Hatsuki、Yoshida Miki、Nagasawa Miho、Mogi Kazutaka
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3991-3991

    • DOI

      10.1038/s41598-019-40530-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vasopressin enhances human preemptive strike in both males and females2019

    • Author(s)
      Kawada Atsushi、Nagasawa Miho、Murata Aiko、Mogi Kazutaka、Watanabe Katsumi、Kikusui Takefumi、Kameda Tatsuya
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 9664-9664

    • DOI

      10.1038/s41598-019-45953-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gonadal steroid hormone secretion during the juvenile period depends on host-specific microbiota and contributes to the development of odor preference2019

    • Author(s)
      Kamimura Itsuka、Watarai Akiyuki、Takamura Takuma、Takeo Atsushi、Miura Kyoko、Morita Hidetoshi、Mogi Kazutaka、Kikusui Takefumi
    • Journal Title

      Developmental Psychobiology

      Volume: in press Issue: 5 Pages: 670-678

    • DOI

      10.1002/dev.21827

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] イヌ飼育による唾液細菌叢構成変化が宿主の行動に及ぼす影響2022

    • Author(s)
      山岡未来、水田真未、秋山潤、上村いつか、米村夏実、桂川雄太、 安藤俊太郎、山崎修道、遠藤香織、西田淳志、宮内栄治、永澤美保、茂木一孝、菊水健史
    • Organizer
      第21回 アジア獣医師会連合大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イヌ飼育によるだ液細菌叢構成変化が宿主行動に影響を及ぼす2022

    • Author(s)
      山岡未来、水田真未、秋山潤、上村いつか、米村夏実、桂川雄太、 安藤俊太郎、山崎修道、遠藤香織、西田淳志、宮内栄治、永澤美保、茂木一孝、菊水健史
    • Organizer
      第165回 日本獣医学会学術集会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A long-term study of the influences of human-dog interactions2021

    • Author(s)
      Kahori Koyama, Miho Nagasawa, Takefumi Kikusui
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Emotional evaluation of dogs during eye-gaze to human by heart rate variability2021

    • Author(s)
      Haruka Hirasawa, Miho Nagasawa, Takefumi Kikusui
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] イヌ飼育によるだ液細菌叢構成変化が宿主行動に影響を及ぼす2021

    • Author(s)
      山岡未来、秋山潤、水田真未、上村いつか、安藤俊太郎、山崎修道、遠藤香織、西田淳志、永澤美保、茂木一孝、菊水健史
    • Organizer
      第164回日本獣医学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Oxytocin and tears in non-human mammals2021

    • Author(s)
      Takefumi Kikusui
    • Organizer
      MET Conference 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 社会内分泌学:社会をつくる内分泌の役割2020

    • Author(s)
      菊水健史
    • Organizer
      日本神経科学
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Oxytocin modulates emotional tear2019

    • Author(s)
      Takefumi Kikusui, Kaori Murata, Toshihiro Imada, Kai Jin, Kazutaka Mogi, Miho Nagasawa, Shigeru Nakamura, Kazuo Tsubota
    • Organizer
      Neuro2019 日本神経科学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] オキシトシンによる情動性の涙の制御2019

    • Author(s)
      菊水健史
    • Organizer
      第92回日本生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] イヌとヒトの共生の歴史2019

    • Author(s)
      菊水健史
    • Organizer
      FASAVATOKYO 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動物の感覚2019

    • Author(s)
      菊水健史
    • Organizer
      自治医科大学「実験動物慰霊の会」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒトとイヌの関係とその効果2019

    • Author(s)
      菊水健史
    • Organizer
      第8回「ペットとの共生推進協議会シンポジウム」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒトとイヌ・共生と互恵的関係」-家族をつなぐホルモンの効果-2019

    • Author(s)
      菊水健史
    • Organizer
      2019年群馬県高崎市市民講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動物の多様な感覚と行動2019

    • Author(s)
      菊水健史
    • Organizer
      2019年筑波実験動物研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 社会内分泌学2019

    • Author(s)
      菊水健史
    • Organizer
      第1271回東京大学生物科学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動物学からみた「目」のもつ社会機能2019

    • Author(s)
      菊水健史
    • Organizer
      View2019学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 母子間関係性の内分泌制御2019

    • Author(s)
      菊水健史
    • Organizer
      2019「薬物・精神・行動の会」特別講演
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 哺乳類の性2019

    • Author(s)
      菊水健史
    • Organizer
      新学術領域研究「性スペクトラム」アウトリーチ講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Book] 社会の起源2019

    • Author(s)
      菊水 健史、市川 眞澄
    • Total Pages
      162
    • Publisher
      共立出版
    • ISBN
      4320057961
    • Related Report
      2019 Annual Research Report
  • [Remarks] 研究室研究成果

    • URL

      https://ahir-azb.theblog.me/

    • Related Report
      2022 Annual Research Report
  • [Remarks] 研究室論文発表

    • URL

      https://sites.google.com/carazabu.com/lab-kaizai/home/publications?authuser=0

    • Related Report
      2022 Annual Research Report
  • [Remarks] 研究室WEBサイト

    • URL

      https://ahir-azb.theblog.me/

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi