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Elucidation of effects of prenatal environment on neurodevelopmental disorders, brain sex differentiation and obesity: a birth cohort study

Research Project

Project/Area Number 19H01071
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionHokkaido University

Principal Investigator

Kishi Reiko  北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449)

Co-Investigator(Kenkyū-buntansha) 池田 敦子 (荒木 敦子)  北海道大学, 保健科学研究院, 教授 (00619885)
小林 澄貴  北海道大学, 環境健康科学研究教育センター, 特任准教授 (10733371)
齊藤 卓弥  北海道大学, 大学病院, 特任教授 (20246961)
湊屋 街子  北海道大学, 環境健康科学研究教育センター, 客員研究員 (50733367)
山崎 圭子  北海道大学, 環境健康科学研究教育センター, 特任講師 (60732120)
中島 そのみ  札幌医科大学, 保健医療学部, 准教授 (70325877)
宮下 ちひろ  北海道大学, 環境健康科学研究教育センター, 特任教授 (70632389)
白石 秀明  北海道大学, 大学病院, 講師 (80374411)
アイツバマイ ゆふ  北海道大学, 環境健康科学研究教育センター, 特任講師 (90752907)
三浦 りゅう  北海道大学, 環境健康科学研究教育センター, 客員研究員 (20506414)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2021: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2020: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2019: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Keywords環境化学物質 / 遺伝子発現 / 環境疫学 / 内分泌かく乱作用 / バイオマーカー / 出生コホート / 神経発達障害 / 第二次性徴 / 肥満 / 出生コーホート / 性分化
Outline of Research at the Start

胎児期、乳幼児期は脆弱で環境化学物質による次世代影響が最も懸念され、生涯に及ぶ健康や疾病を規定する時期である。本研究はライフコース疫学として、2つの出生コーホート(母児514組および20,926組)の子どもを前向きに追跡し、学童期から思春期に①発達障害およびその基礎にある認知特性への影響、②子どもの思春期における脳の性分化や第二次性徴発来時期への影響、③出生時に低体重であった児の肥満リスク・体格発達の軌跡とバイオマーカーの関係を検討する。健康障害を引き起こす環境要因として環境化学物質の生体濃度を実測し、曝露濃度と健康障害リスクの関係を、社会経済要因等を合わせて検討する。

Outline of Final Research Achievements

In this study, we prospectively followed a birth cohort of children as a life-course epidemiological study. We evaluated the effects on developmental disorders such as ADHD (Attention Deficit Hyperactivity Disorder) and their underlying "cognitive characteristics" from school age to adolescence. Additionally, the effects on brain sex differentiation, the onset of the secondary sexual characteristics at puberty, and the presence or absence of increased risk of obesity in children who were underweight at birth were investigated. The association between fetal exposure to MEHPs and ADHD at age 6 years was increased with prenatal exposure to MEHPs, but this association disappeared at age 8 years.

Academic Significance and Societal Importance of the Research Achievements

胎児期から幼少時期は、生体の可塑性が高く環境要因が生涯に及ぶ健康を規定する重要な時期(疾病の胎児期・乳幼児期起源説/Developmental Origins of Health and Disease、DOHaD)とされる。近年は、胎児期から乳幼児期の環境により受けた健康影響を出生コーホート研究として、思春期、成人期以降まで追跡するライフコース疫学の重要性が広く認識されてきた。本研究では、胎児期から乳幼児期、学童期、思春期など長期的な人生の諸段階で、効果的な予防的介入に結び付けられる多くの科学的なデータを報告していくことができる。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (76 results)

All 2022 2021 2020 2019 Other

All Journal Article (30 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 30 results,  Open Access: 19 results) Presentation (34 results) (of which Int'l Joint Research: 16 results,  Invited: 3 results) Book (11 results) Remarks (1 results)

  • [Journal Article] Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis2022

    • Author(s)
      Toloza Freddy J K、Derakhshan Arash、Mannisto Tuija、Bliddal Sofie、Popova Polina V、Carty David M、Chen Liangmiao、Taylor Peter、Mosso Lorena、Oken Emily、Suvanto Eila、Itoh Sachiko、Kishi Reiko、et al
    • Journal Title

      The Lancet Diabetes & Endocrinology

      Volume: 10 Issue: 4 Pages: 243-252

    • DOI

      10.1016/s2213-8587(22)00007-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of exposure to prenatal per?uoroalkyl substances and estrogen receptor 1 polymorphisms with the second to fourth digit ratio in school-aged children: The Hokkaido study2022

    • Author(s)
      Nishimura Yoko、Moriya Kimihiko、Kobayashi Sumitaka、Ikeda- Araki Atsuko、Sata Fumihiro、Mitsui Takahiko、Itoh Sachiko、Miyashita Chihiro、Cho Kazutoshi、Kon Masafumi、Nakamura Michiko、Kitta Takeya、Murai Sachiyo、Kishi Reiko、Shinohara Nobuo
    • Journal Title

      Reproductive Toxicology

      Volume: 109 Pages: 10-18

    • DOI

      10.1016/j.reprotox.2022.02.002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonylphenol exposure in 7-year-old Japanese children between 2012 and 2017? Estimation of daily intakes based on novel urinary metabolites2022

    • Author(s)
      Ringbeck Benedikt、Bury Daniel、Ikeda-Araki Atsuko、Ait Bamai Yu、Ketema Rahel Mesfin、Miyashita Chihiro、Br?ning Thomas、Kishi Reiko、Koch Holger M.
    • Journal Title

      Environment International

      Volume: 161 Pages: 107145-107145

    • DOI

      10.1016/j.envint.2022.107145

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium2022

    • Author(s)
      Lozano Manuel、Yousefi Paul、Broberg Karin、Soler-Blasco Raquel、Miyashita Chihiro、Pesce Giancarlo、Kim Woo Jin、Rahman Mohammad、Bakulski Kelly M.、Haug Line S.、Ikeda-Araki Atsuko、et al
    • Journal Title

      Environmental Research

      Volume: 204 Pages: 112093-112093

    • DOI

      10.1016/j.envres.2021.112093

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phthalates mixture on allergies and oxidative stress biomarkers among children: The Hokkaido study2022

    • Author(s)
      Ketema Rahel Mesfin、Ait Bamai Yu、Miyashita Chihiro、Saito Takeshi、Kishi Reiko、Ikeda-Araki Atsuko
    • Journal Title

      Environment International

      Volume: 160 Pages: 107083-107083

    • DOI

      10.1016/j.envint.2022.107083

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study2022

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Miyashita Chihiro、Ikeda-Araki Atsuko、Goudarzi Houman、Nakajima Tamie、Kishi Reiko
    • Journal Title

      Reproductive Toxicology

      Volume: 107 Pages: 22-32

    • DOI

      10.1016/j.reprotox.2021.11.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study2022

    • Author(s)
      Itoh Sachiko、Yamazaki Keiko、Suyama Satoshi、Ikeda-Araki Atsuko、Miyashita Chihiro、Ait Bamai Yu、Kobayashi Sumitaka、Masuda Hideyuki、Yamaguchi Takeshi、Goudarzi Houman、Okada Emiko、Kashino Ikuko、Saito Takuya、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 159 Pages: 107026-107026

    • DOI

      10.1016/j.envint.2021.107026

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan2022

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Ikeda-Araki Atsuko、Miyashita Chihiro、Goudarzi Houman、Iwasaki Yusuke、Nakajima Tamie、Kishi Reiko
    • Journal Title

      Reproductive Toxicology

      Volume: 107 Pages: 112-122

    • DOI

      10.1016/j.reprotox.2021.12.004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertensive Disorders during Pregnancy and Anthropometric Measurement of Children up to 7 Years of Age: The Hokkaido Birth Cohort Study in Japan2021

    • Author(s)
      Poudel Kritika、Kobayashi Sumitaka、Miyashita Chihiro、Yamaguchi Takeshi、Tamura Naomi、Ikeda-Araki Atsuko、Ait Bamai Yu、Itoh Sachiko、Yamazaki Keiko、Masuda Hideyuki、Itoh Mariko、Kishi Reiko
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 20 Pages: 10951-10951

    • DOI

      10.3390/ijerph182010951

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study2021

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Ikeda-Araki Atsuko、Miyashita Chihiro、Itoh Sachiko、Goudarzi Houman、Iwasaki Yusuke、Mitsui Takahiko、Moriya Kimihiko、Shinohara Nobuo、Cho Kazutoshi、Kishi Reiko
    • Journal Title

      Reproductive Toxicology

      Volume: 105 Pages: 221-231

    • DOI

      10.1016/j.reprotox.2021.09.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health2021

    • Author(s)
      Miura Ryu、Ikeda-Araki Atsuko、Ishihara Toru、Miyake Kunio、Miyashita Chihiro、Nakajima Tamie、Kobayashi Sumitaka、Ishizuka Mayumi、Kubota Takeo、Kishi Reiko
    • Journal Title

      Science of The Total Environment

      Volume: 783 Pages: 147035-147035

    • DOI

      10.1016/j.scitotenv.2021.147035

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secular trends of urinary phthalate metabolites in 7-year old children and association with building characteristics: Hokkaido study on environment and children's health2021

    • Author(s)
      Ketema Rahel Mesfin、Ait Bamai Yu、Ikeda-Araki Atsuko、Saito Takeshi、Kishi Reiko
    • Journal Title

      International Journal of Hygiene and Environmental Health

      Volume: 234 Pages: 113724-113724

    • DOI

      10.1016/j.ijheh.2021.113724

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hokkaido birth cohort study on environment and children’s health: cohort profile 20212021

    • Author(s)
      Kishi Reiko、Ikeda-Araki Atsuko、Miyashita Chihiro、Itoh Sachiko、Kobayashi Sumitaka、Ait Bamai Yu、Yamazaki Keiko、Tamura Naomi、et al.
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 26 Issue: 1 Pages: 1-20

    • DOI

      10.1186/s12199-021-00980-y

    • NAID

      210000159057

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study2021

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Goudarzi Houman、Araki Atsuko、Miyashita Chihiro、Sasaki Seiko、Okada Emiko、Iwasaki Yusuke、Nakajima Tamie、Kishi Reiko
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 9994-9994

    • DOI

      10.1038/s41598-021-89285-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment2021

    • Author(s)
      Machiko Minatoya, Reiko Kishi
    • Journal Title

      Int J Environ Res Public Health .

      Volume: 18(7) Issue: 7 Pages: 3585-3585

    • DOI

      10.3390/ijerph18073585

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health2021

    • Author(s)
      Miyake Kunio、Miyashita Chihiro、Ikeda-Araki Atsuko、Miura Ryu、Itoh Sachiko、Yamazaki Keiko、Kobayashi Sumitaka、Masuda Hideyuki、Ooka Tadao、Yamagata Zentaro、Kishi Reiko
    • Journal Title

      Clinical Epigenetics

      Volume: 13 Issue: 1 Pages: 74-74

    • DOI

      10.1186/s13148-021-01063-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children’s Health2021

    • Author(s)
      Tamura Naomi、Hanaoka Tomoyuki、Ito Kumiko、Araki Atsuko、Miyashita Chihiro、Ito Sachiko、Kobayashi Sumitaka、Ito Yoichi、Minakami Hisanori、Cho Kazutoshi、Endo Toshiaki、Baba Tsuyoshi、Sengoku Kazuo、Miyamoto Toshinobu、Ogasawara Katsuhiko、Kishi Reiko
    • Journal Title

      Maternal and Child Health Journal

      Volume: 25(4) Issue: 4 Pages: 645-655

    • DOI

      10.1007/s10995-020-03035-w

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between atopic dermatitis and children's mental and behavioral health: The Hokkaido Study2020

    • Author(s)
      Machiko Minatoya, Satoshi Suyama, Reiko Kishi
    • Journal Title

      Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)

      Volume: 67 Issue: 10 Pages: 745-751

    • DOI

      10.11236/jph.67.10_745

    • NAID

      130007959247

    • ISSN
      0546-1766, 2187-8986
    • Year and Date
      2020-10-15
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of childhood wheeze and modified DNA methylation at 7 years of age according to maternal folate levels during pregnancy in the Hokkaido Study.2020

    • Author(s)
      Miyashita Chihiro, Araki Atsuko, Miura Ryu, Ait Bamai Yu, Kobayashi Sumitaka, Itoh Sachiko, Ito Kumiko, Tsai Meng‐Shan, Kishi Reiko
    • Journal Title

      Pediatric Allergy and Immunology

      Volume: 32 Issue: 3 Pages: 514-523

    • DOI

      10.1111/pai.13425

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for motor coordination problems in preschool‐age children2020

    • Author(s)
      Suyama Satoshi、Yagyu Kazuyori、Araki Atsuko、Miyashita Chihiro、Itoh Sachiko、Minatoya Machiko、Yamazaki Keiko、Tamura Naomi、Nakai Akio、Saito Takuya、Kishi Reiko
    • Journal Title

      Pediatrics International

      Volume: 62 Issue: 10 Pages: 1177-1183

    • DOI

      10.1111/ped.14275

    • NAID

      120007160282

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: The Hokkaido study on environment and children's health.2020

    • Author(s)
      Ait Bamai Yu、Goudarzi Houman、Araki Atsuko、Okada Emiko、Kashino Ikuko、Miyashita Chihiro、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 143 Pages: 105979-105979

    • DOI

      10.1016/j.envint.2020.105979

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children2020

    • Author(s)
      Araki Atsuko、Ait Bamai Yu、Bastiaensen Michiel、Van den Eede Nele、Kawai Toshio、Tsuboi Tazuru、Miyashita Chihiro、Itoh Sachiko、Goudarzi Houman、Konno Satoshi、Covaci Adrian、Kishi Reiko
    • Journal Title

      Environmental Research

      Volume: 183 Pages: 109212-109212

    • DOI

      10.1016/j.envres.2020.109212

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study2020

    • Author(s)
      Ketema Rahel Mesfin、Araki Atsuko、Ait Bamai Yu、Saito Takeshi、Kishi Reiko
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 25 Issue: 1 Pages: 28-28

    • DOI

      10.1186/s12199-020-00869-2

    • NAID

      50014448481

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of exposure to prenatal phthalate esters and bisphenol A and polymorphisms in the ESR1 gene with the second to fourth digit ratio in school-aged children: Data from the Hokkaido study2020

    • Author(s)
      Nishimura Yoko、Moriya Kimihiko、Kobayashi Sumitaka、Araki Atsuko、Sata Fumihiro、Mitsui Takahiko、Itoh Sachiko、Miyashita Chihiro、Cho Kazutoshi、Kon Masafumi、Nakamura Michiko、Kitta Takeya、Murai Sachiyo、Kishi Reiko、Shinohara Nobuo
    • Journal Title

      Steroids

      Volume: 159 Pages: 108637-108637

    • DOI

      10.1016/j.steroids.2020.108637

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants: The Hokkaido study on environment and children's health2020

    • Author(s)
      Yamazaki Keiko、Itoh Sachiko、Araki Atsuko、Miyashita Chihiro、Minatoya Machiko、Ikeno Tamiko、Kato Shizue、Fujikura Kaori、Mizutani Futoshi、Chisaki Yoichi、Kishi Reiko
    • Journal Title

      Environmental Research

      Volume: 189 Pages: 109840-109840

    • DOI

      10.1016/j.envres.2020.109840

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study2020

    • Author(s)
      Kashino Ikuko、Sasaki Seiko、Okada Emiko、Matsuura Hideyuki、Goudarzi Houman、Miyashita Chihiro、Okada Eisaku、Ito Yoichi M.、Araki Atsuko、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 136 Pages: 105355-105355

    • DOI

      10.1016/j.envint.2019.105355

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between Maternal Serum Folate Concentrations in the First Trimester and the Risk of Birth Defects: The Hokkaido Study of Environment and Children’s Health2019

    • Author(s)
      Ito Kumiko、Hanaoka Tomoyuki、Tamura Naomi、Sasaki Seiko、Miyashita Chihiro、Araki Atsuko、Ito Sachiko、Minakami Hisanori、Cho Kazutoshi、Endo Toshiaki、Baba Tsuyoshi、Miyamoto Toshinobu、Sengoku Kazuo、Tamakoshi Akiko、Kishi Reiko
    • Journal Title

      Journal of Epidemiology

      Volume: 29 Issue: 4 Pages: 164-171

    • DOI

      10.2188/jea.JE20170185

    • NAID

      130007624300

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2019-04-05
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal tobacco exposure and ADHD symptoms at pre-school age: the Hokkaido Study on Environment and Children’s Health2019

    • Author(s)
      Minatoya M, Araki A, Itoh S, Yamazaki K, Kobayashi S, Miyashita C, Sasaki S, Kishi R
    • Journal Title

      Environ Health Prev Med

      Volume: 24 Issue: 1 Pages: 74-74

    • DOI

      10.1186/s12199-019-0834-4

    • NAID

      50014276980

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study: a prospective birth cohort.2019

    • Author(s)
      Kobayashi S, Sata F, Hanaoka T, Braimoh TS, Ito K, Tamura N, Araki A, Itoh S, Miyashita C, Kishi R.
    • Journal Title

      BMJ Open

      Volume: 9(2) Issue: 2 Pages: e023200-e023200

    • DOI

      10.1136/bmjopen-2018-023200

    • NAID

      120006552871

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A2019

    • Author(s)
      Miura Ryu、Araki Atsuko、Minatoya Machiko、Miyake Kunio、Chen Mei-Lien、Kobayashi Sumitaka、Miyashita Chihiro、Yamamoto Jun、Matsumura Toru、Ishizuka Mayumi、Kubota Takeo、Kishi Reiko
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41598-019-48916-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Introduction of the birth cohort and latest findings: the Hokkaido Study2022

    • Author(s)
      Ikeda-Araki A., Miyashita C., Kishi R.
    • Organizer
      International Symposium on Clean Environment and Planetary Health in Asia (CEPHA) 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 学童のプラスチック添加剤への曝露実態 :北海道スタディ2022

    • Author(s)
      池田敦子, アイツバマイゆふ, Ketema R. M., Gys C., Bastiaensen M., Covaci A., 岸玲子
    • Organizer
      第92回日本衛生学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 出生コホートによる縦断的な研究成果とこれからの疫学調査―北海道スタディ2022

    • Author(s)
      宮下ちひろ
    • Organizer
      第92回日本衛生学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 妊娠中の環境化学物質曝露と胎児発育:遺伝環境交互作用の疫学研究(文献レビュー)2022

    • Author(s)
      小林澄貴
    • Organizer
      第92回日本衛生学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Impact of environmental chemical exposure on childhood asthma and allergies, and infections2021

    • Author(s)
      Ikeda-Araki A., Miyashita C., Ait Bamai Y., Kishi R.
    • Organizer
      The Pacific Basin Consortium for Environment and Health- 2021 Focus Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Association of phthalates exposure and oxidative stress biomarkers with wheeze, rhino conjunctivitis and eczema in children: Hokkaido Study2021

    • Author(s)
      Ketema R. M., Aitbamai Y., Saito T., Kishi R., Ikeda-Araki A.
    • Organizer
      ISES2021 Virtual Experience
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mixture effect of phthalate metabolites in children’s wheeze, rhino conjunctivitis and eczema: The Hokkaido study2021

    • Author(s)
      Ketema R. M., Aitbamai Y., Saito T., Kishi R., Ikeda-Araki A.
    • Organizer
      The 5th FHS International Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The protocol for the study about association between radio frequency wave and children health: The Hokkaido study on environment and children health2021

    • Author(s)
      Yamazaki K., Araki A., Miyashita C., Tamura N., Hikage T., Omiya M., Mizuta M., Kishi R.
    • Organizer
      proc. of XXXIV General Assembly and Scientific Symposium (GASS) of the International Union of Radio Science (Union Radio Scientifique Internationale-URSI)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Prospective study of postnatal depression in relation to infant development in Japan2021

    • Author(s)
      Uno A., Nakajima S., Sasaki S., Kato S., Itoh S., Yamazaki K., Kishi R
    • Organizer
      4th Global Public Health Conference 2021(GLOBEHEAL 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学物質のアディポカインへの影響、子どもの発育・発達との関連:北海道スタディ2021

    • Author(s)
      湊屋街子
    • Organizer
      第80回日本公衆衛生学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 胎児期の有機フッ素化合物ばく露と臍帯血中アディポサイトカイン濃度の関係の検討2021

    • Author(s)
      湊屋街子
    • Organizer
      第80回日本公衆衛生学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 妊娠中の有機フッ素化合物曝露と児の出生時体格との関連:受容体の遺伝型による影響2021

    • Author(s)
      小林澄貴
    • Organizer
      日本衛生学会若手研究者夏の集い2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 「北海道における毒性学研究」、胎児期の環境化学物質曝露による出生時の性ホルモンかく乱作用: 環境と子どもの健康に関する北海道スタディ2021

    • Author(s)
      荒木敦子, 岸玲子
    • Organizer
      第23回環境ホルモン学会研究発表会"One Healthと環境ホルモン研究”
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 妊婦の血中フタル酸エステル類と脂肪酸濃度:遺伝環境交互作用の影響―北海道スタディ2021

    • Author(s)
      小林澄貴, 佐田文宏, 荒木敦子, 宮下ちひろ, ホウマヌゴウダルジ, 那須民江, 岸玲子
    • Organizer
      第91回日本衛生学会学術総会(Web開催)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Urinary cotinine levels of Japanese school children and associated demographic characteristics: the Hokkaido Study.2020

    • Author(s)
      Minatoya M., Miyashita C., Araki A., Ait Bamai Y., Kobayashi S., Kisi R.
    • Organizer
      10th VIRTUAL International Conference Children’s Health and Environment Online
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phthalates in house dust and their metabolites in children's urine summary of the finding in Japan.2020

    • Author(s)
      Ait Bamai Y., Araki A., Kishi R.
    • Organizer
      30th Annual Meeting International Society of Exposure Science (ISES). (Virtual).
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Indoor Environmental Quality and Children's Health.2020

    • Author(s)
      Ait Bamai Y
    • Organizer
      Environmental, Safety Technology and Health Program. (Thailands, Virtual).
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PFAS and BPA exposures in utero and their alteration of DNA methylation at birth: the Hokkaido Study in collaboration with Taiwan cohorts2020

    • Author(s)
      Araki A., Miyashita C., Miura R., Wang S.-L. J., Chen M.-L., Kishi R.
    • Organizer
      32nd Annual Conference of the International Society for Environmental Epidemiology virtual conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mercury levels in pregnant women in Japanese general population and children’s birth size2020

    • Author(s)
      Araki A., Miyashita C., Kobayashi S., Kishi R.
    • Organizer
      32nd Annual Conference of the International Society for Environmental Epidemiology virtual conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 妊娠中の母のフタル酸エステル類曝露と子どもの肥満の関連の検討2020

    • Author(s)
      湊屋街子, 岸玲子
    • Organizer
      第79回日本公衆衛生学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胎児期の環境要因と低出生体重:環境と子どもの健康に関する北海道スタディ2020

    • Author(s)
      宮下ちひろ
    • Organizer
      第79回日本公衆衛生学会学術総会:出生コホート連携シンポジウム.
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胎児期有機フッ素化合物曝露と脂肪酸濃度:遺伝子との相互作用の影響―北海道スタディ2020

    • Author(s)
      小林澄貴, 佐田文宏, ホウマヌ・グウダルジ, 荒木敦子, 宮下ちひろ, 佐々木成子, 岡田恵美子, 岩崎雄介, 那須民江, and 岸玲子
    • Organizer
      第90回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 環境と子どもの健康に関する北海道研究(北海道スタディ)からの小児気管支喘息リスクスコア作成2020

    • Author(s)
      西條泰明, 佐藤遊洋, 吉岡英治, 小林澄貴, 宮下ちひろ, 湊屋街子, 荒木敦子, and 岸玲子
    • Organizer
      第90回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎児期の環境要因ばく露による出生体重、体格への影響とそのメカニズム2020

    • Author(s)
      湊屋街子
    • Organizer
      第90回 日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 妊娠中有機フッ素化合物曝露と臍帯血中の性ホルモン濃度との関連:遺伝環境相互作用の影響-北海道スタディ2020

    • Author(s)
      小林澄貴, 佐田文宏, 荒木敦子, 宮下ちひろ, 伊藤佐智子, グウダルジホウマヌ, 岩崎雄介, 三井貴彦, 守屋仁彦, 篠原信雄, 長和俊, 岸玲子
    • Organizer
      第30回日本疫学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Tobacco smoke exposure during pregnancy and early childhood and child anthropometric outcomes at school age: the Hokkaido Study.2019

    • Author(s)
      Minatoya M., Miyashita C., Araki A., Kishi R.
    • Organizer
      DOHaD 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environmental Chemical Exposures and Health Studies for Sustainable DEvelopment Goals.2019

    • Author(s)
      Minatoya M., Araki A., Kishi R.
    • Organizer
      ISEE-ISES AC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prenatal exposure to phthalates and childhood anthropometoric and metaolic related outcomes: the Hokkaido Study.2019

    • Author(s)
      Minatoya M., Miyashita C., Ait Bamai Y., Araki A., Kishi R.
    • Organizer
      ISEE-ISES AC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mixture Chemical Exposure in Utero and Boys Reproductive Hormone Levels at Birth: the Hokkaido Study.2019

    • Author(s)
      Araki A, Miyashita C, Itoh S, Mitsui T, Goudarzi H, Cho K, Moriya K, Nakajima T, Iwasaki Y, Hori T, Kajiwara J, Shinohara N, Kishi R
    • Organizer
      ISESISEE-AC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Capacity building and increasing awareness on environmental chemical exposures and prevention of their hazards.2019

    • Author(s)
      Araki A, Machiko M, Kishi R
    • Organizer
      Pacific Basin Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 有機フッ素化合物(PFASs)の胎児期曝露が児の健康へ及ぼす多様な影響2019

    • Author(s)
      岸玲子
    • Organizer
      第22回環境ホルモン学会研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 学童期の肥満に関連する要因の検討:北海道スタディ2019

    • Author(s)
      湊屋街子, 宮下ちひろ, 三浦りゅう, 荒木敦子, 岸玲子
    • Organizer
      第71回北海道公衆衛生学会.
    • Related Report
      2019 Annual Research Report
  • [Presentation] 「環境化学物質と健康障害の予防」に関するWHO CC(研究協力センター)の取り組みとWHOによる子どもの環境と健康研修モジュールの紹介2019

    • Author(s)
      荒木敦子, 湊屋街子, 岸玲子
    • Organizer
      第71回北海道公衆衛生学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アトピー性皮膚炎と子どもの行動発達の関連の検討:北海道スタディ2019

    • Author(s)
      湊屋街子, 須山聡, 岸玲子
    • Organizer
      第78回日本公衆衛生学会総会
    • Related Report
      2019 Annual Research Report
  • [Book] Health Impacts of Developmental Exposure to Environmental Chemicals.2020

    • Author(s)
      Kishi R., Grandjean P.
    • Total Pages
      557
    • Publisher
      Springer Nature
    • Related Report
      2020 Annual Research Report
  • [Book] Indoor Environmental Quality and Health Risk toward Healthier Environment for All.2020

    • Author(s)
      Kishi R., Norback D., Araki A.
    • Total Pages
      333
    • Publisher
      Springer Singapore
    • Related Report
      2020 Annual Research Report
  • [Book] Impacts of Developmental Exposure to Environmental Chemicals on Human Health with Global Perspectives. Health Impacts of Developmental Exposure to Environmental Chemicals2020

    • Author(s)
      Kishi R.
    • Total Pages
      20
    • Publisher
      Springer Nature
    • Related Report
      2020 Annual Research Report
  • [Book] Health Impacts of Developmental Exposure to Environmental Chemicals. (Chapter 22) Further Direction of Research and Policy Making of Environment and Children’s Health2020

    • Author(s)
      Kishi R., Araki A.
    • Total Pages
      13
    • Publisher
      Springer Nature
    • Related Report
      2020 Annual Research Report
  • [Book] Health Impacts of Developmental Exposure to Environmental Chemicals. (Chapter 2) Environmental Exposures and Adverse Pregnancy-Related Outcomes2020

    • Author(s)
      Minatoya M., Hanaoka T., Kishi R.
    • Total Pages
      14
    • Publisher
      Springer Nature
    • Related Report
      2020 Annual Research Report
  • [Book] Health Impacts of Developmental Exposure to Environmental Chemicals. (Chapter 12) Environmental Pollution and Recent Data on Asian Children’s Health in Relation to Pre- and Early Post-natal Exposure to Persistent Organic Pollutants, Including PCBs, PCDD/PCDFs, and Organochlorine Pesticides2020

    • Author(s)
      Miyashita C.
    • Total Pages
      22
    • Publisher
      Springer Nature
    • Related Report
      2020 Annual Research Report
  • [Book] Health Impacts of Developmental Exposure to Environmental Chemicals. (Chapter 19) Gene-Environment Interactions to Detect Adverse Health Effects on the Next Generation2020

    • Author(s)
      Sata F., Kobayashi S., Kishi R.
    • Total Pages
      28
    • Publisher
      Springer Nature
    • Related Report
      2020 Annual Research Report
  • [Book] Indoor Environmental Quality and Health Risk toward Healthier Environment for All. (Chapter 8) Semi-Volatile Organic Compounds (SVOCs): Phthalates and Phosphorous Frame Retardants and Health Risks.2020

    • Author(s)
      Ait Bamai Y.
    • Total Pages
      20
    • Publisher
      Springer Singapore
    • Related Report
      2020 Annual Research Report
  • [Book] Indoor Environmental Quality and Health Risk toward Healthier Environment for All. (Chapter 7) Aldehydes, volatile organic compounds (VOCs), and health.2020

    • Author(s)
      Araki A., Mesfin Rahel Ketema, Ait Bamai Y., Kishi R.
    • Total Pages
      30
    • Publisher
      Springer Singapore
    • Related Report
      2020 Annual Research Report
  • [Book] Indoor Environmental Quality and Health Risk toward Healthier Environment for All. (Chapter 1) Importance of Indoor Environmental Quality on Human Health toward Achievement of the SDGs.2020

    • Author(s)
      Kishi R., Araki A.
    • Total Pages
      16
    • Publisher
      Springer Singapore
    • Related Report
      2020 Annual Research Report
  • [Book] The Hokkaido Study on Environment and Children’s Health.(Chapter9) Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease.2019

    • Author(s)
      Kishi R., Araki A., Miyashita C., Kobayashi S., Miura R., Minatoya M.
    • Total Pages
      19
    • Publisher
      Springer
    • Related Report
      2019 Annual Research Report
  • [Remarks] 北海道大学 環境健康科学研究教育センター 研究業績・成果

    • URL

      https://www.cehs.hokudai.ac.jp/research

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report 2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

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