• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Associative and neural mechanisms underlying extinction of voluntary behaviour

Research Project

Project/Area Number 19H01775
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionWaseda University

Principal Investigator

Kosaki Yutaka  早稲田大学, 文学学術院, 教授 (80738469)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Keywords消去 / 連合学習 / 道具的行動 / 行動再発 / 動物 / 更新効果 / 文脈条件づけ / 行為と習慣 / 薬物依存 / 線条体 / 道具的条件づけ / 自発行動 / ラット / 連合学習理論
Outline of Research at the Start

我々ヒトを含む動物の行動は、その多くが学習によって形成される。行動を形成する際の学習については、その理論的分析や神経基盤の解明が進んでいるが、一旦形成された行動が何らかの要因により消失していく場面、「消去」において、どのようなメカニズムがそのような消去学習を支えているか、多くのことが未解明である。本研究では、ラットを対象として学習理論に基づく行動実験と神経科学的操作を組み合わせ、行動の消去に関するメカニズムを解明する。消去メカニズムの解明は、行動の基礎理論として重要であるのみならず、薬物依存や、多くの精神疾患で見られる非適応的な行動を適切に消去するための手がかりを得ることにも繋がる。

Outline of Final Research Achievements

The current project focused on the extinction of learned behaviour, and more specifically potential changes in the associative structure controlling instrumental behaviour during extinction learning. The results from individual experiments in the current project offered some new insight into this issue. First, the renewal of extinguished behaviour turned out to be a result of hierarchical control exerted by contextual stimuli, and not resulted from associative competition between instrumental behaviour and contextual stimuli as envisaged by Rescorla-Wagner (1972) model (i.e., protection from extinction). Second, the associative structure underlying instrumental behaviour, whether S-R habit process or R-O goal-directed process, did not change when the behaviour re-emerged after extinction; both types of behaviour showed renewal effect while maintaining their original associative status.

Academic Significance and Societal Importance of the Research Achievements

自発行動の消去について理解することは、我々ヒトを含む動物がどのように行動を変容させることで環境に適応するかという、心理学・行動科学が設定しうる最も根源的な問いに答える上で、極めて重要である。同時に、消去が困難であり、また容易に再発する行動、例えば薬物依存や行動嗜癖について基礎的な理解を得て、適切な治療などに応用する上でも重要性が高い。その意味では本研究で得られた成果は、上記の科学的理解、および社会への還元において着実な前進をもたらしたと言える。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (13 results)

All 2022 2021 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (6 results) Funded Workshop (3 results)

  • [Journal Article] Measurement of the exploration?exploitation response of dogs through a concurrent visual discrimination task2022

    • Author(s)
      Shinoda Kumi、Kosaki Yutaka、Nagasawa Miho、Kikusui Takefumi
    • Journal Title

      Behavioural Processes

      Volume: 199 Pages: 104644-104644

    • DOI

      10.1016/j.beproc.2022.104644

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Higher-Order Conditioning in the Spatial Domain2021

    • Author(s)
      Bouchekioua Youcef、Kosaki Yutaka、Watanabe Shigeru、Blaisdell Aaron P.
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 15 Pages: 1-7

    • DOI

      10.3389/fnbeh.2021.766767

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spatial inference without a cognitive map: the role of higher‐order path integration2020

    • Author(s)
      Bouchekioua Youcef、Blaisdell Aaron P.、Kosaki Yutaka、Tsutsui‐Kimura Iku、Craddock Paul、Mimura Masaru、Watanabe Shigeru
    • Journal Title

      Biological Reviews

      Volume: 96 Issue: 1 Pages: 52-65

    • DOI

      10.1111/brv.12645

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions2020

    • Author(s)
      Poulter Steven L.、Kosaki Yutaka、Sanderson David J.、McGregor Anthony
    • Journal Title

      Brain and Neuroscience Advances

      Volume: 4 Pages: 1-4

    • DOI

      10.1177/2398212820972599

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Biology matters: The role of stimulus modality, duration, and context in the production of different types of CR in Pavlovian fear conditioning in mice.2021

    • Author(s)
      Kosaki, Y., Otsuka, A., & Yamagishi, S.
    • Organizer
      The 81st Annual Meeting of the Japanese Society for Animal Psychology
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of ultrasonic vocalizations to methamphetamine-associated cue in the absence of the drug: a conditioned compensatory response in mice.2021

    • Author(s)
      Nagai, T., & Kosaki, Y.
    • Organizer
      The 81st Annual Meeting of the Japanese Society for Animal Psychology
    • Related Report
      2021 Annual Research Report
  • [Presentation] Abnormal transition of stimulus representation in ketamine-treated mice: An implication for positive symptoms of schizophrenia.2021

    • Author(s)
      Suzuki, R., & Kosaki, Y.
    • Organizer
      The 81st Annual Meeting of the Japanese Society for Animal Psychology
    • Related Report
      2021 Annual Research Report
  • [Presentation] Exploring the associative mechanisms underlying instrumental ABA renewal in rats2019

    • Author(s)
      Yutaka Kosaki, Shun Fujimaki
    • Organizer
      The 79th Annual Meeting of the Japanese Society for Animal Psychology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of pre-exposure to methamphetamine on instrumental conditioning in mice2019

    • Author(s)
      Miki Nakayama, Yutaka Kosaki
    • Organizer
      The 79th Annual Meeting of the Japanese Society for Animal Psychology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Methamphetamine-induced taste aversion/avoidance in mice2019

    • Author(s)
      Risako Miki, Yutaka Kosaki
    • Organizer
      The 79th Annual Meeting of the Japanese Society for Animal Psychology
    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] The 79th Annual Meeting of the Japanese Society for Animal Psychology2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] 第2回学習心理学研究会2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] 第3回学習心理学研究会2019

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi