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A production method of Tc-99m medical radioactive isotopes by hot atoms and hydrated MoO3 porous targets

Research Project

Project/Area Number 19H02429
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 26020:Inorganic materials and properties-related
Research InstitutionNagaoka University of Technology

Principal Investigator

Suematsu Hisayuki  長岡技術科学大学, 工学研究科, 教授 (30222045)

Co-Investigator(Kenkyū-buntansha) 鈴木 達也  長岡技術科学大学, 工学研究科, 教授 (70323839)
南口 誠  長岡技術科学大学, 工学研究科, 教授 (90272666)
Do T.M.Dung  長岡技術科学大学, 工学研究科, 助教 (90638420)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords医療用放射性同位体 / ホットアトム / 医療用放射性同位元素 / 放射性同位元素 / 医療用
Outline of Research at the Start

含水層状MoO3結晶に中性子照射し通水するだけで99Moを生成・水相に回収するシーズ(特願2018-182149)を基にし、核反応で生成した99Moのホットアトムをターゲット内部から水相に取り出すためのMoO3多孔体を作製し、研究用原子炉での中性子照射実験と放射能測定を行う。これにより、困難な同位体分離や危険な高温NaOH溶液への溶解なしに、99Moとその娘核である99mTcを用いた製剤開発を行う。この技術により、これまで100%輸入していた99Moの、生産国産化と供給安定化させる技術開発を目指す。

Outline of Final Research Achievements

Alfa-MoO3 porous sintered bodies, alfa-MoO3 dendrites and beta-MoO3 whiskers were prepared and irradiated by neutrons. After the irradiation, they were dispersed in water. beta-MoO3 whiskers showed the highest recovery ratio of Mo-99 into water of 67%. These results were thought to be caused by the long Mo-O interlayer distance, the hydration property and the short width of beta- MoO3 whiskers, in which water and 99Mo can easily diffuse. In this research, a novel Mo-99 production method only disperse the neutron irradiated target in water has been developed.

Academic Significance and Societal Importance of the Research Achievements

本研究により、高温濃NaOH溶液へのターゲット溶解での潜在的危険性や、Mo-98からMo-99の同位体分離技術の開発なしに、中性子照射したβ- MoO3ウイスカーターゲットを水に分散・フィルター濾過するだけでMo-99水溶液を抽出する技術の開発に成功した。これにより、Mo-99とその娘核種であるTc-99mの医療用放射性同位体製剤の、国内安定供給法確立に道を拓いた。本技術は、高濃縮U-235燃料を用いた原子炉を必要とせず、世界の核拡散防止にも大きな貢献が可能と考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (13 results)

All 2022 2021 2019 Other

All Int'l Joint Research (4 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] ベトナム原子力研究所/ハノイ工科大学(ベトナム)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ハノイ工科大/ベトナム原子力研究所(ベトナム)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] インド工科大学マドラス校(インド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ベトナム原子力研究所(ベトナム)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Hydration Process of β-MoO3 Powder2022

    • Author(s)
      N. M. Chu, N. D. Hieu, T. M. D. Do, T. Nakayama, K. Niihara and H. Suematsu
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 61 Issue: SB Pages: SB1018-SB1018

    • DOI

      10.35848/1347-4065/ac2a72

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of β-MoO3 Whiskers by a Thermal Evaporation Method with Oxygen Gas Flow2022

    • Author(s)
      N. M. Chu, N. D. Hieu, T. M. D. Do, T. Nakayama, K. Niihara, and H. Suematsu
    • Journal Title

      J. Am. Ceram. Soc.

      Volume: 105 Issue: 3 Pages: 1622-1628

    • DOI

      10.1111/jace.18192

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of β-MoO3 Nanowhiskers from Core/shell Molybdenum/molybdenum Oxide Wire by Pulsed Wire Discharge2021

    • Author(s)
      N. M. Chu, N. D. Hieu, T. M. D. Do, T. Nakayama, K. Niihara, H. Suematsu
    • Journal Title

      Inter. J. Appl. Ceram. Technol.

      Volume: 18 Issue: 3 Pages: 889-901

    • DOI

      10.1111/ijac.13684

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle Synthesis of Transition-metal Borides by Pulsed Discharge of Compacted Powder2021

    • Author(s)
      D. H. Nguyen, M. C. Ngo, Y. Tokoi, T.-M.-D. Do, T. Nakayama, H. Suematsu and K. Niihara
    • Journal Title

      J. Am. Ceram. Soc.

      Volume: 104 Issue: 9 Pages: 4351-4367

    • DOI

      10.1111/jace.17780

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Equation to Determine the Sizes of Various Light and Heavy Metallic Nanoparticles Prepared by Pulsed Wire Discharge2021

    • Author(s)
      H. D. Nguyen, T. Sasaki, C. M. Ngo, Y. Tokoi, T.-M.-D. Do, T. Nakayama, H. Suematsu, and K. Niihara
    • Journal Title

      J. Appl. Phys.

      Volume: 130 Issue: 18 Pages: 185901-185901

    • DOI

      10.1063/5.0064989

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Molybdenum Carbide Nanoparticles by using a Pulse Wire Discharge Method in Kerosene and Argon Ambience2019

    • Author(s)
      N. M. Chu, N. D. Hieu, D. T. M. Dung, R. Sarathi, T. Nakayama, and H. Suematsu
    • Journal Title

      J. Am. Ceram. Soc.

      Volume: 102 Issue: 12 Pages: 7108-7115

    • DOI

      10.1111/jace.16621

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Two-step pressurization method in pulsed electric current sintering of dense and porous MoO3 targets for 99Mo/99mTc radioactive isotope production2021

    • Author(s)
      H. Suematsu, S. Sato, T. Q. Thang, M. Nanko, T. M. D. Do, T. Nakayama and K. Niihara
    • Organizer
      th International Congress on Ceramics, Apr. 25-30, 2021, Virtual, Korea
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] MoO3 porous materials for neutron irradiation targets for production of 99Mo/99mTc2019

    • Author(s)
      H. Suematsu, M. Seki, T. M. D. Do, M. Nanko, T. Suzuki, D. V. Dong T. Nakayama and K. Niihara
    • Organizer
      43th International Conference and Expo on Advanced Ceramics and Composites, Daytona Beach, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] モリブデン-99製造用ターゲット材料及びその製造方法2022

    • Inventor(s)
      末松久幸 他
    • Industrial Property Rights Holder
      末松久幸 他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-063746
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-12-25  

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