| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Outline of Final Research Achievements |
A method to utilize short-lived carbanions, which have promising potential for organic synthesis but have been difficult to control their reactivity, has been developed. Halogenated aryl anions that undergo benzyne formation or halogen dance were investigated, and a precise in situ transmetalation using metal-diamine complexes has been established. To demonstrate the synthetic utility of this method, total syntheses of biologically active natural products such as lamellarins, dictyodendrins, and carbazomycins were accomplished.
|
