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Elucidation of hierarchical functional control of plant ion transporters driven by intracellular regulatory factors

Research Project

Project/Area Number 19H02880
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 38030:Applied biochemistry-related
Research InstitutionTohoku University

Principal Investigator

Uozumi Nobuyuki  東北大学, 工学研究科, 教授 (40223515)

Co-Investigator(Kenkyū-buntansha) 石丸 泰寛  東北大学, 工学研究科, 准教授 (80590207)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2021: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords膜輸送体 / 脂質修飾 / 浸透圧 / 恒常性 / イオン輸送 / イオン輸送体 / リン酸化 / Ca
Outline of Research at the Start

植物は乾燥・脱水・塩害などの環境変化にさらされていることから恒常性維持は生存に重要である.それを担う植物イオン輸送体は養分吸収,浸透圧調節,膜電位形成,細胞内酵素の活性化と不活化などに直接関与して恒常性の維持,増殖と分化において重要な役割を担っている.本研究では,これまで申請者が行ってきたイオン輸送体に関する結果に基づいて,未解明となっているイオン輸送体の機能と役割とその統御の機構の解明をはかる.イオン輸送体を一括して調節する細胞内分子の同定と作用機構の解明をめざし、植物におけるイオン輸送体の機能発現に至る統御機構の解明をすすめる.

Outline of Final Research Achievements

I
Living cells need to adapt to various changes in the environment, and have a mechanism to maintain homeostasis in response to drought, dehydration, salt damage, etc. The plant ion transporter functions as a molecular mechanism, and performs nutrient absorption, osmoregulation, membrane potential formation, and activation and inactivation of intracellular enzymes. Ion transport system located in biological membrane play important roles in maintaining homeostasis, proliferation and differentiation in response to environmental changes. In this study, we have elucidated the functions and roles of ion transport system, which have not been well characterized, and their control mechanism. We have identified ion transport system to adapt to environmental changes and obtained knowledge on the control mechanism of membrane ion transport.

Academic Significance and Societal Importance of the Research Achievements

地球環境は短期的にも長期的にも変化が激しく,地球上の生物はその変化に適応している.砂漠化などの環境変化は地球規模の課題となっている.生物は環境変化の中で細胞内恒常性を維持するために,生体膜で機能するイオン輸送体は重要な役割を果たしている.本研究では,これまで知られていなかった植物のイオン輸送体やその先祖型の輸送体の機能や調節機構を分子レベルから調べた.これにより,新たなイオン輸送体の分子機構の一端が明らかとなり,生物の環境適応性に関する知見のいくつかが明らかとなった.環境変化に耐性力を持つ植物の知的基盤を確立にあたり,本研究の成果は寄与すると考えられる.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (13 results)

All 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] University of Milan(イタリア)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Loss of cell wall integrity genes cpxA and mrcB causes flocculation in Escherichia coli2021

    • Author(s)
      Sugawara Keita、Toyoda Hayato、Kimura Mami、Hayasaka Shunsuke、Saito Hiromi、Kobayashi Hiroshi、Ihara Kunio、Ida Tomoaki、Akaike Takaaki、Ando Eiji、Hyodo Mamoru、Hayakawa Yoshihiro、Hamamoto Shin、Uozumi Nobuyuki
    • Journal Title

      Biochemical Journal

      Volume: 478 Issue: 1 Pages: 41-59

    • DOI

      10.1042/bcj20200723

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Calcium-Regulated Phosphorylation Systems Controlling Uptake and Balance of Plant Nutrients2020

    • Author(s)
      Saito Shunya、Uozumi Nobuyuki
    • Journal Title

      Frontiers in Plant Science

      Volume: 11 Pages: 1-11

    • DOI

      10.3389/fpls.2020.00044

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional characterization of multiple PAS domain-containing diguanylate cyclases in Synechocystis sp. PCC 68032020

    • Author(s)
      Ishikawa Ko、Chubachi Chihiro、Tochigi Saeko、Hoshi Naomi、Kojima Seiji、Hyodo Mamoru、Hayakawa Yoshihiro、Furuta Tadaomi、Kera Kota、Uozumi Nobuyuki
    • Journal Title

      Microbiology

      Volume: 166 Issue: 7 Pages: 659-668

    • DOI

      10.1099/mic.0.000929

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diverse Physiological Functions of Cation Proton Antiporters across Bacteria and Plant Cells2020

    • Author(s)
      Tsujii Masaru、Tanudjaja Ellen、Uozumi Nobuyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 12 Pages: 4566-4566

    • DOI

      10.3390/ijms21124566

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of Arabidopsis TPK2 and KCO3 reveals structural properties required for K+ channel function2020

    • Author(s)
      Uehara Chihiro、Takeda Kota、Ibuki Tatsuki、Furuta Tadaomi、Hoshi Naomi、Tanudjaja Ellen、Uozumi Nobuyuki
    • Journal Title

      Channels

      Volume: 14 Issue: 1 Pages: 336-346

    • DOI

      10.1080/19336950.2020.1825894

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hik36?Hik43 and Rre6 act as a two-component regulatory system to control cell aggregation in Synechocystis sp. PCC68032020

    • Author(s)
      Kera Kota、Yoshizawa Yuichiro、Shigehara Takehiro、Nagayama Tatsuya、Tsujii Masaru、Tochigi Saeko、Uozumi Nobuyuki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-020-76264-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The mechanosensitive channel YbdG from Escherichia coli has a role in adaptation to osmotic up-shock.2019

    • Author(s)
      Shun Amemiya, Hayato Toyoda, Mami Kimura, Hiromi Saito, Hiroshi Kobayashi, Kunio Ihara 3 , Kiyoto Kamagata 4 , Ryuji Kawabata 5 , Setsu Kato, Yutaka Nakashimada, Tadaomi Furuta, Shin Hamamoto, Nobuyuki Uozumi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 (33) Issue: 33 Pages: 12281-12292

    • DOI

      10.1074/jbc.ra118.007340

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for potassium transport activity of Arabidopsis KEA1-KEA6.2019

    • Author(s)
      Masaru Tsujii, Kota Kera, Shin Hamamoto, Takashi Kuromori, Toshiharu Shikanai, Nobuyuki Uozumi
    • Journal Title

      Scientific Report

      Volume: 9 (1), 10040 Issue: 1 Pages: 10040-10040

    • DOI

      10.1038/s41598-019-46463-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Isolation of natural ion channel inhibiters in Arabidopsis thaliana2021

    • Author(s)
      Kanane Sato, Shunya Saito, Megumi Kato, Shin Hamamoto, Taishin Kakei, Masaru Kono, Matteo Grenzi, Alex Costa, Yasuhiro Ishimaru, Nobuyuki Uozumi
    • Organizer
      Pacifichem2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple CBL-CIPK pairs regulate Arabidopsis guard cell ion channels2019

    • Author(s)
      Shunya Saito, Misaki Sato, Shin Hamamoto, Philipp Koster, Jeorg Kudla and Nobuyuki Uozumi
    • Organizer
      18th International Workshop on Plant Membrane Biology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法2021

    • Inventor(s)
      魚住信之 遠藤晃輔 浜本晋 池ノ上芳章
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-042163
    • Filing Date
      2021
    • Acquisition Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] ジフェニル尿素化合物誘導体2019

    • Inventor(s)
      魚住信之,有澤美枝子,鈴木喬太
    • Industrial Property Rights Holder
      魚住信之,有澤美枝子,鈴木喬太
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-145811
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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