Regulation of humoral and cellular immune responses by innate immune receptor Gyc76C in Drosophila
| Project/Area Number |
19H03365
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 自然免疫 / ショウジョウバエ / 液性応答 / 細胞性応答 / cGMP経路 / 液性免疫応答 / 細胞性免疫応答 / NF-κB経路 / NF-κB 経路 |
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| Outline of Research at the Start |
近年自然免疫系が、病原体成分だけでなく、自己由来のリガンド（内因性リガンド）も認識し、慢性炎症疾患、生活習慣病などの発症に深く関わることが明らかとなってきた。その際、病原体成分では強い反応が一過的に誘導されるのに対して、内因性リガンドでは弱い反応が持続的に誘導され、慢性炎症となる。したがって、これらの疾患発症の理解と、それを標的とした創薬を考える際には、このような自然免疫応答の違いが、どのようにして生じるのかを理解することが重要である。本研究では、ショウジョウバエを用いてこの問題に迫る。
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| Outline of Final Research Achievements |
Innate immunity is involved in chronic inflammatory diseases, cancer metastasis, and lifestyle diseases by recognition of self-ligands. Therefore, understanding of regulation mechanisms of innate immune system is indispensable for understanding of these diseases and drug discovery. We have identified novel cGMP signaling pathway that modulates NF-κB pathway in innate immunity. In this study, we have identified a novel receptor, Gyc76C, which regulates innate immunity. In this study, we have elucidated one aspect of the molecular mechanism by which Gyc76C regulates humoral and cellular immunity.
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| Academic Significance and Societal Importance of the Research Achievements |
自然免疫系が、当初その関連が予想もされなかった、慢性炎症疾患や、ガン転移、生活習慣病などと深い関わりがあることが明らかとなってきた。病原体成分では強い反応が一過的に誘導されるのに対して、慢性炎症では弱い反応が持続的に誘導される。したがって、それらの疾患の理解や創薬には、自然免疫がどのように調節されているかを理解することが重要である。本研究により、同じ受容体が、液性免疫と細胞性免疫を調節する分子機構が明らかとなり、自然免疫制御機構の理解に重要な進展が見られた。
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection2021
Author(s)
Yuhki Indo, Shugo Kitahara, Mikado Tomokiyo, Shota Araki, Md Aminul Islam, Binghui Zhou, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa
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Journal Title
Front Immunol
Volume: 12
Pages: 652923-652923
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Selection of Immunobiotic Ligilactobacillus salivarius Strains from the Intestinal Tract of Wakame-Fed Pigs: Functional and Genomic Studies2020
Author(s)
Binghui Zhou, Leonardo Albarracin, Yuhki Indo, Lorena Arce, Yuki Masumizu, Mikado Tomokiyo, Md. Aminul Islam, Valeria Garcia-Castillo, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Hidetoshi Morita, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa
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Journal Title
Microorganisms
Volume: 8
Issue: 11
Pages: 1659-1659
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A receptor guanylate cyclase, Gyc76C, mediates humoral and cellular responses in distinct ways in Drosophila immunity.2020
Author(s)
Shinzo Iwashita, Hiroaki Suzuki, Akira Goto, Tomohito Oyama, Hirotaka Kanoh, Takayuki Kuraishi, Naoyuki Fuse, Tamaki Yano, Yoshiteru Oshima, Julian A. T. Dow, Shireen-Anne Davies, Shoichiro Kurata
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Journal Title
Front. Immunol.
Volume: 11
Pages: 35-35
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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