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Elucidation of the Rab regulatory network that induces bacterial species-specific xenophagy

Research Project

Project/Area Number 19H03471
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 49050:Bacteriology-related
Research InstitutionKyoto University

Principal Investigator

Nakagawa Ichiro  京都大学, 医学研究科, 教授 (70294113)

Co-Investigator(Kenkyū-buntansha) 野澤 孝志  京都大学, 医学研究科, 准教授 (10598858)
相川 知宏  京都大学, 医学研究科, 助教 (70725499)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsゼノファジー / A群レンサ球菌 / ユビキチン化 / Fboxプロテイン / 菌体表層糖鎖 / GAC / ガレクチン / -A群レンサ球菌 / SLO / Nga / ゴルジ体 / 黄色ブドウ球菌 / RabGAP / RabGEF / オートファジー / 上皮間接着 / TBC1D9 / 細胞内カルシウム
Outline of Research at the Start

本研究では、細菌種特異的にゼノファジーを誘導するRabタンパク質制御ネットワークと、その活性化に関わる細菌性因子を特定し、細菌種特異的なゼノファジー制御系を明らかとすることを目的とする。宿主細胞内に侵入した菌は、p62やNDP52などのユビキチンへのアダプター分子を介してゼノファジーによって認識されるが、菌種をどのように認識するのかについては明らかではない。そこで、A群レンサ球菌と黄色ブドウ球菌を用いて菌種特異的な動態を示す小胞輸送制御システムであるRabの制御因子であるRabGAP/RabGEFが、細菌性因子によってどのように制御されているのかを明らかとする。

Outline of Final Research Achievements

Xenophagy is a phenomenon in which bacteria invading the cell are recognized as foreign and degraded by autophagy. We have analyzed the recognition and elimination by xenophagy of bacteria invading the cell by producing mutants of the carbohydrate synthesis system at the topmost surface of group A Streptococcus bacteria. The mutant was found to recognize group A streptococcal polysaccharide antigens and induce xenophagy, and the recognition was found to involve the FBXO2 protein, a component of the intracellular ubiquitin ligase complex, whose function in bacterial infection was previously unknown.

Academic Significance and Societal Importance of the Research Achievements

本研究では、細胞内に侵入した菌の認識と排除に、菌体表層の糖を認識してユビキチン化を誘導する新たなメカニズムを明らかとした。実際に、ゼノファジー誘導においては感染する菌の種類によって動員される細胞内のメンブレントラフィッキングに関わる分子が大きく異なっていることから、以前からどのように菌種を見分けているのかという点が不明であったが、今回の研究で、その一端を明らかにできたと考えている。宿主細胞内には、まだまだ機能が明らかとなっていないユビキチンリガーゼが存在しており、我々が想像している以上に、細胞内の異物を細かくかつ正確に認識している可能性がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (52 results)

All 2021 2020 2019 Other

All Journal Article (23 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 23 results,  Open Access: 19 results) Presentation (26 results) (of which Invited: 9 results) Remarks (3 results)

  • [Journal Article] FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan2021

    • Author(s)
      Yamada Akihiro、Hikichi Miyako、Nozawa Takashi、Nakagawa Ichiro
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 11

    • DOI

      10.15252/embr.202152584

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor2021

    • Author(s)
      Yamawaki T, Nakakido M, Ujiie K, Aikawa C, Nakagawa I, Tsumoto K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 6 Pages: 1-7

    • DOI

      10.1016/j.bbrc.2021.05.056

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection.2021

    • Author(s)
      Aikawa C, Kawashima K, Fukuzaki C, Nakakido M, Murase K, Nozawa T, Tsumoto K, Nakagawa I
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 20 Pages: 177-183

    • DOI

      10.1016/j.bbrc.2021.06.021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patient‐specific establishment of bacterial composition within the peri‐implant microbiota during the earliest weeks after implant uncovering2021

    • Author(s)
      Shimogishi Masahiro、Watanabe Takayasu、Shibasaki Masaki、Shiba Takahiko、Komatsu Keiji、Nemoto Takashi、Ishihara Kazuyuki、Nakano Yoshio、Iwata Takanori、Kasugai Shohei、Nakagawa Ichiro
    • Journal Title

      Journal of Periodontal Research

      Volume: 56 Issue: 5 Pages: 964-971

    • DOI

      10.1111/jre.12898

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An In Vitro Mixed Infection Model With Commensal and Pathogenic Staphylococci for the Exploration of Interspecific Interactions and Their Impacts on Skin Physiology2021

    • Author(s)
      Kohda Katsunori、Li Xuan、Soga Naoki、Nagura Risa、Duerna Tie、Nakajima Saeko、Nakagawa Ichiro、Ito Masakazu、Ikeuchi Akinori
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 11 Pages: 712360-712360

    • DOI

      10.3389/fcimb.2021.712360

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biological Effect of Streptococcus pyogenes-Released Extracellular Vesicles on Human Monocytic Cells, Induction of Cytotoxicity, and Inflammatory Response2021

    • Author(s)
      Murase Kazunori、Aikawa Chihiro、Nozawa Takashi、Nakatake Ayako、Sakamoto Kuniyo、Kikuchi Taisei、Nakagawa Ichiro
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 11 Pages: 711144-711144

    • DOI

      10.3389/fcimb.2021.711144

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021

    • Author(s)
      Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
    • Journal Title

      Autophagy

      Volume: 17 Issue: 1 Pages: 1-382

    • DOI

      10.1080/15548627.2020.1797280

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase2021

    • Author(s)
      Nozawa Takashi、Iibushi Junpei、Toh Hirotaka、Minowa-Nozawa Atsuko、Murase Kazunori、Aikawa Chihiro、Nakagawa Ichiro
    • Journal Title

      mBio

      Volume: 12 Issue: 1

    • DOI

      10.1128/mbio.01974-20

    • NAID

      120006958085

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection2020

    • Author(s)
      Lin Ching-Yu、Nozawa Takashi、Minowa-Nozawa Atsuko、Toh Hirotaka、Hikichi Miyako、Iibushi Junpei、Nakagawa Ichiro
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 10 Pages: 583137-583137

    • DOI

      10.3389/fcimb.2020.583137

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Group A Streptococcus-Containing Autophagosome-Like Vacuoles2020

    • Author(s)
      Nozawa Takashi、Nakagawa Ichiro
    • Journal Title

      Group A Streptococcus

      Volume: 2136 Pages: 223-231

    • DOI

      10.1007/978-1-0716-0467-0_16

    • ISBN
      9781071604663, 9781071604670
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular Group A Streptococcus induces Golgi fragmentation to impair host defenses through Streptolysin O and NAD-glycohydrolase2020

    • Author(s)
      Nozawa Takashi、Iibushi Junpei、Toh Hirotaka、Minowa-Nozawa Atsuko、Murase Kazunori、Aikawa Chihiro、Nakagawa Ichiro
    • Journal Title

      bioRxiv

      Volume: 0 Pages: 207897-207897

    • DOI

      10.1101/2020.07.16.207894

    • NAID

      120006958085

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Streptococcus pyogenes Serotype M3, M28, and M89 Strains Isolated from Human Patients in Japan, 1994 to 20092020

    • Author(s)
      Murase Kazunori、Nozawa Takashi、Aikawa Chihiro、Nagao Miki、Ikebe Tadayoshi、Yoshida Akemi、Kikuchi Taisei、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 9 Issue: 42

    • DOI

      10.1128/mra.01047-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phylogenetic diversity in fim and mfa gene clusters between Porphyromonas gingivalis and Porphyromonas gulae, as a potential cause of host specificity2020

    • Author(s)
      Fujiwara-Takahashi Kaori、Watanabe Takayasu、Shimogishi Masahiro、Shibasaki Masaki、Umeda Makoto、Izumi Yuichi、Nakagawa Ichiro
    • Journal Title

      Journal of Oral Microbiology

      Volume: 12 Issue: 1 Pages: 1775333-1775333

    • DOI

      10.1080/20002297.2020.1775333

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Two Streptococcus suis Strains Isolated from Asymptomatic Pigs2020

    • Author(s)
      Minowa-Nozawa Atsuko、Nozawa Takashi、Takamatsu Daisuke、Yoshida Akemi、Murase Kazunori、Kikuchi Taisei、Ishida-Kuroki Kasumi、Nitta Yoshihiro、Sekizaki Tsutomu、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 9 Issue: 47

    • DOI

      10.1128/mra.01142-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps.2020

    • Author(s)
      Tanaka M, Kinoshita-Daitoku R, Kiga K, Sanada T, Zhu B, Okano T, Aikawa C, Iida T, Ogura Y, Hayashi T, Okubo K, Kurosawa M, Hirahashi J, Suzuki T, Nakagawa I, Nangaku M, Mimuro H.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3251-3251

    • DOI

      10.1038/s41598-020-60306-w

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.2020

    • Author(s)
      Nozawa T, Sano S, Minowa-Nozawa A, Toh H, Nakajima S, Murase K, Aikawa C, Nakagawa I.
    • Journal Title

      Nat Commun.

      Volume: 11 Issue: 1 Pages: 770-770

    • DOI

      10.1038/s41467-020-14533-4

    • NAID

      120006840172

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy.2019

    • Author(s)
      Toh H, Nozawa T, Minowa-Nozawa A, Hikichi M, Nakajima S, Aikawa C, Nakagawa I.
    • Journal Title

      Autophagy

      Volume: 14 Issue: 2 Pages: 1-13

    • DOI

      10.1080/15548627.2019.1628539

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Streptococcus pneumoniae Strains HU-OH (Serotype 3, Sequence Type 183 [ST183]), NU83127 (Serotype 4, ST246), and ATCC 49619 (Serotype 19F, ST1203)2019

    • Author(s)
      Nagaoka Kentaro、Konno Satoshi、Murase Kazunori、Kikuchi Taisei、Morinaga Yoshitomo、Yanagihara Katsunori、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 8 Issue: 9

    • DOI

      10.1128/mra.01504-18

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy2019

    • Author(s)
      Lin Ching-Yu、Nozawa Takashi、Minowa-Nozawa Atsuko、Toh Hirotaka、Aikawa Chihiro、Nakagawa Ichiro
    • Journal Title

      Cellular Microbiology

      Volume: 21 Issue: 4

    • DOI

      10.1111/cmi.12981

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells.2019

    • Author(s)
      Toh H, Lin CY, Nakajima S, Aikawa C, Nozawa T, Nakagawa I.
    • Journal Title

      Front Cell Infect Microbiol.

      Volume: 9 Pages: 398-398

    • DOI

      10.3389/fcimb.2019.00398

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia2019

    • Author(s)
      Takahashi Ichiro, Hosomi Koji, Nagatake Takahiro, Tobou Hirokazu, Yamamoto Daiki, Hayashi Ikue, Kurashima Yosuke, Sato Shintaro, Shibata Naoko, Goto Yoshiyuki, Maruyama Fumito, Nakagawa Ichiro, Kuwae Asaomi, Abe Akio, Kunisawa Jun, Kiyono Hiroshi
    • Journal Title

      International Immunology

      Volume: 32 Issue: 2 Pages: 133-141

    • DOI

      10.1093/intimm/dxz071

    • NAID

      120006888456

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients2019

    • Author(s)
      Funahashi Kenta、Shiba Takahiko、Watanabe Takayasu、Muramoto Keiko、Takeuchi Yasuo、Ogawa Takuya、Izumi Yuichi、Sekizaki Tsutomu、Nakagawa Ichiro、Moriyama Keiji
    • Journal Title

      Progress in Orthodontics

      Volume: 20 Issue: 1 Pages: 11-11

    • DOI

      10.1186/s40510-019-0265-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete Genome Sequences of Eight Methicillin-Resistant Staphylococcus aureus Strains Isolated from Patients in Japan2019

    • Author(s)
      Hikichi Miyako、Nagao Miki、Murase Kazunori、Aikawa Chihiro、Nozawa Takashi、Yoshida Akemi、Kikuchi Taisei、Nakagawa Ichiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 8 Issue: 47 Pages: 01212-19

    • DOI

      10.1128/mra.01212-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生命金属の新潮流2021

    • Author(s)
      中川一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 化膿連鎖球菌由来金属獲得蛋白質 MtsA に対する機能阻害剤の探索2021

    • Author(s)
      中木戸 誠,竹内 美結,長門石 曉,相川 知宏,中川 一路,津本 浩平
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] -A 群レンサ球菌の増殖に必要な鉄獲得機構に対する阻害剤の探索2021

    • Author(s)
      相川 知宏,長門石 曉,中木戸 誠,妹尾 暁暢,星野 将人,野澤 孝志,村瀬 一典,津本 浩平,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ESCRT 機構による A 群レンサ球菌感染制御2021

    • Author(s)
      野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] GBP1 は TBK1 のリン酸化を介して A 群レンサ球菌に対する選択 的オートファジーを制御する2021

    • Author(s)
      曵地 京,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A 群レンサ球菌が産生する細胞外小胞の病原性への関与2021

    • Author(s)
      村瀬 一典,相川 知宏,野澤 孝志,中武 彩子,菊地 泰生,中川 一 路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] オートファジー関連因子 ATG9 は A 群レンサ球菌の細胞内への侵 入を制御する2021

    • Author(s)
      飯伏 純平,藤 博貴,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] TBC1D9を介したカルシウムシグナリングはTBK1依存性ゼノファジーを制御する2020

    • Author(s)
      中川一路
    • Organizer
      第32回日本生体防御学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 化膿連鎖球菌由来金属獲得蛋白質 MtsA に対する機能阻害剤の探索2020

    • Author(s)
      中木戸 誠,竹内 美結,長門石 曉,相川 知宏,中川 一路,津本 浩平
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] A 群レンサ球菌の増殖に必要な鉄獲得機構に対する阻害剤の探索2020

    • Author(s)
      相川 知宏,長門石 曉,中木戸 誠,妹尾 暁暢,星野 将人,野澤 孝志,村瀬 一典,津本 浩平,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ESCRT 機構による A 群レンサ球菌感染制御2020

    • Author(s)
      野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] GBP1 は TBK1 のリン酸化を介して A 群レンサ球菌に対する選択 的オートファジーを制御する2020

    • Author(s)
      曵地 京,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] オートファジー関連因子 ATG9 は A 群レンサ球菌の細胞内への侵 入を制御する2020

    • Author(s)
      飯伏 純平,藤 博貴,野澤 孝志,中川 一路
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A群レンサ球菌の分泌毒素NAD-glycohydrolaseはATG14-PIK3C3複合体および RAB1依存的なオートファゴソーム形成を阻害する2019

    • Author(s)
      藤博貴、中島慎太郎、 相川知宏、 野澤敦子、 野澤孝志、 中川一路
    • Organizer
      第51回レンサ球菌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 曵地京、野澤孝志、中川一路2019

    • Author(s)
      A群レンサ球菌に対するゼノファジー誘導の分子機構
    • Organizer
      第51回レンサ球菌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A群レンサ球菌感染に対するゼノファジーの制御2019

    • Author(s)
      中川一路
    • Organizer
      第62回日本感染症学会中日本地方会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 分子間相互作用阻害に基づく 菌種特異的な増殖阻害剤の開発2019

    • Author(s)
      中川一路
    • Organizer
      第92回日本生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Regulation of xenophagy in group A Streptococcus infection2019

    • Author(s)
      中川一路
    • Organizer
      第18回淡路国際面系と感染フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Xenophagy induction mechanism during Group A Streptococcus infection2019

    • Author(s)
      野澤 孝志,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A 群レンサ球菌感染に対するゼノファジーの制御2019

    • Author(s)
      中川一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 物理化学的アプローチによる低分子阻害剤の探索および抗体阻害 剤の開発2019

    • Author(s)
      中木戸誠 ,相川知宏,長門石曉,妹尾暁暢,竹内美 結 ,星野 将人 ,下村 拓矢 ,Jose M. M. Caaveiro ,中川 一路, 津本浩平
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A 群レンサ球菌は宿主細胞内膜輸送経路を破綻させることで上皮 バリアシステムの恒常性を低下させる2019

    • Author(s)
      飯伏 純平,藤 博貴,野澤 孝志,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] デンタルインプラントの口腔内露出後に生じる周囲細菌叢の経時 変化2019

    • Author(s)
      下岸将博 ,渡辺孝康 ,柴崎真樹 ,中野善夫 ,春日井昇 平 ,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A 群レンサ球菌の毒素 NAD-glycohydrolase は宿主リン脂質ホス ホイノシタイドへの結合能を有する2019

    • Author(s)
      藤 博貴 ,野澤 孝志 ,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インターフェロン誘導性の抗病原体因子 GBP1 は TBK1 と複合体 を形成してゼノファジーを制御する2019

    • Author(s)
      曵地 京,野澤 孝志,中川 一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 化合物 H1 の A 群レンサ球菌増殖抑制メカニズムおよび抗菌薬と の併用効果の検証2019

    • Author(s)
      相川知宏、星野将人、中木戸誠、長門石暁、村瀬一典、津本浩平、中川一路
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Remarks] 京都大学大学院医学研究科微生物感染症学分野

    • URL

      http://www.bac.med.kyoto-u.ac.jp

    • Related Report
      2021 Annual Research Report
  • [Remarks] http://www.bac.med.kyoto-u.ac.jp

    • Related Report
      2020 Annual Research Report
  • [Remarks] http://www.bac.med.kyoto-u.ac.jp

    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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