Attempt of segmentation of positive / negative factor and absolute evaluation of intra-tumor immunity

• Project/Area Number: 19H03729
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Osaka University
• Principal Investigator: Wada Hisashi 大阪大学, 医学系研究科, 特任教授(常勤) (70243459)
• Co-Investigator(Kenkyū-buntansha): 佐藤 永一 東京医科大学, 医学部, 准教授 (60408101) ; 垣見 和宏 東京大学, 医学部附属病院, 特任教授 (80273358) ; 牧野 知紀 大阪大学, 医学系研究科, 助教 (80528620) ; 岩堀 幸太 大阪大学, 医学系研究科, 特任講師(常勤) (80566448) ; 森本 晶子 大阪大学, 医学系研究科, 特任助教(常勤) (60601193)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: がん / 癌 / 腫瘍内浸潤免疫細胞 / フローサイトメトリー / 多重蛍光免疫組織化学染色 / RNAシークエンス / 免疫チェックポイント阻害剤 / 腫瘍内浸潤免疫担当細胞 / 腫瘍組織浸潤効果T細胞 / 免疫抑制因子 / 制御性T細胞 / 効果T細胞 / MDSC / Treg / TAM / ImmunoGram / ImmunoScore / 腫瘍浸潤T細胞 / T細胞疲弊 / 免疫チェックポイント / 骨髄由来抑制細胞

Outline of Research at the Start

腫瘍組織内浸潤免疫担当細胞側の効果側・抑制側の各因子の強度を多方面から解析し、個人間・がん種間の絶対的評価を決定する。このため、新鮮腫瘍組織よりの抽出生細胞を主に用い、二つの因子のフローサイトメーター解析、機能解析、さらなる亜分画化、遺伝子的・組織学的解析、臨床データとの比較、を実施する。多くのがん種・症例を横並びに解析していく事で、絶対的な評価を行うことを第一とする。最終的に両側因子、さらには亜分画化各因子を包括する総合的免疫状態のための評価方法の確立を試み、がん種ごと、症例ごとの絶対的評価につなげる。

Outline of Final Research Achievements

The role of immune cells in tumor tissue can be divided into two major groups: the effector cells that contribute to the antitumor effect and the suppressor cells that suppress the antitumor effect. The balance is diversified among cancer types and patients, and this diversification is one of the reasons why the efficacy of tumor immunotherapy is limited. In this study, we used tumor tissue infiltrating immune cells from various cancer types and performed functional analysis of living cells and scoring using multiplex fluorescent immunohistochemical staining and genetic analysis and succeeded in objectively identifying tumor tissue infiltrating immune cells as a complex.

Academic Significance and Societal Importance of the Research Achievements

抗PD-1抗体を中心とした併用免疫療法の臨床試験が様々ながん種に対して世界中で数多く実施されているが、有効性においては限定的である。腫瘍組織内免疫細胞を複合体として客観的に捉えることによって、抗PD-1抗体を始めとする免疫チェックポイント阻害剤の併用免疫療法において有効性を示す患者を層別化した臨床試験の実施に繋がり、利益を得る被験者の増加、不利益を被る被験者の減少に貢献することが期待される。

Research Products

• [Journal Article] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer (2022)
  • Author(s): Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura and Hisashi Wada
  • Journal Title: Sci Rep. Volume: 12 Issue: 1 Pages: 1-12
  • DOI: 10.1038/s41598-022-09458-5
  • Peer Reviewed / Open Access
• [Journal Article] Tumor-infiltrating ICOS+ Effector Regulatory T-Cells in Oral Squamous Cell Carcinoma as a Promising Biomarker for Prognosis and ‘Hot’ Tumor (2022)
  • Author(s): HITOMI KAJIKAWA, MICHINARI HIRATA, MIYA HARUNA, AZUMI UEYAMA, KATSUTOSHI HIROSE, ATSUNARI KAWASHIMA, KOTA IWAHORI, KAZUHIDE MATSUNAGA, SATORU TOYOSAWA, NARIKAZU UZAWA and HISASHI WADA
  • Journal Title: Anticancer Research Volume: 42 Issue: 5 Pages: 2383-2393
  • DOI: 10.21873/anticanres.15717
  • Peer Reviewed / Open Access
• [Journal Article] Tumor endothelial cell-induced CD8 + T-cell exhaustion via GPNMB in hepatocellular carcinoma (2022)
  • Author(s): Sakano Yoshihiro、Noda Takehiro、Kobayashi Shogo、Sasaki Kazuki、Iwagami Yoshifumi、Yamada Daisaku、Tomimaru Yoshito、Akita Hirofumi、Gotoh Kunihito、Takahashi Hidenori、Asaoka Tadafumi、Tanemura Masahiro、Wada Hisashi、Doki Yuichiro、Eguchi Hidetoshi
  • Journal Title: Cancer Science Volume: - Issue: 5 Pages: 1625-1638
  • DOI: 10.1111/cas.15331
  • Peer Reviewed / Open Access
• [Journal Article] CD15+ Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Colorectal Cancer Cells (2022)
  • Author(s): Kenta Miyoshi, Eiichi Sato, Kenji Katsumata, Gentaro Fukushima, Ryutaro Udo, Emi Nishimura, Tomoya Tago, Kenta Kasahara, Junichi Mazaki, Masanobu Enomoto, Tetsuo Ishizaki, Yuichi Nagakawa, and Akihiko Tsuchida
  • Journal Title: Anticancer Research Volume: 42 Issue: 1 Pages: 459-470
  • DOI: 10.21873/anticanres.15504
  • Peer Reviewed / Open Access
• [Journal Article] Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab (2021)
  • Author(s): Maeda Yuka、Wada Hisashi、Sugiyama Daisuke、Saito Takuro、Irie Takuma、Itahashi Kota、Minoura Kodai、Suzuki Susumu、Kojima Takashi、Kakimi Kazuhiro、Nakajima Jun、Funakoshi Takeru、Iida Shinsuke、Oka Mikio、Shimamura Teppei、Doi Toshihiko、Doki Yuichiro、Nakayama Eiichi、Ueda Ryuzo、Nishikawa Hiroyoshi
  • Journal Title: Nature Communications Volume: 12(1) Issue: 1 Pages: 7280-7280
  • DOI: 10.1038/s41467-021-27574-0
  • Peer Reviewed / Open Access
• [Journal Article] Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors (2021)
  • Author(s): Saito T, Kurose K, Kojima T, Funakoshi T, Sato E, Nishikawa H, Nakajima J, Seto Y, Kakimi K, Iida S, Doka Y, Oka M, Ueda R, Wada H.
  • Journal Title: Nagoya Journal of Medical Science Volume: 83 Issue: 4 Pages: 827-840
  • DOI: 10.18999/nagjms.83.4.827
  • NAID: 120007174347
  • ISSN: 0027-7622
  • URL: https://nagoya.repo.nii.ac.jp/records/2001663
  • Peer Reviewed / Open Access
• [Journal Article] Two distinct phenotypes of immunologically hot gastric cancer subtypes. (2021)
  • Author(s): Saito N, Kobayashi Y, Nagaoka K, Kushihara Y, Sato Y, Wada I, Kakimi K, Seto Y.
  • Journal Title: Biochem Biophys Rep. Volume: 28 Pages: 1-6
  • DOI: 10.1016/j.bbrep.2021.101167
  • Peer Reviewed / Open Access
• [Journal Article] 多重蛍光免疫染色法を用いた食道がん化学療法の効果予測 (2021)
  • Author(s): 山本慧、和田尚
  • Journal Title: 癌と化学療法 Volume: 48 Pages: 336-340
• [Journal Article] The impact of ICOS+ regulatory T cells and Helicobacter pylori infection on the prognosis of patients with gastric and colorectal cancer: potential prognostic benefit of pre-operative eradication therapy (2021)
  • Author(s): Urakawa Shinya、Yamasaki Makoto、Makino Tomoki、Kurokawa Yukinori、Yamamoto Kei、Goto Kumiko、Haruna Miya、Hirata Michinari、Morimoto-Okazawa Akiko、Kawashima Atsunari、Iwahori Kota、Mizushima Tsunekazu、Sato Eiichi、Mori Masaki、Doki Yuichiro、Wada Hisashi
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 70 Issue: 2 Pages: 443-452
  • DOI: 10.1007/s00262-020-02696-4
  • Peer Reviewed / Open Access
• [Journal Article] Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer (2020)
  • Author(s): Haruna Miya、Hirata Michinari、Iwahori Kota、Kanazawa Takayuki、Yamamoto Yoko、Goto Kumiko、Kawashima Atsunari、Morimoto-Okazawa Akiko、Funaki Soichiro、Shintani Yasushi、Kumanogoh Atsushi、Wada Hisashi
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 43 Issue: 3 Pages: 399-403
  • DOI: 10.1248/bpb.b19-00702
  • NAID: 130007804428
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2020-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Clinical importance of the expression of CD4+CD8+ T cells in Renal Cell Carcinoma. (2020)
  • Author(s): Nishida K, Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Yamamoto K, Yamamoto Y, Sawada M, Kato R, Kato T, Hatano K, Ujike T, Fujita K, Uemura M, Morimoto-Okazawa A, Iwahori K, Yamasaki M, Ohkura N, Sakaguchi S, Nonomura N, Doki Y, Wada H.
  • Journal Title: Int Immunol Volume: Jan24 Issue: 5 Pages: 347-357
  • DOI: 10.1093/intimm/dxaa004
  • Peer Reviewed / Open Access
• [Journal Article] PD-1+ Tim3+ tumor-infiltrating CD8 T cells sustain the potential for IFN-γ production, but lose cytotoxic activity in ovarian cancer (2020)
  • Author(s): Sawada Masaaki、Goto Kumiko、Morimoto-Okazawa Akiko、Haruna Miya、Yamamoto Kei、Yamamoto Yoko、Nakagawa Satoshi、Hiramatsu Kosuke、Matsuzaki Shinya、Kobayashi Eiji、Kawashima Atsunari、Hirata Michinari、Iwahori Kota、Kimura Toshihiro、Ueda Yutaka、Kimura Tadashi、Wada Hisashi
  • Journal Title: International Immunology Volume: 32 Issue: 6 Pages: 397-405
  • DOI: 10.1093/intimm/dxaa010
  • Peer Reviewed / Open Access
• [Journal Article] Tumour Grade Significantly Correlates With Total Dysfunction of Tumour Tissue-Infiltrating Lymphocytes in Renal Cell Carcinoma (2020)
  • Author(s): Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Nishida K, Nojima S, Yamamoto Y, Kato T, Hatano K, Ujike T, Nagahara A, Fujita K, Morimoto-Okazawa A, Iwahori K, Uemura M, Imamura R, Ohkura N, Morii E, Sakaguchi S, Wada H, Nonomura N.
  • Journal Title: Sci Rep . Volume: 10 Issue: 1 Pages: 6220-6220
  • DOI: 10.1038/s41598-020-63060-1
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneity of Treg/Th17 According to Cancer Progression and Modification in Biliary Tract Cancers via Self-Producing Cytokines. (2020)
  • Author(s): Kinoshita M, Kobayashi S, Gotoh K, Kubo M, Hayashi K, Iwagami Y, Yamada D, Akita H, Noda T, Asaoka T, Takeda Y, Tanemura M, Eguchi H, Urakawa S, Goto K, Maekawa K, Wada H, Mori M, Doki Y.
  • Journal Title: Dig Dis Sci. Volume: 65 Issue: 10 Pages: 2937-2948
  • DOI: 10.1007/s10620-019-06011-9
  • Peer Reviewed / Open Access
• [Journal Article] Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor‐infiltrating cells (2020)
  • Author(s): Sato Y、Wada I、Odaira K、Hosoi A、Kobayashi Y、Nagaoka K、Karasaki T、Matsushita H、Yagi K、Yamashita H、Fujita M、Watanabe S、Kamatani T、Miya F、Mineno J、Nakagawa H、Tsunoda T、Takahashi S、Seto Y、Kakimi K
  • Journal Title: Clinical & Translational Immunology Volume: 9 Issue: 10 Pages: 9-9
  • DOI: 10.1002/cti2.1194
  • Peer Reviewed / Open Access
• [Journal Article] Neoadjuvant Chemotherapy With Anthracycline-Based Regimen for BRCAness Tumors in Triple-Negative Breast Cancer (2020)
  • Author(s): Teraoka Saeko、Sato Eiichi、Narui Kazutaka、Yamada Akimitsu、Fujita Tomoyuki、Yamada Kimito、Oba Mari、Ishikawa Takashi
  • Journal Title: Journal of Surgical Research Volume: 250 Pages: 143-147
  • DOI: 10.1016/j.jss.2019.12.047
  • Peer Reviewed / Open Access
• [Journal Article] Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non?small cell lung cancer (2020)
  • Author(s): Sugiyama Eri、Togashi Yosuke、Takeuchi Yoshiko、Shinya Sayoko、Tada Yasuko、Kataoka Keisuke、Tane Kenta、Sato Eiichi、Ishii Genichiro、Goto Koichi、Shintani Yasushi、Okumura Meinoshin、Tsuboi Masahiro、Nishikawa Hiroyoshi
  • Journal Title: Science Immunology Volume: 5 Issue: 43 Pages: 3937-3937
  • DOI: 10.1126/sciimmunol.aav3937
  • NAID: 120006845852
  • Peer Reviewed / Open Access
• [Journal Article] Multispectral quantitative immunohistochemical analysis of tumor-infiltrating lymphocytes in relation to programmed death-ligand 1 expression in triple-negative breast cancer (2020)
  • Author(s): Tomoharu Sugie, Eiichi Sato , Yuji Kozuka, et al.
  • Journal Title: Breast Cancer. Volume: 27(4) Issue: 4 Pages: 519-526
  • DOI: 10.1007/s12282-020-01110-2
  • Peer Reviewed / Open Access
• [Journal Article] An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells (2020)
  • Author(s): Shogo Kumagai, Yosuke Togashi, Chika Sakai, Akihito Kawazoe, Masahito Kawazu, Toshihide Ueno, Eiichi Sato, Takeshi Kuwata, Takahiro Kinoshita, Masami Yamamoto, Sachiyo Nomura, Tetsuya Tsukamoto, Hiroyuki Mano, Kohei Shitara, Hiroyoshi Nishikawa
  • Journal Title: Immunity Volume: 14 Issue: 1 Pages: 187-203
  • DOI: 10.1016/j.immuni.2020.06.016
  • NAID: 120006952281
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors. (2020)
  • Author(s): Ishihara M, Tono Y, Miyahara Y, Muraoka D, Harada N, Kageyama S, Sasaki T, Hori Y, Soga N, Uchida K, Shiraishi T, Sato E, Kanda H, Mizuno T, Webster GA, Ikeda H, Katayama N, Sugimura Y, Shiku H.
  • Journal Title: Cancer Immunol Immunother Volume: 69 Issue: 4 Pages: 663-675
  • DOI: 10.1007/s00262-020-02483-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tumor‐infiltrating M2 macrophage in pretreatment biopsy sample predicts response to chemotherapy and survival in esophageal cancer (2020)
  • Author(s): Yamamoto Kei、Makino Tomoki、Sato Eiichi、Noma Toshiki、Urakawa Shinya、Takeoka Tomohira、Yamashita Kotaro、Saito Takuro、Tanaka Koji、Takahashi Tsuyoshi、Kurokawa Yukinori、Yamasaki Makoto、Nakajima Kiyokazu、Mori Masaki、Doki Yuichiro、Wada Hisashi
  • Journal Title: Cancer Science Volume: 111 Issue: 4 Pages: 1103-1112
  • DOI: 10.1111/cas.14328
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Value of the Combined Index of Plasma Fibrinogen and the Neutrophil?Lymphocyte Ratio in Gastric Cancer (2020)
  • Author(s): Yamamoto Masaaki、Kurokawa Yukinori、Kobayashi Noboru、Takahashi Tsuyoshi、Miyazaki Yasuhiro、Tanaka Koji、Makino Tomoki、Yamasaki Makoto、Nakajima Kiyokazu、Mori Masaki、Doki Yuichiro
  • Journal Title: World Journal of Surgery Volume: 44 Issue: 1 Pages: 207-212
  • DOI: 10.1007/s00268-019-05193-7
  • Peer Reviewed / Open Access
• [Journal Article] What is the most useful body composition parameter for predicting toxicities of preoperative chemotherapy for gastric cancer? (2020)
  • Author(s): Hashimoto Tadayoshi、Kurokawa Yukinori、Takahashi Tsuyoshi、Saito Takuro、Yamashita Kotaro、Tanaka Koji、Makino Tomoki、Yamasaki Makoto、Motoori Masaaki、Kimura Yutaka、Nakajima Kiyokazu、Mori Masaki、Doki Yuichiro
  • Journal Title: Surgery Today Volume: 50 Issue: 5 Pages: 509-515
  • DOI: 10.1007/s00595-019-01915-5
  • Peer Reviewed / Open Access
• [Journal Article] Peritumoral Lymphatic Vessels Associated with Resistance to Neoadjuvant Chemotherapy and Unfavorable Survival in Esophageal Cancer (2020)
  • Author(s): Hara Takeo、Makino Tomoki、Yamasaki Makoto、Tanaka Koji、Yamashita Kotaro、Nogi Yuya、Saito Takuro、Takahashi Tsuyoshi、Kurokawa Yukinori、Tatsumi Mitsuaki、Nakajima Kiyokazu、Morii Eiichi、Eguchi Hidetoshi、Doki Yuichiro
  • Journal Title: Annals of Surgical Oncology Volume: 27 Issue: 10 Pages: 3762-3769
  • DOI: 10.1245/s10434-020-08474-x
  • Peer Reviewed / Open Access
• [Journal Article] Immunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors (2020)
  • Author(s): Yoko Yamamoto, Kota Iwahori, Soichiro Funaki, Mitsunobu Matsumoto, Michinari Hirata, Tetsuya Yoshida, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Masato Minami, Eiichi Sato, Atsushi Kumanogoh, Yasushi Shintani, Meinoshin Okumura, Hisashi Wada
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 4064-4064
  • DOI: 10.1038/s41598-020-61053-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endogenous CXCL9 affects prognosis by regulating tumor-infiltrating NK cells in intrahepatic cholangiocarcinoma (2020)
  • Author(s): Fukuda Y, Asaoka T, Eguchi H, Yokota Y, Kubo M1, Kinoshita M, Urakawa S, Iwagami Y, Tomimaru Y, Akita H, Noda T, Gotoh K, Kobayashi S, Hirata M, Wada H, Mori M, Doki Y.
  • Journal Title: Cancer Sci. Volume: 111 Issue: 2 Pages: 323-333
  • DOI: 10.1111/cas.14267
  • Peer Reviewed / Open Access
• [Journal Article] Molecular Barcode Sequencing for Highly Sensitive Detection of Circulating Tumor DNA in Patients with Esophageal Squamous Cell Carcinoma (2019)
  • Author(s): Hagi Takaomi、Kurokawa Yukinori、Takahashi Tsuyoshi、Saito Takuro、Yamashita Kotaro、Tanaka Koji、Makino Tomoki、Yamasaki Makoto、Nakajima Kiyokazu、Mori Masaki、Doki Yuichiro
  • Journal Title: Oncology Volume: 98 Issue: 4 Pages: 222-229
  • DOI: 10.1159/000504808
  • Peer Reviewed / Open Access
• [Journal Article] Peri-operative monocyte count is a marker of poor prognosis in gastric cancer: increased monocytes are a characteristic of myeloid-derived suppressor cells. (2019)
  • Author(s): Shinya Urakawa, Makoto Yamasaki, Kumiko Goto, Miya Haruna, Michinari Hirata, Akiko Morimoto-Okazawa, Atsunari Kawashima, Kota Iwahori, Tomoki Makino, Yukinori Kurokawa, Tomomi Yamada, Masaki Mori, Yuichiro Doki, Hisashi Wada.
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 68 Issue: 8 Pages: 1341-1350
  • DOI: 10.1007/s00262-019-02366-0
  • Peer Reviewed
• [Journal Article] Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment (2019)
  • Author(s): Iwahori Kota、Shintani Yasushi、Funaki Soichiro、Yamamoto Yoko、Matsumoto Mitsunobu、Yoshida Tetsuya、Morimoto-Okazawa Akiko、Kawashima Atsunari、Sato Eiichi、Gottschalk Stephen、Okumura Meinoshin、Kumanogoh Atsushi、Wada Hisashi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2636-2636
  • DOI: 10.1038/s41598-019-39345-5
  • Peer Reviewed / Open Access
• [Journal Article] Phenotypic Analysis of Tumor Tissue?Infiltrating Lymphocytes in Tumor Microenvironment of Bladder Cancer and Upper Urinary Tract Carcinoma (2019)
  • Author(s): Kawashima Atsunari、Kanazawa Takayuki、Jingushi Kentaro、Kato Taigo、Ujike Takeshi、Nagahara Akira、Fujita Kazutoshi、Morimoto-Okazawa Akiko、Iwahori Kota、Uemura Motohide、Imamura Ryoichi、Wada Hisashi、Nonomura Norio
  • Journal Title: Clinical Genitourinary Cancer Volume: 17 Issue: 2 Pages: 114-124
  • DOI: 10.1016/j.clgc.2018.11.004
  • Peer Reviewed
• [Journal Article] Serum Antibody Against NY-ESO-1 and XAGE1 Antigens Potentially Predicts Clinical Responses to Anti?Programmed Cell Death-1 Therapy in NSCLC (2019)
  • Author(s): Ohue Yoshihiro、Kurose Koji、Karasaki Takahiro、Isobe Midori、Yamaoka Takaaki、Futami Junichiro、Irei Isao、Masuda Takeshi、Fukuda Masaaki、Kinoshita Akitoshi、Matsushita Hirokazu、Shimizu Katsuhiko、Nakata Masao、Hattori Noboru、Yamaguchi Hiroyuki、Fukuda Minoru、Nozawa Ryohei、Kakimi Kazuhiro、Oka Mikio
  • Journal Title: Journal of Thoracic Oncology Volume: 14 Issue: 12 Pages: 2071-2083
  • DOI: 10.1016/j.jtho.2019.08.008
  • NAID: 120006796543
  • Peer Reviewed / Open Access
• [Journal Article] Reduced Neoantigen Expression Revealed by Longitudinal Multiomics as a Possible Immune Evasion Mechanism in Glioma. (2019)
  • Author(s): Nejo T, Matsushita H, Karasaki T, Nomura M, Saito K, Tanaka S, Takayanagi S, Hana T, Takahashi S, Kitagawa Y, Koike T, Kobayashi Y, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Narita Y, Nagane M, Ueki K, Nishikawa R, Aburatani H, Mukasa A, Saito N, Kakimi K.
  • Journal Title: Cancer Immunol Res Volume: in press Issue: 7 Pages: 1148-1161
  • DOI: 10.1158/2326-6066.cir-18-0599
  • Peer Reviewed
• [Journal Article] Severe colitis after PD-1 blockade with nivolumab in advanced melanoma patients: potential role of Th1-dominant immune response in immune-related adverse events: two case reports (2019)
  • Author(s): Yoshino Koji、Nakayama Takayuki、Ito Ayumu、Sato Eiichi、Kitano Shigehisa
  • Journal Title: BMC Cancer Volume: 19 Issue: 1 Pages: 1019-1019
  • DOI: 10.1186/s12885-019-6138-7
  • Peer Reviewed
• [Journal Article] Therapeutic potential of PLK1 inhibition in triple-negative breast cancer (2019)
  • Author(s): Ueda Ai, Oikawa Keiki, Fujita Koji, Ishikawa Akio, Sato Eiichi, Ishikawa Takashi, Kuroda Masahiko, Kanekura Kohsuke
  • Journal Title: Laboratory Investigation Volume: 99 Issue: 9 Pages: 1275-1286
  • DOI: 10.1038/s41374-019-0247-4
  • Peer Reviewed / Open Access
• [Journal Article] PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer (2019)
  • Author(s): Kamada Takahiro、Togashi Yosuke、Tay Christopher、Ha Danbee、Sasaki Akinori、Nakamura Yoshiaki、Sato Eiichi、Fukuoka Shota、Tada Yasuko、Tanaka Atsushi、Morikawa Hiromasa、Kawazoe Akihito、Kinoshita Takahiro、Shitara Kohei、Sakaguchi Shimon、Nishikawa Hiroyoshi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: In press Issue: 20 Pages: 9999-10008
  • DOI: 10.1073/pnas.1822001116
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and pathological predictors of recurrence in breast cancer patients achieving pathological complete response to neoadjuvant chemotherapy (2019)
  • Author(s): Asaoka Mariko、Narui Kazutaka、Suganuma Nobuyasu、Chishima Takashi、Yamada Akimitsu、Sugae Sadatoshi、Kawai Saori、Uenaka Natsuki、Teraoka Saeko、Miyahara Kana、Kawate Takahiko、Sato Eichi、Nagao Toshitaka、Matsubara Yuka、Gandhi Shipra、Takabe Kazuaki、Ishikawa Takashi
  • Journal Title: European Journal of Surgical Oncology Volume: 45 Issue: 12 Pages: 2289-2294
  • DOI: 10.1016/j.ejso.2019.08.001
  • Peer Reviewed
• [Presentation] The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer (2022)
  • Author(s): Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura and Hisashi Wada
  • Organizer: JSMO2022
• [Presentation] 胃癌患者におけるニボルマブ治療の血中治療効果予測マーカーの同定 (2021)
  • Author(s): 野瀬陽平、西塔拓郎、和田尚、黒川幸典、高橋剛、山本和義、牧野知紀、山﨑誠、江口英利、土岐祐一郎
  • Organizer: 第76回日本消化器外科学会総会
• [Presentation] 肝細胞癌において腫瘍血管内皮細胞は腫瘍浸潤Tリンパ球の疲弊化を促進する (2021)
  • Author(s): 阪野佳弘、野田剛広、小林省吾、佐々木一樹、岩上佳史、山田大作、富丸慶人、秋田裕史、後藤邦仁、高橋秀典、和田尚、土岐祐一郎、江口英利
  • Organizer: 第41回日本分子腫瘍マーカー研究会
• [Presentation] Examination of the effect of tumor endothelial cells on the immune microenvironment in hepatocellular carcinoma (2021)
  • Author(s): Yoshihiro Sakano, Takehiro Noda, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hidenori Takahashi, Hisashi Wada, Yuichiro Doki, Hidetoshi Eguchi
  • Organizer: 第59回癌治療学会学術集会
• [Presentation] The potential prognostic benefit of pre-operative eradication therapy to Helicobacter pylori infection on gastric cancer (2021)
  • Author(s): Takuro Saito, Shinya Urakawa, Hisashi Wada, Kotaro Yamashita, Koji Tanaka, Kazuyoshi Yamamoto, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] がん組織の免疫ゲノムプロファイルによる腫瘍免疫の理解 (2021)
  • Author(s): 中川英刀、藤田征志、垣見和宏.
  • Organizer: 第25回日本がん免疫学会総会
  • Invited
• [Remarks] 大阪大学 臨床腫瘍免疫学
  • URL: http://www.climm.med.osaka-u.ac.jp/index.html
• [Remarks] 大阪大学医学系研究科 臨床腫瘍免疫学講座
  • URL: http://www.climm.med.osaka-u.ac.jp/
• [Remarks] 大阪大学医学系研究科・臨床腫瘍免疫学
  • URL: http://www.climm.med.osaka-u.ac.jp/
• [Patent(Industrial Property Rights)] CCR8を抗原として認識するキメラ抗原受容体 (2022)
  • Inventor(s): 大倉永也、坂口志文、和田尚
  • Industrial Property Rights Holder: 大倉永也、坂口志文、和田尚
  • Industrial Property Rights Type: 特許
  • Filing Date: 2022
  • Overseas
• [Patent(Industrial Property Rights)] 新規抗CCR8抗体 (2019)
  • Inventor(s): 大倉永也、田中淳、坂口志文、和田尚、河嶋厚成
  • Industrial Property Rights Holder: 大倉永也、田中淳、坂口志文、和田尚、河嶋厚成
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Acquisition Date: 2021
• [Patent(Industrial Property Rights)] 癌治療用医薬組成物 (2019)
  • Inventor(s): 大倉永也、坂口志文、田中淳、和田尚、河嶋厚成、野々村祝夫
  • Industrial Property Rights Holder: 大倉永也、坂口志文、田中淳、和田尚、河嶋厚成、野々村祝夫
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Acquisition Date: 2021
  • Overseas