| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
This study found that endoplasmic reticulum stress does not induce an inflammatory response alone, but rather has the effect of enhancing that response during an inflammatory response. As a result of this enhanced inflammatory response, ER stress promotes the expression of inflammatory cytokines such as IL-6. The results of this study suggest that chronic inflammation in endoplasmic reticulum stress-related diseases is related to the enhancement of the inflammatory response by endoplasmic reticulum stress, and that endoplasmic reticulum stress may be involved in the development of chronic inflammation.
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