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Study on Genetic and Social Factors in Oral and Cardiovascular Diseases Towards Precision Medicine

Research Project

Project/Area Number 19H03861
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionTohoku University

Principal Investigator

OSAKA KEN  東北大学, 歯学研究科, 教授 (60300935)

Co-Investigator(Kenkyū-buntansha) 竹内 研時  東北大学, 歯学研究科, 准教授 (10712680)
小山 史穂子  地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 疫学統計部主査 (40779542)
相田 潤  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80463777)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2022: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords口腔と全身疾患 / 口腔と認知機能低下 / 口腔疾患 / コホート研究 / 歯周病 / うつ / 認知症 / 肺炎
Outline of Research at the Start

循環器疾患をはじめとする全身疾患に対して口腔が与える影響が注目されてきている。口腔や全身の健康を規定するおもな要因として、遺伝的要因および社会的決定要因(社会経済状態や保健医療制度など、健康を規定する社会環境要因)が相互に関連しあって健康に影響を与えることが、近年の研究で明らかになりつつある。遺伝子と社会環境の相互作用の解明は重要な科学的課題である。しかし、先行研究では、これらの要因を同時に考慮した研究は少ない。そこで、本研究は遺伝子と社会的決定要因の両方向からのアプローチにより、口腔と循環器疾患の関連を明らかにすることを目的とする。

Outline of Final Research Achievements

Comprehensive analyses using various cohorts in Japan, including the Tohoku Medical Megabank, the Japanese Gerontological Evaluation Study (JAGES), and the Longevity Improvement and Fair Evidence Study (LIFE), have elucidated the relationship between oral conditions and systemic diseases. The findings revealed that poor oral health increases the risk of dementia by 10-20%, influences weight loss or gain, and that tooth loss due to weight reduction elevates the risk of mortality. Furthermore, the number of teeth was found to be the highest risk factor for mortality, particularly among men.

Academic Significance and Societal Importance of the Research Achievements

これまで口腔の状況と全身疾患の関係が指摘されてきた。特に口腔と糖尿病の相互関係や認知機能障害との関係が疫学調査で明らかになってきたが、この研究でより大規模で様々なコホート研究を実施することで、より口腔と全身疾患との関係が明らかになった。特に男性では口腔の状況が修正可能な因子のなかで死亡に影響する可能性が非常に高いことや認知機能低下や死亡のリスクを起こすメカニズムについてより迫ることが出来た。一部のデータの入手時期の問題から遺伝情報についての解析はまだ途中であるが、メタボローム解析などを実施した結果も出てきており、今後更により詳細なメカニズムに迫ることが可能となろう。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (22 results)

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article (19 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 18 results,  Open Access: 7 results) Remarks (3 results)

  • [Journal Article] Dental prosthesis use moderates association between tooth loss and risk of depressive symptoms in older adults with severe tooth loss: The JAGES cohort trial2024

    • Author(s)
      Nakazawa Noriko、Takeuchi Kenji、Kusama Taro、Kiuchi Sakura、Kondo Katsunori、Osaka Ken
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 68 Issue: 4 Pages: 578-584

    • DOI

      10.2186/jpr.JPR_D_23_00046

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in prevalence of self‐reported oral hypofunction between older adult patients with rheumatoid arthritis and the general older population: A cross‐sectional study using propensity score matching2024

    • Author(s)
      Kudo Yoko、Takeuchi Kenji、Kusama Taro、Kojima Toshihisa、Waguri‐Nagaya Yuko、Nagayoshi Mako、Kondo Katsunori、Mizuta Kentaro、Osaka Ken、Kojima Masayo
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 00 Issue: 6 Pages: 1-7

    • DOI

      10.1111/joor.13658

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tooth loss mediates the association between smoking and an increased risk of dementia among older adults: The <scp>JAGES</scp> prospective cohort study2024

    • Author(s)
      Kusama Taro、Takeuchi Kenji、Kiuchi Sakura、Tamada Yudai、Tabuchi Takahiro、Osaka Ken
    • Journal Title

      Journal of Clinical Periodontology

      Volume: - Issue: 12 Pages: 1-9

    • DOI

      10.1111/jcpe.13959

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Poor oral health and dementia risk under time‐varying confounding: A cohort study based on marginal structural models2023

    • Author(s)
      Kusama Taro、Takeuchi Kenji、Kiuchi Sakura、Aida Jun、Osaka Ken
    • Journal Title

      Journal of the American Geriatrics Society

      Volume: 72 Issue: 3 Pages: 729-741

    • DOI

      10.1111/jgs.18707

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral Hypofunction and Risk of Weight Change among Independent Older Adults2023

    • Author(s)
      Shiota Chihiro、Kusama Taro、Takeuchi Kenji、Kiuchi Sakura、Osaka Ken
    • Journal Title

      Nutrients

      Volume: 15 Issue: 20 Pages: 4370-4370

    • DOI

      10.3390/nu15204370

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced number of teeth with and without dental prostheses and low frequency of laughter in older adults: Mediation by poor oral function2023

    • Author(s)
      Tamada Yudai、Takeuchi Kenji、Kusama Taro、Saito Masashige、Ohira Tetsuya、Shirai Kokoro、Yamaguchi Chikae、Kondo Katsunori、Aida Jun、Osaka Ken
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 68 Issue: 3 Pages: 441-448

    • DOI

      10.2186/jpr.JPR_D_23_00071

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exposure to household dysfunction at childhood and later number of teeth among older Japanese adults: A life course study from the Japan Gerontological Evaluation Study2023

    • Author(s)
      Abbas Hazem、Takeuchi Kenji、Kiuchi Sakura、Kondo Katsunori、Osaka Ken
    • Journal Title

      Journal of Public Health Dentistry

      Volume: 83 Issue: 3 Pages: 299-308

    • DOI

      10.1111/jphd.12582

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Longitudinal Association Between Oral Status and Cognitive Decline Using Fixed-effects Analysis2022

    • Author(s)
      Kiuchi Sakura、Kusama Taro、Sugiyama Kemmyo、Yamamoto Takafumi、Cooray Upul、Yamamoto Tatsuo、Kondo Katsunori、Osaka Ken、Aida Jun
    • Journal Title

      Journal of Epidemiology

      Volume: 32 Issue: 7 Pages: 330-336

    • DOI

      10.2188/jea.JE20200476

    • NAID

      130007977680

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2022-07-05
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Large contribution of oral status for death among modifiable risk factors in older adults: the JAGES prospective cohort study2022

    • Author(s)
      Nakazawa Noriko、Kusama Taro、Cooray Upul、Yamamoto Takafumi、Kiuchi Sakura、Abbas Hazem、Yamamoto Tatsuo、Kondo Katsunori、Osaka Ken、Aida Jun
    • Journal Title

      The Journals of Gerontology: Series A

      Volume: - Issue: 1 Pages: 167-173

    • DOI

      10.1093/gerona/glac052

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The lack of opportunity to eat together is associated with an increased risk of weight loss among independent older adults: a prospective cohort study based on the JAGES2022

    • Author(s)
      Kusama Taro、Kiuchi Sakura、Tani Yukako、Aida Jun、Kondo Katsunori、Osaka Ken
    • Journal Title

      Age and Ageing

      Volume: 51 Issue: 3 Pages: 1-9

    • DOI

      10.1093/ageing/afac022

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heated Tobacco Products Have Reached Younger or More Affluent People in Japan2021

    • Author(s)
      Igarashi Ayaka、Aida Jun、Kusama Taro、Tabuchi Takahiro、Tsuboya Toru、Sugiyama Kemmyo、Yamamoto Takafumi、Osaka Ken
    • Journal Title

      Journal of Epidemiology

      Volume: 31 Issue: 3 Pages: 187-193

    • DOI

      10.2188/jea.JE20190260

    • NAID

      130007995155

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2021-03-05
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral Status and Dementia Onset: Mediation of Nutritional and Social Factors2021

    • Author(s)
      Kiuchi S.、Cooray U.、Kusama T.、Yamamoto T.、Abbas H.、Nakazawa N.、Kondo K.、Osaka K.、Aida J.
    • Journal Title

      Journal of Dental Research

      Volume: 101 Issue: 4 Pages: 420-427

    • DOI

      10.1177/00220345211049399

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dental prosthetic treatment reduced the risk of weight loss among older adults with tooth loss2021

    • Author(s)
      Kusama Taro、Nakazawa Noriko、Kiuchi Sakura、Kondo Katsunori、Osaka Ken、Aida Jun
    • Journal Title

      Journal of the American Geriatrics Society

      Volume: 69 Issue: 9 Pages: 2498-2506

    • DOI

      10.1111/jgs.17279

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The deterioration of oral function and orofacial appearance mediated the relationship between tooth loss and depression among community-dwelling older adults: A JAGES cohort study using causal mediation analysis2021

    • Author(s)
      Kusama Taro、Kiuchi Sakura、Umehara Noriko、Kondo Katsunori、Osaka Ken、Aida Jun
    • Journal Title

      Journal of Affective Disorders

      Volume: 286 Pages: 174-179

    • DOI

      10.1016/j.jad.2021.02.071

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross‐national comparison of social isolation and mortality among older adults: A 10‐year follow‐up study in Japan and England2020

    • Author(s)
      Saito Masashige、Aida Jun、Cable Noriko、Zaninotto Paola、Ikeda Takaaki、Tsuji Taishi、Koyama Shihoko、Noguchi Taiji、Osaka Ken、Kondo Katsunori
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 2 Pages: 209-214

    • DOI

      10.1111/ggi.14118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wider Dental Care Coverage Associated with Lower Oral Health Inequalities: A Comparison Study between Japan and England2020

    • Author(s)
      Ito Kanade、Cable Noriko、Yamamoto Tatsuo、Suzuki Kayo、Kondo Katsunori、Osaka Ken、Tsakos Georgios、Watt Richard G.、Aida Jun
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 15 Pages: 5539-5539

    • DOI

      10.3390/ijerph17155539

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effort–reward imbalance at work and tooth loss: a cross-sectional study from the J-SHINE project2020

    • Author(s)
      SATO Yukihiro、TSUBOYA Toru、AIDA Jun、SAIJO Yasuaki、YOSHIOKA Eiji、OSAKA Ken
    • Journal Title

      Industrial Health

      Volume: 58 Issue: 1 Pages: 26-34

    • DOI

      10.2486/indhealth.2018-0226

    • NAID

      130007794736

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cohort Study on Laryngeal Cough Reflex, Respiratory Disease, and Death: A Mediation Analysis.2019

    • Author(s)
      Yamamoto T, Aida J, Shinozaki T, Tsuboya T, Sugiyama K, Yamamoto T, Kondo K, Sasaki K, Osaka K
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 1 Issue: 8 Pages: 1-6

    • DOI

      10.1016/j.jamda.2019.01.155

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Income or education, which has a stronger association with dental implant use in elderly people in Japan?2019

    • Author(s)
      Abbas Hazem、Aida Jun、Saito Masashige、Tsakos Georgios、Watt Richard G.、Koyama Shigeto、Kondo Katsunori、Osaka Ken
    • Journal Title

      International Dental Journal

      Volume: 69 Issue: 6 Pages: 454-462

    • DOI

      10.1111/idj.12491

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Remarks] 誰かと食事をする頻度が年に何度かしかない高齢者の体重減少リスクは1.07倍高い

    • URL

      https://www.dent.tohoku.ac.jp/news/view.html#!815

    • Related Report
      2021 Annual Research Report
  • [Remarks] 歯を失うと認知症になるメカニズムを明らかに 男性では人との交流、女性では果物・野菜の摂取が大きく影響

    • URL

      https://www.dent.tohoku.ac.jp/news/view.html#!796

    • Related Report
      2021 Annual Research Report
  • [Remarks] 歯の数が10本未満で入れ歯を使っていない高齢者では孤食に1.81倍なりやすい

    • URL

      https://www.dent.tohoku.ac.jp/news/view.html#!794

    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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