大規模環境疫学研究のためのライフコース統計解析手法の重点的開発と実データ適用

• Project/Area Number: 19H03907
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Chuo University (2022); Keio University (2019-2021)
• Principal Investigator: 竹内 文乃 中央大学, 理工学部, 准教授 (80511196)
• Co-Investigator(Kenkyū-buntansha): 大庭 真梨 国立研究開発法人国立精神・神経医療研究センター, 病院 臨床研究・教育研修部門, 室長 (10574361) ; 大庭 幸治 東京大学, 大学院情報学環・学際情報学府, 准教授 (30422926)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ライフコース疫学 / 疫学統計 / 疫学統計学 / 生物統計学 / 環境疫学

Outline of Research at the Start

本研究では、環境化学物質のように成長発達段階における特定の時期の曝露や複合的・経時的な曝露の影響が問題となるようなリスク因子の健康影響を定量することを目指す疫学研究のための生物統計学的手法の開発を目的とする．
本研究では以下3つの状況において統計解析手法の確立および実データ解析を実施する
①曝露が経時的に測定されている場合に，曝露の影響や影響のある特定の時期を探索
②疾患状態が経時的に評価され，曝露と疾患状態が互いに影響しあっている場合に，特定の時期のリスク因子の影響を定量
③曝露状態が経時的に変化する場合に，その軌跡を推定しつつ結果への影響を評価

Outline of Annual Research Achievements

本年度は、コロナ禍が続いていることもあり、研究代表者・分担者で隔週オンラインでミーティングを行いながら研究を進めた。本研究では、近年世界各国で実施されているライフコース疫学（出生コホート研究）において統計解析上の問題となる「経時曝露」・「経時アウトカム」および経時的に測定されている曝露とアウトカムが因果的に互いに影響し合う状況を研究対象としている。具体的な研究テーマとしては以下の3テーマを設定し、それぞれ論文レビューや数値実験、実データ適用を目指している。
①経時的なリスク因子への曝露が測定されている場合②曝露と疾患状態が互いに影響しあって推移する場合③曝露状態の軌跡を推定しつつ結果に与える影響を評価する場合。
①のテーマについては、方法論に関する論文のレビューを中心に方法論の整理を進め、1700人規模の出生コホート研究データを対象とし、アレルギー発症に関連する各種曝露（リスク因子）の経時測定状況の整理を行った。日本看護科学学会での口頭発表を実施した。②のテーマについては約10万人の妊婦・出生児を対象としたすっしょうコホート研究であるエコチル調査（子どもの健康と環境に関する全国調査）を対象データとしてデータの状況の整理を行い、アレルギー発症に影響する直接効果間接効果の推定を実施して論文を執筆を実施した。③のテーマについては論文のレビューに基づく方法論の整理を行い、総説論文の執筆を進めている。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

年度前半から年内にかけて、コロナ禍でデータ整理等で現地（データセンターや研究事務局所在地）に行く等の研究遂行上必要な行為を行うことができず、実データ利用の開始が遅れた。

Strategy for Future Research Activity

次年度（2022年度）の計画について、3つのテーマそれぞれについて述べる。
①経時的なリスク因子への曝露が測定されている場合：1700人の出生コホート研究データへの実データ適用および論文執筆を行う。
②曝露と疾患状態が互いに影響しあって推移する場合：約10万人の妊婦および出生児を対象とした出生コホート研究であるエコチル調査に方法論を当てはめて論文執筆を行い出版を目指す。
③曝露状態の軌跡を推定しつつ結果に与える影響を評価する場合：方法論の整理及び総説論文の執筆を目指す。

Research Products

• [Journal Article] Changes in Smoking Habits and Behaviors Following the Introduction and Spread of Heated Tobacco Products in Japan and Its Effect on FEV₁ Decline: A Longitudinal Cohort Study (2022)
  • Author(s): Harada Sei、Sata Mizuki、Matsumoto Minako、Iida Miho、Takeuchi Ayano、Kato Suzuka、Hirata Aya、Kuwabara Kazuyo、Shibuki Takuma、Ishibashi Yoshiki、Sugiyama Daisuke、Okamura Tomonori、Takebayashi Toru
  • Journal Title: Journal of Epidemiology Volume: 32 Issue: 4 Pages: 180-187
  • DOI: 10.2188/jea.JE20210075
  • NAID: 130008104930
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2022-04-05
  • Peer Reviewed / Open Access
• [Journal Article] Effects of maternal exposure to lead on secondary sex ratio in Japan: The Japan Environment and Children’s Study (2022)
  • Author(s): Tatsuta Nozomi、Nakai Kunihiko、Nakayama Shoji F.、Takeuchi Ayano、Arima Takahiro、Yaegashi Nobuo、Kamijima Michihiro、Yamazaki Shin、Ohya Yukihiro、Kishi Reiko、Hashimoto Koichi、Mori Chisato、Ito Shuichi、Yamagata Zentaro、Inadera Hidekuni、Nakayama Takeo、Iso Hiroyasu、Shima Masayuki、Kurozawa Youichi
  • Journal Title: Science of The Total Environment Volume: 817 Pages: 152726-152726
  • DOI: 10.1016/j.scitotenv.2021.152726
  • Peer Reviewed / Open Access
• [Journal Article] Accumulated unhealthy behaviours and insomnia in Japanese dwellers with and without cardiovascular risk factors: a cross-sectional study (2022)
  • Author(s): Kato Suzuka、Harada Sei、Iida Miho、Kuwabara Kazuyo、Sugiyama Daisuke、Takeuchi Ayano、Sata Mizuki、Matsumoto Minako、Kurihara Ayako、Hirata Aya、Okamura Tomonori、Takebayashi Toru
  • Journal Title: BMJ Open Volume: 12 Issue: 4 Pages: e052787-e052787
  • DOI: 10.1136/bmjopen-2021-052787
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to PM_2.5 and Lung Function Growth in Pre- and Early-Adolescent Schoolchildren: A Longitudinal Study Involving Repeated Lung Function Measurements in Japan (2022)
  • Author(s): Takebayashi Toru、Taguri Masataka、Odajima Hiroshi、Hasegawa Shuichi、Asakura Keiko、Milojevic Ai、Takeuchi Ayano、Konno Satoshi、Morikawa Miki、Tsukahara Teruomi、Ueda Kayo、Mukai Yasufumi、Minami Mihoko、Nishiwaki Yuuji、Yoshimura Takesumi、Nishimura Masaharu、Nitta Hiroshi
  • Journal Title: Annals of the American Thoracic Society Volume: 19 Issue: 5 Pages: 763-772
  • DOI: 10.1513/annalsats.202104-511oc
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Corrigendum to “Effects of maternal exposure to lead on secondary sex ratio in Japan: The Japan Environment and Children's Study” [Sci. Total Environ. 817 (2022) 152726] (2022)
  • Author(s): Tatsuta Nozomi、Nakai Kunihiko、Nakayama Shoji F.、Takeuchi Ayano、Arima Takahiro、Yaegashi Nobuo、Kamijima Michihiro、Yamazaki Shin、Ohya Yukihiro、Kishi Reiko、Hashimoto Koichi
  • Journal Title: Science of The Total Environment Volume: 829 Pages: 154714-154714
  • DOI: 10.1016/j.scitotenv.2022.154714
  • Peer Reviewed / Open Access
• [Journal Article] Association of the Estimated Coronary Artery Incidence Risk According to the Japan Atherosclerosis Society Guidelines 2017 with Cardio-Ankle Vascular Index (2021)
  • Author(s): Sata Mizuki、Okamura Tomonori、Harada Sei、Sugiyama Daisuke、Kuwabara Kazuyo、Hirata Aya、Takeuchi Ayano、Iida Miho、Kato Suzuka、Matsumoto Minako、Kurihara Ayako、Takebayashi Toru
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 12 Pages: 1266-1274
  • DOI: 10.5551/jat.58719
  • NAID: 130008123360
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Estimated Prevalence of Cronkhite-Canada Syndrome, Chronic Enteropathy Associated With <i>SLCO2A1</i> Gene, and Intestinal Behçet’s Disease in Japan in 2017: A Nationwide Survey (2021)
  • Author(s): Oba Mari S.、Murakami Yoshitaka、Nishiwaki Yuji、Asakura Keiko、Ohfuji Satoko、Fukushima Wakaba、Nakamura Yoshikazu、Suzuki Yasuo
  • Journal Title: Journal of Epidemiology Volume: 31 Issue: 2 Pages: 139-144
  • DOI: 10.2188/jea.JE20190349
  • NAID: 130007981125
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-02-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry (2021)
  • Author(s): Ishibashi Yoshiki、Harada Sei、Takeuchi Ayano、Iida Miho、Kurihara Ayako、Kato Suzuka、Kuwabara Kazuyo、Hirata Aya、Shibuki Takuma、Okamura Tomonori、Sugiyama Daisuke、Sato Asako、Amano Kaori、Hirayama Akiyoshi、Sugimoto Masahiro、Soga Tomoyoshi、Tomita Masaru、Takebayashi Toru
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 7407-7407
  • DOI: 10.1038/s41598-021-86600-9
  • Peer Reviewed / Open Access
• [Journal Article] Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines (2021)
  • Author(s): Nakano Makiko、Shinagawa Takafumi、Eitaki Yoko、Omae Kazuyuki、Takeuchi Ayano、Iwasawa Satoko、Fukai Kota、Yoshioka Noriyuki、Tanaka Shigeru、Koda Shigeki、Sobue Tomotaka、Takebayashi Toru
  • Journal Title: International Archives of Occupational and Environmental Health Volume: -
  • DOI: 10.1007/s00420-021-01658-2
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Asian dust on respiratory symptoms among children with and without asthma, and their sensitivity (2021)
  • Author(s): Hasunuma Hideki、Takeuchi Ayano、Ono Rintaro、Amimoto Yuko、Hwang Yoon Ha、Uno Itsushi、Shimizu Atsushi、Nishiwaki Yuji、Hashizume Masahiro、Askew David J.、Odajima Hiroshi
  • Journal Title: Science of The Total Environment Volume: 753 Pages: 141585-141585
  • DOI: 10.1016/j.scitotenv.2020.141585
  • Peer Reviewed / Open Access
• [Journal Article] 697Change of smoking habits by introducing and spreading heated tobacco products in Japan (2021)
  • Author(s): Harada Sei、Sata Mizuki、Matsumoto Minako、Takeuchi Ayano、Iida Miho、Kato Suzuka、Hirata Aya、Kuwabara Kazuyo、Sugiyama Daisuke、Okamura Tomonori、Takebayashi Toru
  • Journal Title: International Journal of Epidemiology Volume: 50 Issue: Supplement_1
  • DOI: 10.1093/ije/dyab168.261
  • Peer Reviewed / Open Access
• [Journal Article] Correction: Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study (2021)
  • Author(s): Ishibashi Yoshiki、Nishitani Rie、Shimura Akiyoshi、Takeuchi Ayano、Touko Mamoru、Kato Takashi、Chiba Sahoko、Ashidate Keiko、Ishiwata Nobuo、Ichijo Tomoyasu、Sasabe Masataka
  • Journal Title: PLOS ONE Volume: 16 Issue: 10 Pages: e0259430-e0259430
  • DOI: 10.1371/journal.pone.0259430
  • Peer Reviewed / Open Access
• [Journal Article] The association between gestational use of personal care products and neonatal urological abnormality at birth: The Japan Environment and Children’s Study (2020)
  • Author(s): Nishihama Yukiko、Tatsuta Nozomi、Iwai-Shimada Miyuki、Nakai Kunihiko、Arima Takahiro、Fujiwara Ikuma、Yaegashi Nobuo、Takeuchi Ayano、Nakayama Shoji F.
  • Journal Title: Reproductive Toxicology Volume: 93 Pages: 83-88
  • DOI: 10.1016/j.reprotox.2020.01.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery (2020)
  • Author(s): Ishii Masatsugu、Itano Osamu、Shinoda Masahiro、Kitago Minoru、Abe Yuta、Hibi Taizo、Yagi Hiroshi、Takeuchi Ayano、Tsujikawa Hanako、Abe Tokiya、Kitagawa Yuko
  • Journal Title: World Journal of Gastroenterology Volume: 26 Issue: 7 Pages: 725-739
  • DOI: 10.3748/wjg.v26.i7.725
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan (2020)
  • Author(s): Nakamura Takahiro、Nishiwaki Yuji、Hashimoto Kunio、Takeuchi Ayano、Kitajima Tasuku、Komori Kazuhiro、Tashiro Kasumi、Hasunuma Hideki、Ueda Kayo、Shimizu Atsushi、Odajima Hiroshi、Moriuchi Hiroyuki、Hashizume Masahiro
  • Journal Title: Environmental Health and Preventive Medicine Volume: 25 Issue: 1
  • DOI: 10.1186/s12199-020-00846-9
  • NAID: 120006823920
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rate of Reoperation Decreased Significantly After Year 2002 in Patients With Crohn's Disease (2020)
  • Author(s): Shinagawa Takahide、Hata Keisuke、Ikeuchi Hiroki、Fukushima Kouhei、Futami Kitaro、Sugita Akira、Uchino Motoi、Watanabe Kazuhiro、Higashi Daijiro、Kimura Hideaki、Araki Toshimitsu、Mizushima Tsunekazu、Itabashi Michio、Ueda Takeshi、Koganei Kazutaka、Oba Koji、Ishihara Soichiro、Suzuki Yasuo
  • Journal Title: Clinical Gastroenterology and Hepatology Volume: 18 Issue: 4 Pages: 898-907.e5
  • DOI: 10.1016/j.cgh.2019.07.025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study (2020)
  • Author(s): Iwama Noriyuki、The BOSHI Study Group、Oba Mari S.、Satoh Michihiro、Ohkubo Takayoshi、Ishikuro Mami、Obara Taku、Sasaki Satomi、Saito Masatoshi、Murakami Yoshitaka、Kuriyama Shin-ichi、Yaegashi Nobuo、Hoshi Kazuhiko、Imai Yutaka、Metoki Hirohito
  • Journal Title: Hypertension Research Volume: 43 Issue: 6 Pages: 550-559
  • DOI: 10.1038/s41440-020-0416-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Estimating nationwide cases of sexually transmitted diseases in 2015 from sentinel surveillance data in Japan (2020)
  • Author(s): Kawado Miyuki、Hashimoto Shuji、Ohta Akiko、Oba Mari S.、Uehara Ritei、Taniguchi Kiyosu、Sunagawa Tomimasa、Nagai Masaki、Murakami Yoshitaka
  • Journal Title: BMC Infectious Diseases Volume: 20 Issue: 1
  • DOI: 10.1186/s12879-020-4801-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correction to: Estimated prevalence of ulcerative colitis and Crohn's disease in Japan in 2015: an analysis of a nationwide survey. (2020)
  • Author(s): Murakami Y, Nishiwaki Y, Oba MS, Asakura K, Ohfuji S, Fukushima W, Suzuki Y, Nakamura Y.
  • Journal Title: J Gastroenterol. Volume: 55(1) Issue: 1 Pages: 131-131
  • DOI: 10.1007/s00535-019-01637-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of Residual Stenosis on the Angiographic Edge Restenosis of a Second-Generation Drug-Eluting Stent (2019)
  • Author(s): Kozuma Kayoko、Shinozaki Tomohiro、Kozuma Ken、Kashiwabara Kosuke、Oba Koji、Aoki Jiro、Awata Masaki、Nanasato Mamoru、Shiode Nobuo、Tanabe Kengo、Yamaguchi Junichi、Kimura Takeshi、Matsuyama Yutaka
  • Journal Title: International Heart Journal Volume: 60 Issue: 5 Pages: 1050-1060
  • DOI: 10.1536/ihj.18-717
  • NAID: 130007719031
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-09-27
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prevalence of Metabolic Syndrome and Lifestyle Characteristics by Business Type among Japanese Workers in Small- and Medium-sized Enterprises (2019)
  • Author(s): Hozawa Hiroko、Takeuchi Ayano、Oguma Yuko
  • Journal Title: The Keio Journal of Medicine Volume: 68 Issue: 3 Pages: 54-67
  • DOI: 10.2302/kjm.2018-0007-OA
  • NAID: 130007711152
  • ISSN: 0022-9717, 1880-1293
  • Peer Reviewed
• [Journal Article] Efficient hydrogen production using photosystem I enhanced by artificial light harvesting dye (2019)
  • Author(s): Nagakawa Haruki、Takeuchi Ayano、Takekuma Yuya、Noji Tomoyasu、Kawakami Keisuke、Kamiya Nobuo、Nango Mamoru、Furukawa Rei、Nagata Morio
  • Journal Title: Photochemical & Photobiological Sciences Volume: 18 Issue: 2 Pages: 309-313
  • DOI: 10.1039/c8pp00426a
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Randomized Phase II Trial Comparing Site-Specific Treatment Based on Gene Expression Profiling With Carboplatin and Paclitaxel for Patients With Cancer of Unknown Primary Site (2019)
  • Author(s): Hayashi Hidetoshi、Kurata Takayasu、Takiguchi Yuichi、Arai Makoto、Takeda Koji、Akiyoshi Kohei、Matsumoto Koji、Onoe Takuma、Mukai Hirofumi、Matsubara Nobuaki、Minami Hironobu、Toyoda Masanori、Onozawa Yusuke、Ono Akira、Fujita Yoshihiko、Sakai Kazuko、et al.
  • Journal Title: Journal of Clinical Oncology Volume: 37 Issue: 7 Pages: 570-579
  • DOI: 10.1200/jco.18.00771
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Does Posterior Cervical Decompression Conducted by Junior Surgeons Affect Clinical Outcomes in the Treatment of Cervical Spondylotic Myelopathy? Results From a Multicenter Study (2019)
  • Author(s): Nagoshi Narihito、Iwanami Akio、Isogai Norihiro、Ishikawa Masayuki、Nojiri Kenya、Tsuji Takashi、Daimon Kenshi、Takeuchi Ayano、Tsuji Osahiko、Okada Eijiro、Fujita Nobuyuki、Yagi Mitsuru、Watanabe Kota、Nakamura Masaya、Matsumoto Morio、Ishii Ken、Yamane Junichi
  • Journal Title: Global Spine Journal Volume: 9 Issue: 1 Pages: 25-31
  • DOI: 10.1177/2192568218756329
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between blood manganese level during pregnancy and birth size: The Japan environment and children's study (JECS) (2019)
  • Author(s): Yamamoto Midori、Sakurai Kenichi、Eguchi Akifumi、Yamazaki Shin、Nakayama Shoji F.、Isobe Tomohiko、Takeuchi Ayano et al.
  • Journal Title: Environmental Research Volume: 172 Pages: 117-126
  • DOI: 10.1016/j.envres.2019.02.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS) (2019)
  • Author(s): Nakayama Shoji F.、the Japan Environment and Children’s Study Group、Iwai-Shimada Miyuki、Oguri Tomoko、Isobe Tomohiko、Takeuchi Ayano、Kobayashi Yayoi、Michikawa Takehiro、Yamazaki Shin、Nitta Hiroshi、Kawamoto Toshihiro
  • Journal Title: Journal of Exposure Science & Environmental Epidemiology Volume: 29 Issue: 5 Pages: 633-647
  • DOI: 10.1038/s41370-019-0139-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical outcomes and prognostic factors for cavernous hemangiomas of the spinal cord: a retrospective cohort study (2019)
  • Author(s): Nagoshi Narihito、Tsuji Osahiko、Nakashima Daisuke、Takeuchi Ayano、Kameyama Kaori、Okada Eijiro、Fujita Nobuyuki、Yagi Mitsuru、Matsumoto Morio、Nakamura Masaya、Watanabe Kota
  • Journal Title: Journal of Neurosurgery: Spine Volume: 31 Issue: 2 Pages: 271-278
  • DOI: 10.3171/2019.1.spine18854
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association Between Dyslipidemia and Plasma Levels of Branched-Chain Amino Acids in the Japanese Population Without Diabetes Mellitus. (2019)
  • Author(s): Keiko Fukushima, Sei Harada, Ayano Takeuchi, Ayako Kurihara, Miho Iida, Kota Fukai, Kazuyo Kuwabara, Suzuka Kato, Minako Matsumoto, Aya Hirata, Miki Akiyama, Masaru Tomita, Akiyoshi Hirayama, Asako Sato, Chizuru Suzuki, Masahiro Sugimoto, Tomoyoshi Soga, Daisuke Sugiyama, Tomonori Okamura, Toru Takebayashi
  • Journal Title: J Clin Lipidol. Volume: 13 Issue: 6 Pages: 932-939.e2
  • DOI: 10.1016/j.jacl.2019.09.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predictive factors for liver volume and function recovery after resection using three-dimensional analysis (2019)
  • Author(s): Nakano Yutaka、Itano Osamu、Shinoda Masahiro、Kitago Minoru、Yagi Hiroshi、Abe Yuta、Takeuchi Ayano、Takemura Yusuke、Kitagawa Yuko
  • Journal Title: HPB Volume: - Issue: 6 Pages: 845-854
  • DOI: 10.1016/j.hpb.2019.10.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Health Effects of Asian Dust Events: A Literature Review Update of Epidemiological Evidence (2019)
  • Author(s): HASUNUMA Hideki、ICHINOSE Takamichi、UEDA Kayo、ODAJIMA Hiroshi、KANATANI Kumiko、SHIMIZU Atsushi、TAKAMI Akinori、TAKEUCHI Ayano、NISHIWAKI Yuji、WATANABE Masanari、HASHIZUME Masahiro
  • Journal Title: Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) Volume: 74 Issue: 0 Pages: n/a
  • DOI: 10.1265/jjh.19010
  • NAID: 130007772402
  • ISSN: 0021-5082, 1882-6482
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Response to: ‘Comment on ‘Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomised controlled trial’ by Tanaka et al’ by Berkhout et al (2019)
  • Author(s): Tanaka Yoshiya、Oba Koji、Takeuchi Tsutomu
  • Journal Title: Annals of the Rheumatic Diseases Volume: - Issue: 11 Pages: 2019-216593
  • DOI: 10.1136/annrheumdis-2019-216593
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comprehensive Comparative Analysis of Prognostic Value of Systemic Inflammatory Biomarkers for Patients with Stage II/III Colon Cancer (2019)
  • Author(s): Suzuki S, Akiyoshi T, Oba K, Otsuka F, Tominaga T, Nagasaki T, Fukunaga Y, Ueno M
  • Journal Title: Ann Surg Oncol Volume: 27 Issue: 3 Pages: 844-852
  • DOI: 10.1245/s10434-019-07904-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reference value for expiratory time constant calculated from the maximal expiratory flow-volume curve. (2019)
  • Author(s): Ikeda T, Yamauchi Y, Uchida K, Oba K, Nagase T, Yamada Y.
  • Journal Title: BMC Pulm Med. Volume: 19 Issue: 1 Pages: 208-208
  • DOI: 10.1186/s12890-019-0976-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomised controlled trial (2019)
  • Author(s): Tanaka Yoshiya、Oba Koji、Koike Takao、Miyasaka Nobuyuki、Mimori Tsuneyo、Takeuchi Tsutomu et al.
  • Journal Title: Annals of the Rheumatic Diseases Volume: 79 Issue: 1 Pages: 94-102
  • DOI: 10.1136/annrheumdis-2019-216169
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between polymorphisms in EGFR and tumor response during cetuximab and oxaliplatin-based combination therapy in metastatic colorectal cancer: Analysis of data from two clinical trials (2019)
  • Author(s): Maeda H, Hazama S, Iwamoto S, Oba K, Tsunedomi R, Okayama N, Suehiro Y, Yamasaki T, Nakagami Y, Suzuki N, Nagano H, Sakamoto J, Mishima H, Nagata N
  • Journal Title: Oncol Lett Volume: 18(5) Pages: 4555-4562
  • DOI: 10.3892/ol.2019.10787
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] JOIN trial: treatment outcome and recovery status of peripheral sensory neuropathy during a 3-year follow-up in patients receiving modified FOLFOX6 as adjuvant treatment for stage II/III colon cancer. (2019)
  • Author(s): Yoshino T, Kotaka M, Shinozaki K, Touyama T, Manaka D, Matsui T, Ishigure K, Hasegawa J, Inoue K, Munemoto Y, Takagane A, Ishikawa H, Ishida H, Ogata Y, Oba K, Goto K, Sakamoto J, Maehara Y, Ohtsu A.
  • Journal Title: Cancer Chemother Pharmacol Volume: 84(6) Issue: 6 Pages: 1269-1277
  • DOI: 10.1007/s00280-019-03957-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Utility of a Three-Dimensional Printed Pelvic Model for Lateral Pelvic Lymph Node Dissection Education: A Randomized Controlled Trial (2019)
  • Author(s): Hojo Daisuke、Murono Koji、Nozawa Hiroaki、Kawai Kazushige、Hata Keisuke、Tanaka Toshiaki、Oba Koji、Ishihara Soichiro
  • Journal Title: Journal of the American College of Surgeons Volume: 229 Issue: 6 Pages: 552-559e3
  • DOI: 10.1016/j.jamcollsurg.2019.08.1443
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Open-label clinical trial of bezafibrate treatment in patients with fatty acid oxidation disorders in Japan; 2nd report QOL survey (2019)
  • Author(s): Shiraishi H、Yamada K、Oki E、Ishige M、Fukao T、Hamada Y、Sakai N、Ochi F、Watanabe A、Kawakami S、Kuzume K、Watanabe K、Sameshima K、Nakamagoe K、Tamaoka A、Asahina N、Yokoshiki S、Miyakoshi T、Oba K、Isoe T、Hayashi H、Yamaguchi S、Sato N
  • Journal Title: Molecular Genetics and Metabolism Reports Volume: 20 Pages: 100496-100496
  • DOI: 10.1016/j.ymgmr.2019.100496
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of metastatic lymph node regression grade after neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer (2019)
  • Author(s): Tominaga T, Akiyoshi T, Yamamoto N, Oba K, Nagasaki T, Yamaguchi T, Konishi T, Fukunaga Y, Ueno M
  • Journal Title: Surgery Volume: 166 Issue: 6 Pages: 1061-1067
  • DOI: 10.1016/j.surg.2019.06.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Detection of atypical data in multicenter clinical trials using unsupervised statistical monitoring (2019)
  • Author(s): Trotta Laura、Kabeya Yuusuke、Buyse Marc、Doffagne Erik、Venet David、Desmet Lieven、Burzykowski Tomasz、Tsuburaya Akira、Yoshida Kazuhiro、Miyashita Yumi、Morita Satoshi、Sakamoto Junichi、Praveen Paurush、Oba Koji
  • Journal Title: Clinical Trials Volume: 16 Issue: 5 Pages: 512-522
  • DOI: 10.1177/1740774519862564
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development and Validation of a Prediction Model for Organ-Specific Recurrences After Curative Resection of Colon Cancer (2019)
  • Author(s): Nagata Hiroshi、Ishihara Soichiro、Oba Koji、Tanaka Toshiaki、Hata Keisuke、Kawai Kazushige、Nozawa Hiroaki
  • Journal Title: Diseases of the Colon & Rectum Volume: 62 Issue: 9 Pages: 1043-1054
  • DOI: 10.1097/dcr.0000000000001430
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risk-Stratified Incidence of Renal Replacement Therapy Initiation: A Longitudinal Analysis Using Medical Claims and Health Checkup Data (2019)
  • Author(s): Sugiyama Takehiro、Oba Koji、Kobayashi Yasuki
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 248 Issue: 2 Pages: 125-135
  • DOI: 10.1620/tjem.248.125
  • NAID: 130007668328
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] One‐Day Versus Three‐Day Dexamethasone in Combination with Palonosetron for the Prevention of Chemotherapy‐Induced Nausea and Vomiting: A Systematic Review and Individual Patient Data‐Based Meta‐Analysis (2019)
  • Author(s): Okada Yuki、Oba Koji、Furukawa Naoto、Kosaka Yoshimasa、Okita Kenji、Yuki Satoshi、Komatsu Yoshito、Celio Luigi、Aapro Matti
  • Journal Title: The Oncologist Volume: 24 Issue: 12 Pages: 1593-1600
  • DOI: 10.1634/theoncologist.2019-0133
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Skin thickness score as a surrogate marker of organ involvements in systemic sclerosis: a retrospective observational study. (2019)
  • Author(s): Matsuda KM, Yoshizaki A, Kuzumi A, Fukasawa T, Ebata S, Miura S, Toyama T, Yoshizaki A, Sumida H, Asano Y, Oba K, Sato S.
  • Journal Title: Arthritis Res Ther Volume: 21 Issue: 1 Pages: 129-129
  • DOI: 10.1186/s13075-019-1919-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort (2019)
  • Author(s): Kobayashi Sumitaka、Kishi Reiko、Saijo Yasuaki、Ito Yoshiya、Oba Koji、Araki Atsuko、Miyashita Chihiro、Itoh Sachiko、Minatoya Machiko、Yamazaki Keiko、Ait Bamai Yu、Sato Tosiya、Yamazaki Shin、Nakayama Shoji F.、Isobe Tomohiko、Nitta Hiroshi
  • Journal Title: Environment International Volume: 125 Pages: 418-429
  • DOI: 10.1016/j.envint.2019.01.051
  • NAID: 120006878536
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Factors associated with PPSV23 coverage among older adults in Japan: a nationwide community-based survey (2019)
  • Author(s): Murakami Yoshitaka、Kanazu Shinichi、Petigara Tanaz、Oba Mari Saito、Nishiwaki Yuji、Watanabe Akira
  • Journal Title: BMJ Open Volume: 9 Issue: 7 Pages: e030197-e030197
  • DOI: 10.1136/bmjopen-2019-030197
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Low-dose <i>l</i>-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial (2019)
  • Author(s): Katsunuma Toshio、Fujisawa Takao、Maekawa Takanobu、Akashi Kenichi、Ohya Yukihiro、Adachi Yuichi、Hashimoto Koji、Mizuno Mihoko、Imai Takanori、Oba Mari S.、Sako Mayumi、Ohashi Yasuo、Nakamura Hidefumi
  • Journal Title: Allergology International Volume: 68 Issue: 3 Pages: 335-341
  • DOI: 10.1016/j.alit.2019.02.001
  • NAID: 130007678453
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anthracycline could be essential for triple-negative breast cancer: A randomised phase II study by the Kanagawa Breast Oncology Group (KBOG) 1101 (2019)
  • Author(s): Narui Kazutaka、Ishikawa Takashi、Shimizu Daisuke、Yamada Akimitsu、Tanabe Mikiko、Sasaki Takeshi、Oba Mari S. et al.
  • Journal Title: The Breast Volume: 47 Pages: 1-9
  • DOI: 10.1016/j.breast.2019.06.003
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 「新型コロナウイルス感染症による日本看護科学学会（JANS）会員の研究活動への影響と学会に求める支援に関する調査」から見えてきたJANS会員のタイプ別コロナ禍における研究への影響とその要因 (2021)
  • Author(s): 竹内文乃
  • Organizer: 日本看護科学学会
  • Invited
• [Presentation] Apply Joint model to life course epidemiological data -birth cohort in Japan- (2020)
  • Author(s): Ayano Takeuchi
  • Organizer: 41st Annual Conference of International Society for Clinical Biostatistics.
  • Int'l Joint Research
• [Presentation] Cohort study and environmental exposure -recent progress in Japan-. (2019)
  • Author(s): Takeuchi A.
  • Organizer: 3rd International Conference on Econometrics and Statistics.
  • Int'l Joint Research / Invited
• [Book] Textbook of Clinical Trials in Oncology A Statistical Perspective (2019)
  • Author(s): Susan Halabi, Stefan Michiels et al.
  • Total Pages: 626
  • Publisher: Chapman and Hall/CRC
  • ISBN: 9784254180510