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Elucidation of pathophysiology and creation of definitive diagnostic criteria in of sarcopenic dysphagia

Research Project

Project/Area Number 19H03979
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionTokyo Women's Medical University

Principal Investigator

Wakabayashi Hidetaka  東京女子医科大学, 医学部, 教授 (80508797)

Co-Investigator(Kenkyū-buntansha) 糸田 昌隆  大阪歯科大学, 医療保健学部, 教授 (10624984)
貴島 真佐子  大阪歯科大学, 医療保健学部, 講師(非常勤) (40838091)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywordsサルコペニア / 摂食嚥下障害 / リハビリテーション栄養
Outline of Research at the Start

サルコペニアの摂食嚥下障害の病態、リスク因子、診断を解明するために、以下の研究を行う。①超音波エコーによる嚥下関連筋の筋肉量・輝度の変化を継時的にみる(症例報告・集積)。②超音波エコーによる嚥下関連筋の筋肉量・輝度と、咽頭残留との関連をみる(横断研究)。③サルコペニアの摂食嚥下障害の様々なセッティングでの有病割合およびリスク因子を調べる(横断研究、多施設データベース研究)。④サルコペニアの摂食嚥下障害診断フローチャートを改訂して確定診断を創る研究。

Outline of Final Research Achievements

467 patients with dysphagia were included in the Japanese Sarcopenic Dysphagia Database. The mean age was 80.4 years, 105 (23%) had probable sarcopenic dysphagia, 182 (39%) had possible sarcopenic dysphagia, and 179 (38%) had no sarcopenic dysphagia. Poor prognostic factors for dysphagia were identified as undernutrition by the GLIM criteria, CRP, modified Glasgow Prognostic Score (mGPS), calf circumference, handgrip strength, and skeletal muscle mass index. Sarcopenic dysphagia was associated with worse improvement in swallowing function and ADL than dysphagia due to other causative diseases.

Academic Significance and Societal Importance of the Research Achievements

摂食嚥下障害の原因としてサルコペニア(筋肉量と筋力の低下)があることは、10年前にはほとんど認識されていなかった。今回、サルコペニアの摂食嚥下障害に関する多くのエビデンスを構築したことで、超高齢社会の日本では、高齢者の摂食嚥下障害の原因としてサルコペニアが重要なことが明らかになった。サルコペニアの摂食嚥下障害に関連する因子や機能予後が悪いことを明らかにしたので今後、摂食嚥下リハビリテーションの臨床現場でサルコペニアが見落とされる可能性が低くなると考える。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (26 results)

All 2023 2022 2021 2020 2019

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 9 results) Presentation (13 results) (of which Int'l Joint Research: 5 results,  Invited: 11 results)

  • [Journal Article] The Relationship between Low Skeletal Muscle Mass and Subsequent Oral Intake Ability among the Aged Population2023

    • Author(s)
      Nakao-Kato Mari、Izumi Shin-Ichi、Nishioka Shinta、Momosaki Ryo、Wakabayashi Hidetaka
    • Journal Title

      Healthcare

      Volume: 11 Issue: 5 Pages: 729-729

    • DOI

      10.3390/healthcare11050729

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Undernutrition on Swallowing Function and Activities of Daily Living in Hospitalized Patients: Data from the Japanese Sarcopenic Dysphagia Database2023

    • Author(s)
      Abe Sayaka、Kokura Yoji、Maeda Keisuke、Nishioka Shinta、Momosaki Ryo、Matsuoka Hiroki、Tomii Yasuomi、Sugita Shinnosuke、Shimizu Kenta、Esashi Nanami、Wakabayashi Hidetaka
    • Journal Title

      Nutrients

      Volume: 15 Issue: 5 Pages: 1291-1291

    • DOI

      10.3390/nu15051291

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between board-certified physiatrist involvement and functional outcomes in sarcopenic dysphagia patients: a retrospective cohort study of the Japanese Sarcopenic Dysphagia Database2023

    • Author(s)
      Nagai Takako、Wakabayashi Hidetaka、Nishioka Shinta、Momosaki Ryo
    • Journal Title

      Journal of Rural Medicine

      Volume: 18 Issue: 1 Pages: 21-27

    • DOI

      10.2185/jrm.2022-026

    • ISSN
      1880-487X, 1880-4888
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional prognosis in patients with sarcopenic dysphagia: An observational cohort study from the Japanese sarcopenic dysphagia database2022

    • Author(s)
      Nagai Takako、Wakabayashi Hidetaka、Nishioka Shinta、Momosaki Ryo
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 22 Issue: 10 Pages: 839-845

    • DOI

      10.1111/ggi.14466

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity and Specificity of Body Mass Index for Sarcopenic Dysphagia Diagnosis among Patients with Dysphagia: A Multi-Center Cross-Sectional Study2022

    • Author(s)
      Togashi Shintaro、Wakabayashi Hidetaka、Ohinata Hironori、Nishioka Shinta、Kokura Yoji、Momosaki Ryo
    • Journal Title

      Nutrients

      Volume: 14 Issue: 21 Pages: 4494-4494

    • DOI

      10.3390/nu14214494

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discriminative Evaluation of Sarcopenic Dysphagia Using Handgrip Strength or Calf Circumference in Patients with Dysphagia Using the Area under the Receiver Operating Characteristic Curve2022

    • Author(s)
      Kishimoto Hiroshi、Wakabayashi Hidetaka、Nishioka Shinta、Momosaki Ryo
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 1 Pages: 118-118

    • DOI

      10.3390/jcm12010118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sarcopenia Is Associated with Fecal Incontinence in Patients with Dysphagia: Implication for Anal Sarcopenia2022

    • Author(s)
      S Mizuno, H Wakabayashi, M Yamakawa, F Wada, R Kato, Y Furiya, S Nishioka, R Momosaki
    • Journal Title

      J Nutr Health Aging

      Volume: 26 Issue: 1 Pages: 84-88

    • DOI

      10.1007/s12603-021-1711-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of Hoarseness and Its Association with Severity of Dysphagia in Patients with Sarcopenic Dysphagia2022

    • Author(s)
      H Wakabayashi, M Kishima, M Itoda, I Fujishima, K Kunieda, T Ohno, T Shigematsu, F Oshima, T Mori, N Ogawa, S Nishioka, R Momosaki, M Yamada, S Ogawa
    • Journal Title

      J Nutr Health Aging

      Volume: 26 Issue: 3 Pages: 266-271

    • DOI

      10.1007/s12603-022-1754-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Inflammation and Functional Outcome in Patients with Sarcopenic Dysphagia2022

    • Author(s)
      T Mori, H Wakabayashi, M Kishima, M Itoda, I Fujishima, K Kunieda, T Ohno, T Shigematsu, F Oshima, N Ogawa, S Nishioka, R Momosaki, A Shimizu, Y Saito, M Yamada, S Ogawa
    • Journal Title

      J Nutr Health Aging

      Volume: 26 Issue: 4 Pages: 400-406

    • DOI

      10.1007/s12603-022-1769-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rehabilitation nutrition for individuals with frailty, disability, sarcopenic dysphagia, or sarcopenic respiratory disability2022

    • Author(s)
      Mizuno S, Wakabayashi H, Wada F
    • Journal Title

      Curr Opin Clin Nutr Metab Care

      Volume: 25 Issue: 1 Pages: 29-36

    • DOI

      10.1097/mco.0000000000000787

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Construction and Quality Evaluation of the Japanese Sarcopenic Dysphagia Database2021

    • Author(s)
      S Mizuno, H Wakabayashi, I Fujishima, M Kishima, M Itoda, M Yamakawa, F Wada, R Kato, Y Furiya, S Nishioka, R Momosaki
    • Journal Title

      J Nutr Health Aging

      Volume: 25 Issue: 7 Pages: 926-932

    • DOI

      10.1007/s12603-021-1646-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of swallowing-related muscle mass assessed by ultrasonography in malnourished patient with Wallenberg syndrome: A case report2021

    • Author(s)
      Hidetaka Wakabayashi, Masako Kishima, Masataka Itoda
    • Journal Title

      J Gen Fam Med

      Volume: 22 Issue: 6 Pages: 341-343

    • DOI

      10.1002/jgf2.428

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of swallowing function and muscle using ultrasonography in general and family medicine2020

    • Author(s)
      Hidetaka Wakabayashi
    • Journal Title

      J Gen Fam Med

      Volume: 21 Issue: 2 Pages: 1-2

    • DOI

      10.1002/jgf2.298

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Sarcopenic Dysphagia, Respiratory Sarcopenia, and Rehabilitation Nutrition2023

    • Author(s)
      Hidetaka Wakabayashi
    • Organizer
      Annual convention of Taiwan Academy of Physical Medicine and Rehabilitation
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Respiratory sarcopenia: A position paper by four professional organizations2023

    • Author(s)
      Hidetaka Wakabayashi, Susumu Sato, Shinjiro Miyazaki, Akira Tamaki, Yoshihiro Yoshimura, Hidenori Arai, Dai Fujiwara, Hideki Katsura, Atsuyoshi Kawagoshi, Ryo Kozu, Keisuke Maeda, Sumito Ogawa, Jun Ueki
    • Organizer
      13th International Conference on Frailty and Sarcopenia Research
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リハビリテーション栄養と呼吸サルコペニア-最新情報と未来に向けて2022

    • Author(s)
      若林秀隆
    • Organizer
      第6回日本リハビリテーション医学会秋季学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] リハビリテーション栄養からみた対策2022

    • Author(s)
      若林秀隆
    • Organizer
      第32回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] サルコペニアの摂食嚥下障害のセッティング別有病割合2021

    • Author(s)
      若林秀隆、水野聡子、和田太、百崎良、藤島一郎、重松孝、國枝顕二郎、巨島文子
    • Organizer
      第58回日本リハビリテーション医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Sarcopenic dysphagia and rehabilitation nutrition2021

    • Author(s)
      Wakabayashi H, Fujishima I
    • Organizer
      2nd World Dysphagia Summit
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 全身のサルコペニアについて最近の考え方と嚥下障害への影響2021

    • Author(s)
      若林秀隆
    • Organizer
      第26・27回 合同学術大会日本摂食嚥下リハビリテーション学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Sarcopenic dysphagia, rehabilitation nutrition and rehabilitation pharmacotherapy2019

    • Author(s)
      Hidetaka Wakabayashi
    • Organizer
      5th Asian Conference on Frailty and Sarcopenia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Symptoms of patients with cachexia and their therapy: Swallowing problems.2019

    • Author(s)
      Hidetaka Wakabayashi
    • Organizer
      12th International Conference on Cachexia, Sarcopenia & Muscle Wasting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] サルコペニアの摂食嚥下障害と医科歯科連携2019

    • Author(s)
      若林秀隆
    • Organizer
      第25回日本摂食嚥下リハビリテーション学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] リハビリテーション栄養によるサルコペニア・フレイル介入2019

    • Author(s)
      若林秀隆
    • Organizer
      第6回日本サルコペニア・フレイル学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] リハビリテーション栄養の視点で考える誤嚥性肺炎予防2019

    • Author(s)
      若林秀隆
    • Organizer
      第29回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 2020年代のリハ栄養の展望と課題2019

    • Author(s)
      若林秀隆
    • Organizer
      第9回日本リハビリテーション栄養学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited

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Published: 2019-04-18   Modified: 2024-01-30  

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