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Boosting peripheral vision with neuromodulation technology

Research Project

Project/Area Number 19H03992
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionNational Rehabilitation Center for Persons with Disabilities

Principal Investigator

Nakamura Kimihiro  国立障害者リハビリテーションセンター(研究所), 研究所脳機能系障害研究部, 主任研究官 (40359633)

Co-Investigator(Kenkyū-buntansha) 高野 弘二  国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究員 (00510588)
伊藤 和之  国立障害者リハビリテーションセンター(研究所), 自立支援局(研究所併任), 教務課長 (10501091)
幕内 充  国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究室長 (70334232)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords周辺視 / 機能的磁気共鳴画像 / ニューロフィードバック / 視覚認知 / 脳刺激法 / crowding / 脳機能画像 / 経頭蓋脳刺激
Outline of Research at the Start

ヒトの視覚機能には、視野中心部の対象を高速かつ正確に分析する「中心視」と、その外側のより広い範囲の視野情報の処理を担当する「周辺視」がある。周辺視は、日常生活の様々な局面に関わるほか、視覚障害や読み書き障害との関連も注目されており、周辺視機能の向上のために様々な訓練プログラムが考案されてきた。最近の神経科学研究から、周辺視には大脳皮質レベルにおける機能的制約のため、中心視のように精密な視覚分析は難しいことが示されている。本研究計画では、周辺視と脳機能との関係に着目し、経頭蓋脳刺激法とニューロフィードバックを組み合わせて、周辺視の機能増幅のための安全で新しい介入手法の開発を目指す。

Outline of Final Research Achievements

Human vision consists of "central vision" for fast/accurate analysis of objects in the center of the visual field and "peripheral vision" for visual information in a wider area outside of the central vision. We examined whether peripheral vision can be amplified with neurofeedback technology targeting “visual crowding”, a key factor limiting the spatial resolution of peripheral vision. We built online fMRI data-processing pipelines to extract the occipital cortex for peripheral vision and a neurofeedback procedure with real-time fMRI analysis, allowing us to effectively amplify the occipital cortex activity in one hour. In eye-tracking experiments, however, no consistent trend has yet been obtained due to a large inter-subject variability in behavioral indices. These results indicate that the visual cortex for peripheral vision can be modulated in a short period of time. Further analysis with additional samples is needed to determine the effects of training at the behavioral level.

Academic Significance and Societal Importance of the Research Achievements

周辺視は、自動車運転やスポーツ、街中での移動など日常生活の様々な局面で重要な役割を担うほか、識字学習や網膜疾患における残存視機能としても重要である。周辺視機能は、様々な訓練プログラムによって改善できるとされているが、視野機能訓練には確立された手法がなく、機能的介入の有効性については未知の部分も多い。本研究課題では、周辺視に関わる後頭葉皮質を選択手に機能増幅するためのニューロフィードバック手法を確立し、これに伴う行動変化を検討した。今後の検証で神経構造への機能的介入による促進効果を得られれば、読み書き障害や網膜疾患の病態理解や障害支援、安全性の高い新たな訓練手法の開発のための基礎的知見となる。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (12 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 7 results)

  • [Int'l Joint Research] INSERM(フランス)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Graphomotor memory in Exner’s area enhances word learning in the blind2021

    • Author(s)
      Mizuochi-Endo Tomomi、Itou Kazuyuki、Makuuchi Michiru、Kato Baku、Ikeda Kazuhisa、Nakamura Kimihiro
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 17298-17298

    • DOI

      10.1038/s42003-021-01971-z

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperactive sensorimotor cortex during voice perception in spasmodic dysphonia2020

    • Author(s)
      Kanazawa Yuji、Kishimoto Yo、Tateya Ichiro、Ishii Toru、Sanuki Tetsuji、Hiroshiba Shinya、Aso Toshihiko、Omori Koichi、Nakamura Kimihiro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 17298-17298

    • DOI

      10.1038/s41598-020-73450-0

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Neural systems for phonology contribute to the act of writing.2023

    • Author(s)
      Yokoi, M., Takano, K., Uno, T., Nakamura, K.
    • Organizer
      Annual Meeting 2023, Cognitive Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The anterior temporal semantic hub in the left and right hemispheres: A unified system or two separate systems for meaning?2023

    • Author(s)
      Uno, T., Teichmann, M., Takano, K., Yokoi, M., Nakamura, K.
    • Organizer
      Annual Meeting 2023, Cognitive Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 機械学習を用いた認知機能に対するfMRI ニューロフィードバックシステムの構築2023

    • Author(s)
      高野弘二 小松知章 中村仁洋
    • Organizer
      第100回 日本生理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Early activation of Broca’s area causally contributes to speeded reading2022

    • Author(s)
      Uno, T., Takano, K., Nakamura, K.
    • Organizer
      Annual Meeting 2022, Cognitive Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early activation of Broca's area plays a causal role in visual word recognition2021

    • Author(s)
      Uno, T., Takano, K., Nakamura, K.
    • Organizer
      Annual Meeting 2021, Cognitive Neuroscience Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phonological priming reveals a key role of phonology in writing.2021

    • Author(s)
      Yokoi, M., Takano, K., Nakamura, K.
    • Organizer
      Annual Meeting 2021, Cognitive Neuroscience Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 視覚障害者の言語学習における書字運動記憶とExner領域の役割.2020

    • Author(s)
      水落 智美 伊藤 和之 幕内 充 加藤 麦 池田 和久 中村 仁洋
    • Organizer
      第43回 日本神経科学大会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] Early activation of Broca's area plays a causal role in visual word recognition2020

    • Author(s)
      Uno, T., Takano, K., Nakamura, K.
    • Organizer
      Annual Meeting 2021, Cognitive Neuroscience Society
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phonological priming reveals a key role of phonology in writing.2020

    • Author(s)
      Yokoi, M., Takano, K., Nakamura, K.
    • Organizer
      Annual Meeting 2021, Cognitive Neuroscience Society
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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