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Arterial blood pressure regulation during exercise by muscle pump and cardiopulmonary baroreflex

Research Project

Project/Area Number 19H03998
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionNagoya University

Principal Investigator

Katayama Keisho  名古屋大学, 総合保健体育科学センター, 教授 (40343214)

Co-Investigator(Kenkyū-buntansha) 石田 浩司  名古屋大学, 総合保健体育科学センター, 教授 (50193321)
小河 繁彦  東洋大学, 理工学部, 教授 (80553841)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords動的運動 / 筋交感神経活動 / 血圧 / 心肺圧受容器反射 / 筋ポンプ作用 / 循環調節 / 血管運動神経活動 / 運動 / 動脈血圧 / 心肺圧受容器 / 血圧調節 / 筋交換神経活動
Outline of Research at the Start

運動時の動脈血圧の上昇は,活動筋への血流量(酸素運搬)と,脳や心臓など生命維持に不可欠な臓器への血流を維持することに貢献する.これまで我々は,筋ポンプによる静脈還流量の増加が心肺圧受容器を刺激し,血管運動神経活動を抑制することを明らかにした.この結果は,筋ポンプによる心肺圧受容器刺激が,血圧が過度に上昇しないように末梢血管抵抗を調節することを示唆する.
本研究ではこれまでの研究成果をさらに発展させ,特に高齢者において,運動時の血圧上昇に対する筋ポンプ機能および心肺圧受容器機能の影響を明らかにし,運動時の血圧調節メカニズムのさらなる解明を目的とし研究を進める.

Outline of Final Research Achievements

Precise regulation of sympathetic vasomotor outflow is necessary during exercise to maintain arterial blood pressure. Previous studies have reported that muscle sympathetic nerve activity decrease from rest during dynamic leg exercise at low intensity. In contrast, when exercise is above moderate intensity, sympathetic vasomotor outflow increases during exercise. Graded isolation of the muscle metaboreflex was achieved by post-exercise ischemia (PEI) following low- and high-intensity isometric handgrip exercise, before the onset of leg cycling. We found that high-intensity muscle metaboreflex activation attenuates muscle pump-induced cardiopulmonary baroreflex inhibition of sympathetic vasomotor outflow during dynamic leg cycling.

Academic Significance and Societal Importance of the Research Achievements

高強度運動時において,骨格筋由来の代謝受容器反射を介した血管運動神経活動の賦活が,心肺圧受容器反射による血管運動神経活動の抑制を減弱することは,非活動部位での末梢血管収縮により活動筋へ優先的に血液(酸素)を運搬することに貢献する.しかしながら,近年の研究において,慢性心不全患者や2型糖尿病患者では,低運動強度においても血圧が過度に上昇することが報告されている.この原因は不明であるが,骨格筋の代謝受容器反射の増大あるいは心肺圧受容器反射の感受性低下による血管運動神経活動の調節不全が,過度な血圧上昇に関係しているかもしれない.これらの点についてはさらなる研究が必要である.

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Int'l Joint Research] テキサス大学・アーリントン校(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Sympathetic vasomotor outflow during low‐intensity leg cycling in healthy older males2022

    • Author(s)
      Katayama Keisho、Saito Mitsuru、Ishida Koji、Shimizu Kaori、Shiozawa Kana、Mizuno Sahiro、Ogoh Shigehiko
    • Journal Title

      Experimental Physiology

      Volume: 107 Issue: 8 Pages: 825-833

    • DOI

      10.1113/ep090497

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood pressure and coeliac artery blood flow responses during increased inspiratory muscle work in healthy males2022

    • Author(s)
      Shiozawa Kana、Kashima Hideaki、Mizuno Sahiro、Ishida Koji、Katayama Keisho
    • Journal Title

      Experimental Physiology

      Volume: 107 Issue: 9 Pages: 1094-1104

    • DOI

      10.1113/ep090504

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Age and sex differences in blood pressure responses during hyperpnoea2021

    • Author(s)
      Shimizu Kaori、Shiozawa Kana、Ishida Koji、Saito Mitsuru、Mizuno Sahiro、Akima Hiroshi、Katayama Keisho
    • Journal Title

      Experimental Physiology

      Volume: 106 Issue: 3 Pages: 736-747

    • DOI

      10.1113/ep089171

    • NAID

      120007164828

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The hyperpnoea of exercise in health: Respiratory influences on neurovascular control2020

    • Author(s)
      Sheel A. William、Taylor Joshua Landen、Katayama Keisho
    • Journal Title

      Experimental Physiology

      Volume: - Issue: 12 Pages: 1984-1989

    • DOI

      10.1113/ep088103

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle pump-induced inhibition of sympathetic vasomotor outflow during low-intensity leg cycling is attenuated by muscle metaboreflex activation2020

    • Author(s)
      Katayama Keisho、Barbosa Thales C.、Kaur Jasdeep、Young Benjamin E.、Nandadeva Damsara、Ogoh Shigehiko、Fadel Paul J.
    • Journal Title

      Journal of Applied Physiology

      Volume: 128 Issue: 1 Pages: 1-7

    • DOI

      10.1152/japplphysiol.00639.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Blood pressure and limb blood flow responses during hyperpnoea are not affected by menstrual cycle phase in young women2020

    • Author(s)
      Shimizu Kaori、Shiozawa Kana、Ishida Koji、Saito Mitsuru、Mizuno Sahiro、Akima Hiroshi、Katayama Keisho
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 275 Pages: 103387-103387

    • DOI

      10.1016/j.resp.2020.103387

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] High-intensity respiratory muscle interval training protocol develops inspiratory muscle fatigue2022

    • Author(s)
      Sato Suzuna, Ishida Koji, Tanaka Noriko, Katayama Keisho
    • Organizer
      67th American College of Sports Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes in splanchnic blood flow and blood pressure during inspiratory resistive breathing2022

    • Author(s)
      Shiozawa Kana, Kashima Hideaki, Mizuno Sahiro, Ishida Koji, Katayama Keisho
    • Organizer
      69th American College of Sports Medicine
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 呼吸筋トレーニングへのインターバルプロトコルの応用2022

    • Author(s)
      佐藤鈴菜,石田浩司,田中憲子,片山敬章
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 呼吸筋活動の増加が腹部内臓血流に及ぼす影響2022

    • Author(s)
      塩澤華奈,鍛島秀明,水野沙紘,石田浩司,片山敬章
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 運動時の循環調節に対する呼吸筋活動の影響2022

    • Author(s)
      片山敬章
    • Organizer
      第30回日本運動生理学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 呼吸筋活動の増加に対する循環応答:年齢および性別の影響2020

    • Author(s)
      清水香,塩澤華奈,齊藤満,石田浩司,水野沙洸,秋間広,片山敬章
    • Organizer
      第75回 日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 動的運動時の呼吸筋活動増加による循環応答:性差の影響2020

    • Author(s)
      塩澤華奈,清水香,齊藤満,石田浩司,水野沙洸,片山敬章
    • Organizer
      第75回 日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Inspiratory muscle strength and diaphragm thickness in elderly women.2019

    • Author(s)
      Shimizu K., Shiozawa K., Watanabe K., Saito M., Ishida K., Akima H., and Katayama K.
    • Organizer
      65th American College of Sports Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of increased respiratory muscle activation on blood flow to inactive and active limb muscles.2019

    • Author(s)
      Shiozawa K., Goto K., Shimizu K., Saito M., Ishida K., Zhang L., Sheel W., and Katayama K.
    • Organizer
      5th American College of Sports Medicine
    • Related Report
      2019 Annual Research Report
  • [Presentation] 呼吸筋活動の増加が運動時の活動筋および非活動筋の血流に及ぼす影響2019

    • Author(s)
      片山敬章,塩澤華奈,清水 香,張 魯玉,齊藤 満,石田浩司.
    • Organizer
      第74回 日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 月経周期は呼吸筋活動の増加にともなう循環応答に影響しない2019

    • Author(s)
      清水 香,塩澤華奈,石田浩司,齊藤 満,秋間 広,片山敬章.
    • Organizer
      第74回 日本体力医学会大会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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