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Influence of elastic force produced by cross-bridge and titin on the force enhancement by stretch-shortening cycle

Research Project

Project/Area Number 19H04011
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionRitsumeikan University

Principal Investigator

Fukutani Atsuki  立命館大学, スポーツ健康科学部, 講師 (80722644)

Co-Investigator(Kenkyū-buntansha) 杉 晴夫  帝京大学, 医学部, 名誉教授 (20082076)
伊坂 忠夫  立命館大学, スポーツ健康科学部, 教授 (30247811)
八木 直人  公益財団法人高輝度光科学研究センター, 分光推進室, 特別研究員 (80133940)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywordsミオシン / アクチン / タイチン / 小角散乱 / クロスブリッジ / 反動動作 / X線回折 / 生体
Outline of Research at the Start

ヒト生体の身体運動の多くは反動動作を伴う。これは、反動動作を用いることで身体運動パフォーマンスが増強することを、だれもが体で知っているからである。これほど広く用いられている反動動作であるが、そのメカニズムに関しては未解決な部分が残されている。そこで本研究では、筋収縮の源であるクロスブリッジや、筋細胞内に存在する人体最大のタンパク質であるタイチンに着目し、分子レベルでの挙動を観察することで、なぜ反動動作によって発揮筋力が増大するのかを明らかにする。

Outline of Final Research Achievements

The purpose of this study was to examine the mechanism of force enhancement by stretch-shortening cycle focused on cross-bridge behaviours. We used small angle X-ray diffraction to confirm the structutral changes of cross bridges during stretch-shortening cycle. As a result, the number of attached cross bridges decreased although the force attained during the countermovement (eccentric contraction) increased. This results suggest that the larger force attained during the eccentric contraction was caused by increased force per attahced cross bridge not by increased number of attached cross bridges. This mechanism can explain the force enhancement by stretch-shortening cycle.

Academic Significance and Societal Importance of the Research Achievements

我々が高く跳ぶことを考えた場合、だれもが沈み込んだ後に (反動動作を行った後に)跳ぶ。これは、誰しもが経験的に、反動動作を使うことで運動パフォーマンスが増強することを知っているからである。このような誰もが使っている反動動作ではあるが、そのメカニズムに関しては不明な点が残されている。本研究は、クロスブリッジの挙動に着目し、そのメカニズムの一部を解明した。このような知見が蓄積することで、より効果的に反動効果を引き出すことが出来るようになる。反動動作はスポーツ動作だけでなく日常動作にも多く含まれることを踏まえると、スポーツパフォーマンス向上だけでなく、リハビリテーションにも有意義な知見となりうる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (16 results)

All 2022 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] カルガリー大学(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] カロリンスカ研究所(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Residual force enhancement is attenuated for quick stretch conditions2022

    • Author(s)
      Fukutani Atsuki、Herzog Walter
    • Journal Title

      Journal of Biomechanics

      Volume: 136 Pages: 111076-111076

    • DOI

      10.1016/j.jbiomech.2022.111076

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of the relative muscle volume of triceps surae among sprinters, runners, and untrained participants2020

    • Author(s)
      Fukutani A, Tsuruhara Y, Miyake Y, Takao K, Ueno H, Otsuka M, Suga T, Terada M, Nagano A, Isaka T.
    • Journal Title

      Physiol Rep

      Volume: 19 Issue: 19

    • DOI

      10.14814/phy2.14588

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in stretch-shortening cycle and residual force enhancement between muscles.2020

    • Author(s)
      Fukutani A, Herzog W.
    • Journal Title

      J Biomech

      Volume: 112 Pages: 110040-110040

    • DOI

      10.1016/j.jbiomech.2020.110040

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Muscle Recruitment Pattern of the Hamstring Muscles in Hip Extension and Knee Flexion Exercises.2020

    • Author(s)
      Yanagisawa O, Fukutani A.
    • Journal Title

      J Hum Kinet

      Volume: 72 Issue: 1 Pages: 51-59

    • DOI

      10.2478/hukin-2019-0124

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-activation affects the effect of stretch-shortening cycle by modulating fascicle behavior.2019

    • Author(s)
      Fukutani A, Shimoho K, Isaka T.
    • Journal Title

      Biol Open

      Volume: 8 Issue: 12

    • DOI

      10.1242/bio.044651

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of muscle length on the stretch-shortening cycle in skinned rabbit soleus.2019

    • Author(s)
      Fukutani A, Isaka T.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 18350-18350

    • DOI

      10.1038/s41598-019-54959-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current Understanding of Residual Force Enhancement: Cross-Bridge Component and Non-Cross-Bridge Component.2019

    • Author(s)
      Fukutani A, Herzog W.
    • Journal Title

      Int J Mol Sci

      Volume: 20 Issue: 21 Pages: 5479-5479

    • DOI

      10.3390/ijms20215479

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contribution of the Achilles tendon to force potentiation in a stretch-shortening cycle.2019

    • Author(s)
      Fukutani A, Sawatsky A, Leonard T, Herzog W.
    • Journal Title

      J Exp Biol

      Volume: 222

    • DOI

      10.1242/jeb.204032

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of stretch magnitude on the stretch-shortening cycle in skinned muscle fibres.2019

    • Author(s)
      Fukutani A, Herzog W.
    • Journal Title

      J Exp Biol

      Volume: 222

    • DOI

      10.1242/jeb.206557

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Does stretching velocity affect residual force enhancement?2019

    • Author(s)
      Fukutani A, Leonard T, Herzog W.
    • Journal Title

      J Biomech

      Volume: 89 Pages: 143-147

    • DOI

      10.1016/j.jbiomech.2019.04.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Isometric preactivation before active lengthening increases residual force enhancement.2019

    • Author(s)
      Fukutani A, Shimoho K, Isaka T.
    • Journal Title

      Scand J Med Sci Sports

      Volume: 29 Issue: 8 Pages: 1153-1160

    • DOI

      10.1111/sms.13454

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Influence of fiber type on stretch shortening cycle and residual force enhancement.2019

    • Author(s)
      Fukutani A, Herzog W.
    • Organizer
      27th Congress of the International Society of Biomechanics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relative muscle volume of triceps surae differs among sprinters, runners and untrained subjects.2019

    • Author(s)
      Tsuruhara Y, Fukutani A, Ueno H, Suga T, Terada M, Nagano A, Isaka T.
    • Organizer
      27th Congress of the International Society of Biomechanics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Stretch-Shortening Cycle is Prominent in the Reduced Force Condition.2019

    • Author(s)
      Fukutani A, Herzog W.
    • Organizer
      Rocky mountain muscle symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2023-01-30  

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