Molecular design of innovative drugs based on molecular assembly

• Project/Area Number: 19H05458
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: University of Tsukuba
• Principal Investigator: 長崎 幸夫 筑波大学, 数理物質系, 教授 (90198309)
• Co-Investigator(Kenkyū-buntansha): 佐々木 茂貴 長崎国際大学, 薬学部, 教授 (10170672) ; 吉冨 徹 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主任研究員 (20585799) ; 丸山 達生 神戸大学, 工学研究科, 教授 (30346811) ; 案浦 健 国立感染症研究所, 寄生動物部, 室長 (90407239) ; 富田 勉 株式会社タイムラプスビジョン(研究部), 研究部, 代表取締役 (30772488) ; 池田 豊 筑波大学, 数理物質系, 助教 (70425734)
• Project Period (FY): 2019-04-23 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥626,210,000 (Direct Cost: ¥481,700,000、Indirect Cost: ¥144,510,000); Fiscal Year 2023: ¥114,140,000 (Direct Cost: ¥87,800,000、Indirect Cost: ¥26,340,000); Fiscal Year 2022: ¥114,010,000 (Direct Cost: ¥87,700,000、Indirect Cost: ¥26,310,000); Fiscal Year 2021: ¥116,220,000 (Direct Cost: ¥89,400,000、Indirect Cost: ¥26,820,000); Fiscal Year 2020: ¥126,880,000 (Direct Cost: ¥97,600,000、Indirect Cost: ¥29,280,000); Fiscal Year 2019: ¥154,960,000 (Direct Cost: ¥119,200,000、Indirect Cost: ¥35,760,000)
• Keywords: 抗酸化薬 / アミノ酸 / 自己組織化薬 / 短鎖脂肪酸 / サルコペニア / 癌悪液質 / PPARα / コントロールドリリース / 分子組織化薬 / 感染症 / オリゴ核酸 / ペプチド脂質 / シトリン欠損症 / 抗酸化 / 脂質ペプチド / 抗酸化剤 / 核酸 / ペプチドゲル / パーキンソン / 遺伝子 / がん

Outline of Research at the Start

本研究では有機合成による低分子医薬品の開発や、鍵と鍵穴を作用機序とする酵素や受容体をターゲットとするバイオ医薬品などに限界が見えつつある中、「分子組織化」に基づく新しい薬物の開発を目標に、分担者とともに基礎研究を推進し、概念の確立を目指す。本研究は「分子の組織体」を用いて、これまで困難とされてきた薬理活性を発現させるところにあり、この「分子の組織体による薬理活性」をこれまでにない作用機序に基づく新たな創薬概念として提唱する。本研究では、wet系実験研究ならではの発見を大切にし、「多数分子が組織的・協同的に働く」という概念を創薬分野に導入・確立することが本研究の最大の特徴である。

Outline of Annual Research Achievements

従来のビタミンや様々な抗酸化剤は低分子ゆえに正常細胞内のレドックス反応を破壊する重大な欠点があった。我々は自己組織能を持つ高分子に抗酸化剤を共有結合すると、正常細胞への取り込みが抑制されるために副作用を低減させ、炎症部位に集積して活性酸素種(ROS)を効果的に消去することを見出した。この成果は、低分子単独の薬理活性物質を自己組織化させることによって、低分子単独では得られない生体機能や治療効果を実現できる可能性を示すものである。これまでの有機合成による低分子医薬品の開発や、鍵と鍵穴を作用機序とする酵素や受容体をターゲットとするバイオ医薬品などに限界が見えるつつある中、本研究では「分子の組織体」を用いて、これまで困難とされてきた薬理活性を発現させるところにあり、この「分子の組織体による薬理活性」をこれまでにない作用機序に基づく新たな創薬概念として提唱した。目的を達成するために本研究では、wet系実験研究ならではの発見を大切にし、「多数分子が組織的・協同的に働く 」という概念を創薬分野に導入・確立することが本研究の最大の特徴である。これまでに抗酸化型、アミノ酸型、短鎖脂肪酸型自己組織化薬を設計し、がんやうつ病、肝障害、膵臓障害など様々な動物モデルを作製し、その効果の実証をしてきた。また、隣接基効果による新薬合成では隣接基効果により初めて選択的に機能する分子を設計し、細胞実験で実証を進めている。また、生体内環境でゲル化する分子設計では腫瘍環境から細胞内への展開を進め、動物実験にも成功しつつある。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

Assessment Rating

Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Research Products

• [Int'l Joint Research] ベトナム国家大学国際大学(ベトナム)
• [Int'l Joint Research] フィリピン原子力研究所(フィリピン)
• [Int'l Joint Research] タイ国立科学技術研究所(タイ)
• [Int'l Joint Research] ベトナム国家大学国際大学(ベトナム)
• [Int'l Joint Research] フィリピン原子力研究所(フィリピン)
• [Int'l Joint Research] タイ国立科学技術研究所(タイ)
• [Journal Article] Self-assembling butyric acid prodrug acts as a sensitizer for cancer radiotherapy (2024)
  • Author(s): Shashni Babita、Nagasaki Yukio
  • Journal Title: Nano Today Volume: 54 Pages: 102103-102103
  • DOI: 10.1016/j.nantod.2023.102103
  • Peer Reviewed
• [Journal Article] An orally deliverable ornithine-based self-assembling polymer nanomedicine ameliorates hyperammonemia in acetaminophen-induced acute liver injury (2023)
  • Author(s): Ding Yuanyuan、Koda Yuta、Shashni Babita、Takeda Naoki、Zhang Xuguang、Tanaka Naoki、Nishikawa Yuji、Nagasaki Yukio
  • Journal Title: Acta Biomaterialia Volume: 168 Pages: 515-528
  • DOI: 10.1016/j.actbio.2023.07.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Design of Antioxidant Nanoparticle, which Selectively Locates and Scavenges Reactive Oxygen Species in the Gastrointestinal Tract, Increasing The Running Time of Mice (2023)
  • Author(s): Toriumi Takuto、Ohmori Hajime、Nagasaki Yukio
  • Journal Title: Advanced Science Volume: 10 Issue: 27
  • DOI: 10.1002/advs.202301159
  • Peer Reviewed
• [Journal Article] Newly Designed Cysteine-Based Self-Assembling Prodrugs for Sepsis Treatment (2023)
  • Author(s): Koda Yuta、Nagasaki Yukio
  • Journal Title: Pharmaceutics Volume: 15 Issue: 6 Pages: 1775-1775
  • DOI: 10.3390/pharmaceutics15061775
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of redox nanoparticles for improving survival of transplanted cells in a mouse model of ischemic stroke (2023)
  • Author(s): Hirata Koji、Marushima Aiki、Nagasaki Yukio、Ishikawa Hiroshi、Matsumura Hideaki、Mujagi Arnela、Hirayama Aki、Toyomura Junko、Ohyama Akihiro、Takaoka Shohei、Bukawa Hiroki、Matsumura Akira、Ishikawa Eiichi、Matsumaru Yuji
  • Journal Title: Human Cell Volume: 36 Issue: 5 Pages: 1703-1715
  • DOI: 10.1007/s13577-023-00940-4
• [Journal Article] Designing poly(gamma-aminobutyric acid)-based nanoparticles for the treatment of major depressive disorders (2023)
  • Author(s): Tri Bui Duc、Shashni Babita、Matsui Hirofumi、Nagasaki Yukio
  • Journal Title: Journal of Controlled Release Volume: 360 Pages: 110-121
  • DOI: 10.1016/j.jconrel.2023.06.021
  • Peer Reviewed
• [Journal Article] Direct evidence for the involvement of intestinal reactive oxygen species in the progress of depression via the gut-brain axis (2023)
  • Author(s): Ikeda Yutaka、Saigo Naoki、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 295 Pages: 122053-122053
  • DOI: 10.1016/j.biomaterials.2023.122053
  • Peer Reviewed / Open Access
• [Journal Article] Self-assembling polymer-based short chain fatty acid prodrugs ameliorate non-alcoholic steatohepatitis and liver fibrosis (2023)
  • Author(s): Shashni Babita、Tajika Yuya、Ikeda Yutaka、Nishikawa Yuji、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 295 Pages: 122047-122047
  • DOI: 10.1016/j.biomaterials.2023.122047
  • Peer Reviewed
• [Journal Article] Recent advances in self-assembling redox nanoparticles as a radiation protective agent (2023)
  • Author(s): Feliciano Chitho P.、Cammas-Marion Sandrine、Nagasaki Yukio
  • Journal Title: AIMS Molecular Science Volume: 10 Issue: 1 Pages: 52-69
  • DOI: 10.3934/molsci.2023005
  • Peer Reviewed
• [Journal Article] Design of a new self-assembling antioxidant nanomedicine to ameliorate oxidative stress in zebrafish embryos (2023)
  • Author(s): Shashni Babita、Tamaoki Junya、Kobayashi Makoto、Nagasaki Yukio
  • Journal Title: Acta Biomaterialia Volume: 159 Pages: 367-381
  • DOI: 10.1016/j.actbio.2023.01.012
  • Peer Reviewed
• [Journal Article] Short-chain fatty acid-releasing nano-prodrugs for attenuating growth and metastasis of melanoma (2023)
  • Author(s): Shashni Babita、Nagasaki Yukio
  • Journal Title: Acta Biomaterialia Volume: 159 Pages: 226-236
  • DOI: 10.1016/j.actbio.2023.01.054
  • Peer Reviewed
• [Journal Article] Design of cysteine-based self-assembling polymer drugs for anticancer chemotherapy (2022)
  • Author(s): Koda Yuta、Nagasaki Yukio
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 220 Pages: 112909-112909
  • DOI: 10.1016/j.colsurfb.2022.112909
  • Peer Reviewed
• [Journal Article] Antioxidative Self-Assembling Nanoparticles Attenuate the Development of Steatohepatitis and Inhibit Hepatocarcinogenesis in Mice (2022)
  • Author(s): Watahiki Takahisa、Okada Kosuke、Miura Ikuru、To Keii、Tanaka Seiya、Warabi Eiji、Kanno Naomi、Yamagata Kenji、Gotoh Naohiro、Suzuki Hideo、Ariizumi Shunichi、Tsuchiya Kiichiro、Nagasaki Yukio、Shoda Junichi
  • Journal Title: Antioxidants Volume: 11 Issue: 10 Pages: 1939-1939
  • DOI: 10.3390/antiox11101939
  • Peer Reviewed / Open Access
• [Journal Article] Design of self-assembling anti-epileptic drug for long-acting drug delivery <i>in vivo</i> (2022)
  • Author(s): Ikeda Yutaka、Tajika Yuya、Nagasaki Yukio
  • Journal Title: Biomaterials Science Volume: 10 Issue: 21 Pages: 6307-6314
  • DOI: 10.1039/d2bm01064j
  • Peer Reviewed
• [Journal Article] Sorafenib-loaded silica-containing redox nanoparticles for oral anti-liver fibrosis therapy (2022)
  • Author(s): Tran Hao Thi、Vong Long Binh、Nishikawa Yuji、Nagasaki Yukio
  • Journal Title: Journal of Controlled Release Volume: 345 Pages: 880-891
  • DOI: 10.1016/j.jconrel.2022.04.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A silica-based antioxidant nanoparticle for oral delivery of Camptothecin which reduces intestinal side effects while improving drug efficacy for colon cancer treatment (2022)
  • Author(s): Nguyen-Trinh Quynh Nhu、Trinh Kim Xuyen Thi、Trinh Nhu-Thuy、Vo Van Toi、Li Nan、Nagasaki Yukio、Vong Long Binh
  • Journal Title: Acta Biomaterialia Volume: 143 Pages: 459-470
  • DOI: 10.1016/j.actbio.2022.02.036
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Self-Assembling Antioxidants for Ischemia-Reperfusion Injuries. (2022)
  • Author(s): Toru Yoshitomi, Yukio Nagasaki Y.
  • Journal Title: Antioxid Redox Signal. Volume: 36 Issue: 1-3 Pages: 70-80
  • DOI: 10.1089/ars.2021.0103
  • Peer Reviewed
• [Journal Article] Self-assembling antioxidants for ischemia-reperfusion injuries, Antioxidants and Redox Signaling (2022)
  • Author(s): Toru Yoshitomi, Yukio Nagasaki
  • Journal Title: Forum Article “REDOX THERANOSTICS” Volume: Vol. 36, No. 1-3 Pages: 80-80
  • Peer Reviewed
• [Journal Article] Design of enzyme-responsive short-chain fatty acid-based self-assembling drug for alleviation of type 2 diabetes mellitus (2021)
  • Author(s): Shashni Babita、Tajika Yuya、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 275 Pages: 120877-120877
  • DOI: 10.1016/j.biomaterials.2021.120877
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antioxidant Nanomedicine Significantly Enhances the Survival Benefit of Radiation Cancer Therapy by Mitigating Oxidative Stress‐Induced Side Effects (2021)
  • Author(s): Kim Ahram、Yonemoto Chiaki、Feliciano Chitho P.、Shashni Babita、Nagasaki Yukio
  • Journal Title: Small Volume: 17 Issue: 21 Pages: 2008210-2008210
  • DOI: 10.1002/smll.202008210
  • Peer Reviewed
• [Journal Article] An Antioxidant Nanoparticle Enhances Exercise Performance in Rat High‐intensity Running Models (2021)
  • Author(s): Toriumi Takuto、Kim Ahram、Komine Shoichi、Miura Ikuru、Nagayama Suminori、Ohmori Hajime、Nagasaki Yukio
  • Journal Title: Advanced Healthcare Materials Volume: 10 Issue: 10 Pages: 2100067-2100067
  • DOI: 10.1002/adhm.202100067
  • Peer Reviewed
• [Journal Article] Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers (2021)
  • Author(s): Shashni Babita、Nagasaki Yukio
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 2 Pages: 92-92
  • DOI: 10.3390/jpm11020092
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Management of tumor growth and angiogenesis in triple-negative breast cancer by using redox nanoparticles (2021)
  • Author(s): Shashni Babita、Nishikawa Yuji、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 269 Pages: 120645-120645
  • DOI: 10.1016/j.biomaterials.2020.120645
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Molecular design of a high-performance polymeric carrier for delivery of a variety of boronic acid-containing drugs (2021)
  • Author(s): Ahram Kim, Yuya Suzuki, Yukio Nagasaki
  • Journal Title: Acta Biomaterialia Volume: 121 Pages: 554-565
  • DOI: 10.1016/j.actbio.2020.12.015
  • Peer Reviewed
• [Journal Article] Non-isotope enriched phenylboronic acid-decorated dual-functional nano-assembles for an actively targeting BNCT drug (2021)
  • Author(s): Kim, A. Suzuki, M. Matsumoto, Y. Fukumitsu, N. Nagasaki, Y.
  • Journal Title: Biomaterials Volume: 268 Pages: 120551-120551
  • DOI: 10.1016/j.biomaterials.2020.120551
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Improving silymarin oral bioavailability using silica-installed redox nanoparticle to suppress inflammatory bowel disease (2021)
  • Author(s): Nguyen Thu-Ha Thi、Trinh Nhu-Thuy、Tran Han Ngoc、Tran Hao Thi、Le Phong Quoc、Ngo Dai-Nghiep、Tran-Van Hieu、Van Vo Toi、Vong Long Binh、Nagasaki Yukio
  • Journal Title: Journal of Controlled Release Volume: 331 Pages: 515-524
  • DOI: 10.1016/j.jconrel.2020.10.042
  • Peer Reviewed
• [Journal Article] Antioxidant nanomedicine with cytoplasmic distribution in neuronal cells shows superior neurovascular protection properties (2020)
  • Author(s): Mujagic Arnela、Marushima Aiki、Nagasaki Yukio、Hosoo Hisayuki、Hirayama Aki、Puentes Sandra、Takahashi Toshihide、Tsurushima Hideo、Suzuki Kensuke、Matsui Hirofumi、Ishikawa Eiichi、Matsumaru Yuji、Matsumura Akira
  • Journal Title: Brain Research Volume: 1743 Pages: 146922-146922
  • DOI: 10.1016/j.brainres.2020.146922
  • Peer Reviewed
• [Journal Article] Fibrinolytic tissue plasminogen activator installed redox-active nanoparticles (t-PA@iRNP) for cancer therapy (2020)
  • Author(s): Mei Ting、Shashni Babita、Maeda Hiroshi、Nagasaki Yukio
  • Journal Title: Biomaterials Volume: 259 Pages: 120290-120290
  • DOI: 10.1016/j.biomaterials.2020.120290
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Redox injectable gel protects osteoblastic function against oxidative stress and suppresses alveolar bone loss in a rat peri-implantitis model (2020)
  • Author(s): Ozawa R, Saita M, Sakaue S, Okada R, Sato T, Kawamata R, Sakurai T, Hamada N, Kimoto K, Nagasaki Y
  • Journal Title: Acta Biomaterialia Volume: 110 Pages: 82-94
  • DOI: 10.1016/j.actbio.2020.04.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Design of amino acid-based self-assembled nano-drugs for therapeutic applications (2020)
  • Author(s): Vong Long Binh、Trinh Nhu-Thuy、Nagasaki Yukio
  • Journal Title: Journal of Controlled Release Volume: 326 Pages: 140-149
  • DOI: 10.1016/j.jconrel.2020.06.009
  • Peer Reviewed
• [Journal Article] 自己組織化抗酸化薬による腎虚血再灌流障害治療 (2020)
  • Author(s): 長崎 幸夫
  • Journal Title: 臨床透析 Volume: 36(12)/pp Pages: 1587-1589
• [Journal Article] Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges (2020)
  • Author(s): Vong Long Binh、Nagasaki Yukio
  • Journal Title: Antioxidants Volume: 9 Issue: 9 Pages: 791-791
  • DOI: 10.3390/antiox9090791
  • NAID: 120007188759
  • Peer Reviewed
• [Presentation] Antioxidant nanoparticles that scavenge the intestinal ROS lead to health, (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: Materials Research Meeting 2023 (MRM2023), organized by International Union of Materials Research Societies--International Conference in Asia (IUMRS-ICA)
  • Invited
• [Presentation] 分子組織化薬の設計と機能 (2023)
  • Author(s): 長崎幸夫
  • Organizer: 第32回ポリマー材料フォーラム
  • Invited
• [Presentation] Antioxidant Nanoparticles Mitigating Intestinal Oxidative Stress for Enhanced Overall Health (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: The Annual Symposium of Taiwanese Society of Biomadical Engineering (TSBME2023)
  • Invited
• [Presentation] サプリメントからドラッグへ -自己組織化によるアミノ酸ドラッグの設計- (2023)
  • Author(s): 長崎幸夫
  • Organizer: 日本アミノ酸学会第17回学術集会
  • Invited
• [Presentation] Antioxidant nanoparticles that scavenge the intestinal ROS lead to health, (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: The 6th International Symposium of Materials on Regenerative Medicine (ISOMRM2023)
  • Invited
• [Presentation] Biomaterials for Unmet Needs (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: Taipei-Tech Biomaterials Research and Commercialization Forum in The 6th International Symposium of Materials on Regenerative Medicine (ISOMRM2023)
• [Presentation] Antioxidant nanoparticles that scavenge the intestinal ROS lead to health (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: The 4th International Conference on Nanomaterials for Health, Energy and the Environment
• [Presentation] Polymer-based micelle-type antioxidant enhances exercise performance, (2023)
  • Author(s): Takuto Toriumi, Hajime Ohmori, Yukio Nagasaki
  • Organizer: ACS 2023
• [Presentation] Orally administered polymer micelle-type antioxidants that scavenge the intestinal ROS lead to health, (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: ACS 2023
• [Presentation] Orally administered polymer micelle-type (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: Biomaterials International 2023
• [Presentation] Antioxidant nanoparticles that scavenge the intestinal ROS lead to health, (2023)
  • Author(s): Yukio Nagasaki
  • Organizer: International Conference on Precision Nanomedicine in Theranostics & The 2023 Annual Meeting of Taiwan Nanomedicine Society
• [Presentation] 腸内活性酸素種を消去する抗酸化ナノ粒子が健康を導 (2023)
  • Author(s): 長崎 幸夫
  • Organizer: フリーラジカルスクール
• [Presentation] Design of molecular self-assembling drugs (2022)
  • Author(s): Yukio Nagasaki
  • Organizer: The 9th International Conference in Vietnam on the Development of Biomedical Engineering (BME9)
  • Int'l Joint Research / Invited
• [Presentation] Antioxidant Nanospace Materials for Novel Therapeutic System (2022)
  • Author(s): Yukio Nagasaki
  • Organizer: The 5th International Conference on Nanospace Materials (ICNM2022)
  • Int'l Joint Research / Invited
• [Presentation] Antioxidant Nanoparticle for Oxidative Stress Diseases (2022)
  • Author(s): Yukio Nagasaki
  • Organizer: The 10th Joint Meeting of Society for Free Radical Research Australasia and Japan
  • Int'l Joint Research / Invited
• [Presentation] Direct evidence for the involvement of intestinal reactive oxygen species in the progress of depression via the gut-brain axis (2022)
  • Author(s): Yukio Nagsaki, Naoki Saigo, Yutaka Ikeda
  • Organizer: The 10th Bienimal Meeting of the Society for Free Radical Research, Asia (SFRR-Asia 2022)
  • Int'l Joint Research / Invited
• [Presentation] Antioxidant nanoparticles that scavenge the intestinal ROS lead to health, (2022)
  • Author(s): Yukio Nagasaki
  • Organizer: The 12th International Forum on Post-Genome Symposium (IFPT'12)
  • Int'l Joint Research / Invited
• [Presentation] Molecular design of Self-assembling drugs, Gelsympo2022, Tomamu, Hokkaido (2022)
  • Author(s): Yukio Nagasaki
  • Organizer: Gelsympo2022
  • Int'l Joint Research / Invited
• [Presentation] Pharmacologically active polymer micelles for novel therapeutics (2022)
  • Author(s): Yukio Nagasaki
  • Organizer: The 84th Prague Meeting on Macromolecules (PMM), Frontiers of Polymer Colloids -From Synthesis to Macro-scale and Nano-scale Applicatoins
  • Int'l Joint Research / Invited
• [Presentation] Novel drug development based on self-assembly (2021)
  • Author(s): Yukio Nagasaki
  • Organizer: The 11th International Conference on Post-Genomic Technologies (IPFT 11th)
  • Int'l Joint Research / Invited
• [Presentation] Novel drug development based on self-assembly (2021)
  • Author(s): Yukio Nagasaki
  • Organizer: 第 72回コロイドおよび界面化学討論会国際シンポジウム
  • Int'l Joint Research / Invited
• [Presentation] 自己組織化を基盤とする新しい創薬 (2021)
  • Author(s): 長崎幸夫
  • Organizer: 第 72回コロイドおよび界面化学討論会
  • Invited
• [Presentation] 工学から医療へ ー材料を工夫すれば抗酸化剤もこんなに使える！ (2021)
  • Author(s): 長崎幸夫
  • Organizer: 2021年電子情報通信学会 ソサイエティ大会
  • Invited
• [Presentation] Design of amino acid self-assembling polymeric nano-drugs for therapeutic applications (1K12IL) (2021)
  • Author(s): Long B inh Vong, Yukio Nagasaki
  • Organizer: 第70回高分子年次大会
  • Invited
• [Presentation] An enzyme-metabolizable short-chain fatty acid polymer for therapeutics of various disease (2021)
  • Author(s): Babita Shashni, Yuya Tajika, Yukio Nagasaki
  • Organizer: Materials Research Meeting 2021 (MRM2021)
  • Int'l Joint Research
• [Presentation] Poly(DOPA)-based nanoparticle prevents rapid excretion of DOPA and improves therapeutic performances (2021)
  • Author(s): Yukio Nagasaki, Long Binh Vong, Yuna Sato, Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee Hutamekalin
  • Organizer: XXV World Congress of Neurology (WCN 2021)
  • Int'l Joint Research
• [Presentation] Nanoparticle type antioxidants increased the therapeutic efficiency against cancer radiotherapy, significantly suppressing the radiation-induced adverse effects (2021)
  • Author(s): Yukio Nagasaki, Kim Ahram, Yonemoto Chiaki, Shashni Babita, Feliciano P. Chitho
  • Organizer: 1st JCA-AACR Precision Cancer Medicine International Conference
  • Int'l Joint Research
• [Presentation] Nanoparticle-type antioxidants reduce adverse effects peculiar to low molecular weight antioxidants and increased the therapeutic efficiency to versatile oxidative stress-related diseases (2021)
  • Author(s): Yukio Nagasaki
  • Organizer: European Society of Medicine Forum Review
  • Int'l Joint Research
• [Presentation] Antioxidant nanoparticle improves radiation efficiency on cancer therapy (2021)
  • Author(s): Yukio Nagasaki, Ahram Kim, Chiaki Yonemoto, Chitho P. Feliciano, Babita Shashni
  • Organizer: 2021 CRS Virtual Annual Meeting
  • Int'l Joint Research
• [Presentation] Design of Short-Chain Fatty Acid-based Self-Assembling Drug for Alleviation of Type 2 Diabetes Mellitus (2021)
  • Author(s): Babita Shashni, Yuya Tajika, Yukio Nagasaki
  • Organizer: 2021 CRS Virtual Annual Meeting
  • Int'l Joint Research
• [Presentation] Intestinal Selective Polymer-Based Antioxidant Rescues DEPRESSION-Intestinal ROS Elimination Impacts Cerebral Dysfunctions Via Gut-Brain Axis- (2021)
  • Author(s): Naoki Saigo, Yukio Nagasaki, Yutaka Ikeda
  • Organizer: Materials Research Meeting 2021 (MRM2021)
  • Int'l Joint Research
• [Presentation] A Novel Nano Fenton Reactor Towards Potent and Safe Pro-oxidant Cancer Therapy (2021)
  • Author(s): Ahram Kim, Tomoo Aso, Yukio Nagasaki
  • Organizer: Materials Research Meeting 2021 (MRM2021)
  • Int'l Joint Research
• [Presentation] ewly designed short-chain fatty acid-based self-assembling nanoparticle drugs for non-alcoholic steatohepatitis (NASH) (2021)
  • Author(s): Yuya Tajika, Babita Shashni, Yuji Nishikawa, Yukio Nagasaki
  • Organizer: Materials Research Meeting 2021 (MRM2021)
  • Int'l Joint Research
• [Presentation] A Nanoparticle-type Antioxidants Enhances Exercise Performance in High-intensity Running (2021)
  • Author(s): Takuto Toriumi, Ahram Kim, Shoichi Komine, Ikuru Miura, Suminori Nagayama, Hajime Ohmori, Yukio Nagasaki
  • Organizer: Materials Research Meeting 2021 (MRM2021)
  • Int'l Joint Research
• [Presentation] Design and Application of Novel Self-assembled Nanoparticle Drugs for Short-Chain Fatty Acid-Based Therapy via Intestinal Nano-Controlled Release Syste (2021)
  • Author(s): Yukio Nagasaki
  • Organizer: Biointerface International Zurich 2021
  • Int'l Joint Research
• [Presentation] Protective Effect of Intestinal ROS Scavenger against DEPRESSION (2021)
  • Author(s): Naoki Saigo, Yukio Nagasaki, Yutaka Ikeda
  • Organizer: Biointerface International Zurich 2021
  • Int'l Joint Research
• [Presentation] 分子組織化を基盤とする新しい創薬 (2021)
  • Author(s): 長崎幸夫
  • Organizer: 電子情報通信学会有機エレクトロニクス研究会
• [Presentation] 外傷性脳損傷に対するレドックスナノ粒子の脳保護効果 (2021)
  • Author(s): 丸島愛樹, 高橋利英, 長崎幸夫, 室井 愛, Sandra Puentes, Arnela Mujagic, 松村 明
  • Organizer: 第34回 日本酸化ストレス学会関東支部会
• [Presentation] Redox nanoparticles with Cytoplasmic Distribution in Neuronal Cells Shows Superior Neurovascular Protection Properties (2021)
  • Author(s): Arnela Mujagic, Aiki Marushima, Yukio Nagasaki, Hisayuki Hosoo, Aki Hirayama, Sandra Puente, Toshihide Takahashi, Hideo Tsurushima, Kensuke Suzuki, Hirofumi Matsui, Eiichi Ishikawa, Yuji Matsumaru, Akira Matsumura
  • Organizer: 第34回 日本酸化ストレス学会関東支部会
• [Presentation] Design of sorafenib-loaded antioxidant nanoparticle for treatment of liver fibrosis by oral administration (2021)
  • Author(s): Hao Thi Tran, Long Binh Vong, Yuji Nishikawa, Yukio Nagasaki
  • Organizer: 第34回 日本酸化ストレス学会関東支部会
• [Presentation] ナノ粒子型抗酸化剤の癌放射線治療に対する効果 (2021)
  • Author(s): 長崎幸夫、キム アラム、米元 千秋、シャスニ バビタ、フェリシアノ チト
  • Organizer: 第31回MRS-J年次大会
• [Presentation] 腫瘍内ROS消去はがん放射線治療効果を増強する (2021)
  • Author(s): 長崎 幸夫、キム アラム、米元 千秋、シャスニ バビタ、フェリシアノ チト
  • Organizer: 第43回日本バイオマテリアル学会大会
• [Presentation] 高分子抗てんかん薬の設計と評価 (2021)
  • Author(s): 池田 豊、田鹿 裕也、長崎 幸夫
  • Organizer: 第43回日本バイオマテリアル学会大会
• [Presentation] 抗酸化ナノ粒子の抗うつ効果 (2021)
  • Author(s): 齋江 直輝、池田 豊、長崎 幸夫
  • Organizer: 第43回日本バイオマテリアル学会大会
• [Presentation] GABA-containing polymeric nanoparticle, a new biomaterial to treat major depressive disorders (2021)
  • Author(s): Bui Duc Tri, Yukio Nagasaki
  • Organizer: 第43回日本バイオマテリアル学会大会
• [Presentation] An enzyme responsive self-assembling poly(ethylene glycol)-b-poly(vinyl ester)s radio sensitizes tumor for the radiation therapy (2021)
  • Author(s): Babita Shashni, Yukio Nagasaki
  • Organizer: 第43回日本バイオマテリアル学会大会
• [Presentation] 自己組織化抗酸化ナノ粒子は高強度走行能力を向上する (2021)
  • Author(s): 鳥海 拓都、金 雅覽、小峰 昇一、三浦 征、永山 純礼、大森 肇、長崎 幸夫
  • Organizer: 第43回日本バイオマテリアル学会大会
• [Presentation] 腫瘍内ROS消去はがん放射線治療効果を増強する (2021)
  • Author(s): Yukio Nagasaki, Kim Ahram, Yonemoto Chiaki, Shashni Babita, Feliciano P. Chitho
  • Organizer: 日本放射線腫瘍学会第34回学術集会
• [Presentation] NanoGABA, a new amino acid-based polymeric nanoparticle for the treatment of depression (2021)
  • Author(s): Bui Duc Tri, Yukio Nagasaki
  • Organizer: 日本アミノ酸学会第15回学術大会
• [Presentation] 糖尿病治療を目指した酪酸からなるナノ粒子が糖尿病関連疾患にも効果があるだろうか？ (2021)
  • Author(s): 長崎幸夫、Shashni Babita、田鹿裕也
  • Organizer: 第36回日本糖尿病合併症学会
• [Presentation] 酪酸放出型ナノ粒子(NanoBA) は非アルコール性脂肪肝炎を抑制する (2021)
  • Author(s): 長崎 幸夫、田鹿 裕也、Shashni Babita、西川 祐司
  • Organizer: 第28回肝細胞研究会
• [Presentation] ソラフェニブ内封抗酸化ナノ粒子(sora@siRNP) は副作用を低減し、肝線維症を改善する (2021)
  • Author(s): Tran Thi Hao、Vong Binh Long 、西川 祐司、長崎 幸夫
  • Organizer: 第28回肝細胞研究会
• [Presentation] A novel nano-delivery system for short chain fatty acids to overcome various diseases (2021)
  • Author(s): Babita Shashni, Yuya Tajika, Yukio Nagasaki
  • Organizer: 第70回高分子討論会
• [Presentation] 自己組織化抗酸化剤の(RNP)の最近の展開 (2021)
  • Author(s): 長崎幸夫
  • Organizer: 第70回高分子討論会
• [Presentation] 高分子抗てんかん薬の設計と評価 (2021)
  • Author(s): 池田 豊、田鹿裕也、長崎幸夫
  • Organizer: 第70回高分子討論会
• [Presentation] 高分子ミセル型抗酸化薬は高強度走行能力を大幅に向上する (2021)
  • Author(s): 鳥海拓都、金雅覽、小峰昇一、三浦征、永山純礼、大森肇、長崎幸夫
  • Organizer: 第50回医用高分子研究会
• [Presentation] 高分子てんかん薬の開発 (2021)
  • Author(s): 池田豊、田鹿裕也、長崎幸夫
  • Organizer: 第50回医用高分子研究会
• [Presentation] 短鎖脂肪酸を放出する分子組織化薬の設計と糖尿病治療 (2021)
  • Author(s): 長崎幸夫、Shashni Babita、 田鹿裕也
  • Organizer: 第50回医用高分子研究会
• [Presentation] Novel design of GABA-containing polymeric nanoparticles for the treatment of depression (2021)
  • Author(s): Bui Duc Tri, Yukio Nagasaki
  • Organizer: 第37回日本DDS学会学術集会
• [Presentation] 抗酸化剤の腫瘍へのデリバリーが放射線治療に及ぼす影響 (2021)
  • Author(s): 長崎幸夫、キムアラム、米元千秋、シャスニ バビータ、フェリシアーノ チト
  • Organizer: 第37回日本DDS学会学術集会
• [Presentation] ラット運動能力を飛躍的に向上させる新しいナノ粒子型抗酸化剤 (2021)
  • Author(s): 長崎幸夫、鳥海拓都、金 雅覽、小峰昇一、三浦 征、永山 純礼、大森 肇
  • Organizer: 第21回日本抗加齢医学会総会
• [Presentation] 腸内細菌叢で着目される酪酸を放出する分子組織化薬の設計と糖尿病治療 (2021)
  • Author(s): 長崎幸夫、Shashni Babita
  • Organizer: 第21回日本抗加齢医学会総会
• [Presentation] 酪酸を放出する分子組織化薬の設計と糖尿病治療 (2021)
  • Author(s): Babita Shashni、長崎幸夫
  • Organizer: 第25回腸内細菌学会学術集会
• [Presentation] oes scavenging reactive oxygen species in the tumor environment diminish the effect of radiotherapy? (2021)
  • Author(s): Yukio Nagasaki, Ahram Kim, Chiaki Yonemoto, Babita Shashni, Chitho Feliciano
  • Organizer: 第70回高分子年次大会
• [Presentation] PEG-b-poly(vinylbutyrate) self-assembling nanoparticle enhanced radiation-sensitizing effect on melanoma-bearing mice (2021)
  • Author(s): Babita Shashni, Yukio Nagasaki
  • Organizer: 第70回高分子年次大会
• [Presentation] 腫瘍内ROS消去はがん放射線治療効果を増強する (2021)
  • Author(s): 長崎幸夫、米元千秋、金 雅覽、フェリシアノ チト、バビータ シャシュニ
  • Organizer: 第74回日本酸化ストレス学会
• [Presentation] レドックスナノ粒子による新たな神経保護療法の実用化 (2021)
  • Author(s): 丸島愛樹、長崎 幸夫、Mujagic Arnela、細尾 久幸、平山 暁、松井 裕史、秋本 大輔、渡邉 真哉、石川 栄一、松丸 祐司
  • Organizer: 第74回日本酸化ストレス学会
• [Presentation] パーキンソン病治療を目指したL-DOPA分子組織化薬(NanoDOPA)の開発 (2021)
  • Author(s): 長崎 幸夫、佐藤憂菜、Long Binh Vong、Pennapa Chonpathompikunlert, Supita Tanasawet, Pilaiwanwadee Hutamekalin
  • Organizer: 第62回日本神経学会学術大会
• [Presentation] The novel design and application of GABA-based polymeric nanoparticles in the treatment of depression (2021)
  • Author(s): Bui Duc Tri, Nagasaki Yukio
  • Organizer: 日本アミノ酸学会第15回学術大会
• [Presentation] ポリマーベース抗酸化剤の鬱病に対する保護効果 (2021)
  • Author(s): 齋江直輝、長崎幸夫、池田 豊
  • Organizer: 第70回高分子討論会
• [Presentation] Synhtesis and application of Nylon-4-based nanoparticles as a medicine to treat dipression's disease (2021)
  • Author(s): Duc Tri Bui, Yukio Nagasaki
  • Organizer: 第70回高分子討論会
• [Presentation] Development an oral nanomedicine for liver fibrosis treatment (2021)
  • Author(s): Hao Thi Tran, Long Binh Vong, Van Toi Vo, Yuji Nishikawa, Yukio Nagasaki
  • Organizer: 第37回日本DDS学会学術集会
• [Presentation] 分子組織化薬の設計と機能 (2021)
  • Author(s): 長崎幸夫
  • Organizer: 高分子学会東海支部東海シンポジウム(On-Line)
  • Invited
• [Presentation] Protective Effect of Intestinal ROS Scavenger against DEPRESSION (2021)
  • Author(s): Naoki Saigo
  • Organizer: Biointerface International Zurich 2021(On-line hybrid)
  • Int'l Joint Research
• [Presentation] パーキンソン病治療を目指した L-DOPA 分子組織化薬(NanoDOPA)の開発 (2021)
  • Author(s): 佐藤憂菜
  • Organizer: 第14回パーキンソン病・運動障害疾患コングレス（On-line)
• [Presentation] esign of novel self-assembling based drugs (2020)
  • Author(s): Yukio Nagasaki
  • Organizer: 11th International Symposium on Organic Molecular Electronics ISOME2020
  • Int'l Joint Research / Invited
• [Presentation] くすりって1億円もしていいんですか？～これからの創薬をめざす！～ (2020)
  • Author(s): 長崎幸夫
  • Organizer: 第10回CSJ化学フェスタ「くすりがやってくる～病気の細胞の気持ち～」(on-line)
  • Invited
• [Presentation] Design of novel self-assembling based drugs, The 30th Frontier Scientists Workshop (2020)
  • Author(s): Yukio Nagasaki
  • Organizer: The 30th Frontier Scientists Workshop Recent Advances in Medical Polymers for Therapeutic Applications(on-line)
  • Int'l Joint Research / Invited
• [Presentation] 自己組織化を基盤とした新しい創薬 (2020)
  • Author(s): 長崎幸夫
  • Organizer: 電気情報通信学会OME研究会(On-line)
  • Invited
• [Presentation] Development of self-assembling polymeric nano-drugs for therapeutic applications (2020)
  • Author(s): Binh Long Vong, Yukio Nagasaki
  • Organizer: 第69回高分子年次大会
  • Invited
• [Presentation] 短鎖脂肪酸分子組織化薬の設計 (2020)
  • Author(s): 長崎幸夫
  • Organizer: The 36th Annual Meeting of the DDS Society of Japan
• [Presentation] 短鎖脂肪酸分子組織化薬の設計 (2020)
  • Author(s): Shashni Babita
  • Organizer: 第 49 回医用高分子シンポジウム
• [Presentation] 新しい抗酸化ナノ粒子による酸化ストレス関連疾患の減衰 (2020)
  • Author(s): Shashni Babita
  • Organizer: the 73rd Japan Oxidative Stress Society / 20th Japan NO Society Joint Academic Meeting
• [Presentation] Development of self-assembling polymeric nano-drugs for therapeutic applications (2020)
  • Author(s): Vong Binh Long
  • Organizer: 第69回高分子年次大会
• [Presentation] 非アルコール性脂肪肝炎の治療を目指したオルニチン含有ナノドラッグの開発 (2020)
  • Author(s): リー ヤロスラブ
  • Organizer: 第27回肝細胞研究会(On-line)
• [Presentation] Self-assembling polymer antioxidants amazingly improve exercise performance (2020)
  • Author(s): Toriumi Takuto
  • Organizer: 3rd GLowing Polymer Symposium in Kanto (GPS-K2020, On-line)
• [Presentation] Development of orally-administered phenylbutyrate-based self-assembling nanodrug for hyperammonemia treatment and mitigation of liver damage (2020)
  • Author(s): Lee Yaroslav
  • Organizer: 3rd GLowing Polymer Symposium in Kanto (GPS-K2020, On-line)
• [Presentation] Self-assembling and enzyme-metabolizable short-chain fatty acid nanoparticle for the treatment of diabetes (2020)
  • Author(s): Shashni Babita
  • Organizer: 3rd GLowing Polymer Symposium in Kanto (GPS-K2020, On-line)
• [Presentation] Silica-installed Redox Polymeric Nanoparticles Improve Silymariine Oral Bioavailability to Suppress Inflammation in Colitis Mice (2020)
  • Author(s): Nguyen Thu-Ha Thi
  • Organizer: 3rd GLowing Polymer Symposium in Kanto (GPS-K2020, On-line)
• [Presentation] Sialic acid-targeting polymeric nanoparticles as self-assembling BNCT drug (2020)
  • Author(s): Kim Ahram
  • Organizer: 3rd GLowing Polymer Symposium in Kanto (GPS-K2020, On-line)
• [Presentation] Design of PEG-b-poly(vinyl short-chain fatty acid ester)s for the liver disease treatments (2020)
  • Author(s): Yuya Tajika
  • Organizer: 3rd GLowing Polymer Symposium in Kanto (GPS-K2020, On-line)
• [Presentation] Self-assembled polydopamine nanodrug improves symptoms in Parkinson’s disease model mice without inducing dyskinesia (2020)
  • Author(s): Vong Long Binh
  • Organizer: 3rd GLowing Polymer Symposium in Kanto (GPS-K2020, On-line)
• [Presentation] ポリペプチドをベースとする分子組織化薬の開発 (2020)
  • Author(s): 長崎 幸夫
  • Organizer: 第69回高分子討論会Ol-line併用開催
• [Presentation] Therapeutic efficacy of self-assembling short-chain fatty acid nanomedicine against diabetes (2020)
  • Author(s): Shashni Babita
  • Organizer: 第69回高分子討論会Ol-line併用開催
• [Presentation] 非アルコール性脂肪肝炎治療を目指したオルニチン送達システムの開発 (2020)
  • Author(s): リーヤロスラブ
  • Organizer: 第36回日本DDS学会学術集会
• [Presentation] パーキンソン病治療を目指したL-DOPA分子組織化薬(NanoDOPA)の開発 (2020)
  • Author(s): 長崎 幸夫
  • Organizer: 第36回日本DDS学会学術集会
• [Presentation] 抗腫瘍効果を示す組織プラスミノーゲンアクティベータ内封抗酸化ナノ粒子の設計 (2020)
  • Author(s): Mei Ting
  • Organizer: 第36回日本DDS学会学術集会
• [Presentation] ポリペプチドをベースとする分子組織化薬の開発 (2020)
  • Author(s): 長崎 幸夫
  • Organizer: 第30回バイオ・高分子シンポジウム、On-line開催
• [Presentation] 短鎖脂肪酸分子組織化薬の分子設計 (2020)
  • Author(s): 長崎 幸夫
  • Organizer: 第24回腸内細菌学会学術集会
• [Presentation] 高強度長時間走行に与える自己組織化抗酸化薬の効果 (2020)
  • Author(s): 鳥海 拓都
  • Organizer: 第69回高分子年次大会
• [Presentation] Targeting hypersialyated B16 melanoma using a phenylboronic acid-installed polymeric nanoparticle towards a novel BNCT agent (2020)
  • Author(s): Kim Ahram
  • Organizer: 第69回高分子年次大会
• [Presentation] Design and Synthesis of Antioxidant Nanomedicine to Combat Oxidative Stress Related Diseas (2020)
  • Author(s): Shashni Babita
  • Organizer: 第69回高分子年次大会
• [Presentation] Self-assembling short-chain fatty acid nanomedicine for the treatment of diabetes (2020)
  • Author(s): Babita Shashni
  • Organizer: 第30回日本MRS年次大会
• [Presentation] 自己組織化抗酸化剤は高強度走行時間を大幅に延長する (2020)
  • Author(s): 鳥海 拓都
  • Organizer: 第29回ポリマー材料フォーラム(On-line)
• [Presentation] 経口投与型ポリオルニチン自己組織化ナノ粒子による急性肝障害治療薬の開発 (2020)
  • Author(s): リー ヤロスラブ
  • Organizer: 日本アミノ酸学会第14回学術大会（on-line)
• [Presentation] 放射線治療における副作用の低減を目指した抗酸化ナノ粒子の設計と評価 (2020)
  • Author(s): 金 雅覽
  • Organizer: 第73回酸化ストレス学会(オンライン開催)
• [Presentation] 自己組織化抗酸化薬が高強度走行に及ぼす影響 (2020)
  • Author(s): 鳥海 拓都
  • Organizer: 第69回高分子討論会Ol-line併用開催
• [Presentation] 高血中滞留性を持つ新規抗酸化剤による高強度走行への影響 (2020)
  • Author(s): 鳥海 拓都
  • Organizer: 第75回日本体力医学会（on-line)
• [Presentation] 脂肪肝炎(NASH)に対する短鎖脂肪酸型自己組織化薬の設計 (2020)
  • Author(s): 田鹿 裕也
  • Organizer: 第69回高分子討論会Ol-line併用開催
• [Presentation] 高アンモニア血症治療を目指したフェニル酪酸含有ナノ粒子の設計と評価 (2020)
  • Author(s): リー ヤロスラブ
  • Organizer: 第69回高分子討論会Ol-line併用開催）
• [Presentation] 非アルコール性脂肪肝炎の治療を目指したポリオルニチン組織体の設計と評価 (2020)
  • Author(s): リー ヤロスラブ
  • Organizer: 第69回高分子年次大会
• [Presentation] 放射線治療における副作用の低減を目指した抗酸化ナノ粒 子の設計と評価 (2020)
  • Author(s): 米元 千秋
  • Organizer: 第69回高分子年次大会
• [Presentation] レドックスナノ粒子による虚血性脳卒中に対する脳保護療法の開発 (2020)
  • Author(s): 丸島愛樹
  • Organizer: 第73回日本酸化ストレス学会
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2023)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2023)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2023)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2023)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2023)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2023)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2023
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2021)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2021)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2021)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2021)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021
• [Patent(Industrial Property Rights)] 未公開中であるので公表を控える (2021)
  • Inventor(s): 長崎幸夫、他
  • Industrial Property Rights Holder: 長崎幸夫、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021