| Budget Amount *help |
¥198,900,000 (Direct Cost: ¥153,000,000、Indirect Cost: ¥45,900,000)
Fiscal Year 2023: ¥34,710,000 (Direct Cost: ¥26,700,000、Indirect Cost: ¥8,010,000)
Fiscal Year 2022: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2021: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2020: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2019: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
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| Outline of Final Research Achievements |
In this study, we aimed to clarify the molecular mechanisms of the oxidative stress response mechanism by the KEAP1-NRF2 system, and to demonstrate the contribution of NRF2 to the prevention and treatment of age-related diseases. We elucidated the mechanism by which KEAP1 selectively uses multiple sensor residues. We also demonstrated that NRF2 activation is effective in preventing and treating diseases such as diabetes and dementia. Furthermore, we succeeded in the first space travel experiment with Nrf2 gene knockout mice, and clarified the contribution of NRF2 to space stress response.
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| Assessment Rating |
Ex-post Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.
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Assessment Rating |
Interim Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.
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