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The elucidation of lactocline mechanism of Japanese Black cattle

Research Project

Project/Area Number 19K06355
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 42010:Animal production science-related
Research InstitutionKyushu University

Principal Investigator

Takahashi Hideyuki  九州大学, 農学研究院, 准教授 (60549872)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords黒毛和牛 / 初乳
Outline of Research at the Start

本研究では、黒毛和牛母牛の栄養管理による初乳構成成分に与える影響を検討するとともに、初乳の構成成分が仔牛と育成牛の消化管発達、増体およびラクトクライン機構に与える影響を解明するために以下の点を究明する。①初乳と移行乳を用いて初乳摂取が下部消化管発達、代謝生理機能や増体に与える影響を検討する。②初乳の給与が母牛の血中成長因子およびインスリン分泌変化に与える影響を検討する。③黒毛和牛のラクトクライン機構におけるヒストン脱アセチル化およびヒストンメチル基転移酵素活性状態の解析、遺伝子発現の網羅的影響を検討する。

Outline of Final Research Achievements

The purpose of this study is to focus on the components of colostrum and transitional milk that promote the development of the lower gastrointestinal tract and change the physiological functions in liver tissue and skeletal muscle during calf development, and give it to the calf and the lactocline mechanism during the growing period. As a result, it was clarified that feeding octanic acid, which is a medium-chain fatty acid, to dams at the end of calving increases the glucose concentration in the colostrum and the transitional milk. Glucose is a major source of energy for newborn calves, resulting in good calf nutrition. In addition, as a result of milk replacer feeding to calves, a rapid increase in glucose was observed, suggesting that lower gastrointestinal development may have been promoted.

Academic Significance and Societal Importance of the Research Achievements

黒毛和牛の飼養管理は、各県や各地域によりマニュアルが策定されておりマニュアル通りに飼料摂取を行っても日本飼養標準が策定している成長曲線通りに成長することが出来ない仔牛が存在する。また、飼料の種類や飼料摂取量が均一にも関わらず消化不良性の下痢が発生する個体も存在する。特に早期肥育は穀物飼料を多給する肥育期を前倒しで始める。したがって、仔牛の下部消化管発達は重要であり、本研究成果は早期肥育技術へ応用可能な成果である。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (2 results)

All 2021

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results)

  • [Journal Article] Glucagon-like peptide 2 (GLP-2) in bovine colostrum and transition milk2021

    • Author(s)
      Inabu Yudai、Yamamoto Hiroshi、Yamano Haruki、Taguchi Yutaka、Okada Shunnosuke、Etoh Tetsuji、Shiotsuka Yuji、Fujino Ryoichi、Takahashi Hideyuki
    • Journal Title

      Heliyon

      Volume: 7 Issue: 5 Pages: e07046-e07046

    • DOI

      10.1016/j.heliyon.2021.e07046

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of feeding high volumes of milk replacer on reproductive performance and on concentrations of metabolites and hormones in blood of Japanese black heifer calves2021

    • Author(s)
      Taguchi Yutaka、Inabu Yudai、Hayasaki Koki、Maeda Noriyuki、Kanmera Yoshiro、Yamasaki Seiji、Ota Noboru、Mukawa Kenji、Tsuboi Arisa、Miyamoto Hirokuni、Etoh Tetsuji、Shiotsuka Yuji、Fujino Ryoichi、McMahon Christopher D.、Takahashi Hideyuki
    • Journal Title

      Animal Science Journal

      Volume: 92 Issue: 1 Pages: 1-9

    • DOI

      10.1111/asj.13505

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2019-04-18   Modified: 2023-01-30  

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