Elucidation of epigenetic mechanisms that memorize inter-tissue communication
| Project/Area Number |
19K06608
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 43050:Genome biology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脂肪組織 / 交感神経系 / 視床下部 / エピゲノム / 代謝制御 / 摂食制御 / 神経 / ヒストン脱メチル化 / ノルアドレナリン / レプチン |
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| Outline of Research at the Start |
肥満、2 型糖尿病などの生活習慣病の病因の解明と予防は、超高齢化多死社会をむかえる我が国において大きな課題となっている。本研究では、脂肪組織と神経の情報伝達に着目し、組織間の情報伝達を記憶するエピゲノム（後天的ゲノム修飾）の仕組みを明らかにすることを目的とする。本研究で得られる成果は、メタボリックシンドロームの予防・治療への足がかりとなる。
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| Outline of Final Research Achievements |
The onset of lifestyle-related diseases can be considered to be due to abnormal interactions between tissues mediated by environmental cues. From the analysis of epigenome-modifying enzyme (JMJD1A) knockout mice, this study revealed that 1) epigenome changes are important for inducing the expression of thermogenic genes in white adipose tissue under cold stimulation and 2) the sensitivity of the hypothalamus to leptin secreted from adipose tissue is regulated by the epigenome-modifying enzyme. This study elucidated a part of the inter-tissue communication and epigenome regulation involved in the onset of lifestyle-related diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
エピゲノムは外的環境に依存して後天的に書き換えられる遺伝情報である。生活習慣や食習慣などの環境要因はエピゲノムとして細胞に記憶され、脂肪を蓄積あるいは燃焼しやすい体質を作ったり、食欲の制御に働いていると考えられる。本研究では、脂肪を燃焼する体質がエピゲノムによって制御されること、エピゲノム修飾酵素が食欲の抑制に働いていることを明らかにした。本研究で得られた研究成果は、生活習慣病の予防・治療への足がかりとなる。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis2022
Author(s)
Murakami K, Sasaki Y, Asahiyama M, Yano W, Takizawa T, Kamiya W, Matsumura Y, Anai M, Osawa T, Fruchart JC, Fruchart-Najib J, Aburatani H, Sakai J, Kodama T, Tanaka T.
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Journal Title
Cells
Volume: 11
Issue: 4
Pages: 720-720
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ubiquitination-dependent and -independent repression of target genes by SETDB1 reveal a context-dependent role for its methyltransferase activity during adipogenesis2021
Author(s)
Zhang J, Matsumura Y, Kano Y, Yoshida A, Kawamura T, Hirakawa H, Inagaki T, Tanaka T, Kimura H, Yanagi S, Fukami K, Doi T, Osborne TF, Kodama T, Aburatani H, Sakai J.
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Journal Title
Genes Cells
Volume: 26
Issue: 7
Pages: 513-529
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content.2020
Author(s)
Sasaki Y, Asahiyama M, Tanaka T, Yamamoto S, Murakami K, Kamiya W, Matsumura Y, Osawa T, Anai M, Fruchart JC, Aburatani H, Sakai J, Kodama T.
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Journal Title
Sci Rep
Volume: 10
Issue: 1
Pages: 7817-7817
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] PPARα activation directly upregulates thrombomodulin in the diabetic retina.2020
Author(s)
Shiono A, Sasaki H, Sekine R, Abe Y, Matsumura Y, Inagaki T, Tanaka T, Kodama T, Aburatani H, Sakai J, Takagi H.
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Journal Title
Sci Rep
Volume: 10
Issue: 1
Pages: 10837-10837
DOI
Related Report
Peer Reviewed / Open Access
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