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The fundamental research for development of new leishmanicidal medicine; Tropical Shiun-Ko

Research Project

Project/Area Number 19K07155
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47050:Environmental and natural pharmaceutical resources-related
Research InstitutionTokyo University of Science (2020-2021)
Tokushima Bunri University (2019)

Principal Investigator

Mori-Yasumoto Kanami  東京理科大学, 薬学部薬学科, 講師 (70412393)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsリーシュマニア症 / 薬用植物 / 天然活性物質 / 熱帯感染症 / 抗リーシュマニア
Outline of Research at the Start

リーシュマニア症は重篤な昆虫媒介性熱帯原虫症であるが特効薬が未だに存在せず、早期の治療薬開発が望まれている。申請者らは、漢方薬・紫雲膏がリーシュマニア原虫に対する選択的阻害活性を有し臨床的に高い効果があること、活性本体がキノン系化合物群のシコニン類であることを明らかにし、また罹患者の多い熱帯地域の植物資源から原虫に対する選択的阻害活性が非常に高い他のキノン系化合物群を発見している。本研究課題では、新たなシーズ探索と、活性キノン系化合物群のリーシュマニア原虫に対する薬理作用を明らかにし、現地の植物資源を用いて安価な「熱帯紫雲膏」を開発し、途上国の生活向上という社会実装を見据えた研究展開を行う。

Outline of Final Research Achievements

In this research project, basic research was conducted to develop inexpensive tropical shiunkou using local plant resources. We investigated the leishmanicidal constituents from tropical plants and the ability of active known quinone compounds to induce Leishmania protozoan apoptosis. The protozoan mitochondrial membrane potential was investigated by JC-1 to evaluate the ability of the compound to induce apoptosis. Furthermore, from the plant extracts that showed activity in the preliminary test, the isolated structures of 23 active compounds from Plumbaginaceae and Legumes were determined, and their leishmanicidal activity was examined. The changes in membrane potential at JC-1 were investigated for isolated compounds and known active quinone compounds. In addition, in preparation for tropical shiunkou, the components of known active quinone compounds were quantified.

Academic Significance and Societal Importance of the Research Achievements

本研究は、未だに明確な治療薬がなく顧みられない熱帯病であるリーシュマニア症に焦点を当て、現地の植物資源を用いて安価な「熱帯紫雲膏」を開発し、途上国の生活向上という社会実装を見据えた研究展開を行うための基礎研究である。発症国の植物資源から新たな治療薬の種を探し、有望な植物由来化合物を見いだした。また、原虫のアポトーシス誘導能を検討する試験法を検討した。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2020 2019

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Leishmanicidal phenolic compounds derived from Dalbergia cultrata2020

    • Author(s)
      Mori-Yasumoto Kanami、Hashimoto Yukihiro、Agatsuma Yutaka、Fuchino Hiroyuki、Yasumoto Ko、Shirota Osamu、Satake Motoyoshi、Sekita Setsuko
    • Journal Title

      Natural Product Research

      Volume: ー Issue: 23 Pages: 1-9

    • DOI

      10.1080/14786419.2020.1744140

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of peptides and low molecular weight components of the giant ant Dinoponera quadriceps venom2019

    • Author(s)
      R?dis-Baptista Gandhi、Dodou Hilania V.、Prieto-da-Silva ?lvaro R. B.、Zaharenko Andr? J.、Kazuma Kohei、Nihei Ken-ichi、Inagaki Hidetoshi、Mori-Yasumoto Kanami、Konno Katsuhiro
    • Journal Title

      Biological Chemistry

      Volume: 0 Issue: 0

    • DOI

      10.1515/hsz-2019-397ja-01

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 抗リーシュマニア活性を有する薬用植物の探索(その31)ミャンマー産植物 PYINER LANKAR Sophora exigua の成分について2020

    • Author(s)
      渡邊絢女, 安元加奈未, 安元剛, 渕野裕之, 佐竹元吉, 代田修
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] ズイナ (Itea japonica)のポリフェノール成分について2019

    • Author(s)
      代田修、三好達也、安元(森)加奈未
    • Organizer
      第58回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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