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Analysis of the effect of drugs affecting the community composition in the intestinal microflora on the absorption of food allergens and the development of allergy

Research Project

Project/Area Number 19K07164
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47060:Clinical pharmacy-related
Research InstitutionHiroshima University

Principal Investigator

Yokooji Tomoharu  広島大学, 医系科学研究科(薬), 准教授 (70389120)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords食物アレルギー / 抗菌薬 / 腸内細菌 / 感作 / 消化管吸収 / 食物アレルゲン / アレルゲン感作 / 腸内細菌叢
Outline of Research at the Start

本研究は、腸内細菌叢の分布に変化をおよぼす薬剤の服用が食物抗原タンパク質の消化管透過性や抗原の感作に与える影響を分子・細胞レベルで明らかにすることを目的とする。近年、一部の腸内細菌が消化管上皮細胞間のタイトジャンクションの形態維持に関与していることが報告されている。しかし、腸内細菌叢の変動が食物抗原の吸収や感作にどの程度寄与するのかはわかっていない。本研究によって、腸内細菌叢の変動と食物抗原の吸収亢進の観点から食物アレルギーの症状誘発や感作を助長する要因が明らかにされれば、食物アレルギーの予防や新規治療法の開発に手がかりが得られるものと期待される。

Outline of Final Research Achievements

The prevalence of food allergy has increased in Japan. Some epidemiological studies have showed that changes in community composition in the intestinal microflora might cause the development of allergic diseases. In this study, we examined the effect of antibiotics including vancomycin, ampicillin and kanamycin on the community composition in the intestinal microflora and the sensitization to egg white allergen, ovalbumin. As the results, oral administration of vancomycin, ampicillin and kanamycin altered the community composition in the intestinal microflora partly and decreased the sensitization of ovalbumin in the rat model.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果では、抗菌薬の服用による腸内細菌叢の変化とアレルギー疾患の増加との関連性を明確に示すことができなかった。一方で、抗菌薬の服用によりOVAの感作は減少傾向を示したことから、ラットモデルにおいて抗菌薬の服用により変動した細菌種を網羅的に解析することで、アレルギー疾患の予防に有用な知見が得られる可能性がある。抗菌薬の使用とアレルギー疾患の発症との関連性を明らかにすることで、食物アレルギーの予防や新規治療法の開発に手がかりが得られるものと期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2020 2019

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (7 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria2022

    • Author(s)
      Koga Y, Yokooji T, Ogino R, Taogoshi T, Takahagi S, Ishii K, Chinuki Y, Morita E, Hide M, Matsuo H.
    • Journal Title

      Allergology International

      Volume: 71 Issue: 1 Pages: 94-102

    • DOI

      10.1016/j.alit.2021.08.007

    • NAID

      130008145226

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of allergens for food-dependent exercise-induced anaphylaxis to shrimp2021

    • Author(s)
      Akimoto S, Yokooji T, Ogino R, Chinuki Y, Taogoshi T, Adachi A, Morita E, Matsuo H.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 5400-5400

    • DOI

      10.1038/s41598-021-84752-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of peroxidase-1 and beta-glucosidase as cross-reactive wheat allergens in grass pollen-related wheat allergy2021

    • Author(s)
      Ogino R, Chinuki Y, Yokooji T, Takizawa D, Matsuo H, Morita E
    • Journal Title

      Allergology International

      Volume: 70 Issue: 2 Pages: 215-222

    • DOI

      10.1016/j.alit.2020.09.005

    • NAID

      130008024312

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise-induced allergic reactions on desensitization to wheat after rush oral immunotherapy2020

    • Author(s)
      Furuta T, Tanaka K, Tagami K, Matsui T, Sugiura S, Kando N, Kanie Y, Naito M, Izumi H, Tanaka A, Sjoelander S, Yokooji T, Matsuo H, Ito K.
    • Journal Title

      Allergy

      Volume: 75 Issue: 6 Pages: 1414-1422

    • DOI

      10.1111/all.14182

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a liquid chromatography-tandem mass spectrometry method for quantification of the egg allergen ovalbumin in rat plasma2019

    • Author(s)
      Ogino R, Yokooji T, Omoto A, Taogoshi T, Morita E, Matsuo H.
    • Journal Title

      Allergology International

      Volume: 68 Issue: 3 Pages: 372-374

    • DOI

      10.1016/j.alit.2018.12.005

    • NAID

      130007678472

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the allergenicity of ω5-gliadin-deficient Hokushin wheat (1BS-18) in a wheat allergy rat model.2019

    • Author(s)
      Yamada Y, Yokooji T, Ninomiya N, Taogoshi T, Morita E, Matsuo H.
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 20 Pages: 100702-100702

    • DOI

      10.1016/j.bbrep.2019.100702

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats.2019

    • Author(s)
      Fukushima T, Yokooji T, Hirano T, Kataoka Y, Taogoshi T, Matsuo H.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 12 Pages: e0226165-e0226165

    • DOI

      10.1371/journal.pone.0226165

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 高親和性IgE 受容体の架橋検出による自己免疫性蕁麻疹の新規検査法の有用性2022

    • Author(s)
      古賀 祐基, 横大路 智治, 荻野 龍平, 垰越 崇範, 高萩 俊輔, 石井 香, 千貫 祐子, 森田 栄伸, 秀 道広, 松尾 裕彰
    • Organizer
      第23回日本ヒスタミン学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 質量分析装置を用いた食品中小麦γ-グリアジン定量法の開発2021

    • Author(s)
      小別所 貴弘, 大本 亜沙妃, 垰越 崇範, 横大路 智治, 松尾 裕彰
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食物アレルゲンに対する経口免疫寛容および脱感作モデルラットの作製2021

    • Author(s)
      國本 恭平, 山田 行徳, 猪口 紘生, 大橋 凌, 垰越 崇範, 横大路 智治, 松尾 裕彰
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effects of non-steroidal anti-inflammatory drugs on sensitization to the egg-white allergen ovalbumin in rats2020

    • Author(s)
      Takahiro Fukushima, Tomoharu Yokooji, Taiki Hirano, Yuta Kataoka, Takanori Taogoshi, Hiroaki Matsuo
    • Organizer
      JSA/WAO Joint Congress 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the allergenicity and induction ability for oral tolerance of ω5-gliadin-deficient Hokushin wheat (1BS-18) in a wheat allergy rat model2020

    • Author(s)
      Yukinori Yamada, Tomoharu Yokooji, Naoki Ninomiya, Takanori Taogoshi, Eishin Morita, Hiroaki Matsuo
    • Organizer
      JSA/WAO Joint Congress 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗原架橋能検出による自己免疫性慢性蕁麻疹の新規検査法の開発2020

    • Author(s)
      古賀 祐基 , 横大路 智治, 濱田 貴行, 中山 史菜, 内藤 瑞季, 千貫 祐子, 森田 栄伸, 松尾 裕彰
    • Organizer
      日本皮膚科学会第138回山陰・第34回島根合同開催地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] Establishment of wheat peroxidase I-specific IgE test to identify wheat-dependent exercise-induced anaphylaxis developed by sensitization to grass pollen2019

    • Author(s)
      Eishin Morita, Ryohei Ogino, Yuko Chinuki, Tomoharu Yokooji, Hiroaki Matsuo
    • Organizer
      49th European Society for Dermatological Research (ESDR) Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Book] 呼吸器/免疫・炎症・アレルギー/骨・関節2020

    • Author(s)
      横大路 智治, 乾 賢一, 赤池 昭紀, 稲垣 直樹, 川合 眞一 他
    • Total Pages
      336
    • Publisher
      中山書店
    • ISBN
      9784521744537
    • Related Report
      2020 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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