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Basic study about the fabrication of tailored medicine through 3D printing technology

Research Project

Project/Area Number 19K07170
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47060:Clinical pharmacy-related
Research InstitutionNagoya City University

Principal Investigator

Tagami Tatsuaki  名古屋市立大学, 医薬学総合研究院(薬学), 准教授 (10609887)

Co-Investigator(Kenkyū-buntansha) 尾関 哲也  名古屋市立大学, 医薬学総合研究院(薬学), 教授 (60277259)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords3Dプリンター / オーダーメイド医薬品 / 小児製剤 / 錠剤 / 坐剤 / フィルム剤 / グミ剤 / 眼科用貼付剤 / 3Dプリンター医薬品 / 個別化医療 / 機械学習 / 薬物放出 / ナノメディシン / 院内製剤 / イオン液体 / 製剤学
Outline of Research at the Start

本研究は、従来の製造法ではできない(もしくは製造困難な)オーダーメイド医薬品のモデルを3Dプリンターで製造し、複数の具体例を通して3Dプリンターで作製した製剤の特性に関する情報を明らかにしながら、3Dプリンター技術の有用性や応用性を数多く発信することを目的とする。本研究は、産業分野(主に工学)で先行して発展してきた3Dプリンター技術および方法論を積極的に取りいれて医学薬学分野に適用していく、分野横断型の研究として位置づけられる。

Outline of Final Research Achievements

The objective of current study is to fabricate the models of tailored medicine which is hard to manufacture by conventional methods. We tried to clarify the information about the drug formulation for 3D printing through the several examples and to provide the usefulness and application of 3D printing technology. As many kinds of material and excipient were applicable by using different types of 3D printer, we reported not only 3D printed tablets but also other dosage forms.

Academic Significance and Societal Importance of the Research Achievements

本研究は、産業分野(主に工学)で先行して発展してきた3Dプリンター技術および方法論を積極的に取りいれて医学薬学分野に適用していく、分野横断型の研究として位置づけられる。3Dプリンターでオーダーメイド医薬品を調製することにより、従来の医薬品では満たすことが困難な患者のニーズを満たすことができる。将来医療機関で薬剤師が3Dプリンター医薬品を製造するための基盤となる研究を行った。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (12 results)

All 2022 2021 2020 2019

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (4 results) (of which Invited: 4 results)

  • [Journal Article] Lyophilized ophthalmologic patches as novel corneal drug formulations using a semi-solid extrusion 3D printer2022

    • Author(s)
      Tagami Tatsuaki、Goto Eiichi、Kida Risako、Hirose Kiyomi、Noda Takehiro、Ozeki Tetsuya
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 617 Pages: 121448-121448

    • DOI

      10.1016/j.ijpharm.2022.121448

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective and simple prediction model of drug release from “ghost tablets” fabricated using a digital light projection-type 3D printer2021

    • Author(s)
      Tagami Tatsuaki、Morimura Chisa、Ozeki Tetsuya
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 604 Pages: 120721-120721

    • DOI

      10.1016/j.ijpharm.2021.120721

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3D printing of gummy drug formulations composed of gelatin and an HPMC-based hydrogel for pediatric use.2021

    • Author(s)
      Tagami T, Ito E, Kida R, Hirose K, Noda T, Ozeki T.
    • Journal Title

      Int J Pharm

      Volume: 594 Pages: 120118-120118

    • DOI

      10.1016/j.ijpharm.2020.120118

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of 3D-printed fish-gelatin-based polymer hydrogel patches for local delivery of PEGylated liposomal doxorubicin.2020

    • Author(s)
      Liu J, Tagami T, Ozeki T.
    • Journal Title

      Marine Drugs

      Volume: 18 Issue: 6 Pages: 325-325

    • DOI

      10.3390/md18060325

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of 3D printing technology for generating hollow-type suppository shells.2020

    • Author(s)
      Tagami T, Ito E, Hayashi N, Sakai N, Ozeki T.
    • Journal Title

      Int J Pharm

      Volume: 589 Pages: 119825-119825

    • DOI

      10.1016/j.ijpharm.2020.119825

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations2019

    • Author(s)
      Tagami T, Yoshimura N, Goto E, Noda T, Ozeki T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 11 Pages: 1898-1905

    • DOI

      10.1248/bpb.b19-00481

    • NAID

      130007740627

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-11-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug Incorporation into Polymer Filament Using Simple Soaking Method for Tablet Preparation Using Fused Deposition Modeling2019

    • Author(s)
      Tagami T, Kuwata E, Sakai N, Ozeki T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 10 Pages: 1753-1760

    • DOI

      10.1248/bpb.b19-00482

    • NAID

      130007722435

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-10-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3D printing of unique water-soluble polymer-based suppository shell for controlled drug release.2019

    • Author(s)
      Tagami T, Hayashi N, Sakai N, Ozeki T.
    • Journal Title

      Int J Pharm

      Volume: 568 Pages: 118494-118494

    • DOI

      10.1016/j.ijpharm.2019.118494

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 3Dプリンター技術が もたらす新たな製剤・医薬品2021

    • Author(s)
      田上 辰秋, 尾関 哲也
    • Organizer
      第29回静岡DDS カンファランス
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 3Dプリンターを用いた医薬品作製2020

    • Author(s)
      田上 辰秋
    • Organizer
      CELLINK LIFESCIENCES ライブウェビナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 3Dプリント技術を活用した新しい製剤技術2020

    • Author(s)
      田上 辰秋
    • Organizer
      第56回薬剤学懇談会研究討論会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 3Dプリンター技術を用いた様々な剤形への医薬品応用2020

    • Author(s)
      田上 辰秋
    • Organizer
      令和元年度 第3回「メディショナルナノテク研究会」
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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