Influence of taking other's perspective on decision-making based on social preferences: fMRI/rTMS verification

• Project/Area Number: 19K07807
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 51020:Cognitive and brain science-related
• Research Institution: Juntendo University
• Principal Investigator: Ogawa Akitoshi 順天堂大学, 医学部, 准教授 (30374565)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 意思決定 / 機能的磁気共鳴画像法 / 経頭蓋磁気刺激法 / 社会的意思決定 / 社会的選好 / 機能的結合 / 経頭蓋磁気刺激 / 安静時脳活動 / 社会行動 / 脳イメージング / 脳機能操作

Outline of Research at the Start

我々は日常生活において社会的選好に基づいた意思決定を行っている。これまでの研究は、背外側前頭前野や内側前頭前野がその神経基盤として関与することを明らかにしてきた。しかし、申請者の最近の研究は、他者の道徳的特性が社会的選好のひとつである不平等嫌悪に関わる社会的意思決定に影響を与えることを明らかにした。そこで申請者は、他者の視点取得が社会的選好に基づく意思決定に影響するという仮説を導いた。本研究は、他者の視点取得に関わる右側頭頭頂接合部の活動・機能的結合を機能的磁気共鳴画像法と繰り返し経頭蓋磁気刺激法により計測・制御して、意思決定における社会的選好の影響の認知・神経基盤を明らかにすることを目指す。

Outline of Final Research Achievements

In this study, we aimed to measure and control the activity and functional connectivity of the right temporoparietal junction (RTPJ) involved in the acquisition of others' viewpoints by functional magnetic resonance imaging (fMRI) and repetitive transcranial magnetic stimulation (rTMS) to investigate the cognitive and neural basis of the influence of social preferences in decision making. We conducted an fMRI-rTMS experiment using Ultimatum Game and conducted model-based data analysis. The results showed causally that the RTPJ is involved in the counterfactual evaluation that influences the acceptance or rejection of the distribution in the game. These results were published in Cerebral Cortex.

Academic Significance and Societal Importance of the Research Achievements

本研究は、右側頭頭頂接合部が他者の視点を取得することに関わるのみならず、分配内容の反実的評価（可能性はあったが実際には実施されなかった分配の評価）に関わることを機能的磁気共鳴画像法と繰り返し経頭蓋磁気刺激法により明らかにした。このことは、社会的意思決定における右側頭頭頂接合部の役割が、これまでの研究より分かっていた以上に広いことを示している。また、本研究の結果は他者の視点を取得することが広く社会的意思決定に影響することを示唆している。

Research Products

• [Journal Article] Role of right temporoparietal junction for counterfactual evaluation of partner’s decision in ultimatum game (2023)
  • Author(s): Ogawa A, Asano S, Osada T, Tanaka M, Tochigi R, Kamagata K, Aoki S, Konishi S
  • Journal Title: Cerebral Cortex Volume: 33 Issue: 6 Pages: 2947-2957
  • DOI: 10.1093/cercor/bhac252
  • Peer Reviewed / Open Access
• [Journal Article] Neural Basis of Social Influence of Observing Other’s Perception in Dot-Number Estimation (2023)
  • Author(s): Ogawa Akitoshi、Kameda Tatsuya、Nakatani Hironori
  • Journal Title: Neuroscience Volume: 515 Pages: 1-11
  • DOI: 10.1016/j.neuroscience.2023.01.035
  • Peer Reviewed / Open Access
• [Journal Article] Deep learning as a computational model in functional neuroimaging (2022)
  • Author(s): 小川 昭利、田中 政輝
  • Journal Title: Cognitive Studies: Bulletin of the Japanese Cognitive Science Society Volume: 29 Issue: 1 Pages: 63-73
  • DOI: 10.11225/cs.2021.060
  • ISSN: 1341-7924, 1881-5995
  • Year and Date: 2022-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Behavioral and neuro-cognitive bases for emergence of norms and socially shared realities via dynamic interaction (2022)
  • Author(s): Kuroda Kiri、Ogura Yukiko、Ogawa Akitoshi、Tamei Tomoya、Ikeda Kazushi、Kameda Tatsuya
  • Journal Title: Communications Biology Volume: 5 Issue: 1 Pages: 1379-1379
  • DOI: 10.1038/s42003-022-04329-1
  • Peer Reviewed / Open Access
• [Journal Article] A causal role of anterior prefrontal-putamen circuit for response inhibition revealed by transcranial ultrasound stimulation in humans (2022)
  • Author(s): Nakajima K, Osada T, Ogawa A, Tanaka M, Oka S, Kamagata K, Aoki S, Oshima Y, Tanaka S, Konishi S
  • Journal Title: Cell Reports Volume: 40 Issue: 7 Pages: 111197-111197
  • DOI: 10.1016/j.celrep.2022.111197
  • Peer Reviewed / Open Access
• [Journal Article] Hypothalamic interaction with reward-related regions during subjective evaluation of foods (2022)
  • Author(s): Ogawa A, Osada T, Tanaka M, Suda A, Nakajima K, Oka S, Kamagata K, Aoki S, Oshima Y, Tanaka S, Hattori N, Konishi S
  • Journal Title: NeuroImage Volume: 264 Pages: 119744-119744
  • DOI: 10.1016/j.neuroimage.2022.119744
  • Peer Reviewed / Open Access
• [Journal Article] Distributive justice and risky decisions: A study with utility models and pupillary responses (2021)
  • Author(s): 小谷 侑輝、齋藤 美松、金 惠?、小川 昭利、上島 淳史、亀田 達也
  • Journal Title: Japanese Journal of Social Psychology Volume: 37 Issue: 1 Pages: 26-35
  • DOI: 10.14966/jssp.1914
  • NAID: 130008069744
  • ISSN: 0916-1503, 2189-1338
  • Year and Date: 2021-07-31
  • Peer Reviewed / Open Access
• [Journal Article] Time‐varying measures of cerebral network centrality correlate with visual saliency during movie watching (2021)
  • Author(s): Ogawa Akitoshi
  • Journal Title: Brain and Behavior Volume: 11 Issue: 9
  • DOI: 10.1002/brb3.2334
  • Peer Reviewed / Open Access
• [Journal Article] Parallel cognitive processing streams in human prefrontal cortex: Parsing areal-level brain network for response inhibition (2021)
  • Author(s): Osada Takahiro、Ogawa Akitoshi、Suda Akimitsu、Nakajima Koji、Tanaka Masaki、Oka Satoshi、Kamagata Koji、Aoki Shigeki、Oshima Yasushi、Tanaka Sakae、Hattori Nobutaka、Konishi Seiki
  • Journal Title: Cell Reports Volume: 36 Issue: 12 Pages: 109732-109732
  • DOI: 10.1016/j.celrep.2021.109732
  • Peer Reviewed / Open Access
• [Journal Article] Connectivity-based localization of human hypothalamic nuclei in functional images of standard voxel size (2020)
  • Author(s): Ogawa Akitoshi、Osada Takahiro、Tanaka Masaki、Kamagata Koji、Aoki Shigeki、Konishi Seiki
  • Journal Title: NeuroImage Volume: 221 Pages: 117205-117205
  • DOI: 10.1016/j.neuroimage.2020.117205
  • Peer Reviewed / Open Access
• [Journal Article] Functional Organization for Response Inhibition in the Right Inferior Frontal Cortex of Individual Human Brains (2020)
  • Author(s): Suda Akimitsu、Osada Takahiro、Ogawa Akitoshi、Tanaka Masaki、Kamagata Koji、Aoki Shigeki、Hattori Nobutaka、Konishi Seiki
  • Journal Title: Cerebral Cortex Volume: 30 Issue: 12 Pages: 6325-6335
  • DOI: 10.1093/cercor/bhaa188
  • Peer Reviewed / Open Access
• [Journal Article] Dissociable Networks of the Lateral/Medial Mammillary Body in the Human Brain (2020)
  • Author(s): Tanaka Masaki、Osada Takahiro、Ogawa Akitoshi、Kamagata Koji、Aoki Shigeki、Konishi Seiki
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: 228-228
  • DOI: 10.3389/fnhum.2020.00228
  • Peer Reviewed / Open Access
• [Journal Article] Network centrality reveals dissociable brain activity during response inhibition in human right ventral part of inferior frontal cortex (2020)
  • Author(s): Uta Fujimoto, Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Akimitsu Suda, Nobutaka Hattori, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Journal Title: Neuroscience Research Volume: 433 Pages: 163-173
  • DOI: 10.1016/j.neuroscience.2020.03.010
  • Peer Reviewed
• [Journal Article] Dissociable roles of left and right temporoparietal junction in strategic competitive interaction (2019)
  • Author(s): Akitoshi Ogawa, Tatsuya Kameda
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: 14 Issue: 10 Pages: 1037-1048
  • DOI: 10.1093/scan/nsz082
  • Peer Reviewed / Open Access
• [Presentation] Neural correlates for other’s equity concern modulating response to distribution in ultimatum game (2022)
  • Author(s): Saki Asano, Akitoshi Ogawa, Reia Tochigi, Masaki Tanaka, Takahiro Osada, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: Neuroscience 2022
• [Presentation] Neural correlates for other’s equity concern modulating response to distribution in ultimatum game (2022)
  • Author(s): Saki Asano, Akitoshi Ogawa, Reia Tochigi, Masaki Tanaka, Takahiro Osada, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: The 28th Annual Meeting of Organization of Human Brain Mapping
  • Int'l Joint Research
• [Presentation] Counterfactual evaluation of partner’s decision in ultimatum game recruits right TPJ (2022)
  • Author(s): Akitoshi Ogawa, Saki Asano, Takahiro Osada, Masaki Tanaka, Reia Tochigi, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: 第6回ヒト脳イメージング研究会
• [Presentation] Behavioral and neuro-cognitive bases for the emergence of a shared reality through social interaction (2022)
  • Author(s): Yukiko Ogura, Kiri Kuroda, Akitoshi Ogawa, Tomoya Tamei, Kazushi Ikeda, Tatsuya Kameda
  • Organizer: NEURO2022
• [Presentation] Localization of hypothalamic nuclei using resting-state functional connectivity in standard voxels (2021)
  • Author(s): Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: The 27th Annual Meeting of Organization of Human Brain Mapping
  • Int'l Joint Research
• [Presentation] Behavioral and neuro-cognitive bases for formation of a shared reality through social interaction (2021)
  • Author(s): Yukiko Ogura, Kiri Kuroda, Akitoshi Ogawa, Tomoya Tamei, Kazushi Ikeda, Tatsuya Kameda
  • Organizer: The 27th Annual Meeting of Organization of Human Brain Mapping
  • Int'l Joint Research
• [Presentation] Identifying likely locations of hypothalamic nuclei based on resting-state functional connectivity in standard voxel resolution (2021)
  • Author(s): Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: 44th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Brain networks of the human Mammillary body revealed by functional and diffusion MRI (2021)
  • Author(s): Masaki Tanaka, Takahiro Osada, Akitoshi Ogawa, Shuyan Han, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: 44th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Use of machine-learning agent in social neuroscience: A case of functional magnetic resonance imaging experiment (2020)
  • Author(s): Akitoshi Ogawa, Tatsuya Kameda
  • Organizer: International Symposium on Artificial Intelligence and Brain Science
  • Int'l Joint Research
• [Presentation] Network centrality dissociates brain regions in right ventral inferior frontal cortex activated for response inhibition (2020)
  • Author(s): Akitoshi Ogawa, Uta Fujimoto, Takahiro Osada, Masaki Tanaka, Akimitsu Suda, Nobutaka Hattori, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: The 26th Annual Meeting of Organization of Human Brain Mapping
  • Int'l Joint Research
• [Presentation] Parcel-based eigenvector centrality reveals configuration of cerebral network during movie-watching (2020)
  • Author(s): Akitoshi Ogawa
  • Organizer: The 26th Annual Meeting of Organization of Human Brain Mapping
  • Int'l Joint Research
• [Presentation] 他者の数知覚の観察による潜在的影響の神経相関 (2020)
  • Author(s): 小川昭利, 亀田達也, 中谷裕教
  • Organizer: 第37回日本認知科学会大会
• [Presentation] Dissociated brain regions for response inhibition in right ventral inferior frontal cortex using network centrality analysis (2020)
  • Author(s): Uta Fujimoto, Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Akimitsu suda, Nobutaka Hattori, Koji Kamagata, Shigeki Aoki, Seiki Konishi
  • Organizer: The 43rd Annual Meeting of the Japan Neuroscience Society
• [Presentation] Strengthened connectivity between left STG and IFG facilitates phoneme acquisition in second language (2020)
  • Author(s): Rieko Okada, Minori Kurahasi, Akitoshi Ogawa
  • Organizer: The 43rd Annual Meeting of the Japan Neuroscience Society
• [Presentation] Parcel-based eigenvector centrality reveals profile of cerebral network during movie-watching (2020)
  • Author(s): Akitoshi Ogawa
  • Organizer: The 43rd Annual Meeting of the Japan Neuroscience Society
• [Presentation] Others' inferences about one's own beliefs: Distinct roles of TPJ in competitive strategic decisions (2019)
  • Author(s): Akitoshi Ogawa, Tatsuya Kameda
  • Organizer: OHBM2019
  • Int'l Joint Research