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Pros and cons of DPP-IV-Inhibitor for pneumonia in the elder

Research Project

Project/Area Number 19K07923
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionKyorin University

Principal Investigator

Ebihara Takae  杏林大学, 医学部, 准教授 (30396478)

Co-Investigator(Kenkyū-buntansha) 神崎 恒一  杏林大学, 医学部, 教授 (80272540)
永井 久美子  杏林大学, 医学部, その他 (60398592)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordspneumonia / aspiration / dpp-iv-inhibitor / DPP-IV阻害剤 / 肺炎 / 誤嚥性肺炎 / 嚥下反射 / 咳反射感受性 / サブスタンスP / 高齢者肺炎 / 上気道防御反射 / DPP-IV / 細胞性免疫 / DPP-IV / 高齢者免疫
Outline of Research at the Start

DPP (Dipeptidyl Peptidase)-IV(酵素活性は、DPP-IV阻害薬はCD26のT細胞活性化を減弱させる可能性があり、分子メカニズムを考慮すると,DPP-IV阻害剤が肺炎発症のリスクを増加させる可能性がある。一方、DPP-IVは、誤嚥性肺炎発症の重要なkey物質であるサブスタンスP変性を不活性化する。したがって、DPP-IV阻害剤は、肺炎発症リスクを低下させる可能性がある。更に、糖尿病は、認知・身体機能、フレイル・サルコペニア等、重要な肺炎発症修飾因子である。以上から、糖尿病発症高齢者の肺炎発症に対するDPP-IV阻害剤の攻罪を、誤嚥性肺炎責任要因と細胞性免疫の観点から、横断・縦断コホート研究を行い調査する。

Outline of Final Research Achievements

DPP-IV inhibitors are very beneficial in terms of cognitive function and blood glucose control in dementia patients with diabetics. However, the effectiveness of oral DPP-IV inhibitors in preventing pneumonia in diabetic patients is unclear. DPP-IV inhibitors may attenuate CD26 T cell activation, while DPP-IV inhibitors has the effect of preventing substance P inactivation, so it may be possible to prevent "aspiration". In this study, the DPP-IV inhibitors group tended to develop pneumonia more frequently than the non-DPP-IV inhibitors group. The mechanism of pneumonia development is different from the previous mechanism of pneumonia development caused by weakening the dopaminergic nervous system and the lower SP nervous system, and DPP-IV inhibitors substances are thought to be a mechanism of pneumonia susceptibility by inhibiting SP inactivation and attenuating incretin hormone activation and T cell activation.

Academic Significance and Societal Importance of the Research Achievements

DPP-IV阻害剤の免疫に関する脆弱性が相次いで報告されている。認知機能と血糖コントロールの観点からは非常に有益な薬剤であるが、低免疫状態で、誤嚥性肺炎リスク群にある要介護高齢者へのDPP-IV阻害剤の安易な使用に警鐘を鳴らす。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (52 results)

All 2024 2023 2022 2021 2020 2019

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 6 results) Presentation (17 results) (of which Int'l Joint Research: 8 results,  Invited: 6 results) Book (24 results)

  • [Journal Article] Who treats older patients with aspiration pneumonia?2023

    • Author(s)
      Ebihara S, Okazaki T, Miura H, Wu X, Ebihara T.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 23 Issue: 3 Pages: 256-257

    • DOI

      10.1111/ggi.14547

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Importance of Skeletal Muscle and Interdisciplinary Team Approach in Managing Pneumonia in Older People2023

    • Author(s)
      Ebihara Satoru、Okazaki Tatsuma、Obata Keisuke、Ebihara Takae
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 15 Pages: 5093-5093

    • DOI

      10.3390/jcm12155093

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive approaches to aspiration pneumonia and dysphagia in the Elderly on the Disease Time-Axis2022

    • Author(s)
      Ebihara T.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 18 Pages: 5323-5323

    • DOI

      10.3390/jcm11185323

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sarcopenic dysphagia and aspiration pneumonia in older people2022

    • Author(s)
      Ebihara S, Miura T, Yoshida N, Nakazawa C, Takahashi R, Ebihara T.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 22 Issue: 12 Pages: 1057-1058

    • DOI

      10.1111/ggi.14503

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aspiration Pneumonia: A Key Concept in Pneumonia Treatment2021

    • Author(s)
      Ebihara Satoru、Miyagi Midori、Otsubo Yuta、Sekiya Hideki、Ebihara Takae
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 9 Pages: 1329-1330

    • DOI

      10.2169/internalmedicine.6576-20

    • NAID

      130008033328

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-05-01
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medical aromatherapy in geriatric syndrome2021

    • Author(s)
      Ebihara Takae、Yamasaki Miyako、Kozaki Koichi、Ebihara Satoru
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 5 Pages: 377-385

    • DOI

      10.1111/ggi.14157

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Respiratory Muscle Weakness as a Risk Factor for Pneumonia in Older People2021

    • Author(s)
      Okazaki Tatsuma、Suzukamo Yoshimi、Miyatake Midori、Komatsu Riyo、Yaekashiwa Masahiro、Nihei Mayumi、Izumi Shinichi、Ebihara Takae
    • Journal Title

      Gerontology

      Volume: Feb 23 Issue: 5 Pages: 1-10

    • DOI

      10.1159/000514007

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors of 90‐day mortality in older people with healthcare‐associated pneumonia2020

    • Author(s)
      Ebihara Takae、Miyamoto Takahide、Kozaki Koichi
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 11 Pages: 1036-1043

    • DOI

      10.1111/ggi.14036

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2.Association between sarcopenia and pneumonia in older people.2020

    • Author(s)
      Okazaki T, Ebihara S, Mori T, Izumi S, Ebihara T.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 20(1) Issue: 1 Pages: 7-13

    • DOI

      10.1111/ggi.13839

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association between eating difficulties and biliary sludge in the gallbladder in older adults with advanced dementia, at end of life2019

    • Author(s)
      Takehide Miyamoto, Takae Ebihara, Koichi Kozaki
    • Journal Title

      Plos one

      Volume: 14 Issue: 7 Pages: e0219538-e0219538

    • DOI

      10.1371/journal.pone.0219538

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cough reflex sensitivity and urge-to-cough deterioration in dementia with Lewy bodies.2019

    • Author(s)
      Takae Ebihara, Peijung Gui, Chika Ooyama, Koichi Kozaki, Satoru Ebihara
    • Journal Title

      European Respiratory Journal Open Research

      Volume: 6 Issue: 1 Pages: 00108-2019

    • DOI

      10.1183/23120541.00108-2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Aspiration pneumonia causes respiratory sarcopenia in older people.2023

    • Author(s)
      Ebihara T, Okazaki K, Kozaki K
    • Organizer
      the IAGG Asia/Oceania Regional Congress 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute hospital dementia morbidity and its multimorbidity-through dementia support activities.2023

    • Author(s)
      Ebihara T, Kozaki K.
    • Organizer
      the IAGG Asia/Oceania Regional Congress 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 教育講演 メディカルアロマテラピーと老年症候群2022

    • Author(s)
      海老原 孝枝
    • Organizer
      第65回日本老年医学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] シンポジウム 病態時間軸で診る、認知症者の誤嚥性肺炎・摂食嚥下障害・EOL2022

    • Author(s)
      海老原 孝枝
    • Organizer
      第41回日本認知症学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Prognostic factors of 90-day mortality in older people with healthcare-associated pneumonia2021

    • Author(s)
      Miyamoto T, Ebihara T, Kozaki K.
    • Organizer
      European Geriatric Medical Society annual meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 医療介護関連肺炎高齢者の90日間予後因子2021

    • Author(s)
      海老原孝枝、宮本孝英、神﨑恒一
    • Organizer
      第63回日本老年医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 杏林大学病院高齢診療科・物忘れセンターの近況2021

    • Author(s)
      Ebihara T
    • Organizer
      7th Geriatric Innovation Forum
    • Related Report
      2021 Research-status Report
  • [Presentation] 認知症における白質病変と肺炎発症2021

    • Author(s)
      宮本孝英、海老原孝枝、神﨑恒一
    • Organizer
      第63回日本老年医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 高齢者の嚥下機能低下と栄養不良の相互関係-高齢者誤嚥性肺炎と栄養2020

    • Author(s)
      海老原孝枝
    • Organizer
      第62回日本老年医学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Relationship between pneumonia and sarcopenia in old people-a cross-sectional study.2020

    • Author(s)
      Ebihara T, Okazaki T, Nagai K, Izumi S, Kozaki K
    • Organizer
      16th International Congress of the European Geriatric Medical Society,
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prognostic factors of 90-day mortality in older people with healthcare-associated pneumonia.2020

    • Author(s)
      Miyamoto T, Ebihara T, Kozaki K.
    • Organizer
      Am Geriatr Soc Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sarcopenia of respiratory muscles and malnutrition induce onset and recurrence of pneumonia in aged people2020

    • Author(s)
      Tatsuma Okazaki, Midori Miyatake, Yoshimi Suzukamo, Shinichi Izumi, Koichi Kozaki, Takae Ebihara
    • Organizer
      International Conference on Frailty and Sarcopenia Research.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 認知症高齢者の誤嚥性肺炎・嚥下障害・低栄養について2019

    • Author(s)
      海老原孝枝
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 認知症と誤嚥性肺炎・摂食嚥下障害2019

    • Author(s)
      海老原孝枝
    • Organizer
      東北大学メジャーセミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 認知症と身体的フレイル2019

    • Author(s)
      神﨑恒一,海老原孝枝
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] The characteristics of swallowing function in the elderly with aspiration pneumonia2019

    • Author(s)
      Takehiro Karaho, Keisuke Kawahara, Yoshiyuki Hayashi, Junko Nakajima, Takae Ebihara, Koichiro Saito
    • Organizer
      European Society For Swallowing Disorders
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between body composition and cognition in geriatric people-A cross-sectional and longitudinal cohort study-2019

    • Author(s)
      Takae Ebihara, Kumiko Nagai, Koichi Kozaki
    • Organizer
      15th International Congress of the EUGMS
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Book] Recent Advances in Pneumonia in Older People2024

    • Author(s)
      Ebihara T and Ebihara S
    • Total Pages
      136
    • Publisher
      MDPI AG
    • ISBN
      9783725804719
    • Related Report
      2023 Annual Research Report
  • [Book] 認知症の併存疾患管理ガイドブック2024

    • Author(s)
      秋下雅弘編集  7章 誤嚥性肺炎・摂食嚥下障害 海老原孝枝
    • Total Pages
      162
    • Publisher
      南山堂
    • ISBN
      9784525213817
    • Related Report
      2023 Annual Research Report
  • [Book] 高齢女性診療Q&A2023

    • Author(s)
      海老原 孝枝
    • Total Pages
      242
    • Publisher
      日本医事新報社
    • ISBN
      9784784913930
    • Related Report
      2022 Research-status Report
  • [Book] 最新知見を現場に活かす 誤嚥性肺炎 治療と予防の新常識2022

    • Author(s)
      海老原 孝枝
    • Total Pages
      188
    • Publisher
      日本医事新報社
    • ISBN
      9784784966790
    • Related Report
      2022 Research-status Report
  • [Book] これだけでわかる! 摂食嚥下障害と誤嚥性肺炎2022

    • Author(s)
      海老原 孝枝
    • Total Pages
      160
    • Publisher
      メディカ出版
    • ISBN
      9784840477901
    • Related Report
      2022 Research-status Report
  • [Book] 高齢者診療のための臨床検査ガイド2022

    • Author(s)
      海老原 孝枝
    • Total Pages
      376
    • Publisher
      診断と治療社
    • ISBN
      9784787825124
    • Related Report
      2022 Research-status Report
  • [Book] JOHNS 咀嚼と嚥下と誤嚥性肺炎2022

    • Author(s)
      海老原 孝枝
    • Total Pages
      116
    • Publisher
      東京医学社
    • ISBN
      9784885635557
    • Related Report
      2022 Research-status Report
  • [Book] 老年科2022

    • Author(s)
      海老原孝枝
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2021 Research-status Report
  • [Book] 日本医師会雑誌2021

    • Author(s)
      海老原孝枝
    • Total Pages
      5
    • Publisher
      日本医師会
    • Related Report
      2021 Research-status Report
  • [Book] 老年内科2021

    • Author(s)
      海老原孝枝
    • Total Pages
      8
    • Publisher
      科学評論社
    • Related Report
      2021 Research-status Report
  • [Book] Aroma Research2021

    • Author(s)
      海老原孝枝
    • Total Pages
      6
    • Publisher
      フレグランスジャーナル社
    • Related Report
      2021 Research-status Report
  • [Book] Journal of Clinical Rehabilitation2021

    • Author(s)
      海老原 覚, 宮城 翠, 鶴岡 広, 原田 孝, 海老原 孝枝
    • Total Pages
      7
    • Publisher
      医歯薬出版
    • Related Report
      2021 Research-status Report
  • [Book] 医学のあゆみ2021

    • Author(s)
      海老原孝枝
    • Total Pages
      7
    • Publisher
      医歯薬出版
    • Related Report
      2021 Research-status Report
  • [Book] Medical Practice2021

    • Author(s)
      海老原孝枝
    • Total Pages
      6
    • Publisher
      文光堂
    • Related Report
      2021 Research-status Report
  • [Book] 新薬と臨床2021

    • Author(s)
      海老原孝枝
    • Total Pages
      5
    • Publisher
      (株)医薬情報研究所
    • Related Report
      2021 Research-status Report
  • [Book] AgingHealth2021

    • Author(s)
      海老原孝枝
    • Total Pages
      4
    • Publisher
      (公財)長寿科学振興財団
    • Related Report
      2021 Research-status Report
  • [Book] 科学評論社2021

    • Author(s)
      海老原孝枝
    • Total Pages
      5
    • Publisher
      呼吸器内科
    • Related Report
      2021 Research-status Report
  • [Book] ますます増える誤嚥性肺炎診療の最前線 誤嚥性肺炎の治療・予防―薬物療法と非薬物療法2021

    • Author(s)
      海老原孝枝
    • Publisher
      日本医師会
    • Related Report
      2020 Research-status Report
  • [Book] アロマテラピーによる高齢者リハビリテーション医療の効率化2021

    • Author(s)
      海老原孝枝
    • Publisher
      科学評論社
    • Related Report
      2020 Research-status Report
  • [Book] 咽頭感覚障害に対するリハビリテーションアプローチ2021

    • Author(s)
      海老原覚、佐々木まどか、大坪優太、宮城翠、鶴岡広、海老原孝枝
    • Publisher
      医歯薬出版
    • Related Report
      2020 Research-status Report
  • [Book] 【高齢者呼吸器疾患の診断から看取りまで】誤嚥性肺炎の診断・治療・予防2020

    • Author(s)
      海老原孝枝
    • Publisher
      ライフサイエンス社
    • Related Report
      2020 Research-status Report
  • [Book] 【管理栄養士が入院を防ぐ!誤嚥性肺炎を起こさないアプローチ】誤嚥性肺炎の兆候2020

    • Author(s)
      海老原孝枝
    • Publisher
      メディカ出版
    • Related Report
      2020 Research-status Report
  • [Book] 改訂版健康長寿診療ハンドブック2019

    • Author(s)
      海老原孝枝
    • Total Pages
      216
    • Publisher
      メジカルビュー社
    • ISBN
      9784758304955
    • Related Report
      2019 Research-status Report
  • [Book] フレイル対策シリーズ各論偏:2019

    • Author(s)
      海老原孝枝
    • Total Pages
      136
    • Publisher
      先端科学社
    • ISBN
      9784865504514
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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