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Construction of infrastructure for elucidation of pathogenesis and therapeutic development of ATTR-type cerebral amyloid angiopahty

Research Project

Project/Area Number 19K07959
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionShinshu University

Principal Investigator

Sekijima Yoshiki  信州大学, 学術研究院医学系, 教授 (60322715)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアミロイド / トランスサイレチン / 遺伝性ATTRアミロイドーシス / 脳アミロイドアンギオパチー / PiB-PET / ATTRアミロイドーシス / アミロイドーシス
Outline of Research at the Start

トランスサイレチン型アミロイドーシスは,頻度の高いアミロイドーシスである.本症に対しては,肝移植,トランスサイレチン四量体安定化薬,遺伝子治療による治療が可能となり長期生存が可能になっている.しかし,これらの治療は脳には作用しないことから,長期生存例において中枢神経症状が頻発しており,この病態の解明・治療法開発が望まれている.
本研究では,この病態の解明および自然経過,本病態に対する治療法の開発を目指す.

Outline of Final Research Achievements

We investigated the clinical characteristics, and distribution and progression pattern of ATTR-type CAA by using PiB-PET imaging.
We enrolled 31 ATTRv amyloidosis patients. Eight patients developed CNS symptoms due to CAA. Mean duration of illness from onset to CNS symptom onset was 17 years. Seven patients developed TFNEs, 2 developed multiple cerebellar hemorrhages, and 2 developed cognitive decline. The amount of PiB accumulation increased as a function of disease duration. Annual increase rate of SUVR in female was significantly greater as compared with that in male. SUVR was significantly increased at the follow-up PET analysis as compared with the first PET analysis. The 3D-SSP analysis demonstrated that CNS amyloid deposition started in the upper middle surface of cerebellar cortex around 10 years after onset, and then spread out into entire surface of cerebellum, Sylvian fissure, and anterior part of longitudinal fissure of cerebrum around 15 years after onset.

Academic Significance and Societal Importance of the Research Achievements

遺伝性ATTRアミロイドーシスは末梢神経障害や心筋症を主症状とする疾患であるが,肝移植,TTR四量体安定化薬(タファミジス),核酸医薬(パチシラン)などの開発によりこれらが克服され,本症患者の予後が改善している.しかし,これらの症状は中枢神経のアミロイドーシスには無効なため,長期生存患者で脳アミロイドアンギオパチーアンギオパチーによる中枢神経症状が大きな問題となっている.
本研究により遺伝性ATTRアミロイドーシスの中枢神経症状の特徴が明らかになった.またPiB-PETが本症における脳アミロイド沈着の早期診断および治療効果判定に有用なバイオマーカーであることが明らかになった.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (80 results)

All 2022 2021 2020 2019

All Journal Article (40 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 27 results,  Open Access: 7 results) Presentation (40 results) (of which Int'l Joint Research: 3 results,  Invited: 29 results)

  • [Journal Article] Abdominal Fat Pad Fine-Needle Aspiration for Diagnosis of Cardiac Amyloidosis in Patients with Non-Ischemic Cardiomyopathy2022

    • Author(s)
      Hasegawa Kanae、Uzui Hiroyasu、Fukuoka Yoshitomo、Miyanaga Dai、Shiomi Yuichiro、Tama Naoto、Ikeda Hiroyuki、Ishida Kentaro、Miyazaki Shinsuke、Sekijima Yoshiki、Naiki Hironobu、Tada Hiroshi
    • Journal Title

      International Heart Journal

      Volume: 63 Issue: 1 Pages: 49-55

    • DOI

      10.1536/ihj.21-430

    • NAID

      130008145721

    • ISSN
      1349-2365, 1349-3299
    • Year and Date
      2022-01-29
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AH amyloid neuropathy: a novel clinical phenotype confirmed by histopathology and mass spectrometry2022

    • Author(s)
      Ohashi Nobuhiko、Katoh Nagaaki、Kasuga Kazuki、Yoshinaga Tsuneaki、Kametani Fuyuki、Yazaki Masahide、Sekijima Yoshiki
    • Journal Title

      Amyloid

      Volume: - Issue: 2 Pages: 1-2

    • DOI

      10.1080/13506129.2022.2049745

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CSF/plasma levels, transthyretin stabilisation and safety of multiple doses of tolcapone in subjects with hereditary ATTR amyloidosis2022

    • Author(s)
      Takahashi Yusuke、Ohashi Nobuhiko、Takasone Ken、Yoshinaga Tsuneaki、Yazaki Masahide、Roberts Michael、Glidden Paul F.、Sekijima Yoshiki
    • Journal Title

      Amyloid

      Volume: - Issue: 3 Pages: 1-7

    • DOI

      10.1080/13506129.2022.2056011

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cervical myelopathy due to amyloid deposition with accompanying cardiac abnormalities2022

    • Author(s)
      Uehara Masashi、Kuraishi Shugo、Ikegami Shota、Oba Hiroki、Takizawa Takashi、Munakata Ryo、Hatakenaka Terue、Kamanaka Takayuki、Miyaoka Yoshinari、Sekijima Yoshiki、Takahashi Jun
    • Journal Title

      The Journal of Spinal Cord Medicine

      Volume: - Issue: 4 Pages: 1-5

    • DOI

      10.1080/10790268.2022.2027322

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel histopathological deposition patterns of EGF-containing fibulin-like extracellular matrix protein 1 amyloidosis: an autopsy case exhibiting a possible association between AEFEMP1 amyloidosis and elastic fibres2022

    • Author(s)
      Ichimata Shojiro、Hata Yukiko、Katoh Nagaaki、Kametani Fuyuki、Yazaki Masahide、Sekijima Yoshiki、Nishida Naoki
    • Journal Title

      Amyloid

      Volume: - Issue: 2 Pages: 1-2

    • DOI

      10.1080/13506129.2021.2020754

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Somatostatin-derived amyloid deposition associated with duodenal neuroendocrine tumour (NET): a report of novel localised amyloidosis associated with NET2021

    • Author(s)
      Ichimata Shojiro、Katoh Nagaaki、Abe Ryuta、Yoshinaga Tsuneaki、Kametani Fuyuki、Yazaki Masahide、Kusama Yukiko、Sano Kenji、Uehara Takeshi、Sekijima Yoshiki
    • Journal Title

      Amyloid

      Volume: 29 Issue: 1 Pages: 64-65

    • DOI

      10.1080/13506129.2021.1979513

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expert consensus on the monitoring of transthyretin amyloid cardiomyopathy2021

    • Author(s)
      Garcia‐Pavia Pablo、Bengel Frank、Brito Dulce、Damy Thibaud、Duca Franz、Dorbala Sharmila、Nativi‐Nicolau Jose、Obici Laura、Rapezzi Claudio、Sekijima Yoshiki、Elliott Perry M.
    • Journal Title

      European Journal of Heart Failure

      Volume: 23 Issue: 6 Pages: 895-905

    • DOI

      10.1002/ejhf.2198

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Feasibility of assessing progression of transthyretin amyloid polyneuropathy using nerve conduction studies: Findings from the Transthyretin Amyloidosis Outcomes Survey (THAOS)2021

    • Author(s)
      Waddington‐Cruz M?rcia、Ando Yukio、Amass Leslie、Kiszko Jan、Chapman Doug、Sekijima Yoshiki、THAOS investigators
    • Journal Title

      Journal of the Peripheral Nervous System

      Volume: 26 Issue: 2 Pages: 160-166

    • DOI

      10.1111/jns.12444

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Absolute quantitative analysis of cardiac amyloidosis using SPECT/CT with 99mTc-pyrophosphate2021

    • Author(s)
      Shin Yanagisawa、Yusuke Takahashi、Jun Sasaki、Ken Takasone、Koji Yoshie、Jun Koyama、Nagaaki Katohi、Masahide Yazaki、Koichiro Kuwahara、Yasunari Fujinaga、Yoshiki Sekijima
    • Journal Title

      Amyloid

      Volume: - Issue: 3 Pages: 1-2

    • DOI

      10.1080/13506129.2021.1903418

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of diagnostic antibodies against immunoglobulin heavy chain variable region for heavy chain amyloidosis (AH amyloidosis)2021

    • Author(s)
      Nakagawa Mayuko、Yazaki Masahide、Kametani Fuyuki、Katoh Nagaaki、Yoshinaga Tsuneaki、Higuchi Keiichi、Sekijima Yoshiki
    • Journal Title

      Pathology International

      Volume: 71 Issue: 4 Pages: 245-254

    • DOI

      10.1111/pin.13081

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性ATTRアミロイドーシス2021

    • Author(s)
      関島 良樹
    • Journal Title

      Pharma Medica

      Volume: 39 Pages: 39-43

    • Related Report
      2021 Annual Research Report
  • [Journal Article] アミロイドーシス治療の進歩2021

    • Author(s)
      関島 良樹
    • Journal Title

      日本内科学会雑誌

      Volume: 110 Pages: 1170-1177

    • Related Report
      2021 Annual Research Report
  • [Journal Article] ATTRアミロイドーシスは決してめずらしい病気ではない2021

    • Author(s)
      関島 良樹
    • Journal Title

      内科

      Volume: 12 Pages: 617-619

    • Related Report
      2021 Annual Research Report
  • [Journal Article] アミロイドニューロパチー2021

    • Author(s)
      関島 良樹
    • Journal Title

      CLINICAL NEUROSCIENCE

      Volume: 39 Pages: 1444-1446

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 遺伝性神経疾患の遺伝カウンセリングと発症前診断2021

    • Author(s)
      中村 勝哉,関島 良樹
    • Journal Title

      臨床神経学

      Volume: 61 Pages: 588-593

    • NAID

      130008093293

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 遺伝性ATTRアミロイドーシス2021

    • Author(s)
      関島良樹
    • Journal Title

      Pharma Medica 39(3):39-43

      Volume: 39 Pages: 39-43

    • Related Report
      2020 Research-status Report
  • [Journal Article] An autopsy case of amyloid tubulopathy exhibiting characteristic spheroid-type deposition.2020

    • Author(s)
      Ichimata S, Hata Y, Abe R, Yoshinaga T, Katoh N, Kametani F, Yazaki M, Sekijima Y, Ehara T, Nishida N
    • Journal Title

      Virchows Arch

      Volume: 477 Issue: 1 Pages: 157-163

    • DOI

      10.1007/s00428-019-02740-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monitoring of asymptomatic family members at risk of hereditary transthyretin amyloidosis for early intervention with disease-modifying therapies2020

    • Author(s)
      Ueda Mitsuharu、Sekijima Yoshiki、Koike Haruki、Yamashita Taro、Yoshinaga Tsuneaki、Ishii Tomonori、Ando Yukio
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 414 Pages: 116813-116813

    • DOI

      10.1016/j.jns.2020.116813

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-invasive detection and differentiation of cardiac amyloidosis using 99mTc-pyrophosphate scintigraphy and 11C-Pittsburgh compound B PET imaging2020

    • Author(s)
      Takasone Ken、Katoh Nagaaki、Takahashi Yusuke、Abe Ryuta、Ezawa Naoki、Yoshinaga Tsuneaki、Yanagisawa Shin、Yazaki Masahide、Oguchi Kazuhiro、Koyama Jun、Sekijima Yoshiki
    • Journal Title

      Amyloid

      Volume: 27 Issue: 4 Pages: 266-274

    • DOI

      10.1080/13506129.2020.1798223

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of Patients with Hereditary Transthyretin Amyloidosis and an Evaluation of the Safety of Tafamidis Meglumine in Japan: An Interim Analysis of an All-case Postmarketing Surveillance2020

    • Author(s)
      Ishii Tomonori、Hirano Yoko、Matsumoto Noriko、Takata Ami、Sekijima Yoshiki、Ueda Mitsuharu、Ando Yukio
    • Journal Title

      Clinical Therapeutics

      Volume: 42 Issue: 9 Pages: 1728-1737.e6

    • DOI

      10.1016/j.clinthera.2020.07.001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution of amyloidosis subtypes based on tissue biopsy site ? Consecutive analysis of 729 patients at a single amyloidosis center in Japan2020

    • Author(s)
      Abe Ryuta、Katoh Nagaaki、Takahashi Yusuke、Takasone Ken、Yoshinaga Tsuneaki、Yazaki Masahide、Kametani Fuyuki、Sekijima Yoshiki
    • Journal Title

      Pathology International

      Volume: 71 Issue: 1 Pages: 70-79

    • DOI

      10.1111/pin.13041

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of novel amyloidosis: glucagon-derived amyloid deposition associated with pancreatic neuroendocrine tumour2020

    • Author(s)
      Ichimata Shojiro、Katoh Nagaaki、Abe Ryuta、Yoshinaga Tsuneaki、Kametani Fuyuki、Yazaki Masahide、Uehara Takeshi、Sekijima Yoshiki
    • Journal Title

      Amyloid

      Volume: 28 Issue: 1 Pages: 72-73

    • DOI

      10.1080/13506129.2020.1785417

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dialysis-related amyloidosis associated with a novel β2-microglobulin variant2020

    • Author(s)
      Mizuno Hiroki、Hoshino Junichi、So Masatomo、Kogure Yuta、Fujii Takeshi、Ubara Yoshifumi、Takaichi Kenmei、Nakaniwa Tetsuko、Tanaka Hideaki、Kurisu Genji、Kametani Fuyuki、Nakagawa Mayuko、Yoshinaga Tsuneaki、Sekijima Yoshiki、Higuchi Keiichi、Goto Yuji、Yazaki Masahide
    • Journal Title

      Amyloid

      Volume: 28 Issue: 1 Pages: 42-49

    • DOI

      10.1080/13506129.2020.1813097

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human amyloidosis, still intractable but becoming curable: the essential role of pathological diagnosis in the selection of type-specific therapeutics.2020

    • Author(s)
      Naiki H, Sekijima Y, Ueda M, Ohashi K, Hoshii Y, Shimoda M, Ando Y.
    • Journal Title

      Pathol Int

      Volume: 70 Issue: 4 Pages: 191-198

    • DOI

      10.1111/pin.12902

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] JCS 2020 Guideline on Diagnosis and Treatment of Cardiac Amyloidosis2020

    • Author(s)
      Kitaoka H, Izumi C, Izumiya Y, Inomata T, Ueda M, Kubo T, Koyama J, Sano M, Sekijima Y, Tahara N, Tsukada N, Tsujita K, Tsutsui H, Tomita T, Amano M, Endo J, Okada A, Oda S, Takashio S, Baba Y, Misumi Y, Yazaki M, Anzai T, Ando Y, Isobe M, Kimura T, Fukuda K; Japanese Circulation Society Joint Working Group.
    • Journal Title

      Cir J

      Volume: 84 Issue: 9 Pages: 1610-1671

    • DOI

      10.1253/circj.cj-20-0110

    • NAID

      130007890677

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee2020

    • Author(s)
      Benson Merrill D.、Buxbaum Joel N.、Eisenberg David S.、Merlini Giampaolo、Saraiva Maria J. M.、Sekijima Yoshiki、Sipe Jean D.、Westermark Per
    • Journal Title

      Amyloid

      Volume: 27 Issue: 4 Pages: 217-222

    • DOI

      10.1080/13506129.2020.1835263

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 遺伝性 ATTR アミロイドーシス(家族性アミロイドポリニューロパチー)2020

    • Author(s)
      関島良樹
    • Journal Title

      Clinical Neuroscience

      Volume: 38 Pages: 336-338

    • Related Report
      2020 Research-status Report
  • [Journal Article] 遺伝性ATTRアミロイドーシス2020

    • Author(s)
      関島良樹
    • Journal Title

      遺伝子医学

      Volume: 32 Pages: 513-516

    • Related Report
      2020 Research-status Report
  • [Journal Article] 野生型ATTRアミロイドーシス2020

    • Author(s)
      関島良樹
    • Journal Title

      BioClinica

      Volume: 35 Pages: 513-516

    • Related Report
      2020 Research-status Report
  • [Journal Article] 不治の病から治療可能な疾患に ―アミロイドーシス治療の最前線―2020

    • Author(s)
      関島良樹
    • Journal Title

      自律神経

      Volume: 57 Pages: 114-117

    • NAID

      130007873275

    • Related Report
      2020 Research-status Report
  • [Journal Article] 野生型トランスサイレチンアミロイドーシスと脳塞栓症2020

    • Author(s)
      関島良樹
    • Journal Title

      神経内科

      Volume: 93 Pages: 476-480

    • Related Report
      2020 Research-status Report
  • [Journal Article] 心アミロイドーシスの治療 -ATTRv, ATTRwtに対する治療-2020

    • Author(s)
      関島良樹
    • Journal Title

      Heart View

      Volume: 24 Pages: 1092-1098

    • Related Report
      2020 Research-status Report
  • [Journal Article] 遺伝性ATTRアミロイドーシス(FAP)を見逃すな! ―手根管症候群は重要なサイン―2020

    • Author(s)
      関島良樹
    • Journal Title

      Peripheral Nerve 31(2); 250-51

      Volume: 31 Pages: 250-251

    • Related Report
      2020 Research-status Report
  • [Journal Article] A Statement on the Appropriate Administration of Tafamidis in Patients With Transthyretin Cardiac Amyloidosis2019

    • Author(s)
      Endo Jin、Sano Motoaki、Izumiya Yasuhiro、Tsujita Kenichi、Nakamura Kazufumi、Tahara Nobuhiro、Kuwahara Koichiro、Inomata Takayuki、Ueda Mitsuharu、Sekijima Yoshiki、Ando Yukio、Tsutsui Hiroyuki、Isobe Mitsuaki、Fukuda Keiichi
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 1 Pages: 15-17

    • DOI

      10.1253/circj.CJ-19-0811

    • NAID

      130007772713

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-12-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The current status of the Transthyretin Amyloidosis Outcomes Survey (THAOS) in Japan2019

    • Author(s)
      Sekijima Yoshiki、Mundayat Rajiv、Ishii Tomonori、Ando Yukio
    • Journal Title

      Amyloid

      Volume: 26 Issue: sup1 Pages: 61-62

    • DOI

      10.1080/13506129.2019.1583182

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Patient profile with ATTR-FAP and evaluation of the safety and efficacy of tafamidis meglumine in Japan - interim analysis in post-marketing surveillance2019

    • Author(s)
      Ishii Tomonori、Sekijima Yoshiki、Ando Yukio
    • Journal Title

      Amyloid

      Volume: 26 Issue: sup1 Pages: 45-46

    • DOI

      10.1080/13506129.2019.1582508

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of cerebral amyloid angiopathy-type hereditary ATTR amyloidosis with Y69H (p.Y89H) variant displaying transient focal neurological episodes as the main symptom2019

    • Author(s)
      Yamada Yumi、Fukushima Takao、Kodama Satoshi、Shimizu Hiroshi、Kakita Akiyoshi、Makino Kunihiko、Sekijima Yoshiki
    • Journal Title

      Amyloid

      Volume: 26 Issue: 4 Pages: 251-252

    • DOI

      10.1080/13506129.2019.1632829

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Length-dependent truncal Aδ-fiber dysfunction in hereditary transthyretin amyloidosis: An intra-epidermal electrical stimulation study2019

    • Author(s)
      Kodaira Minori、Ohashi Nobuhiko、Morita Hiroshi、Sekijima Yoshiki
    • Journal Title

      Clinical Neurophysiology

      Volume: 130 Issue: 6 Pages: 903-910

    • DOI

      10.1016/j.clinph.2019.03.007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological demyelinating features in hereditary ATTR amyloidosis.2019

    • Author(s)
      Ohashi N, Kodaira M, Morita H, Sekijima Y.
    • Journal Title

      Amyloid

      Volume: 26 Issue: 1 Pages: 15-23

    • DOI

      10.1080/13506129.2018.1564903

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis2019

    • Author(s)
      Buxbaum Joel N.、Brannagan Thomas、Buades-Reines Juan、Cisneros Eugenia、Conceicao Isabel、Kyriakides Theodoros、Merlini Giampaolo、Obici Laura、Plante-Bordeneuve Violaine、Rousseau Antoine、Sekijima Yoshiki、Imai Akira、Waddington Cruz M?rcia、Yamada Masahito
    • Journal Title

      Amyloid

      Volume: 26 Issue: 1 Pages: 10-14

    • DOI

      10.1080/13506129.2018.1554563

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Central neurological manifestations2021

    • Author(s)
      Sekijima Y
    • Organizer
      3rd European ATTR Amyloidosis meeting for Patients and Doctors
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent progress in the Diagnosis and Treatment of ATTR Amyloidosis2021

    • Author(s)
      Sekijima Y
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 神経内科医が知っておくべきトランスサイレチン型アミロイドーシスの診断と治療 最前線2021

    • Author(s)
      関島 良樹
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 高齢者の手根管症候群に潜むATTRアミロイドーシスの早期診断2021

    • Author(s)
      関島 良樹
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 家族性アミロイドーシスに対するパティシランの臨床2021

    • Author(s)
      関島 良樹
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ATTRアミロイド-シスの病態解明と治療の最先端2021

    • Author(s)
      関島 良樹
    • Organizer
      第62回日本神経病理学会総会学術研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ATTRvアミロイドーシスの治療ゴールを見据えた早期診断の重要性とsiRNA治療薬への期待2021

    • Author(s)
      関島 良樹
    • Organizer
      第31回日本心臓核医学会総会・学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 進化を遂げる遺伝性ATTRアミロイドーシス治療2021

    • Author(s)
      関島 良樹
    • Organizer
      日本人類遺伝学会66回大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ATTRアミロイドーシス治療の最前線2021

    • Author(s)
      関島 良樹
    • Organizer
      第39回日本神経治療学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 日常診療に潜むATTRvアミロイドーシス2021

    • Author(s)
      関島 良樹
    • Organizer
      第39回日本神経治療学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 肝移植後長期生存例に多発する脳アミロイドアンギオパチー2021

    • Author(s)
      関島 良樹
    • Organizer
      第8回日本アミロイドーシス学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Recent Progress in the Diagnosis and Treatment of ATTR Amyloidosis2021

    • Author(s)
      関島良樹
    • Organizer
      WCC2021-World Congress of Cardiology 2021
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 全身性アミロイドーシス治療の最近の進歩 -蛋白質天然構造の安定化から核酸医薬まで-2020

    • Author(s)
      関島良樹
    • Organizer
      第5回JCVA学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 伝性神経疾患の発症前診断と遺伝カウンセリング ~家族性アミロイドポリニューロパチーを中心に~2020

    • Author(s)
      関島良樹
    • Organizer
      第44回日本遺伝カウンセリング学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] siRNAによる遺伝性ATTRアミロドーシスの最新治療と非集積地での診断2020

    • Author(s)
      関島良樹
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 遺伝性ATTRアミロイドーシス(FAP)を見逃すな -手根管症候群は重要なサイン-2020

    • Author(s)
      関島良樹
    • Organizer
      第31回日本末梢神経学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Red flags for Early Diagnosis in Hereditary ATTR Amyloidosis.2020

    • Author(s)
      Sekijima Y
    • Organizer
      XVII International Symposium on Amyloidosis
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 遺伝性ATTRアミロイドーシス,New Stage ~病態形成から考えるsiRNAによる治療意義~2020

    • Author(s)
      関島良樹
    • Organizer
      第38回日本神経治療学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 核酸医薬を用いたトランスサイレチン型アミロイドーシス治療2020

    • Author(s)
      関島良樹
    • Organizer
      73回日本自律神経学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 核酸医薬を用いたトランスサイレチン型アミロイドーシス治療2020

    • Author(s)
      関島良樹
    • Organizer
      第39回日本認知症学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 核酸医薬によるATTRアミロイドーシス治療の最前線 -実臨床における有用性と今後の展望-2020

    • Author(s)
      関島良樹
    • Organizer
      核酸医薬シンポジウム2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 遺伝性ATTR(ATTRv)アミロイドーシス治療の現状と課題2020

    • Author(s)
      関島良樹
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 遺伝性神経疾患の発症前診断と遺伝カウンセリング2020

    • Author(s)
      関島良樹
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Utility of LMD and LC-MS/MS for immunostaining negative cases in diagnosis of amyloidosis2020

    • Author(s)
      Yoshinaga T, Yazaki M, Abe R, Takasone K, Takahashi Y, Katoh N, Kametani F, Sekijima Y
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] FAP患者における体幹部長さ依存性Aδ線維機能障害と四肢末梢神経障害との関連2020

    • Author(s)
      小平農、大橋信彦、森田洋、関島良樹
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 電気生理学的に脱髄所見を呈するATTR-FAPとDADS型CIDPの差異2020

    • Author(s)
      大橋信彦、小平農、森田洋、関島良樹
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 全内科横断的疾患”アミロイドーシス”の診断と治療の最前線-全身性アミロイド-シスからアルツハイマー病まで-2020

    • Author(s)
      関島良樹
    • Organizer
      日本内科学会第144回信越地方会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 遺伝性神経疾患の発症前診断と遺伝カウンセリング ~家族性アミロイドポリニューロパチーを中心に~2020

    • Author(s)
      関島良樹
    • Organizer
      第43回日本遺伝カウンセリング学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 電気生理学的脱髄所見を呈するATTR-FAPとDADS型CIDPの差2020

    • Author(s)
      大橋信彦、小平農、森田洋、関島良樹
    • Organizer
      第30回日本末梢神経学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 全身性アミロイドーシスの最近の話題 -野生型ATTRアミロイドーシスを中心に-2020

    • Author(s)
      関島良樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 99mTc-PypとC-PiB PETを用いた非侵襲的な心アミロイドーシス診断法の確立2020

    • Author(s)
      高曽根健、高橋佑介、阿部隆太、小口和浩、吉長恒明、加藤修明、矢﨑正英、関島良樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ATTR型脳軟膜アミロイドーシス/脳アミロイドアンギオパチーの臨床的特徴2020

    • Author(s)
      中尾聡、宮﨑大吾、吉長恒明、矢﨑正英、関島良樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] V30M型ATTRアミロイドーシス患者での脳アミロイドーシスのPiB-PETを用いた経時的変化の検討2020

    • Author(s)
      高橋佑介、高曽根健、阿部隆太、吉長恒明、加藤 修明、小口和浩、矢﨑正英、関島良樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] アミロイドーシスタイピング依頼例における陰性例の要因検討2020

    • Author(s)
      吉長恒明、高曽根健、高橋佑介、阿部隆太、中川真優子、加藤修明、矢﨑正英、関島良樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 本邦の単一アミロイドーシス診断センターにおける連続729例のアミロイドーシス診断実績2020

    • Author(s)
      阿部隆太、吉長恒明、加藤修明、矢﨑正英、亀谷富由樹、関島良樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Amyloid Interactome2020

    • Author(s)
      亀谷富由樹、吉長恒明、矢﨑正英、関島良樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 遺伝性ATTRアミロイドーシス患者の心筋・末梢神経における沈着アミロイド蛋白の臓器内多様性の検討2020

    • Author(s)
      中川真優子、矢﨑正英、吉長恒明、関島良樹、亀谷富由樹
    • Organizer
      第7回日本アミロイドーシス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 不治の病から治療可能な疾患に ―アミロイドーシス治療の最前線―2020

    • Author(s)
      関島良樹
    • Organizer
      第72回日本自律神経学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] アミロイドーシスの診断と治療 update ―ガイドラインとその先の展望―2020

    • Author(s)
      関島良樹
    • Organizer
      第37回日本神経治療学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 進歩を遂げた遺伝性ATTRアミロイドーシス/FAP治療-siRNA 製剤の可能性-2020

    • Author(s)
      関島良樹
    • Organizer
      第37回日本神経治療学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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