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Quantitative analysis of the contribution of tumor vascular injury to the anti-tumor effect of X-rays using boron neutron capture reaction

Research Project

Project/Area Number 19K08134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionOsaka Medical and Pharmaceutical University

Principal Investigator

ONO KOJI  大阪医科薬科大学, BNCT共同臨床研究所, 所長 (90122407)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsBNCT / 腫瘍細胞選択的殺細胞効果 / 硼素化合物 / BPA / BSH / 悪性脳腫瘍 / ホウ素ー中性子線量 / 殺細胞効果 / 生存率曲線 / 指数曲線の傾き / 腫瘍血管 / コロニー形成率 / 腫瘍治癒率 / 造腫瘍性細胞率 / 腫瘍血管損傷の寄与 / 抗腫瘍効果 / 線量増殖遅延関係 / 線量細胞生存率関係 / ホウ素中性子捕獲反応線量 / 腸管上皮細胞 / 血管内皮細胞 / X線による腫瘍血管損傷 / 抗腫瘍効果への寄与の定量 / BNCTの抗腫瘍効果の利用
Outline of Research at the Start

腫瘍細胞選択的な集積能を持つ硼素薬剤BPAを投与したマウスの腫瘍に低速中性子を照射すると中性子と硼素原子核の反応で極短飛程の極高LETが極短飛程の粒子が放出され、効果は硼素を集積した腫瘍細胞に略限定される。この効果をコロニー法で求めた細胞生存率と増殖遅延日数で調べ関係を求め、X線照射時の場合と比較する。その差を腫瘍細胞以外の腫瘍内構造、特に腫瘍血管に対する放射線の効果と見なし、定量的に評価する。斯うした研究はBNCRを利用する以外には手段がない。得られたデータはSRSやSRT時のX線一回第線量照射の効果を説明できる可能性が在る。

Outline of Final Research Achievements

Boron neutron capture therapy (BNCT) is expected to have s selective cytocidal effect on tumor cells, but in addition to its antitumor effect, damage to the vascular system that supports the growth of tumors should also contribute significantly. X-ray therapy is not selective to tumor cells, so it is considered that vascular damage also contributes significantly. In this study, the data from basic and clinical research on BNCT was reanalyzed, and it was found that the number of cells required to cure a tumor can be accurately estimated by the direct cytocidal effect. In addition, an analysis of the results of BNCT for glioblastoma revealed that the results can be reasonably explained by the direct cytocidal effect.

Academic Significance and Societal Importance of the Research Achievements

BNCTの特性である抗腫瘍効果の腫瘍細胞選択的特徴が明らかになった。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2023 2020

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 8 results)

  • [Journal Article] The effects of BPA-BNCT on normal bone: determination of the CBE value in mice2023

    • Author(s)
      Iwasaki Ryota、Yoshikawa Ryutaro、Umeno Ryo、Seki Azusa、Matsukawa Takehisa、Takeno Satoshi、Yokoyama Kazuhito、Mori Takashi、Suzuki Minoru、Ono Koji
    • Journal Title

      Journal of Radiation Research

      Volume: 64 Issue: 5 Pages: 795-803

    • DOI

      10.1093/jrr/rrad054

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: <i>in vitro</i> study2023

    • Author(s)
      Hu Naonori、Suzuki Minoru、Masunaga Shin-ichiro、Kashino Genro、Kinashi Yuko、Chen Yi-Wen、Liu Yong、Uehara Koki、Mitsumoto Toshinori、Tanaka Hiroki、Ono Koji
    • Journal Title

      Journal of Radiation Research

      Volume: 64 Issue: 5 Pages: 811-815

    • DOI

      10.1093/jrr/rrad056

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of TP53 status of tumor cells including the type and the concentration of administered 10B delivery agents on compound biological effectiveness in boron neutron capture therapy.2023

    • Author(s)
      Masunaga S, Sanada Y, Takata T, Tanaka H, Sakurai Y, Suzuki M, Kirihata M, Ono K.
    • Journal Title

      Journal of Radiation Research

      Volume: 64(2) Issue: 2 Pages: 399-411

    • DOI

      10.1093/jrr/rrad001

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proposal of recommended experimental protocols for <i>in vitro</i> and <i>in vivo</i> evaluation methods of boron agents for neutron capture therapy2023

    • Author(s)
      Hattori Yoshihide、Andoh Tooru、Kawabata Shinji、Hu Naonori、Michiue Hiroyuki、Nakamura Hiroyuki、Nomoto Takahiro、Suzuki Minoru、Takata Takushi、Tanaka Hiroki、Watanabe Tsubasa、Ono Koji
    • Journal Title

      Journal of Radiation Research

      Volume: 64 Issue: 6 Pages: 859-869

    • DOI

      10.1093/jrr/rrad064

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reevaluation of CBE value of BPA for hepatocytes2020

    • Author(s)
      Ono Koji、Tanaka Hiroki、Suzuki Minoru
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 161 Pages: 109159-109159

    • DOI

      10.1016/j.apradiso.2020.109159

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness2020

    • Author(s)
      Shin-ichiro Masunaga, Yu Sanada, Keizo Tano, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Koji Ono
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 6 Pages: 876-885

    • DOI

      10.1093/jrr/rraa048

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Boron neutron capture therapy for clear cell sarcoma2020

    • Author(s)
      Fujimoto T., Suzuki M., Sudo T., Fujita I., Sakuma T., Sakurai Y., Hirose T., Morishita M., Takata T., Tamari Y., Tanaka Hi., Ando T., Kawamoto T., Hara H., Fukase N., Kawakami Y., Shigemoto R., Matsumoto T., Ichikawa H., Ono K., Kuroda R. yosuke、Akisue Toshihiro
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 166 Pages: 109324-109324

    • DOI

      10.1016/j.apradiso.2020.109324

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Boron neutron capture therapy for head and neck cancer: Relevance of nuclear-cytoplasmic volume ratio and anti-tumor effect. -A preliminary report-2020

    • Author(s)
      Teruhito Aihara, Junichi Hiratsuka, Nobuhiko Kamitani, Hirotake Nishimura, Koji Ono
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 163 Pages: 109212-109212

    • DOI

      10.1016/j.apradiso.2020.109212

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma2020

    • Author(s)
      H. Yanagie, M. Yanagawa, T. Higuchi, N. Dewi, Y. Nonaka, A. Shinohara, T. Matsukawa, K. Yokoyama, M. Suzuki, S. Masunaga, Y. Sakurai, H. Tanaka, K. Ono, H. Yamauchi, M. Ono, J. Nakajima, S. Higashi, H. Takahashi
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 163 Pages: 109202-109202

    • DOI

      10.1016/j.apradiso.2020.109202

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2019-04-18   Modified: 2025-01-30  

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