Development of accelerator produced radionuclides for radioisotope therapy application

• Project/Area Number: 19K08173
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Osaka University
• Principal Investigator: Ooe Kazuhiro 大阪大学, 医学部附属病院, 特任助教(常勤) (90610303)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 核医学治療 / 加速器製造核種 / ベータ線放出核種

Outline of Research at the Start

本研究では核医学治療のための放射性核種として、加速器による国内製造が可能な核種を新たに開発する。現在、腫瘍治療に用いられる放射性核種はすべて海外からの輸入に頼っている状況であり、安定供給のためには加速器による国内製造を行うことが必須である。本研究では近年大きく注目されている診断と治療を融合的に進めるtheranosticsも念頭に置き、ベータ線による治療およびガンマ線による単一光子放射断層撮影(SPECT)が可能と期待される、銀-111およびセリウム-141の加速器を用いた製造手法の開発、並びにこれらの核種の分離精製手法の開発を行う。

Outline of Final Research Achievements

In this study, we aimed to develop accelerator produced radionuclides, which can be supplied domestically, for radioisotope therapy. As candidate radionuclides, silver-111 and cerium-141 were selected, and accelerator production and purification methods for these radionuclides were investigated. As for Ag-111, excitation functions in the nuclear reaction between palladium and deuterium beam were obtained, and the separation of Ag-111 from palladium by anion exchange method was successfully carried out. As for cerium-141, barium oxide was selected as an appropriate target material. The production of cerium-141 in the nuclear reaction between barium oxide and helium-4 beam was conducted, and separation of Ce-141 from barium oxide by extraction chromatography was achieved.

Academic Significance and Societal Importance of the Research Achievements

核医学治療用の放射性核種は、現在すべて輸入に頼っており、その供給が海外情勢に大きな影響を受ける。そのため、治療用の放射性核種を国内製造・供給することに大きな期待が寄せられている。本研究では銀-111およびセリウム-141について、加速器による製造法と、ターゲット物質からの分離精製法の開発を達成し、治療用核種の加速器を用いた国内製造・供給に向けて大きな一歩となると考えられる。

Research Products

• [Presentation] 乾式分離と純水を用いた溶解によるアスタチン211の分離精製 (2021)
  • Author(s): 大江一弘、豊嶋厚史、寺本高啓、永田光知郎、床井健運、中川創太、渡部 直史、白神宜史、吉村崇、篠原厚、畑澤順
  • Organizer: 第61回日本核医学会学術総会(2021)
• [Presentation] Preparation of an astatine-211 aqueous solution by dry distillation and dissolution in pure water (2021)
  • Author(s): Kazuhiro Ooe, Atsushi Toyoshima, Takahiro Teramoto, Kojiro Nagata, Yuichiro Kadonaga, Akimitsu Kanda, Katsuyuki Tokoi, Sota Nakagawa, Tadashi Watabe, Yoshifumi Shirakami, Takashi Yoshimura, Atsushi Shinohara, and Jun Hatazawa
  • Organizer: Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021 Annual Meeting
  • Int'l Joint Research
• [Presentation] Production and separation of theranostic radionuclide Ag-111 from Pd target (2020)
  • Author(s): Kazuhiro Ooe, Tadashi Watabe, Yoshifumi Shirakami, Daiki Mori, Takuya Yokokita, Yukiko Komori, Hiromitsu Haba and Jun Hatazawa
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting (SNMMI 2020)
  • Int'l Joint Research
• [Presentation] 核医学利用に向けたAg-111の加速器による製造と分離精製 (2020)
  • Author(s): 大江一弘、渡部直史、白神宜史、森大輝、横北卓也、小森有希子、羽場宏光、畑澤順
  • Organizer: 日本放射化学会第64回討論会(2020)
• [Presentation] 治療用核種Ag-111のPd標的からの加速器製造と分離精製 (2020)
  • Author(s): 大江一弘、渡部直史、白神宜史、森大輝、横北卓也、小森有希子、羽場宏光、畑澤順
  • Organizer: 第60回日本核医学会学術総会
• [Presentation] Increased uptake of At-211 in thyroid gland by the preparation with ascorbic acid for targeted alpha therapy of thyroid cancer (2019)
  • Author(s): Kazuhiro Ooe, Tadashi Watabe, Kazuko Kaneda-Nakashima, Yuwei Liu, Yoshifumi Shirakami, Atsushi Toyoshima, Eku Shimosegawa, Mitsuhiro Fukuda, Atsushi Shinohara, Jun Hatazawa
  • Organizer: The 11th International Symposium on Targeted-Alpha-Therapy (TAT11)
  • Int'l Joint Research
• [Presentation] Dissolution of dry distilled At-211 with non-toxic aqueous solutions (2019)
  • Author(s): Kazuhiro Ooe, Tadashi Watabe, Yoshifumi Shirakami, Soichiro Ichimura, Honoka Obata, Takumi Ikeda, Zi Jian Zhang, Kojiro Nagata, Atsushi Toyoshima, Takashi Yoshimura, Atsushi Shinohara, and Jun Hatazawa
  • Organizer: Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Determination of Rn-219 radioactivity in exhaled breath from patients treated with Ra-223 (2019)
  • Author(s): Kazuhiro Ooe, Tadashi Watabe, Takashi Kamiya, Takashi Yoshimura, Makoto Hosono, Atsushi Shinohara, Jun Hatazawa
  • Organizer: 第59回日本核医学会学術総会