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Cardiac allograft vasculopathy analyzed by intra-voxel incoherent motion diffusion MRI

Research Project

Project/Area Number 19K08209
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionTokyo Women's Medical University

Principal Investigator

Nagao Michinobu  東京女子医科大学, 医学部, 准教授 (60533081)

Co-Investigator(Kenkyū-buntansha) 布田 伸一  東京女子医科大学, 医学部, 教授 (20172744)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心臓移植 / MRI / 移植後冠動脈病変 / T1 mapping / 拡散強調 / 心筋マッピング / 冠動脈病変 / IVIM / 拡散強調画像 / PET / 心筋血流予備能
Outline of Research at the Start

心臓移植は従来の治療法では救命できないような心不全患者の治療法として世界で実施されている。しかし慢性拒絶である移植心冠動脈病変が患者の長期予後改善の障壁となっている。移植心冠動脈病変はびまん性に冠動脈内膜が肥厚し内腔が狭小化する疾患であり、その原因は解明されていない。また中小動脈のびまん性病変のため、冠動脈造影ではその初期病変を捉えにくい。そのため半年~1年ごとに侵襲や危険を伴う冠動脈血管内エコーや心筋生検を実施しなければならない。本研究は、冠動脈血管内エコーや心筋生検にかわる移植心冠動脈病変を検出するための心臓MRIの拡散強調画像を応用した低侵襲画像診断法を開発することである。

Outline of Final Research Achievements

Cardiac MRI was performed on 27 patients after heart transplantation. Cardiac MRI included cine imaging for cardiac function, T1, T2 mapping and IVIM diffusion-weighted for myocardial evaluation, and MR angiography for coronary artery lesions. Invasive myocardial biopsy was performed in all patients and analyzed for cardiac allograft vasculopathy and rejection. Patients with pathologically proven Quilty lesions associated with lymphocytic infiltration had significantly prolonged myocardial T1 values, which have been reported to be associated with the development of rejection and myocardial damage caused by post-transplant immunosuppressive agents, and T1 mapping was used to detect them. T1 mapping is expected to be a noninvasive, low patient burden means of detecting these lesions.

Academic Significance and Societal Importance of the Research Achievements

心臓移植後患者には、一年毎のカテーテル検査による冠動脈造影と心筋生検を実施し、移植後冠動脈病変や拒絶反応を評価することが必要とされている。患者にとって大きな負担とリスクであった。心臓MRIでは、放射線被ばくや造影剤を使用せずに冠動脈病変と心筋性状を同時に評価できる。MRI心筋マッピング技術進歩は著しく、心筋の浮腫、炎症、線維化を定量化した多くの情報を得られる。それらを統合的に解析し、診断精度や予後を予測するradiomicsも進化している。生検による病理組織とT1, T2, IVIMを対比し関連性を明らかにすることは、心臓移植後患者の侵襲的検査の軽減や心筋生検の代替えとなることが期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (29 results)

All 2022 2021 2020 2019

All Journal Article (27 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 27 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Relation of Left Atrial Flow, Volume, and Strain to Paroxysmal Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy2022

    • Author(s)
      Nakao Risako、Nagao Michinobu、Higuchi Satoshi、Minami Yuichiro、Shoda Morio、Ando Kiyoe、Yamamoto Atsushi、Sakai Akiko、Watanabe Eri、Sakai Shuji、Hagiwara Nobuhisa
    • Journal Title

      The American Journal of Cardiology

      Volume: 166 Pages: 72-80

    • DOI

      10.1016/j.amjcard.2021.11.016

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of Three-Dimensional Computed Tomography to Image Archived Fatty Tissue of Arrhythmogenic Cardiomyopathy2021

    • Author(s)
      Uto Kenta、Nagao Michinobu、Yoshizawa Saeko、Kikuchi Noriko、Hagiwara Nobuhisa、Nagashima Yoji
    • Journal Title

      Circulation Journal

      Volume: 85 Issue: 10 Pages: 1896

    • DOI

      10.1253/circj.CJ-21-0521

    • NAID

      130008091406

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-09-24
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 13N-ammonia positron emission tomography-derived left-ventricular strain in patients after heart transplantation validated using cardiovascular magnetic resonance feature tracking as reference2021

    • Author(s)
      Kawakubo Masateru、Nagao Michinobu、Kikuchi Noriko、Yamamoto Atsushi、Nakao Risako、Matsuo Yuka、Kaneko Koichiro、Watanabe Eri、Sasaki Masayuki、Nunoda Shinichi、Sakai Shuji
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 36 Issue: 1 Pages: 70-81

    • DOI

      10.1007/s12149-021-01686-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 13?N-ammonia PET-derived right ventricular longitudinal strain and myocardial flow reserve in right coronary artery disease2021

    • Author(s)
      Kawakubo Masateru、Nagao Michinobu、Yamamoto Atsushi、Nakao Risako、Matsuo Yuka、Kaneko Koichiro、Watanabe Eri、Sakai Akiko、Sasaki Masayuki、Sakai Shuji
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 49 Issue: 6 Pages: 1870-1880

    • DOI

      10.1007/s00259-021-05647-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 13N-ammonia positron emission tomography-derived endocardial strain for the assessment of ischemia using feature-tracking in high-resolution cine imaging2021

    • Author(s)
      Kawakubo Masateru、Nagao Michinobu、Yamamoto Atsushi、Nakao Risako、Matsuo Yuka、Fukushim Kenji、Watanabe Eri、Sakai Akiko、Sasaki Masayuki、Sakai Shuji
    • Journal Title

      Journal of Nuclear Cardiology

      Volume: XX Issue: 5 Pages: 2103-2114

    • DOI

      10.1007/s12350-021-02677-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of 3D computed tomography to image fatty tissue: a case of left-dominant arrhythmogenic cardiomyopathy2021

    • Author(s)
      Imamura Yasutaka、Nagara Kimiko、Uto Kenta、Kimura Yuya、Nagao Michinobu
    • Journal Title

      European Heart Journal - Cardiovascular Imaging

      Volume: 22 Issue: 8 Pages: e132-e132

    • DOI

      10.1093/ehjci/jeaa419

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute Myocarditis Complicating Systemic Lupus Erythematosus2021

    • Author(s)
      Kikuchi Noriko、Watanabe Eri、Nagao Michinobu、Yoshizawa Saeko、Kobashigawa Tsuyoshi、Hagiwara Nobuhisa
    • Journal Title

      Circulation: Cardiovascular Imaging

      Volume: 14 Issue: 2 Pages: 185-189

    • DOI

      10.1161/circimaging.120.011319

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Non-physiological Aortic Flow and Aortopathy in Adult Patients with Transposition of the Great Arteries after the Jatene Procedure: A Pilot Study Using Echo Planar 4D Flow MRI2021

    • Author(s)
      Shiina Yumi、Inai Kei、Nagao Michinobu
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 20 Issue: 4 Pages: 439-449

    • DOI

      10.2463/mrms.mp.2020-0101

    • NAID

      130008123687

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bicuspid aortic valve morphology and aortic valvular outflow jets: An experimental analysis using an MRI-compatible pulsatile flow circulation system2021

    • Author(s)
      K. Hattori, N. Nakama, J. Takada, G. Nishimura, R. Moriwaki, E. Kawasaki, M. Nagao, Y. Goto, H. Niinami, K. Iwasaki
    • Journal Title

      Scientific Reports

      Volume: 11:2066 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-021-81845-w

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognosis and recurrence in cardiac sarcoidosis: Serial assessment of BMIPP SPECT and FDG-PET2021

    • Author(s)
      Yamamoto Atsushi、Nagao Michinobu、Watanabe Eri、Imamura Yasutaka、Suzuki Atsushi、Fukushima Kenji、Ando Kiyoe、Nakao Risako、Sakai Akiko、Momose Mitsuru、Sakai Shuji、Hagiwara Nobuhisa
    • Journal Title

      Journal of Nuclear Cardiology

      Volume: XX Issue: 3 Pages: 919-929

    • DOI

      10.1007/s12350-021-02567-0

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot2021

    • Author(s)
      Tsuchiya Nanae、Nagao Michinobu、Shiina Yumi、Miyazaki Shohei、Inai Kei、Murayama Sadayuki、Sakai Shuji
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-91125-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk stratification in coronary artery disease using NH3-PET myocardial flow reserve and CAD-RADS on coronary CT angiography2021

    • Author(s)
      Yamamoto Atsushi、Nagao Michinobu、Ando Kiyoe、Nakao Risako、Fukushima Kenji、Matsuo Yuka、Momose Mitsuru、Sakai Shuji、Hagiwara Nobuhisa
    • Journal Title

      The International Journal of Cardiovascular Imaging

      Volume: 37 Issue: 11 Pages: 3335-3342

    • DOI

      10.1007/s10554-021-02312-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronary flow quantification estimated by dynamic 320-detector CT angiography: validation by <sup>13</sup>N ammonia PET myocardial flow reserve2021

    • Author(s)
      Matsuo Yuka、Nagao Michinobu、Yamamoto Atsushi、Ando Kiyoe、Nakao Risako、Fukushima Kenji、Momose Mitsuru、Sakai Akiko、Sato Kayoko、Sakai Shuji
    • Journal Title

      The British Journal of Radiology

      Volume: 94 Issue: 1127

    • DOI

      10.1259/bjr.20201415

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk Factors of Coronary Calcium Onset in Healthy Japanese Individuals: A Longitudinal Study Using Low-Dose Chest CT2021

    • Author(s)
      Izoe Yukako、Nagao Michinobu、Chida Koichi
    • Journal Title

      Cardiovascular Imaging Asia

      Volume: 5 Issue: 3 Pages: 100-100

    • DOI

      10.22468/cvia.2021.00185

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation dose for 320‐row dose‐modulated dynamic coronary CT angiography2021

    • Author(s)
      Izoe Yukako、Nagao Michinobu、Tokai Mei、Hashimoto Hiroyuki、Tanaka Isao、Chida Koichi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 22 Issue: 9 Pages: 307-312

    • DOI

      10.1002/acm2.13390

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential of Liver T<sub>1</sub> Mapping for the Detection of Fontan-associated Liver Disease in Adults2021

    • Author(s)
      Shiina Yumi、Inai Kei、Ohashi Ryoko、Nagao Michinobu
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 20 Issue: 3 Pages: 295-302

    • DOI

      10.2463/mrms.mp.2020-0063

    • NAID

      130008082655

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secondary sarcopenia assessed by computed tomography can predict hospitalization for heart failure in adults with Fontan circulation2021

    • Author(s)
      Shiina Yumi、Nagao Michinobu、Shimomiya Yamato、Inai Kei
    • Journal Title

      Journal of Cardiology

      Volume: 77 Issue: 1 Pages: 10-16

    • DOI

      10.1016/j.jjcc.2020.06.009

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between myocardial hypoxia and fibrosis in hypertrophic cardiomyopathy: analysis by T2* BOLD and T1 mapping MRI2020

    • Author(s)
      Ando K, Nagao M, Watanabe E, Sakai A, Suzuki A, Nakao R, Ishizaki U, Sakai S, Hagiwara N.
    • Journal Title

      Eur Radiol

      Volume: 印刷中 Issue: 8 Pages: 4327-4336

    • DOI

      10.1007/s00330-020-06779-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Papillary muscle ischemia on high-resolution cine imaging of nitrogen-13 ammonia positron emission tomography: Association with myocardial flow reserve and prognosis in coronary artery disease2020

    • Author(s)
      Nakao Risako、Nagao Michinobu、Yamamoto Atsushi、Fukushima Kenji、Watanabe Eri、Sakai Shuji、Hagiwara Nobuhisa
    • Journal Title

      Journal of Nuclear Cardiology

      Volume: - Issue: 1 Pages: 293-303

    • DOI

      10.1007/s12350-020-02231-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aortic Vorticity, Helicity, and Aortopathy in Adult Patients with Tetralogy of Fallot: Pilot Study Using Four-Dimensional Flow Magnetic Resonance Images2020

    • Author(s)
      Shiina Yumi、Inai Kei、Miyazaki Shohei、Nagao Michinobu
    • Journal Title

      Pediatric Cardiology

      Volume: 42 Issue: 1 Pages: 169-177

    • DOI

      10.1007/s00246-020-02466-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] New transluminal attenuation gradient derived from dynamic coronary CT angiography: diagnostic ability of ischemia detected by 13N-ammonia PET2020

    • Author(s)
      Kojima Tsukasa、Nagao Michinobu、Yabuuchi Hidetake、Yamasaki Yuzo、Shirasaka Takashi、Kawakubo Masateru、Fukushima Kenji、Kato Toyoyuki、Yamamoto Atsushi、Nakao Risako、Sakai Akiko、Watanabe Eri、Sakai Shuji
    • Journal Title

      Heart and Vessels

      Volume: 36 Issue: 4 Pages: 433-441

    • DOI

      10.1007/s00380-020-01712-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Myocardial Flow Reserve in Coronary Artery Disease with Low Attenuation Plaque: Coronary CTA and 13N-ammonia PET Assessments2020

    • Author(s)
      Yamamoto Atsushi、Nagao Michinobu、Ando Kiyoe、Nakao Risako、Sakai Akiko、Watanabe Eri、Momose Mitsuru、Sato Kayoko、Fukushima Kenji、Sakai Shuji、Hagiwara Nobuhisa
    • Journal Title

      Academic Radiology

      Volume: - Pages: S17-S24

    • DOI

      10.1016/j.acra.2020.11.012

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low Radiation Dose and High Image Quality of 320-Row Coronary Computed Tomography Angiography Using a Small Dose of Contrast Medium and Refined Scan Timing Prediction2020

    • Author(s)
      Shirasaka Takashi、Nagao Michinobu、Yamasaki Yuzo、Kojima Tsukasa、Kondo Masatoshi、Hamasaki Hiroshi、Kamitani Takeshi、Kato Toyoyuki、Asayama Yoshiki
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: 44 Issue: 1 Pages: 7-12

    • DOI

      10.1097/rct.0000000000000951

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The relationship between extracellular volume fraction in symptomatic adults with tetralogy of Fallot and adverse cardiac events2020

    • Author(s)
      Shiina Yumi、Taniguchi Kota、Nagao Michinobu、Takahashi Tatsunori、Niwa Koichiro、Kawakubo Masateru、Inai Kei
    • Journal Title

      Journal of Cardiology

      Volume: 75 Issue: 4 Pages: 424-431

    • DOI

      10.1016/j.jjcc.2019.09.009

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Unique haemodynamics in a patient with apicoaortic conduit dysfunction who underwent transcatheter aortic valve replacement2020

    • Author(s)
      Domoto Satoru、Nagao Michinobu、Isomura Shogo、Yamaguchi Junichi、Niinami Hiroshi
    • Journal Title

      European Heart Journal - Cardiovascular Imaging

      Volume: January Issue: 6 Pages: 652-652

    • DOI

      10.1093/ehjci/jez323

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prediction of Cardiac Resynchronization Therapy Response in Dilated Cardiomyopathy Using Vortex Flow Mapping on Cine Magnetic Resonance Imaging2019

    • Author(s)
      Nakao Risako、Nagao Michinobu、Fukushima Kenji、Sakai Akiko、Watanabe Eri、Kawakubo Masateru、Sakai Shuji、Hagiwara Nobuhisa
    • Journal Title

      Circulation Reports

      Volume: 1 Issue: 8 Pages: 333-341

    • DOI

      10.1253/circrep.CR-18-0024

    • NAID

      130007689207

    • ISSN
      2434-0790
    • Year and Date
      2019-08-09
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Feature-Tracking MRI Fractal Analysis of Right Ventricular Remodeling in Adults with Congenitally Corrected Transposition of the Great Arteries2019

    • Author(s)
      Kawakubo Masateru、Nagao Michinobu、Ishizaki Umiko、Shiina Yumi、Inai Kei、Yamasaki Yuzo、Yoneyama Masami、Sakai Shuji
    • Journal Title

      Radiology: Cardiothoracic Imaging

      Volume: 1 Issue: 4 Pages: e190026-e190026

    • DOI

      10.1148/ryct.2019190026

    • NAID

      120007098323

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Precision and accuracy of T1 mapping in allograft rejection: ready for prime time?2022

    • Author(s)
      Shinichi Nunota, Michinobu Nagao, et al
    • Organizer
      ISHLT 2022, 42nd Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Detection of Quilty Lesions in Endomyocardial Biopsies of Cardiac Transplantation Patients Using Cardiac Magnetic Resonance T1 and T2 Mapping2021

    • Author(s)
      Noriko Kikucho, Michinobu Nagao, et al
    • Organizer
      Japan Circulation Society Annual Meeting 2022
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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