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Elucidation of the relationship between bacterial colonization in the lower airway and the pathogenesis of severe asthma: a longitudinal and comprehensive study

Research Project

Project/Area Number 19K08649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionKindai University (2021)
Kyoto University (2019-2020)

Principal Investigator

MATSUMOTO Hisako  近畿大学, 医学部, 教授 (60359809)

Co-Investigator(Kenkyū-buntansha) 伊藤 功朗  京都大学, 医学研究科, 准教授 (40447975)
小熊 毅  京都大学, 医学研究科, 特定助教 (50601324)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords閉塞性気道疾患 / 下気道細菌叢 / 重症喘息 / SE感作 / 喀痰症状 / microbiome / 混合性炎症 / 黄色ブドウ球菌 / 気流閉塞 / 2型炎症
Outline of Research at the Start

重症喘息の病態に真菌や細菌の下気道への定着が関与する可能性が示されつつある。本研究では、重症喘息例の下気道における細菌・真菌を検索し、微生物定着の有無と血清ペリオスチンを含めた炎症性サイトカイン・メディエーター、真菌や細菌成分への感作、免疫能や内因性ペプチドとの関係を検討する。縦走的、包括的検討により下気道の微生物が喘息の重症化に寄与する機序が明らかになれば、より良い重症喘息の管理につながると考えられる。

Outline of Final Research Achievements

The detection of Staphylococcus aureus in sputum in patients with bronchiectasis, including those with asthma complications, was associated with allergic inflammation and eosinophilic inflammation, potentially via enterotoxin sensitization. On the other hand, the distribution of allergic and eosinophilic inflammation was not identical. In cases of obstructive airway diseases, including severe asthma, high sputum occupancy of γ-Proteobacteria and Haemophilus spp. was associated with not only neutrophilic airway inflammation but also moderate eosinophilic/type 2 airway inflammation (mixed inflammation) and sputum symptoms.

Academic Significance and Societal Importance of the Research Achievements

本研究では重症喘息を含む閉塞性気道疾患例で、喀痰中Proteobacterium綱(G陰性桿菌)の検出は好中球性炎症と関係することが確認されたが、中等度までの好酸球/2型炎症も併存すること、強い好酸球性炎症例ではG陰性桿菌定着が少ないこと、喀痰症状にはG陰性桿菌と好酸球性炎症がともに寄与することを明らかにした。近年重症喘息のみならず、COPDや気管支拡張症でも末梢血好酸球数が管理指標の一つとなってきたが、本研究結果は末梢血好酸球数の解釈も含め、閉塞性気道疾患の長期管理において重要な知見になると考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (14 results)

All 2021 2020 2019

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] The importance of central airway dilatation in patients with bronchiolitis obliterans2021

    • Author(s)
      Kogo M, Matsumoto H, et al.
    • Journal Title

      ERJ Open Res

      Volume: 25 Issue: 4 Pages: 00123-2021

    • DOI

      10.1183/23120541.00123-2021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Airway clearance ameliorated the control of diffuse panbronchiolitis accompanied by asthma and leukocytoclastic vasculitis2021

    • Author(s)
      Tashima N, Matsumoto H, et al.
    • Journal Title

      Allergology International

      Volume: 70 Issue: 1 Pages: 131-133

    • DOI

      10.1016/j.alit.2020.07.003

    • NAID

      130007966794

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High serum free IL-18 is associated with decreased omalizumab efficacy: findings from a 2-year omalizumab treatment study2020

    • Author(s)
      Morimoto C, Matsumoto H, et al.
    • Journal Title

      J Asthma

      Volume: 20 Issue: 9 Pages: 1-10

    • DOI

      10.1080/02770903.2020.1766061

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of omalizumab in various allergic diseases2020

    • Author(s)
      Okayama Y, Matsumoto H, et al.
    • Journal Title

      Allergology International

      Volume: 69 Issue: 2 Pages: 167-177

    • DOI

      10.1016/j.alit.2020.01.004

    • NAID

      130007832953

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of serum periostin in the management of asthma and its comorbidities.2020

    • Author(s)
      Matsumoto H.
    • Journal Title

      Respir Investig

      Volume: 58 Issue: 3 Pages: 144-54

    • DOI

      10.1016/j.resinv.2020.02.003

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study2020

    • Author(s)
      Sunadome H, Matsumoto H, Izuhara Y, Nagasaki T, Kanemitsu Y, Ishiyama Y, Morimoto C, Oguma T, Ito I, Murase K, Muro S, Kawaguchi T, Tabara Y, Chin K, Matsuda F, Hirai T.
    • Journal Title

      Allergology International

      Volume: 69 Issue: 1 Pages: 46-52

    • DOI

      10.1016/j.alit.2019.05.012

    • NAID

      130007788689

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis.2020

    • Author(s)
      Niwamoto T, Handa T, Matsui S, Yamamoto H, Yoshifuji H, Abe H, MatsumotoH, Kodama Y, Chiba T, Seno H, Mimori T, Hirai T.
    • Journal Title

      Modern Rheumatology

      Volume: in press Issue: 1 Pages: 235-240

    • DOI

      10.1080/14397595.2019.1703522

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions2019

    • Author(s)
      Konishi S, Yano T, Tanaka H, Mizuno T, Kanoh H, Tsukita K, Namba T, Tamura A, Yonemura S, Gotoh S, Matsumoto H, Hirai T, Tsukita S.
    • Journal Title

      Life Sci Alliance

      Volume: 2 Issue: 4 Pages: e201900414-e201900414

    • DOI

      10.26508/lsa.201900414

    • NAID

      120007144472

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study.2019

    • Author(s)
      Sato R, Handa T, Matsumoto H, Kubo T, Hirai T.
    • Journal Title

      BMC Pulm Med

      Volume: 19 Issue: 1 Pages: 247-247

    • DOI

      10.1186/s12890-019-1012-6

    • NAID

      120006773960

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model.2019

    • Author(s)
      Cui S, Ito I, Nakaji H, Iwata T, Matsumoto H, Oguma T, Tajiri T, Nagasaki T, Kanemitsu Y, Izuhara H, Mishima M, Niimi A.
    • Journal Title

      Respir Physiol Neurobiol.

      Volume: 263 Pages: 1-8

    • DOI

      10.1016/j.resp.2019.02.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] COPD・ACO・喘息例における喀痰細菌叢の検討2021

    • Author(s)
      森本千絵、松本久子 他
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] COPD・ACO・喘息例における喀痰細菌叢の検討2021

    • Author(s)
      森本千絵、松本久子、他
    • Organizer
      第61回日本呼吸器学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Roles of sensitization to Staphylococcus enterotoxin in patients with bronchiectasis2020

    • Author(s)
      Morimoto C, Matsumoto H, et al.
    • Organizer
      Eur Respir Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Book] Roles of periostin in asthma. In: Kudo A, editor: Periostin2019

    • Author(s)
      Matsumoto H
    • Total Pages
      5
    • Publisher
      Springer
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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