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Identification and functional analysis of pathogenic fibroblasts in atopic dermatitis

Research Project

Project/Area Number 19K08912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54020:Connective tissue disease and allergy-related
Research InstitutionSaga University

Principal Investigator

Nunomura Satoshi  佐賀大学, 医学部, 准教授 (70424728)

Co-Investigator(Kenkyū-buntansha) 出原 賢治  佐賀大学, 医学部, 教授 (00270463)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアトピー性皮膚炎 / 線維芽細胞 / ペリオスチン / 病的線維芽細胞 / マウスモデル / 細胞外マトリクス
Outline of Research at the Start

アトピー性皮膚炎(AD)は,アレルギー性の炎症性皮膚疾患であり,強い痒みと慢性湿疹を特徴とする。本研究では,1)アトピー性皮膚炎を発症したマウスの線維芽細胞集団のプロファイリングを行い,病的線維芽細胞亜集団を特定する。2)同定した病的線維芽細胞を除去したマウスにおけるアレルギー性炎症の状態を解析する。本研究の成果により,病的線維芽細胞を標的にしたアトピー性皮膚炎の新たな治療戦略の基盤構築が期待される。

Outline of Final Research Achievements

In this study, we focused on the diversity of fibroblasts and aimed to identify pathological fibroblasts and their functions in atopic dermatitis. We found that some fibroblasts in both the experimental atopic dermatitis model using MC903 and the spontaneous atopic dermatitis model using FADS mice have a population that expresses periostin at high levels. Furthermore, we generated periostin-deficient FADS mice and performed functional analysis. Herein, we showed that periostin-deficient FADS mice exhibited reduced dermatitis and itch-scratch behavior.

Academic Significance and Societal Importance of the Research Achievements

本研究では、ペリオスチンを高発現する一部の線維芽細胞が今回アトピー性皮膚炎の病態形成にかかわる細胞であることを明らかにするとともに、皮膚炎や掻痒において重要な役割を担っていることを明らかにした.本研究の成果は、ペリオスチンあるいはペリオススチンを発現する線維芽細胞がアトピー性皮膚炎の皮膚炎やかゆみーひっかき行動の新たな治療戦略の基盤構築につながるものである.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2022 2020 2019 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Remarks (1 results)

  • [Journal Article] Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts2019

    • Author(s)
      Nunomura Satoshi、Ejiri Naoko、Kitajima Midori、Nanri Yasuhiro、Arima Kazuhiko、Mitamura Yasutaka、Yoshihara Tomohito、Fujii Kazuki、Takao Keizo、Imura Johji、Fehling Hans Joerg、Izuhara Kenji、Kitajima Isao
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 202X Issue: 6 Pages: 32926-9

    • DOI

      10.1016/j.jid.2018.10.047

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] FADSマウスを用いたアレルギー研究2022

    • Author(s)
      布村聡
    • Organizer
      第8回総合アレルギー講習会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] FADSマウス:新たなアトピー性皮膚炎マウスモデル2020

    • Author(s)
      布村聡
    • Organizer
      日本皮膚科学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] FADSマウス:アトピー性皮膚炎,ならびにアトピー性角結膜炎の新たなマウスモデル2020

    • Author(s)
      布村聡
    • Organizer
      環境医学研究所・順天堂かゆみ研究センター第6回学術シンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] アレルギー疾患の病態生理最前線-新しいモデルマウスによるアトピー性皮膚炎の病態解明2019

    • Author(s)
      布村聡
    • Organizer
      第6回総合アレルギー講習会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] The IL-13/periostin/IL-24 pathway regulates epidermal barrier function in atopic dermatitis2019

    • Author(s)
      Mitamura Y, Nunomura S, Nanri Y, Izuhara K
    • Organizer
      13th World Immune Regulation Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of facial atopic dermatitis with scratching (FADS) mice by deleting Ikk2 in dermal fibroblasts2019

    • Author(s)
      Nunomura S, Ejiri N, Kitajima M, Nanri Y, Arima K, Mitamura Y, Yoshihara T, Fujii K, Takao K, Imura J, Fehling HJ, Izuhara K, Kitajima I
    • Organizer
      EAACI Congress 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Facial Atopic Dermatitis with Scratching (FADS) mouse: A novel animal model exhibiting severe itching2019

    • Author(s)
      Nunomura S, Kitajima I, Ejiri N, Kitajima M, Nanri Y, Izuhara K
    • Organizer
      10th World Congress of Itch
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Facial Atopic Dermatitis Scratching(FADS)マウスはアトピー性皮膚炎モデルである2019

    • Author(s)
      布村聡、北島勲、江尻直子、北島緑、南里康弘、有馬和彦、三田村康貴、吉原智仁、藤井一希、高雄啓三、井村穣二、出原賢治
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Research-status Report
  • [Remarks] 研究活動ガイド

    • URL

      https://researcher.admin.saga-u.ac.jp/details/425

    • Related Report
      2020 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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