• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Indentification of abnormal neural network for the innovation of epilepsy surgery

Research Project

Project/Area Number 19K09494
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Iwasaki Masaki  国立研究開発法人国立精神・神経医療研究センター, 病院, 部長 (00420018)

Co-Investigator(Kenkyū-buntansha) 土岐 圭伊子  国立研究開発法人国立精神・神経医療研究センター, 病院 手術・中央材料部, 医師 (00831893)
飯島 圭哉  国立研究開発法人国立精神・神経医療研究センター, 病院, 医員 (10751878)
宮崎 智之  横浜市立大学, 医学部, 准教授 (30580724)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsてんかん / 脳波 / 位相解析 / 頭蓋内電極 / 転帰 / てんかん外科 / 麻酔 / てんかん性放電 / 脳波高周波振動 / 薬剤抵抗性てんかん / 外科治療
Outline of Research at the Start

本研究は、麻酔薬曝露により誘導される異常脳波の解析手法を構築し、さらにその分子基盤を解明することによって、てんかん性異常の正確な同定法を構築することを目的に行う。頭蓋内脳波を測定するてんかん患者を対象に、麻酔薬暴露下に記録された脳波を位相カップリングに基づいた解析によって評価する。それらを切除検体の分子生物学的・遺伝学的解析結果および臨床データと比較することで、てんかん外科の治療計画においててんかん性異常を短時間で正確に同定する手法を開発し、前向き試験に向けた基礎データを獲得する。

Outline of Final Research Achievements

We developed a method to diagnose the brain regions responsible for drug-resistant focal epilepsy by analyzing the EEG recorded under anesthesia during surgery. The phase-amplitude coupling between high-frequency oscillations and slow waves was found to be particularly large at the epileptogenic zone just before the maximum anesthetic concentration was reached. The analysis of the EEG phase-amplitude coupling under specific anesthetic conditions enable us to promptly diagnose the epileptogenic zone during surgery.

Academic Significance and Societal Importance of the Research Achievements

Sevoflurane暴露下の脳波モジュレーションインデックス(MI)を解析することでてんかん外科手術後の転帰を予測できる可能性や、頭蓋内電極留置の適否を判断したり、最適な留置部位の評価に応用できる可能性が示唆された。また、MIによる評価は従来の脳波判読と異なり判読者の主観が入らず、客観的かつ半自動的な解析を可能にする。本研究の成果により、てんかん外科の術前検査の効率が上がり、かつ安全性が高められると期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (13 results)

All 2022 2021 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (3 results)

  • [Int'l Joint Research] Wayne State University(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Wayne State University(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Wayne State University(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone2022

    • Author(s)
      Wada Keiko、Sonoda Masaki、Firestone Ethan、Sakakura Kazuki、Kuroda Naoto、Takayama Yutaro、Iijima Keiya、Iwasaki Masaki、Mihara Takahiro、Goto Takahisa、Asano Eishi、Miyazaki Tomoyuki
    • Journal Title

      Clinical Neurophysiology

      Volume: 134 Pages: 1-8

    • DOI

      10.1016/j.clinph.2021.11.004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Predictors of Seizure Outcome after Repeat Pediatric Epilepsy Surgery: Reasons for Failure, Sex, Electrophysiology, and Temporal Lobe Surgery2022

    • Author(s)
      IWASAKI Masaki、IIJIMA Keiya、TAKAYAMA Yutaro、KAWASHIMA Takahiro、TACHIMORI Hisateru、KIMURA Yuiko、YOKOSAKO Suguru、KOSUGI Kenzo、KANEKO Yuu
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 62 Issue: 3 Pages: 125-132

    • DOI

      10.2176/nmc.oa.2021-0315

    • NAID

      130008125856

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery2022

    • Author(s)
      Kosugi Kenzo、Iijima Keiya、Yokosako Suguru、Takayama Yutaro、Kimura Yuiko、Kaneko Yuu、Sumitomo Noriko、Saito Takashi、Nakagawa Eiji、Sato Noriko、Iwasaki Masaki
    • Journal Title

      Frontiers in Neurology

      Volume: 13 Pages: 831126-831126

    • DOI

      10.3389/fneur.2022.831126

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corpus callosotomy in pediatric patients with non-lesional epileptic encephalopathy with electrical status epilepticus during sleep2021

    • Author(s)
      Yokosako Suguru、Muraoka Norihiro、Watanabe Shiena、Kosugi Kenzo、Takayama Yutaro、Iijima Keiya、Kimura Yuiko、Kaneko Yu、Sumitomo Noriko、Saito Takashi、Nakagawa Eiji、Iwasaki Masaki
    • Journal Title

      Epilepsy & Behavior Reports

      Volume: 16 Pages: 100463-100463

    • DOI

      10.1016/j.ebr.2021.100463

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient Detection of High-frequency Biomarker Signals of Epilepsy by a Transfer-learning-based Convolutional Neural Network2021

    • Author(s)
      Takayanagi Yuki、Takayama Yutaro、Iijima Keiya、Iwasaki Masaki、Ono Yumie
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 10 Issue: 0 Pages: 158-165

    • DOI

      10.14326/abe.10.158

    • NAID

      130008132136

    • ISSN
      2187-5219
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-Institutional Experience of Chronic Intracranial Electroencephalography Based on the Combined Usage of Subdural and Depth Electrodes2021

    • Author(s)
      Takayama Yutaro、Ikegaya Naoki、Iijima Keiya、Kimura Yuiko、Yokosako Suguru、Muraoka Norihiro、Kosugi Kenzo、Kaneko Yuu、Yamamoto Tetsuya、Iwasaki Masaki
    • Journal Title

      Brain Sciences

      Volume: 11 Issue: 3 Pages: 307-307

    • DOI

      10.3390/brainsci11030307

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epilepsy surgery in children under 3 years of age: surgical and developmental outcomes2021

    • Author(s)
      Iwasaki Masaki、Iijima Keiya、Kawashima Takahiro、Tachimori Hisateru、Takayama Yutaro、Kimura Yuiko、Kaneko Yuu、Ikegaya Naoki、Sumitomo Noriko、Saito Takashi、Nakagawa Eiji、Takahashi Akio、Sugai Kenji、Otsuki Taisuke
    • Journal Title

      Journal of Neurosurgery: Pediatrics

      Volume: 28 Issue: 4 Pages: 395-403

    • DOI

      10.3171/2021.4.peds21123

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳波ガンマエントロピー解析とFDG-PETを用いた脳梁離断術後の二期的根治術における発作転帰の予測2021

    • Author(s)
      小杉健三、飯島圭哉、横佐古卓、高山裕太郎、木村唯子、金子裕、岩崎真樹
    • Organizer
      第54回日本てんかん学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] EIEEで発症したてんかんに対する外科治療:早期手術の是非2021

    • Author(s)
      岩崎真樹、住友典子、飯島圭哉、高山裕太郎、木村唯子、金子裕、齋藤貴志、中川栄二
    • Organizer
      第54回日本てんかん学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 硬膜下・深部電極を併用した頭蓋内電極留置術の有効性と限界2021

    • Author(s)
      高山裕太郎、池谷直樹、飯島圭哉、木村唯子、横佐古卓、小杉健三、金子裕、岩崎真樹
    • Organizer
      第44回日本てんかん外科学会
    • Related Report
      2021 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi