• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of animal model of heterotopic ossification and its application to control of ossification

Research Project

Project/Area Number 19K09570
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Yoshii Toshitaka  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50583754)

Co-Investigator(Kenkyū-buntansha) 大川 淳  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507)
湯浅 将人  東京医科歯科大学, 医学部附属病院, 非常勤講師 (80808254)
平井 高志  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (40510350)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords異所性骨化 / 骨化モデル
Outline of Research at the Start

異所性骨化は外傷、熱傷、神経損傷などを契機におこり、重度のADL制限の原因となる。また進行性骨化性線維異形成症、脊柱靱帯骨化症は、遺伝的要素と外傷が異所性骨化に関与し、全身骨化や四肢麻痺をひきおこす重篤な疾患である。本研究では、線溶系酵素プラスミンのノックアウトマウス、プラスミノーゲンアンチセンスオリゴヌクレオチド投与、重度熱傷等の手法を用い、異所性骨化、靱帯骨化動物モデルを確立し、その骨化成長に対する制御方法を開発する。異所性骨化モデルの確立は関連疾患の様々な研究に役立ち、実臨床に近いモデル動物の骨化を制御できれば、治療法のない異所性骨化、靭帯骨化に対する革新的な治療法の開発に繋がる。

Outline of Final Research Achievements

The main objective of this study is to clarify the pathogenesis of heterotopic ossification. Heterotopic calcification and ossification were observed after muscle injury in ABCC6 mutant mice, which are thought to be the causative gene of Pseudoxanthoma Elasticum. Similarly, heteroopic calcification was observed in plasminogen KO mice, a fibrinolytic enzyme, suggesting that multiple factors with different mechanisms are involved in ectopic ossification. In addition, when ectopic ossification was induced in chondrocyte reporter mice, the ossification mechanism was found to be endochondral ossification.

Academic Significance and Societal Importance of the Research Achievements

異所性石灰化・骨化疾患は骨化性筋炎やアジア人に多い脊柱靱帯骨化症(後縦靱帯骨化症、黄色靱帯骨化症、びまん性特発性骨増殖症など)、延いては動脈硬化などQOLや生命予後に大きく関与する疾患を含んでいる。本研究はその病態に関する新たな知見を見出したことにより、そのいずれかの段階でブロックすることができれば、異所性骨化性疾患の予防薬を創出しうると考える。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (55 results)

All 2022 2021 2020 2019

All Journal Article (34 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 2 results) Presentation (18 results) (of which Int'l Joint Research: 7 results,  Invited: 7 results) Book (3 results)

  • [Journal Article] Determining the pharmacologic window of bisphosphonates that mitigates severe injury-induced osteoporosis and muscle calcification, while preserving fracture repair.2022

    • Author(s)
      Saito M, Moore-Lotridge SN, Uppuganti S, Egawa S, Yoshii T, Robinette JP, Posey SL, Gibson BHY, Cole HA, Hawley GD, Guelcher SA, Tanner SB, McCarthy JR, Nyman JS, Schoenecker JG.
    • Journal Title

      Osteoporos Int.

      Volume: 33 Issue: 4 Pages: 807-820

    • DOI

      10.1007/s00198-021-06208-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neurological improvement is associated with neck pain attenuation after surgery for cervical ossification of the posterior longitudinal ligament.2021

    • Author(s)
      Koda M,Yoshii T,Egawa S,Sakai K,Kusano K,Nakagawa Y,Hirai T,Wada K,Katsumi K,Kimura A,Furuya T,Maki S,Nagoshi N,Watanabe K,Kanchiku T,Nagamoto Y,Oshima Y,Ando K,Nakashima H,Takahata M,Mori K,Nakajima H,Murata K,Matsunaga S,Kaito T,Yamada K,Kobayashi S,Kato S,Ohba T,Inami S,Fujibayashi S,Katoh H,Kanno H,Takahashi H.
    • Journal Title

      Sci Rep.

      Volume: 11 Issue: 1 Pages: 11910-11910

    • DOI

      10.1038/s41598-021-91268-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perioperative Complications in Posterior Surgeries for Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Nationwide Investigation.2021

    • Author(s)
      Yoshii T, Egawa S,Sakai K,Kusano K,Nakagawa Y,Hirai T,Wada K,Katsumi K,Fujii K,Kimura A,Furuya T,Nagoshi N,Kanchiku T,Nagamoto Y,Oshima Y,Ando K,Takahata M,Mori K,Nakajima H,Murata K,Matsunaga S,Kaito T,Yamada K,Kobayashi S,Kato S,Ohba T,Inami S,Fujibayashi S,Katoh H,Kanno H,Imagama S,Koda M,Kawaguchi Y,Takeshita K,
    • Journal Title

      Clin Spine Surg.

      Volume: 34 Issue: 10 Pages: E594-E600

    • DOI

      10.1097/bsd.0000000000001243

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyapatite/collagen composite graft for posterior lumbar interbody fusion: a comparison with local bone graft.2021

    • Author(s)
      Yoshii T, Hashimoto M, Egawa S, Hirai T, Inose H, Okawa A.
    • Journal Title

      J Orthop Surg Res.

      Volume: 16 Issue: 1 Pages: 639-639

    • DOI

      10.1186/s13018-021-02798-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Lateral Lumbar Interbody Fusion and Posterior Lumbar Interbody Fusion as Corrective Surgery for Patients with Adult Spinal Deformity-A Propensity Score Matching Analysis.2021

    • Author(s)
      Matsukura Y, Yoshii T, Morishita S, Sakai K, Hirai T, Yuasa M, Inose H, Kawabata A, Utagawa K, Hashimoto J, Tomori M, Torigoe I, Yamada T, Kusano K, Otani K, Sumiya S, Numano F, Fukushima K, Tomizawa S, Egawa S, Arai Y, Shindo S, Okawa A.
    • Journal Title

      J Clin Med.

      Volume: 10 Issue: 20 Pages: 4737-4737

    • DOI

      10.3390/jcm10204737

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors Significantly Associated with Postoperative Neck Pain Deterioration after Surgery for Cervical Ossification of the Posterior Longitudinal Ligament: Study of a Cohort Using a Prospective Registry.2021

    • Author(s)
      Koda M,Yoshii T,Egawa S,Sakai K,Kusano K,Nakagawa Y,Hirai T,Wada K,Katsumi K,Kimura A,Furuya T,Maki S,Nagoshi N,Watanabe K, Kanchiku T,Nagamoto Y,Oshima Y,Ando K,Nakashima H,Takahata M,Mori K,Nakajima H,Murata K,Matsunaga S,Kaito T,Yamada K,Kobayashi S,Kato S,Ohba T,Inami S,Fujibayashi S,Katoh H,Kanno H,Takahashi H,
    • Journal Title

      J Clin Med.

      Volume: 10 Issue: 21 Pages: 5026-5026

    • DOI

      10.3390/jcm10215026

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior Cervical Corpectomy with Fusion versus Anterior Hybrid Fusion Surgery for Patients with Severe Ossification of the Posterior Longitudinal Ligament Involving Three or More Levels: A Retrospective Comparative Study.2021

    • Author(s)
      Hirai T, Yoshii T, Sakai K, Inose H, Yuasa M, Yamada T, Matsukura Y, Ushio S, Morishita S, Egawa S, Onuma H, Kobayashi Y, Utagawa K, Hashimoto J, Kawabata A, Tanaka T, Motoyoshi T, Takahashi T, Hashimoto M, Sakaeda K, Kato T, Arai Y, Kawabata S, Okawa A.
    • Journal Title

      J Clin Med.

      Volume: 10 Issue: 22 Pages: 5315-5315

    • DOI

      10.3390/jcm10225315

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective Investigation of Postoperative Complications in Anterior Decompression with Fusion for Severe Cervical Ossification of the Posterior Longitudinal Ligament: A Multi-institutional Study.2021

    • Author(s)
      Egawa S, Yoshii T, Sakai K, Kusano K, Nakagawa Y, Hirai T, Kimura A, Furuya T, Kanchiku T, Nagamoto Y, Takahata M, Mori K, Katoh H, Nagoshi N, Imagama S, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A.
    • Journal Title

      Spine (Phila Pa 1976)

      Volume: 46 Issue: 23 Pages: 1621-1629

    • DOI

      10.1097/brs.0000000000004088

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Surgical Outcomes After Open- and Double-Door Laminoplasties for Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study.2021

    • Author(s)
      Nagoshi N,Yoshii T,Egawa S,Sakai K,Kusano K,Nakagawa Y,Hirai T,Wada K,Katsumi K,Fujii K,Kimura A,Furuya T,Kanchiku T, Nagamoto Y,Oshima Y,Nakashima H,Ando K,Takahata M,Mori K,Nakajima H,Murata K,Matsunaga S,Kaito T,Yamada K,Kobayashi S, Kato S,Ohba T,Inami S,Fujibayashi S,Katoh H,Kanno H,Watanabe K,Imagama S,Koda M,
    • Journal Title

      Spine (Phila Pa 1976)

      Volume: 46 Issue: 23 Pages: E1238-E1245

    • DOI

      10.1097/brs.0000000000004094

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severity of Myelopathy is Closely Associated With Advanced Age and Signal Intensity Change in Cervical Ossification of the Posterior Longitudinal Ligament2021

    • Author(s)
      Hirai T., Yoshii T., Egawa S., Sakai K., Kusano K., Nakagawa Y., … Okawa A
    • Journal Title

      Clinical Spine Surgery: A Spine Publication

      Volume: Publish Ahead of Print Issue: 1 Pages: 1-11

    • DOI

      10.1097/bsd.0000000000001164

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Response to 'Laminectomy is preferred for cervical myelopathy, but laminoplasty may yield better outcomes, including reduced C5 nerve palsy'.2021

    • Author(s)
      Yoshii T,Egawa S, Chikuda H, Furuya T,Watanabe M et al
    • Journal Title

      J Orthop Sci

      Volume: - Issue: 2 Pages: 320-321

    • DOI

      10.1016/j.jos.2020.12.003

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical Outcomes in Selective Laminectomy and Conventional Double-Door Laminoplasty for Cervical Spondylotic Myelopathy.2020

    • Author(s)
      Yoshii T,Tomizawa S,Hirai T,Inose H,Yamada T,Egawa S,Kawabata S,Okawa A et al
    • Journal Title

      Orthopedics

      Volume: 43(4) Issue: 4

    • DOI

      10.3928/01477447-20200521-06

    • Related Report
      2020 Research-status Report
  • [Journal Article] Comparison of anterior decompression with fusion and posterior decompression with fusion for cervical spondylotic myelopathy?A systematic review and meta-analysis2020

    • Author(s)
      Yoshii Toshitaka、Egawa Satroru、Chikuda Hirotaka、Wakao Norimitsu、Furuya Takeo、Kanchiku Tsukasa、Nagoshi Narihito、Fujiwara Yasushi、Yoshida Masahiro、Taguchi Toshihiko、Watanabe Masahiko
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 20 Issue: 6 Pages: 0949-54

    • DOI

      10.1016/j.jos.2019.12.010

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of Perioperative Complications Between Anterior Fusion and Posterior Fusion for Osteoporotic Vertebral Fractures in Elderly Patients: Propensity Score-Matching Analysis Using Nationwide Inpatient Database.2020

    • Author(s)
      Morishita S,Yoshii T,Okawa A,Inose H,Hirai T,Takahisda O,Fushimi T,Fujiwara T
    • Journal Title

      Clin Spine Surg

      Volume: 33(10) Issue: 10 Pages: E586-E592

    • DOI

      10.1097/bsd.0000000000000992

    • Related Report
      2020 Research-status Report
  • [Journal Article] Risk factors related to perioperative systemic complications and mortality in elderly patients with osteoporotic vertebral fractures-analysis of a large national inpatient database.2020

    • Author(s)
      Morisita S, Yoshii T, Okawa A,Inose H, HIrai T,Yuasa M,Fushimi K,Fujiwara T
    • Journal Title

      J Orthop Surg Res

      Volume: 15(1) Issue: 1 Pages: 518-518

    • DOI

      10.1186/s13018-020-02050-5

    • Related Report
      2020 Research-status Report
  • [Journal Article] Identification of Predictive Factors for Mechanical Complications After Adult Spinal Deformity Surgery: A Multi-Institutional Retrospective Study.2020

    • Author(s)
      Kawabata A, Yoshii T, Sakai K, Hirai T, Yuasa M, Inose H, Utagawa K, Hashimoto J, Matsukura Y, Tomori M, Torigoe I, Kusano K, Otani K, Mizuno K, Satoshi S, Kazuyuki F, Tomizawa S, Arai Y, Shindo S, Okawa A
    • Journal Title

      Spine (Phila Pa 1976)

      Volume: 45(17) Issue: 17 Pages: 1185-1192

    • DOI

      10.1097/brs.0000000000003500

    • Related Report
      2020 Research-status Report
  • [Journal Article] Effect of bisphosphonates or teriparatide on mechanical complications after posterior instrumented fusion for osteoporotic vertebral fracture: a multi-center retrospective study.2020

    • Author(s)
      Kawabata A,Yoshii T, HIrai T, Ushio S et al
    • Journal Title

      BMC Musculoskelet Disord

      Volume: 21(1) Issue: 1 Pages: 420-420

    • DOI

      10.1186/s12891-020-03452-6

    • Related Report
      2020 Research-status Report
  • [Journal Article] Comparison of Perioperative Complications in Anterior Decompression with Fusion and Posterior Decompression with Fusion for Cervical Ossification of the Posterior Longitudinal Ligament: Propensity Score Matching Analysis Using a Nation-Wide Inpatient Database.2020

    • Author(s)
      Yoshii T, Morishita S, Inose H, Yuasa M, Hirai T, Okawa A, Fushimi K, Fujiwara T.
    • Journal Title

      Spine

      Volume: 45(16) Issue: 16 Pages: E1006-E1012

    • DOI

      10.1097/brs.0000000000003469

    • Related Report
      2020 Research-status Report
  • [Journal Article] Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study2020

    • Author(s)
      Hirai T., Yoshii T., Ushio S., Hashimoto J., Mori K, Maki S.,… Kawaguchi Y.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 12 Pages: 4055-4055

    • DOI

      10.3390/jcm9124055

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 頸椎後縦靱帯骨化症に対する前方・後方除圧固定術における手術成績と片側上肢麻痺 AMED多施設前向き調査2020

    • Author(s)
      吉井 俊貴, 江川 聡, 坂井 顕一郎, 草野 和生, 中川 幸洋, 勝見 敬一, 國府田 正雄, 和田 簡一郎, 古矢 丈雄, 松山 幸弘, 竹下 克志, 川口 善治, 今釜 史郎, 松本 守雄, 大川 淳, 山崎 正志.
    • Journal Title

      Journal of Spine Research

      Volume: 11(3) Pages: 669-669

    • Related Report
      2020 Research-status Report
  • [Journal Article] 治療法の再整理とアップデートのために 専門家による私の治療 頸椎後縦靱帯骨化症2020

    • Author(s)
      吉井 俊貴
    • Journal Title

      日本医事新報

      Volume: 5041号 Pages: 46-47

    • Related Report
      2020 Research-status Report
  • [Journal Article] 若手医師のための経験すべき"領域別"手術講座(PART 1) 頸椎前方固定術(OPLL) アプローチと除圧の極意2020

    • Author(s)
      吉井 俊貴
    • Journal Title

      整形外科Surgical Technique

      Volume: 10(5) Pages: 570-577

    • Related Report
      2020 Research-status Report
  • [Journal Article] 【脊椎脊髄疾患に対する分類・評価法】(第1章)頸椎 頸椎後縦靱帯骨化症の形態分類2020

    • Author(s)
      吉井 俊貴
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 33(4) Pages: 285-289

    • Related Report
      2020 Research-status Report
  • [Journal Article] A Comparison of Cervical and Thoracolumbar Fractures Associated with Diffuse Idiopathic Skeletal Hyperostosis-A Nationwide Multicenter Study.2020

    • Author(s)
      Hiroyuki Katoh, Eijiro Okada, Toshitaka Yoshii, et al
    • Journal Title

      J Clin Med

      Volume: 9(1) Issue: 1 Pages: 208-208

    • DOI

      10.3390/jcm9010208

    • Related Report
      2019 Research-status Report
  • [Journal Article] The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice.2020

    • Author(s)
      Mieradili Mulati,Toshitaka Yoshii, Atsushi Okawa, Hiroyuki Inose
    • Journal Title

      Bone

      Volume: 130 Pages: 115076-115076

    • DOI

      10.1016/j.bone.2019.115076

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk Factors of Nonunion After Acute Osteoporotic Vertebral Fractures: A Prospective Multicenter Cohort Study.2020

    • Author(s)
      Hiroyuki Inose, Toshitaka Yoshii, Atsushi Okawa et al
    • Journal Title

      Spine

      Volume: - Issue: 13 Pages: 895-902

    • DOI

      10.1097/brs.0000000000003413

    • Related Report
      2019 Research-status Report
  • [Journal Article] Outcomes of Surgery for Thoracic Myelopathy Owing to Thoracic Ossification of The Ligamentum Flavum in a Nationwide Multicenter Prospectively Collected Study in 223 Patients: Is Instrumented Fusion Necessary?2020

    • Author(s)
      Kei Ando, Shiro Imagama,Toshitaka Yoshii, et al
    • Journal Title

      Spine(Phila Pa1976)

      Volume: 45(3) Issue: 3 Pages: E170-E178

    • DOI

      10.1097/brs.0000000000003208

    • Related Report
      2019 Research-status Report
  • [Journal Article] Efficacy of Antibiotic-Loaded Hydroxyapatite/Collagen Composites Is Dependent on Adsorbability for Treating Staphylococcus aureus Osteomyelitis in Rats.2019

    • Author(s)
      Satoru Egawa, Toshitaka Yoshii, Shinichi Sotome
    • Journal Title

      J. Orthop. Res.

      Volume: 38(4) Issue: 4 Pages: 843-851

    • DOI

      10.1002/jor.24507

    • Related Report
      2020 Research-status Report 2019 Research-status Report
  • [Journal Article] Spinal fractures in patients with Diffuse idiopathic skeletal hyperostosis:A nationwide multi-institution survey.2019

    • Author(s)
      Eijiro Okada, Toshitaka Yoshii, Tsuyoshi Yamada, , Atsushi Okawa, Morio Matsumoto, Kota Watanabe et al
    • Journal Title

      J Orthop Sci

      Volume: 24(4) Issue: 4 Pages: 601-606

    • DOI

      10.1016/j.jos.2018.12.017

    • Related Report
      2019 Research-status Report
  • [Journal Article] Comparison of Perioperative Complications Between Anterior Decompression With Fusion and Laminoplasty For Cervical Spondylotic Myelopathy: Propensity Score-matching Analysis Using Japanese Diagnosis Procedure Combination Database.2019

    • Author(s)
      Shingo Morishita, Toshitaka Yoshii, Atsushi Okawa, Kiyohide Fushimi, Takeo Fujiwara
    • Journal Title

      Clin Spine Surg

      Volume: 33(3) Issue: 3 Pages: E101-E107

    • DOI

      10.1097/bsd.0000000000000864

    • Related Report
      2019 Research-status Report
  • [Journal Article] The Size of Intramedullary Fixation Affects Endochondral-Mediated Angiogenesis During Fracture Repair.2019

    • Author(s)
      Masato Yuasa, Masanori Saito, Deke M Blum, Alexander A Hysong, Satoru Egawa, Sasidhar Uppuganti, Toshitaka Yoshii, Atsushi Okawa, Herbert S Schwartz, Stephanie N Moore-Lotridge, Jeffry S Nyman, Jonathan G Schoenecker
    • Journal Title

      J Orthop Trauma

      Volume: 33(19) Issue: 10 Pages: e385-e393

    • DOI

      10.1097/bot.0000000000001555

    • Related Report
      2019 Research-status Report
  • [Journal Article] The characteristics of the patients with radiologically severe cervical ossification of the posterior longitudinal ligament of the spine: A CT-based multicenter cross-sectional study.2019

    • Author(s)
      Kanji Mori,Toshitaka Yoshii, Yoshiharu Kawaguchi et al
    • Journal Title

      J Orthop Sci

      Volume: 19 Issue: 5 Pages: 30313-6

    • DOI

      10.1016/j.jos.2019.09.018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of Surgical Treatment for Degenerative Cervical Myelopathy in Preventing Falls and Fall-Related Neurological Deterioration: A Prospective Multi-Institutional Study.2019

    • Author(s)
      Atsushi Kimura, Katsushi Takeshita, Yasuyuki,Toshitaka Yoshii, et al
    • Journal Title

      Spine

      Volume: - Issue: 11 Pages: E631-E638

    • DOI

      10.1097/brs.0000000000003355

    • Related Report
      2019 Research-status Report
  • [Journal Article] 【頸椎前方手術Up To Date 2】頸椎OPLLに対する骨化浮上術 術式の詳細と手術のコツ2019

    • Author(s)
      吉井 俊貴, 大川 淳
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 32(8) Pages: 735-741

    • Related Report
      2019 Research-status Report
  • [Presentation] 脊椎手術難症例の出血コントロール―当科の工夫ー2021

    • Author(s)
      吉井 俊貴
    • Organizer
      第50回日本脊椎脊髄病学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Cervical ossification of the posterior longitudinal ligament: Epidemiology, treatment2021

    • Author(s)
      Toshitaka Yoshii
    • Organizer
      94th Annual Meeting of the Japanese Orthopaedic Association
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anterior solution for complex and longer continuous OPLL of cervical spine2021

    • Author(s)
      Toshitaka Yoshii
    • Organizer
      APSS-APPOS 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Surgical approach of OPLL, anterior, posterior, combined2021

    • Author(s)
      Toshitaka Yoshii
    • Organizer
      1st Annual Meeting of Cervical Spine Research Committee affiliated with Korean Society of Spine Surgery
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 頚椎後縦靱帯骨化症に対する前方固定術、椎弓形成術の 多施設前向き調査 ‐傾向スコアmatchingによる検討-2021

    • Author(s)
      吉井 俊貴
    • Organizer
      第30回 日本脊椎インストゥルメンテーション学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 理想的な頚椎OPLLの治療を模索する「頚椎後縦靭帯骨化症(OPLL)に対する最良の治療選択2021

    • Author(s)
      吉井 俊貴
    • Organizer
      第11回 最小侵襲脊椎治療学会Mist学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] POSTERIOR APPROACH「Essentially Step To Avoid Complication For Cervical Pedicle Screws」2021

    • Author(s)
      Toshitaka Yoshii
    • Organizer
      CSRS Asia Pacific 2nd Virtual Instructional Course
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ANTERIOR APPROACH「Avoidance of Dysphagia」2021

    • Author(s)
      Toshitaka Yoshii
    • Organizer
      CSRS Asia Pacific 2nd Virtual Instructional Course
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 頸椎後縦靱帯骨化症に対する手術治療における周術期神経合併症と危険因子AMED・厚労科研研究班多施設前向き調査2020

    • Author(s)
      吉井 俊貴, 江川 聡, 坂井 顕一郎, 勝見 敬一, 中川 幸洋, 和田 簡一郎, 竹下 克志, 川口 善治, 今釜 史郎, 松本 守雄, 大川 淳, 山崎 正志
    • Organizer
      第 93 回 日本整形外科学会学術総会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢者骨粗鬆症性 椎体骨折における周術期全身合併症および死亡に関連する因子の検討 全国規模入院データベースを用いた解析2020

    • Author(s)
      森下 真伍, 吉井 俊貴, 大川 淳, 猪瀬 弘之, 平井 高志, 伏見 清秀, 藤原 武男
    • Organizer
      第 49 回 日本脊椎脊髄病学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頚椎後縦靱帯骨化症に対する前方・後方除圧固定術における手術成績と片側上肢麻痺,AMED多施設前向き調査2020

    • Author(s)
      吉井 俊貴, 江川 聡, 坂井 顕一郎, 草野 和生, 中川 幸洋, 勝見 敬一, 國府田 正雄, 和田 簡一郎, 古矢 丈雄, 松山 幸弘, 竹下 克志, 川口 善治, 今釜 史郎, 松本 守雄, 大川 淳, 山崎 正志,
    • Organizer
      第 49 回 日本脊椎脊髄病学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頚椎後縦靱帯骨化症に対する手術治療における周術期神経合併症と危険因子 厚労科研研究班 多施設前向き調査2020

    • Author(s)
      吉井 俊貴, 江川 聡, 坂井 顕一郎, 草野 和生, 中川 幸洋, 勝見 敬一, 國府田 正雄, 和田 簡一郎, 古矢 丈雄, 松山 幸弘, 竹下 克志, 川口 善治, 今釜 史郎, 松本 守雄, 大川 淳, 山崎 正志
    • Organizer
      第29回日本脊椎インストゥルメンテーション学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 硬膜瘻孔を伴うヘモジデリン沈着症に対するMRI balanced sequence法を使用した瘻孔部位同定2020

    • Author(s)
      吉井 俊貴, 平井 高志, 湯浅 将人, 小沼 博明, 猪瀬 弘之, 大川 淳
    • Organizer
      第 49 回 日本脊椎脊髄病学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 頸椎後縦靱帯骨化症に対する前方除圧固定術と後方除圧固定術の周術期合併症 DPCデータベースを用いたpropensity score matching analysis 1708例の検討2019

    • Author(s)
      4.吉井 俊貴, 森下 真伍, 湯浅 将人, 平井 高志, 猪瀬 弘之, 大川 淳
    • Organizer
      第48回 日本脊椎脊髄病学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 11.頸椎後縦靱帯骨化症手術症例の多施設前向き調査 AMED・厚労科研研究班 手術データベースの検討2019

    • Author(s)
      10.吉井 俊貴, 江川 聡, 坂井 顕一郎, 草野 和生, 中川 幸洋, 勝見 敬一, 國府田 正雄, 和田 簡一郎, 古矢 丈雄, 木村 敦, 今釜 史郎, 川口 善治, 竹下 克志, 松本 守雄, 大川 淳, 山崎 正志, AMED・厚労科研脊柱靱帯骨化症多施設研究ワーキンググループ
    • Organizer
      第48回 日本脊椎脊髄病学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脊椎脊髄疾患診療における費用対効果について 頸椎OPLLに対する手術治療 術式別の手術成績と費用対効果2019

    • Author(s)
      吉井 俊貴, 大川 淳
    • Organizer
      第92回 日本整形外科学会学術総会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 靱帯骨化症の治療 最近の取り組み2019

    • Author(s)
      吉井俊貴
    • Organizer
      東京都脊柱靱帯骨化症患者会 医療講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] 頚椎後縦靱帯骨化症に対する前方除圧固定術と後方除圧固定術の周術期合併症DPCデータベースを用いた1708例の検討2019

    • Author(s)
      吉井 俊貴, 森下 真伍, 藤原 武男, 大川 淳
    • Organizer
      第28回 日本脊椎インストゥルメンテーション学会
    • Related Report
      2019 Research-status Report
  • [Book] 最新主要文献とガイドラインでみる 整形外科学レビュー 2021-’222021

    • Author(s)
      松本守雄
    • Total Pages
      296
    • Publisher
      総合医学社
    • ISBN
      9784883787340
    • Related Report
      2021 Annual Research Report
  • [Book] 整形外科(Vol.72 No.3)2021年3月号2021

    • Author(s)
      吉井 俊貴 他
    • Total Pages
      100
    • Publisher
      南江堂
    • Related Report
      2021 Annual Research Report
  • [Book] Ossification of the Posterior Longitudinal Ligament (Third Edition)2020

    • Author(s)
      Toshitaka Yoshii
    • Total Pages
      6
    • Publisher
      Springer
    • ISBN
      9789811538544
    • Related Report
      2020 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi