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Optimization of retinal prosthetic stimulation by artificial intelligence

Research Project

Project/Area Number 19K09949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionOsaka University

Principal Investigator

Miyoshi Tomomitsu  大阪大学, 大学院医学系研究科, 助教 (70314309)

Co-Investigator(Kenkyū-buntansha) 内藤 智之  大阪大学, 大学院医学系研究科, 准教授 (90403188)
森本 壮  大阪大学, 大学院医学系研究科, 寄附講座准教授 (00530198)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords人工網膜 / 電気刺激 / 誘発反応 / 機械学習 / 電気生理 / 閾値 / 外側膝状体 / 人工知能 / 皮質電位
Outline of Research at the Start

人工網膜において網膜を電気的に刺激するパラメータは、カメラで捉えた外界の画像の輝度情報を刺激パルスに単純に変換して作られることが普通であるが、現実に得られる感覚からみるとこれだけでは不十分である。本研究では、我々が提唱した脈絡膜上-経網膜刺激方式の人工網膜について、網膜の多点電極からの刺激によって生じる皮質脳波の多点記録データを人工知能の手法を用いて解析し、より自然刺激の結果に近い感覚を引き起こす最適な刺激パラメータを検討することを目的とする。

Outline of Final Research Achievements

We attempted to evaluate the evoked response in the brain caused by stimulation from the artificial retina of the STS type by using machine learning. By training a recurrent neural network, it was possible to estimate which stimulating electrode in the retina was stimulated, and it was thought that the characteristics of the stimulation could be evaluated using the estimation rate as an index. In the single neuron recording, there was variation in the strength of the response even under the same stimulation conditions, but this was not due to factors such as whether the stimulated site was cell body or axon, as is the case in other stimulation methods. On the other hand, Off-centered cells were found to be excited at a lower threshold than On-centered cells.

Academic Significance and Societal Importance of the Research Achievements

視細胞の変性疾患に対して残存細胞を電気刺激する人工網膜による視機能は、健常人の視覚よりもはるかに分解能が低く、より優れた刺激を開発する必要がある。本研究では誘発反応を使って網膜刺激を定量的に評価する方法を確立した。動物実験の結果ではあるが、将来、人工網膜を埋植した人においても、脳から誘発反応などを非侵襲的に記録し同様の方法を用いることで、刺激パターンを最適化することが原理的に可能であり、QOLの向上に資することが期待される。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (7 results)

All 2022 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Ragner Granit, Haldan Keffer Hartline, George Wald(1967)視細胞,視神経の感覚生理学2022

    • Author(s)
      三好智満
    • Journal Title

      Clinical Neuroscience

      Volume: 40 Pages: 969-972

    • Related Report
      2022 Annual Research Report
  • [Journal Article] CURRENT STATUS AND PROSPECTS OF RETINAL PROSTHESIS2021

    • Author(s)
      三好 智満、不二門 尚
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 26 Issue: 4 Pages: 97-102

    • DOI

      10.20718/jjpa.26.4_97

    • NAID

      130008120328

    • ISSN
      1342-3215, 2432-0986
    • Year and Date
      2021-11-25
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatial Resolution of Suprachoroidal?Transretinal Stimulation Estimated by Recording Single-Unit Activity From the Cat Lateral Geniculate Nucleus2021

    • Author(s)
      Miyoshi Tomomitsu、Morimoto Takeshi、Sawai Hajime、Fujikado Takashi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 15 Pages: 717429-717429

    • DOI

      10.3389/fnins.2021.717429

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Single unit responses by prosthetic retinal stimulation: interaction of two consecutive stimulation2021

    • Author(s)
      Miyoshi Tomomitsu, Morimoto Takeshi, Fujikado Takashi
    • Organizer
      日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Analysis of single unit responses by prosthetic retinal stimulation2021

    • Author(s)
      Miyoshi T, Morimoto T, Fujikado T
    • Organizer
      第98回日本生理学会大会(日本解剖学会合同大会)
    • Related Report
      2020 Research-status Report
  • [Presentation] Estimation of prosthetic retinal stimulating electrode from cortical response by machine learning2020

    • Author(s)
      Miyoshi T, Naito T, Hashizume K, Imai R, Morimoto T, Fujikado T
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Estimation of stimulating electrodes in retinal prosthesis by recurrent neural network2020

    • Author(s)
      Miyoshi T, Naito T, Imai R, Morimoto T, Fujikado T
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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