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Influence of glaucoma on circadian disruption

Research Project

Project/Area Number 19K09956
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionNara Medical University

Principal Investigator

Yoshikawa Tadanobu  奈良県立医科大学, 医学部附属病院, 研究員 (20632764)

Co-Investigator(Kenkyū-buntansha) 大林 賢史  奈良県立医科大学, 医学部, 特任准教授 (30596656)
宮田 季美恵  奈良県立医科大学, 医学部, 助教 (40596748)
緒方 奈保子  奈良県立医科大学, 医学部, 教授 (60204062)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords緑内障 / 生体リズム / 内因性光感受性網膜神経節細胞 / 概日リズム / サーカディアンリズム / メラトニン / 血圧 / 眼圧
Outline of Research at the Start

本研究は緑内障群200名と健常群700名を対象とした横断研究で、緑内障がうつ症状・睡眠障害・認知機能障害や生体リズム指標と関連しているのか、また非視覚的光感受性や緑内障重症度が眼圧・血圧変動と関連しているのか明らかにする。

Outline of Final Research Achievements

Intrinsically photosensitive retinal ganglion cells play important role for regulation of circadian rhythms in the suprachiasmatic nucleus, also known as the circadian master clock. Several experimental and clinical studies have revealed impaired ipRGC structure and function in patients with glaucoma. However, the association between glaucoma and the disruption of circadian rhythms remains to be elucidated.
In 2017, we began the LIGHT study, a hospital-based cohort study of the association between glaucoma and circadian rhythms, to determine whether ipRGC death caused by glaucoma led to circadian rhythm disruption and whether circadian rhythm disruption was involved in glaucoma progression. Cross-sectional analysis of the LIGHT study showed the association of glaucoma with circadian rhythm-related factors, such as nighttime blood pressure, melatonin, asymmetric dimethylarginine, and cognitive function.

Academic Significance and Societal Importance of the Research Achievements

緑内障が視野障害に代表される視機能障害だけでなく、生体リズムの乱れと関連していることを臨床研究で明らかに出来た。この知見は緑内障という眼疾患が全身の様々な疾病発症に影響している可能性を示唆する点で学術的に重要である。また緑内障治療が生活の質や全身の疾病発症の予防につながる可能性を示唆する研究結果であり社会的な影響は大きいと考えられる。本研究成果は今後「緑内障が関与する眼外因子探索」を行う上で基礎的な資料となり得る。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (24 results)

All 2022 2021 2020 2019 2018

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results) Presentation (15 results) (of which Invited: 8 results)

  • [Journal Article] Association Between Postillumination Pupil Response and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study2022

    • Author(s)
      Yoshikawa Tadanobu、Obayashi Kenji、Miyata Kimie、Saeki Keigo、Ogata Nahoko
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 63 Issue: 3 Pages: 24-24

    • DOI

      10.1167/iovs.63.3.24

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between the Asymmetric Dimethylarginine Levels and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study2021

    • Author(s)
      Yoshikawa Tadanobu、Obayashi Kenji、Miyata Kimie、Saeki Keigo、Ogata Nahoko
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 62 Issue: 4 Pages: 7-7

    • DOI

      10.1167/iovs.62.4.7

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lower Cognitive Function in Patients With Functionally and Structurally Severe Glaucoma: The LIGHT Study2021

    • Author(s)
      Yoshikawa Tadanobu、Obayashi Kenji、Miyata Kimie、Saeki Keigo、Ogata Nahoko
    • Journal Title

      Journal of Glaucoma

      Volume: 30 Issue: 10 Pages: 882-886

    • DOI

      10.1097/ijg.0000000000001923

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of visual impairment on mobility functions in elderly: Results of Fujiwara-kyo Eye Study2021

    • Author(s)
      Miyata Kimie、Yoshikawa Tadanobu、Harano Akihiro、Ueda Tetsuo、Ogata Nahoko
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 1 Pages: e0244997-e0244997

    • DOI

      10.1371/journal.pone.0244997

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased melatonin secretion in patients with glaucoma: quantitative association with glaucoma severity in the LIGHT study2020

    • Author(s)
      Yoshikawa Tadanobu、Obayashi Kenji、Miyata Kimie、Saeki Keigo、Ogata Nahoko
    • Journal Title

      Journal of Pineal Research

      Volume: in press Issue: 2

    • DOI

      10.1111/jpi.12662

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Cataract Surgery on Melatonin Secretion in Adults 60 Years and Older2020

    • Author(s)
      Nishi Tomo、Saeki Keigo、Miyata Kimie、Yoshikawa Tadanobu、Ueda Tetsuo、Kurumatani Norio、Obayashi Kenji、Ogata Nahoko
    • Journal Title

      JAMA Ophthalmology

      Volume: 138 Issue: 4 Pages: 405-405

    • DOI

      10.1001/jamaophthalmol.2020.0206

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cataracts and Subclinical Carotid Atherosclerosis in Older Adults ― A Cross-Sectional Study of the HEIJO-KYO Cohort ―2019

    • Author(s)
      Yoshikawa Tadanobu、Obayashi Kenji、Miyata Kimie、Nishi Tomo、Ueda Tetsuo、Kurumatani Norio、Saeki Keigo、Ogata Nahoko
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 10 Pages: 2044-2048

    • DOI

      10.1253/circj.CJ-19-0118

    • NAID

      130007711603

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-09-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Nighttime Blood Pressure in Patients with Glaucoma2019

    • Author(s)
      Yoshikawa Tadanobu、Obayashi Kenji、Miyata Kimie、Saeki Keigo、Ogata Nahoko
    • Journal Title

      Ophthalmology

      Volume: 126 Issue: 10 Pages: 1366-1371

    • DOI

      10.1016/j.ophtha.2019.05.019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between glaucomatous optic disc and depressive symptoms independent of light exposure profiles: a cross-sectional study of the HEIJO-KYO cohort2018

    • Author(s)
      Yoshikawa Tadanobu、Obayashi Kenji、Miyata Kimie、Ueda Tetsuo、Kurumatani Norio、Saeki Keigo、Ogata Nahoko
    • Journal Title

      British Journal of Ophthalmology

      Volume: 印刷中 Issue: 8 Pages: 1119-1122

    • DOI

      10.1136/bjophthalmol-2018-312176

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 緑内障点眼薬アップデート2021

    • Author(s)
      吉川 匡宣
    • Organizer
      奈良県立医科大学眼科同窓会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 緑内障患者におけるAsymmetric dimethylarginineと夜間血圧の関連: LIGHT study2021

    • Author(s)
      吉川 匡宣, 大林賢史, 宮田季美恵, 佐伯圭吾, 緒方奈保子
    • Organizer
      第37回日本眼循環学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 薬剤師のための緑内障点眼薬アップデート2021

    • Author(s)
      吉川 匡宣
    • Organizer
      大阪府薬剤師会学術研修会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 生体リズムに着目した白内障・緑内障研究の最前線2021

    • Author(s)
      吉川 匡宣
    • Organizer
      第9回関西角膜セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 緑内障がもたらす 生体リズムへの影響2021

    • Author(s)
      吉川 匡宣
    • Organizer
      第126・127回京都眼科学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 眼外の因子から緑内障を考える 緑内障がもたらす生体リズムへの影響2020

    • Author(s)
      吉川 匡宣
    • Organizer
      日本緑内障学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 白内障が健康へ及ぼす影響:生体リズムに着目した疫学研究2020

    • Author(s)
      吉川 匡宣
    • Organizer
      日本白内障学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 緑内障重症度と認知機能障害の関連2019

    • Author(s)
      吉川匡宣,大林賢史,宮田季美恵,佐伯圭吾,緒方奈保子
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 緑内障と夜間血圧上昇の関連:LIGHTスタディ横断解析2019

    • Author(s)
      吉川匡宣
    • Organizer
      第8回疫学予防医学研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 緑内障がもたらす生体リズムへの影響2019

    • Author(s)
      吉川匡宣
    • Organizer
      第10回若山眼疾患研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 緑内障がもたらす生体リズムへの影響2019

    • Author(s)
      吉川匡宣
    • Organizer
      第17回奈良県眼科万葉フォーラム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Cataracts and Subclinical Carotid Atherosclerosis in Older Adults: A Cross Sectional Study of the HEIJO-KYO Cohort2019

    • Author(s)
      吉川匡宣
    • Organizer
      奈良県立医科大学眼科同窓会
    • Related Report
      2019 Research-status Report
  • [Presentation] 白内障と動脈硬化進行の関連:平城京スタディ縦断解析2019

    • Author(s)
      吉川匡宣,大林賢史,宮田季美恵,佐伯圭吾,緒方奈保子
    • Organizer
      第58回日本白内障学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Decreased melatonin secretion in severe glaucoma patients2019

    • Author(s)
      吉川匡宣,大林賢史,宮田季美恵,佐伯圭吾,緒方奈保子
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 緑内障患者の眼圧リズム:LIGHTスタディ2019

    • Author(s)
      吉川匡宣
    • Organizer
      第9回時間疫学研究会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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