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Development of new artificial dermis with dynamic support structure for preventing a scar contracture and inducing excellent wound healing

Research Project

Project/Area Number 19K10021
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56070:Plastic and reconstructive surgery-related
Research Institution独立行政法人国立病院機構(東京医療センター臨床研究センター)

Principal Investigator

Ochiai Hiroko  独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 室長 (60374162)

Co-Investigator(Kenkyū-buntansha) 柚木 俊二  地方独立行政法人東京都立産業技術研究センター, 開発本部開発第二部バイオ応用技術グループ, 上席研究員 (20399398)
成田 武文  地方独立行政法人東京都立産業技術研究センター, 開発本部開発第二部バイオ応用技術グループ, 研究員 (20640056)
岡 愛子  独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚・平衡覚研究部, 研究員 (50795721)
平田 恵理  独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚・平衡覚研究部, 研究員 (70795731)
大藪 淑美  地方独立行政法人東京都立産業技術研究センター, 開発本部開発第二部バイオ応用技術グループ, 主任研究員 (80587410)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords瘢痕拘縮 / コラーゲン / 人工真皮 / 皮膚再生 / マウス / 肉芽形成 / 食費 / 植皮 / 創傷治癒
Outline of Research at the Start

メカノバイオロジーの観点から、組織が進展・収縮などの変形を繰り返すと瘢痕化が促進されることが知られている。実際に形成外科分野では、創部をギプスやテーピングなどで外固定することで瘢痕拘縮を予防し、瘢痕を目立たなく治す治療が臨床的に行われている。しかし、植皮を行なった広範囲の創や関節、小児の創部などの外固定は困難で患者に苦痛を強いることが多い。そこで、創部を内側から固定することで瘢痕を目立たなく治す試みを着想した。生体吸収性のコラーゲンのみで組織置換性と力学的支持性を両立した人工真皮(CM)を開発し、マウス実験により効果および安全性の検討を行う。

Outline of Final Research Achievements

Three types of collagen matrix (FCM) with a dense frame structure complexed with a sparse collagen matrix section were created and confirmed to actually have increased mechanical load-bearing capacity. In the implantation experiments, structures with collagen densities of 3% and more than 20% were created, and Teldermis with a collagen density of 3% and no chemical cross-linking was used as a control. From the mouse auricular implantation experiments, granulation and vascular invasion were preferentially observed in the sparse collagen matrix in the artificial dermis incorporating the honeycomb structure of CF, and total engraftment was obtained in the immediate implantation. In addition, wound contraction was more suppressed than that of Teldermis after 2 weeks.

Academic Significance and Societal Importance of the Research Achievements

メカノバイオロジーの観点から、組織が進展・収縮などの変形を繰り返すと瘢痕化が促進されることが知られている。実際に形成外科分野では、創部をギプスやテーピングなどで外固定することで瘢痕拘縮を予防し、瘢痕を目立たなく治す治療が臨床的に行われている。しかし、植皮を行なった広範囲の創や関節、小児の創部などの外固定は困難で患者に苦痛を強いることが多い。そこで、創部を内側から固定することで瘢痕を目立たなく治す試みに応用したい。また、本人工真皮は、瘢痕拘縮を予防するのみならず、力学的支持機能が手術中の操作性向上に寄与することで手術時間の短縮や成績向上に寄与する可能性がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2022 2021 2020 2019 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] A review and case studies of seven female cases of sacral pilonidal sinus required surgery.2022

    • Author(s)
      Eri Hirata, Aiko Oka, Agata Tsujisaka, Marika Otaki, Hiroko Ochiai.
    • Journal Title

      International Journal of Surgical Wound Care

      Volume: 3 Pages: 28-32

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Qualitative Assessment of Community Learning Initiatives for Environmental Awareness and Behaviour Change: Applying UNESCO Education for Sustainable Development (ESD) Framework2022

    • Author(s)
      Oe Hiroko、Yamaoka Yasuyuki、Ochiai Hiroko
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 6 Pages: 3528-3528

    • DOI

      10.3390/ijerph19063528

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relaxing Effect Induced by Forest Sound in Patients with Gambling Disorder2020

    • Author(s)
      Ochiai Hiroko、Song Chorong、Jo Hyunju、Oishi Masayuki、Imai Michiko、Miyazaki Yoshifumi
    • Journal Title

      Sustainability

      Volume: 12 Issue: 15 Pages: 5969-5969

    • DOI

      10.3390/su12155969

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemotherapy-induced Nasopharyngeal Stenosis Treated with Bilateral Facial Artery Musculomucosal Flaps2020

    • Author(s)
      Nishimon Mari、Ochiai Hiroko、Watanabe Shiho、Hirata Eri、Oka Aiko、Yazawa Masaki、Kishi Kazuo
    • Journal Title

      Plastic and Reconstructive Surgery - Global Open

      Volume: Publish Ahead of Print Issue: 8 Pages: e3041-e3041

    • DOI

      10.1097/gox.0000000000003041

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 間葉系幹細胞移植による皮膚創傷の瘢痕化抑制-倫理委員会承認による臨床応用の結果と問題点-2019

    • Author(s)
      落合博子、貴志和生、梅澤明宏
    • Journal Title

      瘢痕・ケロイド治療ジャーナル

      Volume: 13 Pages: 7-9

    • Related Report
      2019 Research-status Report
  • [Presentation] Changes of muscle fiber composition after selective nerve innervation.2021

    • Author(s)
      Shiho Watanabe, Hisashi Sakuma,Taisuke Mori, Masaki Yazawa, Hiroko Ochiai.
    • Organizer
      The 31st EURAPS Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study of patients with congenital bilateral ptosis who underwent initial surgery after childhood.2021

    • Author(s)
      Hiroko Ochiai, Aiko Oka, Eri Matoba, Eri Hirata, Shiho Watanabe, Risa Sano.
    • Organizer
      The 64rd Annual Meeting of Japan Society of Plastic and Reconstructive Surgery
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Changes of muscle fiber composition after selective nerve innervation.2021

    • Author(s)
      Shiho Watanabe, Hisashi Sakuma,Taisuke Mori, Masaki Yazawa, Hiroko Ochiai
    • Organizer
      The 31st EURAPS Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Factors related to eyebrows position in patients with aponeurotic ptosis.2020

    • Author(s)
      Hiroko Ochiai, Aiko Oka, Eri Hirata, Naoko Yagi, Yuuichirou Uoya, Chihiro Nakayama.
    • Organizer
      The 63rd Annual Meeting of Japan Society of Plastic and Reconstructive Surgery
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Remarks] 感覚器センター 再生医療研究室

    • URL

      https://tokyo-mc.hosp.go.jp/section/k-lab_c-3.html

    • Related Report
      2020 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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