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Novel action of PTH/PTHrP in bone-specific blood vessels

Research Project

Project/Area Number 19K10040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57010:Oral biological science-related
Research InstitutionHokkaido University

Principal Investigator

Hasegawa Tomoka  北海道大学, 歯学研究院, 准教授 (50739349)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨特異的血管 / 骨芽細胞 / PTH / PTHrP / endomucin / αSMA / 未分化間葉系細胞 / 骨血管連関 / 細胞・組織 / PTHrP
Outline of Research at the Start

副甲状腺ホルモン(PTH)および副甲状腺ホルモン関連蛋白(PTHrP)の骨特異的血管に対する作用、血管周囲に存在する細胞群への作用、また、骨特異的血管・周囲の細胞群と骨芽細胞系細胞の細胞間連関(骨血管連関)の解析を行い、骨特異的血管におけるPTH/PTHrPの新規作用について明らかにする。

Outline of Final Research Achievements

In this study, we found that intermittent administration of parathyroid hormone (PTH) increased the number and lumen diameter of bone-specific blood vessels and promoted the proliferation of αSMA-positive stromal cells localized around the blood vessels in murine long bones. Furthermore, αSMA-positive perivascular stromal cells may differentiate into vascular smooth muscle cells and osteoblast lineage cells, strongly suggesting the possibility of bone-blood vessel interaction in the anabolic action of PTH.

Academic Significance and Societal Importance of the Research Achievements

本研究は、骨芽細胞系細胞に作用すると考えられてきたPTHが、骨特異的血管や血管周囲細胞の増殖や分化に作用する可能性、また、骨特異的血管と骨芽細胞系細胞の骨血管連関の可能性を明らかにした研究である。骨粗鬆症治療薬として用いられるPTHの骨形成作用は、これまで骨芽細胞と破骨細胞によるカップリング機構にて説明がなされてきたが、今回の研究成果から、骨特異的血管および骨芽細胞系細胞における骨血管連関が寄与する可能性が示唆され、その学術的意義は高いと考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (26 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (10 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (11 results) (of which Invited: 7 results) Book (1 results)

  • [Int'l Joint Research] Shandong University(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Federal University of Sergipe at Lagarto(ブラジル)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] 山東大学口腔医学院(中国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Federal University of Sergipe(ブラジル)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Histochemical characteristics on minimodeling-based bone formation induced by anabolic drugs for osteoporotic treatment2021

    • Author(s)
      YAMAMOTO Tomomaya、HASEGAWA Tomoka、FRAITAS Paulo Henrique Luiz de、HONGO Hiromi、ZHAO Shen、YAMAMOTO Tsuneyuki、NASOORI Alireza、ABE Miki、MARUOKA Haruhi、KUBOTA Keisuke、MORIMOTO Yasuhito、HARAGUCHI Mai、SHIMIZU Tomohiro、TAKAHATA Masahiko、IWASAKI Norimasa、LI Minqi、AMIZUKA Norio
    • Journal Title

      Biomedical Research

      Volume: 42 Issue: 5 Pages: 161-171

    • DOI

      10.2220/biomedres.42.161

    • NAID

      130008090730

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2021-09-21
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histological observation on the initial stage of vascular invasion into the secondary ossification of murine femoral epiphyseal cartilage2021

    • Author(s)
      HASHIMOTO Keiji、HASEGAWA Tomoka、YAMAMOTO Tomomaya、HONGO Hiromi、IMIN Y、ABE Miki、NASOORI Alireza、NAKANISHI Ko、MARUOKA Haruhi、MORIMOTO Yasuhito、KUBOTA Keisuke、SHIMIZU Tomohiro、HARAGUCHI Mai、TAKAHATA Masahiko、IWASAKI Norimasa、LI Minqi、FUJISAWA Toshiaki、AMIZUKA Norio
    • Journal Title

      Biomedical Research

      Volume: 42 Issue: 4 Pages: 139-151

    • DOI

      10.2220/biomedres.42.139

    • NAID

      130008073440

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2021-08-12
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative immunolocalization of tissue nonspecific alkaline phosphatase and ectonucleotide pyrophosphatase/phosphodiesterase 1 in murine bone2021

    • Author(s)
      Yamamoto Tomomaya、Hasegawa Tomoka、Mae Takahito、Hongo Hiromi、Yamamoto Tsuneyuki、Abe Miki、Nasoori Alireza、Morimoto Yasuhito、Maruoka Haruhi、Kubota Keisuke、Haraguchi Mai、Li Minqi
    • Journal Title

      Journal of Oral Biosciences

      Volume: 63 Issue: 3 Pages: 259-264

    • DOI

      10.1016/j.job.2021.08.001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells.2021

    • Author(s)
      Yokoyama A., Hasegawa T., Hiraga T., Yamada T., Yimin, Hongo H., Yamamoto T., Abe M., Yoshida T., Imanishi Y., Kuroshima S., Sasaki M., Freitas PHL., Li M., Amizuka N., Yamazaki Y.
    • Journal Title

      J Bone Miner Metab.

      Volume: 印刷中 Issue: 5 Pages: 810-823

    • DOI

      10.1007/s00774-021-01220-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histochemical assessment on the cellular interplay of vascular endothelial cells and septoclasts during endochondral ossification in mice.2021

    • Author(s)
      Tsuchiya E., Hasegawa T., Hongo H., Yamamoto T., Abe M., Yoshida T., Zhao S., Tsuboi K., Udagawa N., Freitas PHL., Li M., Kitagawa Y., Amizuka N.
    • Journal Title

      Microscopy.

      Volume: 70 Issue: 2 Pages: 201-214

    • DOI

      10.1093/jmicro/dfaa047

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intermittent PTH administration increases bone specific-blood vessels and surrounding stromal cells in murine long bones.2020

    • Author(s)
      Zhao S., Hasegawa T., Hongo H., Yamamoto T., Abe M., Yoshida T., Haraguchi M., Freitas PHL., Li M., Tei K., Amizuka N.
    • Journal Title

      Calcif Tissue Int.

      Volume: 108 Issue: 3 Pages: 391-406

    • DOI

      10.1007/s00223-020-00776-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Osteocytic Osteolysis in PTH-treated Wild-type and Rankl-/- Mice Examined by Transmission Electron Microscopy, Atomic Force Microscopy, and Isotope Microscopy.2020

    • Author(s)
      Hongo H., Hasegawa T., Saito M., Tsuboi K., Yamamoto T., Sasaki M., Abe M., Freitas PHL., Yurimoto H., Udagawa N., Li M., Amizuka N.
    • Journal Title

      J Histochem Cytochem.

      Volume: 68 Issue: 10 Pages: 651-668

    • DOI

      10.1369/0022155420961375

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Immunocytochemical assessment of cell differentiation of podoplanin-positive osteoblasts into osteocytes in murine bone.2020

    • Author(s)
      Nagai T., Hasegawa T., Yimin, Yamamoto T., Hongo H., Abe M., Yoshida T., Yokoyama A., Freitas PHL., Li M., Yokoyama A., Amizuka N.
    • Journal Title

      Histochem Cell Biol.

      Volume: 155 Issue: 3 Pages: 369-380

    • DOI

      10.1007/s00418-020-01937-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histochemical examination on principal collagen fibers in periodontal ligaments of ascorbic acid-deficient ODS-od/od rats.2019

    • Author(s)
      Hasegawa T., Miyamoto Y., Abe M., Qiu Z., Yamamoto T., Yimin, Yoshida T., Yoshino H., Hongo H., Yokoyama A., Sasaki M., Kuroshima S., Hara K., Kobayashi M., Akiyama Y., Maeda T., Freitas PHL., Li M., Amizuka N.
    • Journal Title

      Microscopy.

      Volume: 68 Issue: 5 Pages: 349-358

    • DOI

      10.1093/jmicro/dfz021

    • NAID

      120006891507

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Histological Effects of the Combined Administration of Eldecalcitol and a Parathyroid Hormone in the Metaphyseal Trabeculae of Ovariectomized Rats2018

    • Author(s)
      Hasegawa T., Yamamoto T., Sakai S., Miyamoto Y., Hongo H., Qiu Z., Abe M., Takeda S., Oda K., Freitas PHL., Li M., Endo K., Amizuka N.
    • Journal Title

      Journal of Histochemistry & Cytochemistry

      Volume: 67 Issue: 3 Pages: 169-184

    • DOI

      10.1369/0022155418806865

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 骨組織に対する副甲状腺ホルモン作用の多様性.2021

    • Author(s)
      長谷川智香
    • Organizer
      第41回日本骨形態計測学会
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Invited
  • [Presentation] 骨細胞ネットワークの微細構造と骨基質石灰化.2021

    • Author(s)
      長谷川智香
    • Organizer
      第41回日本骨形態計測学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 骨形成促進剤で誘導されるmodeling-based/remodeling-based bone formationの組織学.2021

    • Author(s)
      網塚憲生、長谷川智香、本郷裕美、山本知真也
    • Organizer
      第41回日本骨形態計測学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 微小環境変化による組織転換:血管および骨の転換メカニズム.2021

    • Author(s)
      長谷川智香
    • Organizer
      第127回日本解剖学会総会・全国学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 副甲状腺ホルモン投与で誘導される皮質骨多孔化について.2021

    • Author(s)
      阿部未来、山本知真也、本郷裕美、網塚憲生、長谷川智香
    • Organizer
      日本解剖学会第67回東北・北海道連合支部学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 副甲状腺ホルモン製剤投与による皮質骨多孔化のメカニズムについて.2021

    • Author(s)
      阿部未来、山本知真也、本郷裕美、Nasoori Alireza、網塚憲生、長谷川智香
    • Organizer
      第63回歯科基礎医学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 骨代謝回転状態によるpodoplanin/PHOSPHO1 陽性骨芽細胞の局在変化.2021

    • Author(s)
      中嶋悠斐、山本知真也、本郷裕美、Nasoori Alireza、網塚憲生、長谷川智香
    • Organizer
      第63回歯科基礎医学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 骨血管連関からみた骨芽細胞系細胞の分化.2020

    • Author(s)
      長谷川智香、趙 申、吉野弘菜、阿部未来
    • Organizer
      第62回歯科基礎医学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 副甲状腺ホルモン間歇投与による皮質骨多孔化の組織化学的検索.2020

    • Author(s)
      阿部未来、山本知真也、本郷裕美、網塚憲生、長谷川智香
    • Organizer
      第62 回歯科基礎医学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 骨特異的血管と骨細胞における組織化学・電顕イメージング.2019

    • Author(s)
      長谷川智香、邱 紫セン、宮本幸奈、山本知真也、網塚憲生
    • Organizer
      第39回日本骨形態計測学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 骨血管連関における細胞間コミュニケーション.2019

    • Author(s)
      長谷川智香、本郷裕美、山本知真也、網塚憲生
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Book] Osteoporotic Fracture and Systemic Skeletal Disorders2022

    • Author(s)
      Hasegawa Tomoka、Hongo Hiromi、Yamamoto Tomomaya、Amizuka Norio
    • Total Pages
      576
    • Publisher
      Springer, Singapore
    • ISBN
      9789811656125
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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