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Study on treatment of jaw bone necrosis using a subpopulation of MSCs that activate immunity

Research Project

Project/Area Number 19K10182
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionThe University of Tokyo

Principal Investigator

Nishizawa Satoru  東京大学, 医学部附属病院, 特任助教 (00646200)

Co-Investigator(Kenkyū-buntansha) 浅輪 幸世  東京大学, 医学部附属病院, 特任講師 (10769912)
星 和人  東京大学, 医学部附属病院, 教授 (30344451)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords細胞治療 / 薬剤関連顎骨壊死 / 間葉系幹細胞 / 再生医療 / 薬剤性顎骨壊死 / 骨粗鬆症 / 顎骨壊死 / 免疫 / ビスフォスフォネート
Outline of Research at the Start

薬剤関連顎骨壊死(ARONJ)の治療法は未確立である。間葉系幹細胞(MSC)の移植療法は有効な治療法と期待されている。しかしMSCは免疫抑制作用を有する細胞であり、感染骨領域が増大した難治性のARONJにMSCを投与することはリスクが高い。一方、MSCの免疫調整機機能や制御メカニズムには未だ不明な点が多く、免疫を活性化することを示す報告もある。そこで本研究ではMSCの免疫制御作用に着目し、免疫活性化作用をもつMSC亜集団を同定する。そして難治性ARONJのモデル動物に投与し、有用性を実証する。

Outline of Final Research Achievements

Drug-related osteonecrosis of the jaw is a disease caused by the administration of drugs such as those for osteoporosis, and no treatment has yet been established. Cell therapy using mesenchymal stem cells is expected to be an effective treatment because mesenchymal stem cells are not only a source of bone-building cells but also provide factors that promote bone cell activity. However, because mesenchymal stem cells are immunosuppressive, their administration for the purpose of treating refractory patients with advanced infection is risky. On the other hand, the immune regulatory function of mesenchymal stem cells remains unclear, and some reports have shown that they activate immunity. In this study, we searched for a subpopulation of mesenchymal stem cells with immune-activating properties and investigated their therapeutic efficacy against refractory drug-induced osteonecrosis of the jaw.

Academic Significance and Societal Importance of the Research Achievements

間葉系幹細胞による顎骨壊死に対する細胞治療の研究は、殆どが発症初期のモデルを用いて評価している。しかし臨床に展開していく上では難治性のモデルを用いた評価をおこなうことが重要である。本研究の特色は、間葉系幹細胞の免疫制御作用に着目し、これまで免疫抑制作用がクローズアップされてきた間葉系幹細胞による細胞治療を感染の進行により憎悪するリスクのある疾患に対し、安全かつ確実に適応させるための方策を新たに作出する点にある。得られた知見は細胞治療の分野において有意義なものとなる可能性がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (3 results)

All 2021 2020

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results)

  • [Journal Article] Histochemical and Morphometrical Analyses of Scarless Wound Healing in Mouse Fetal Model2021

    • Author(s)
      Hiroshi Kawakami , Satoru Nishizawa, Atsuhiko Hikita, Kazuto Hoshi
    • Journal Title

      Tokai J Exp Clin Med .

      Volume: 46 Pages: 33-43

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of Damage-Associated Molecular Patterns from Chondrocytes in Tissue-Engineered Cartilage2020

    • Author(s)
      Fujihara Yuko、Abe Takahiro、Asawa Yukiyo、Nishizawa Satoru、Saijo Hideto、Hikita Atsuhiko、Hoshi Kazuto
    • Journal Title

      Tissue Engineering Part A

      Volume: 00 Issue: 1-2 Pages: 1-9

    • DOI

      10.1089/ten.tea.2019.0185

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glial Fibrillary Acidic Protein as Biomarker Indicates Purity and Property of Auricular Chondrocytes2020

    • Author(s)
      Nishizawa Satoru、Kanazawa Sanshiro、Fujihara Yuko、Asawa Yukiyo、Nagata Satoru、Harai Motohiro、Hikita Atsuhiko、Takato Tsuyoshi、Hoshi Kazuto
    • Journal Title

      BioResearch Open Access

      Volume: 9 Issue: 1 Pages: 51-63

    • DOI

      10.1089/biores.2019.0058

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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