Standardization of high precision high dose rate interstitial brachytherapy for oral cancer
Project/Area Number |
19K10289
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57060:Surgical dentistry-related
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Research Institution | Hiroshima University |
Principal Investigator |
Kakimoto Naoya 広島大学, 医系科学研究科(歯), 教授 (50324794)
|
Co-Investigator(Kenkyū-buntansha) |
Verdonschot RG 広島大学, 医系科学研究科(歯), 助教 (30756094)
中元 崇 広島大学, 医系科学研究科(歯), 准教授 (60403630)
小西 勝 広島大学, 病院(歯), 講師 (60537447)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 口腔癌 / 高線量率組織内照射 / 高精度 / 規格化 |
Outline of Research at the Start |
口腔癌に対する高線量率組織内照射は、根治的治療法の一つとして挙げられる。本研究では、口腔癌における高線量率組織内照射において、高線量率組織内照射の高精度化、アプリケーター挿入時の位置の数値化、画像誘導小線源治療での線量分布の数値化を行い、治療方法を数値化、規格化し、この規格を評価することで、IMRT(Intensity Modulated Radiation Therapy;強度変調放射線治療)のような、全世界に普及可能な治療法として確立することを目指す。
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Outline of Final Research Achievements |
The purpose of this study was to quantify and standardize applicators’ position and dose distribution in high-dose-rate interstitial brachytherapy (HDR-ISBT) for oral cancer patients. Seven patients and 53 flexible tubes that were treated by HDR-ISBT were examined. Prescribed doses were GTV=CTV=PTV=100%, and dose distribution maps were prepared so that V200% was less than 20% of GTV volume. The displacement of the flexible tube position by cross-sectional image comparison based on anatomical landmarks was 1.8 ± 1.3 mm, and the displacement based on the flexible tubes’ comparison was 2.1 ± 1.9 mm, respectively. There was no statistically significant difference between them. Since the flexible tubes are displaced during treatment, to know the amount of change can be used as a reference for treatment planning of HDR-ISBT for oral cancer patients.
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Academic Significance and Societal Importance of the Research Achievements |
口腔癌に対する高線量率組織内照射において、アプリケーター位置および線量分布の数値化を行い、定量的に検討した結果、フレキシブルチューブの位置は1日目と3日目で1.8㎜または2.1㎜の変位量があることが示された。これらの変位量は線量に換算すると6~8%の誤差を生じるため、事前にこれらの誤差を勘案した線量分布図の作成が必要となる。また、より正確な線量処方を行うためには適応放射線治療(Adoptive radiotherapy)を行う必要があると思われれた。
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Treatment outcomes of real-time intraoral sonography-guided implantation technique of 198Au grain brachytherapy for T1 and T2 tongue cancer2021
Author(s)
Konishi M, Fujita M, Takeuchi Y, Kubo K, Imano N, Nishibuchi I, Murakami Y, Shimabukuro K, Wongratwanich P, Verdonschot RG, Kakimoto N, Nagata Y
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Journal Title
J Radiat Res
Volume: 62
Issue: 5
Pages: 871-876
DOI
Related Report
Peer Reviewed