• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Does modulation of muscle function in nasal obstruction during growth affect maxillofacial development?

Research Project

Project/Area Number 19K10377
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Kokai Satoshi  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (50431937)

Co-Investigator(Kenkyū-buntansha) 渡 一平  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10431941)
小野 卓史  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30221857)
加藤 千帆  東京医科歯科大学, 歯学部附属病院, 特任助教 (80706987)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords鼻呼吸障害 / 成長期 / 咀嚼野 / 大脳 / 鼻閉 / 睡眠時無呼吸 / 筋機能訓練 / 睡眠時無呼吸 筋機能訓練 / 顔面発育 / 筋機能
Outline of Research at the Start

本研究では顎顔面発育形成段階である成長期における鼻呼吸障害が、顎口腔周囲筋の筋活動を変調し、筋機能低下をもたらすメカニズムを、遅筋速筋の割合およびエピジェネティクスの代表的な客観的指標であるヒストン修飾分布量、速筋または遅筋特異的な遺伝子発現量の変化を指標として解析し、筋活動の変化が顎顔面形態へ反映されるメカニズムを解明していくことを目的としている。

Outline of Final Research Achievements

The purpose of this study was to elucidate the effects of chronic nasal breathing disorders during growth on the development of the masticatory area of the cerebral cortex, which plays an important role in masticatory movements, using intracortical microelectrical stimulation. The results of the measurement of jaw movement by intracortical microelectrical stimulation of the cortical masticatory area using a high-speed camera revealed that nasal breathing disorder during growth affects the development of maxillofacial motor representations in the same area.

Academic Significance and Societal Importance of the Research Achievements

矯正歯科臨床において、鼻閉や口呼吸を有する者が多く見受けられる。大脳皮質咀嚼野は咀嚼運動の制御に関与する高次機能領域である。本研究は、SpO 2 レベルと大脳皮質咀嚼野に着目し、成長期における鼻呼吸障害が末梢における変化のみならず、咀嚼運動の中枢神経系である大脳皮質咀嚼野の発達に与える影響について初めて明らかにした。今後の歯科臨床のみならず、歯科医学や神経生理学の発展に寄与するところが極めて大きいと考えられる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (11 results)

All 2023 2022 2021 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Histological and contractile changes in the genioglossus muscle after nasal obstruction in growing rats2023

    • Author(s)
      Koecklin Karin Harumi Uchima、Kato Chiho、Abe Yasunori、Yabushita Tadachika、Kokai Satoshi、Ono Takashi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-023-32921-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unilateral nasal obstruction affects development of cortical orofacial motor representation in the cortical masticatory area of growing rats2022

    • Author(s)
      Fujita Akiyo、Kato Chiho、Abe Yasunori、Ishidori Hideyuki、Li Ruixin、Thura Aung Phyo、Ogawa Takuya、Okihara Hidemasa、Kokai Satoshi、Ono Takashi
    • Journal Title

      Neuroscience Letters

      Volume: 783 Pages: 136700-136700

    • DOI

      10.1016/j.neulet.2022.136700

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nasal obstruction during the growth period modulates the Wnt/β‐catenin pathway and brain‐derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus2021

    • Author(s)
      Ishidori Hideyuki、Okihara Hidemasa、Ogawa Takuya、Abe Yasunori、Kato Chiho、Aung Phyo Thura、Fujita Akiyo、Kokai Satoshi、Ono Takashi
    • Journal Title

      European Journal of Neuroscience

      Volume: 55 Issue: 1 Pages: 5-17

    • DOI

      10.1111/ejn.15547

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional Analysis of Rhythmic Jaw Movements Evoked by Electrical Stimulation of the Cortical Masticatory Area During Low Occlusal Loading in Growing Rats2020

    • Author(s)
      Aung Phyo Thura、Kato Chiho、Abe Yasunori、Ogawa Takuya、Ishidori Hideyuki、Fujita Akiyo、Okihara Hidemasa、Kokai Satoshi、Ono Takashi
    • Journal Title

      Frontiers in Physiology

      Volume: 11 Pages: 1-16

    • DOI

      10.3389/fphys.2020.00034

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effects of unilateral nasal obstruction during the growth period on cerebellar neural circuit and function2023

    • Author(s)
      Moe Tanigawa, Chiho Kato, Takashi Ono, Naofumi Uesaka
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan,
    • Related Report
      2022 Annual Research Report
  • [Presentation] Altered neuromuscular behavior during cortically-elicited rhythmic jaw movement in obese Zucker rat2022

    • Author(s)
      Li Ruixin, Kato Chiho, Abe Yasunori, Fujita Akiyo, Ogawa Takuya, Ishidori Hideyuki, Misawa Eri, Okihara Hidemasa, Kokai Satoshi, Ono Takashi
    • Organizer
      第81回日本矯正歯科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Impact of change in food properties on learning/memory function in the growing mice2022

    • Author(s)
      Sun Wenqian, Ogawa Takuya, Okihara Hidemasa, Ishidori Hideyuki, Misawa Eri, Kato Chiho, Ono Takashi
    • Organizer
      第81回日本矯正歯科学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 成長期咀嚼刺激低下はWnt signaling pathwayおよびARHGAP33の分子伝達を変調する2021

    • Author(s)
      三澤 英里, 沖原 秀政, 小川 卓也, 小海 暁, 阿部 泰典, 加藤 千帆, 石通 秀行, 藤田 秋世, 高野 力磨, 谷川 萌, 孫 文倩, 小野 卓史
    • Organizer
      第80回日本矯正歯科学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Unilateral nasal obstruction affects development of motor representation in the cortical masticatory area in growing rats2020

    • Author(s)
      Akiyo Fujita, Chiho Kato, Yasunori Abe, Takuya Ogawa, Phyo Thura Aung, Hideyuki Ishidori, Ruixin Li, Hidemasa Okihara, Satoshi Kokai, Takashi Ono
    • Organizer
      The 9th international Orthodontic Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Low occlusal loading affects the neuromuscular control of jaw movements induced by anterior part of cortical masticatory area in growing rats2020

    • Author(s)
      Phyo Thura Aung, Chiho Kato, Yasunori Abe, Takuya Ogawa, Hideyuki Ishidori, Akiyo Fujita, Ruixin Li, Hidemasa Okihara, Satoshi Kokai, Takashi Ono
    • Organizer
      The 9th international Orthodontic Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス成長期鼻呼吸障害は海馬におけるWnt signaling pathwayに変調をもたらす2019

    • Author(s)
      石通 秀行, 沖原 秀政, 小川 卓也, 小海 暁, 阿部 泰典, 加藤 千帆, ピョースラ・アン , 藤田 秋世, 小野 卓史
    • Organizer
      第78回 日本矯正歯科学会大会
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi