Prevention of cognitive impairment by comprehensive rehabilitation targeting vascular endothelial glycocalyx

• Project/Area Number: 19K11371
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Kitasato University
• Principal Investigator: 東條 美奈子 北里大学, 医療衛生学部, 教授 (80327345)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2023: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 血管内皮細胞機能 / 血管内皮グリコカリックス / 心血管病増悪予防 / 循環器病予防 / 循環器疾病管理 / 心臓リハビリテーション / 血管内皮機能 / 循環器病疾病管理 / 加速度トレーニング / 認知機能 / 心不全

Outline of Research at the Start

血管内皮グリコカリックス（EC-GLX）は血管内皮細胞の増殖・分化・アポトーシス、細胞骨格、血栓形成、炎症制御、免疫などの様々な細胞表面～細胞内シグナル伝達の制御に関わる。それゆえ脆弱EC-GLX領域などを指標とすることで、様々な疾患のスクリーニングや効果的な介入を行なった場合の効果判定が可能になると期待されている。
多疾患有病者である認知機能低下を伴う高齢心不全患者の増加抑制には、疾病管理に関する患者教育と身体活動量増加を目指した包括的リハビリテーションが有用である。本研究では、EC-GLX脆弱化領域を標的とした心血管病リスク評価と認知機能に関する検討を実施する。

Outline of Annual Research Achievements

①横断的研究
動硬化性疾患予防ガイドラインおよび急性・慢性心不全診療ガイドラインに沿った動脈硬化進展予防と心不全治療が行われている高齢慢性心血管疾患患者を対象とし、動脈硬化性疾患および慢性心不全の進行に影響を与える因子を分析する横断研究を行った。心臓二次予防外来において経時的実施されている定期心臓精密検査と、心臓リハビリテーションで系統的に実施される身体機能検査および生活状況調査（生活環境、ADL、身体活動）、心臓リハビリテーション実施状況などの項目を診療録より調査した。新型コロナウイルス感染拡大防止対策に伴うリハビリテーションの診療規模縮小や診療体制の変更に伴い、一時的な研究の中断や登録患者数の減少が課題となっている。
②リハビリテーション介入の効果
新型コロナウイルス感染症対策等により心臓リハビリテーションの長期介入効果が評価できた症例数が限られているため、本研究期間に有意な臨床研究結果を見出すことが難しいと考えられた。そこで研究③として、公開されている心臓・血管組織の遺伝子配列データベースを用いた、AI機能解析モデルを用いた探索的研究を追加した。
③遺伝子配列データベースを用いた新規バイオマーカ候補の抽出
NCBI-Gene Expression Omnibus databaseを用いた解析において、大動脈弁狭窄症患者の病態悪化と関連する重要な遺伝子としてVCAM1, FHL2, RUNX1が見出された。これらのうちVCAM1とFHL2は血管内皮グリコカリックス障害との関連が強く示唆される結果であり、RUNX1は石灰化の進行度を評価する新たなバイオマーカとしての可能性が期待される。さらにこれらの可溶型分子やドメイン結合分子を明らかにすることにより、認知機能低下の新たなバイオマーカや、リハビリテーションの効果判定指標としての新規バイオマーカ候補の検討をすすめている。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

新型コロナウイルス感染症対策等により、臨床研究の症例登録や外来リハビリテーション継続体制の状況に変化が生じ、当初、予定していた方法での研究遂行の困難が予想された。この状況を打破するために、研究の一部については公開されている遺伝子配列データベースを用いた解析に切り替え、目的とする新たな標的分子の探索を進めた。幸い、予測していた以上に良い結果が得られており、その一部はすでに 論文化することができたため、上記区分を（２）とした。

Strategy for Future Research Activity

これまでに得られた臨床研究のデータ解析を継続するとともに、公開遺伝子配列データベースを用いた検討において、高齢心血管患者の病態進行に関与する新たな分子マーカの探索を進めていく。

Research Products

• [Journal Article] Molecular Mechanisms Underlying the Progression of Aortic Valve Stenosis: Bioinformatic Analysis of Signal Pathways and Hub Genes (2023)
  • Author(s): Tojo Taiki、Yamaoka-Tojo Minako
  • Journal Title: International Journal of Molecular Sciences Volume: 24 Issue: 9 Pages: 7964-7964
  • DOI: 10.3390/ijms24097964
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of liver damage assessed through direct bilirubin levels and skeletal muscle weakness in patients with heart failure (2023)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart & Lung Volume: 60 Pages: 87-94
  • DOI: 10.1016/j.hrtlng.2023.03.001
  • Peer Reviewed / Open Access
• [Journal Article] SARC-F predicts poor motor function, quality of life, and prognosis in older patients with cardiovascular disease and cognitive impairment (2023)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Ueno Kensuke、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Experimental Gerontology Volume: 171 Pages: 112021-112021
  • DOI: 10.1016/j.exger.2022.112021
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the spread of COVID-19, social frailty, and depressive symptoms in patients with heart failure (2022)
  • Author(s): Shakuta Saki、Yamashita Masashi、Kamiya Kentaro、Hamazaki Nobuaki、Ueno Kensuke、Nozaki Kohei、Uchida Shota、Noda Takumi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart and Vessels Volume: - Issue: 7 Pages: 992-996
  • DOI: 10.1007/s00380-022-02203-y
  • Peer Reviewed
• [Journal Article] Association between instrumental activities of daily living frequency and clinical outcomes in older patients with cardiovascular disease (2022)
  • Author(s): Kariya Hidenori、Yamaoka-Tojo Minako、Hamazaki Nobuaki、Obara Shinichi、Kitasato Lisa、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: European Journal of Cardiovascular Nursing Volume: 22 Issue: 1 Pages: 64-72
  • DOI: 10.1093/eurjcn/zvac043
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gait speed and 6-minute walking distance are useful for identifying difficulties in activities of daily living in patients with cardiovascular disease (2022)
  • Author(s): Sato Ayaka、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart & Lung Volume: 51 Pages: 46-51
  • DOI: 10.1016/j.hrtlng.2021.09.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of electrical muscle stimulation on physical function in frail older patients with acute heart failure: a randomized controlled trial (2022)
  • Author(s): Tanaka Shinya、Kamiya Kentaro、Matsue Yuya、Yonezawa Ryusuke、Saito Hiroshi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Yamashita Masashi、Wakaume Kazuki、Endo Yoshiko、Maekawa Emi、Yamaoka-Tojo Minako、Shiono Takaaki、Inomata Takayuki、Ako Junya
  • Journal Title: European Journal of Preventive Cardiology Volume: in press Issue: 8 Pages: e286-e288
  • DOI: 10.1093/eurjpc/zwac022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Features of trunk muscle wasting during acute care and physical function recovery with aortic disease (2022)
  • Author(s): Masashi Yamashita
  • Journal Title: J Cachexia Sarcopenia Muscle Volume: 13 Issue: 2 Pages: 1054-1063
  • DOI: 10.1002/jcsm.12935
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between respiratory muscle weakness and frailty status as risk markers for poor outcomes in patients with cardiovascular disease (2022)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Nozaki Kohei、Yamashita Masashi、Uchida Shota、Noda Takumi、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: European Journal of Cardiovascular Nursing Volume: in press Issue: 8 Pages: 782-790
  • DOI: 10.1093/eurjcn/zvac014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Association with Physical Function and Prognosis in Patients with Acute Coronary Syndrome (2022)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 7 Pages: 1847-1847
  • DOI: 10.3390/jcm11071847
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial (2022)
  • Author(s): Tanaka Shinya、Kamiya Kentaro、Matsue Yuya、Yonezawa Ryusuke、Saito Hiroshi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Yamashita Masashi、Wakaume Kazuki、Endo Yoshiko、Maekawa Emi、Yamaoka-Tojo Minako、Shiono Takaaki、Inomata Takayuki、Ako Junya
  • Journal Title: Journal of Cardiovascular Development and Disease Volume: 9 Issue: 4 Pages: 99-99
  • DOI: 10.3390/jcdd9040099
  • Peer Reviewed / Open Access
• [Journal Article] Association between instrumental activities of daily living with the change in left ventricular function in older patients with cardiovascular disease (2021)
  • Author(s): Kariya Hidenori、Yamaoka-Tojo Minako、Obara Shinichi、Noda Chiharu、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart and Vessels Volume: 36 Issue: 9 Pages: 1298-1305
  • DOI: 10.1007/s00380-021-01812-3
• [Journal Article] Low skeletal muscle density combined with muscle dysfunction predicts adverse events after adult cardiovascular surgery (2021)
  • Author(s): Yamashita M, Kamiya K, Matsunaga A, Kitamura T, Hamazaki N, Nozaki K, Ichikawa T, Maekawa E, Meguro K, Yamaoka-Tojo M, Ako J, Miyaji K.
  • Journal Title: Nutr Metab Cardiovasc Dis Volume: － Issue: 6 Pages: 1782-1790
  • DOI: 10.1016/j.numecd.2021.02.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic utility of dynapenia in patients with cardiovascular disease (2021)
  • Author(s): Uchida Shota、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Clinical Nutrition Volume: 40 Issue: 4 Pages: 2210-2218
  • DOI: 10.1016/j.clnu.2020.09.050
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical usefulness of oxygen uptake during usual gait in patients with cardiovascular disease (2021)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Nozaki Kohei、Yanagi Naoya、Ichikawa Takafumi、Matsuzawa Ryota、Nakamura Takeshi、Yamashita Masashi、Uchida Shota、Saito Teppei、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: International Journal of Cardiology Volume: 335 Pages: 118-122
  • DOI: 10.1016/j.ijcard.2021.04.049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hemodynamic Changes During Neuromuscular Electrical Stimulation and Mobility Therapy for an Advanced Heart Failure Patient with Impella 5.0 Device (2021)
  • Author(s): Nozaki Kohei、Hamazaki Nobuaki、Ikeda Yuki、Nihei Manami、Kobayashi Shuken、Kamiya Kentaro、Maekawa Emi、Matsunaga Atsuhiko、Yamaoka-Tojo Minako、Ako Junya
  • Journal Title: International Heart Journal Volume: 62 Issue: 3 Pages: 695-699
  • DOI: 10.1536/ihj.20-632
  • NAID: 130008045566
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between kidney function and outcomes of comprehensive cardiac rehabilitation in patients with heart failure (2021)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Yamamoto Shohei、Nozaki Kohei、Ichikawa Takafumi、Matsuzawa Ryota、Yamashita Masashi、Uchida Shota、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Clinical Research in Cardiology Volume: 111 Issue: 3 Pages: 253-263
  • DOI: 10.1007/s00392-021-01875-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Usefulness of physical function sub-item of SF-36 survey to predict exercise intolerance in patients with heart failure (2021)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Kawabata Masashi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: European Journal of Cardiovascular Nursing Volume: 21 Issue: 2 Pages: 174-177
  • DOI: 10.1093/eurjcn/zvab052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between high‐sensitivity cardiac troponin T, B‐type natriuretic peptide, and physical function in patients with heart failure (2021)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Yanagi Naoya、Maekawa Emi、Yamaoka‐Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 6 Pages: 5092-5101
  • DOI: 10.1002/ehf2.13577
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] COVID-19と全身性炎症反応性微小血管内皮症（SIRME） (2021)
  • Author(s): 東條大輝、東條美奈子
  • Journal Title: 呼吸器内科 Volume: 40 Pages: 407-416
• [Journal Article] Post-intensive care syndrome as a predictor of mortality in patients with critical illness: A cohort study (2021)
  • Author(s): Yanagi Naoya、Kamiya Kentaro、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Valley Thomas S.、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Koike Tomotaka、Yamaoka-Tojo Minako、Arai Masayasu、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: PLOS ONE Volume: 16 Issue: 3 Pages: 0244564-0244564
  • DOI: 10.1371/journal.pone.0244564
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure (2021)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 3715-3715
  • DOI: 10.1038/s41598-020-80641-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quadriceps Strength and Mortality in Older Patients With Heart Failure (2021)
  • Author(s): Nakamura Takeshi、Kamiya Kentaro、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Maekawa Emi、Reed Jennifer L.、Noda Chiharu、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Canadian Journal of Cardiology Volume: 37 Issue: 3 Pages: 476-483
  • DOI: 10.1016/j.cjca.2020.06.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The GLIM criteria for defining malnutrition can predict physical function and prognosis in patients with cardiovascular disease (2021)
  • Author(s): Kootaka Yoshifumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Clinical Nutrition Volume: 40 Issue: 1 Pages: 146-152
  • DOI: 10.1016/j.clnu.2020.04.038
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical and Microbiological Features of Asymptomatic SARS-CoV-2 Infection and Mild COVID-19 in Seven Crewmembers of a Cruise Ship (2020)
  • Author(s): Hoshiyama Takayuki、Wada Tatsuhiko、Nihonyanagi Shin、Kameda Ryo、Yamaoka-Tojo Minako、Fukuda Michinari、Ako Jyunya、Yamaoka Kunihiro、Takayama Yoko
  • Journal Title: Internal Medicine Volume: 59 Issue: 24 Pages: 3135-3140
  • DOI: 10.2169/internalmedicine.5601-20
  • NAID: 130007956151
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-12-15
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of the Simplified Frailty Scale in Predicting Risk of Readmission or Mortality in Elderly Patients Hospitalized with Cardiovascular Disease (2020)
  • Author(s): Aida Keita、Kamiya Kentaro、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: International Heart Journal Volume: 61 Issue: 3 Pages: 571-578
  • DOI: 10.1536/ihj.19-557
  • NAID: 130007849596
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2020-05-30
  • Peer Reviewed / Open Access
• [Journal Article] Vascular Endothelial Glycocalyx Damage in COVID-19 (2020)
  • Author(s): Yamaoka-Tojo Minako
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 24 Pages: 9712-9712
  • DOI: 10.3390/ijms21249712
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19 (2020)
  • Author(s): Yamaoka-Tojo Minako
  • Journal Title: Biomedical Journal Volume: 43 Issue: 5 Pages: 399-413
  • DOI: 10.1016/j.bj.2020.08.007
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of pupil area for all‐cause mortality in patients with heart failure (2020)
  • Author(s): Nozaki Kohei、Hamazaki Nobuaki、Yamamoto Shohei、Kamiya Kentaro、Tanaka Shinya、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Matsunaga Atsuhiko、Yamaoka‐Tojo Minako、Ako Junya
  • Journal Title: ESC Heart Failure Volume: 7 Issue: 5 Pages: 3067-3074
  • DOI: 10.1002/ehf2.12933
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Secondary analyses to assess the profound effects of empagliflozin on endothelial function in patients with type?2 diabetes and established cardiovascular diseases: The placebo‐controlled double‐blind randomized effect of empagliflozin on endothelial function in cardiovascular high risk diabetes mellitus: Multi‐center placebo‐controlled double‐blind randomized trial (2020)
  • Author(s): Tanaka Atsushi、Shimabukuro Michio、Machii Noritaka、Teragawa Hiroki、Okada Yosuke、Shima Kosuke R.、Takamura Toshinari、Taguchi Isao、Hisauchi Itaru、Toyoda Shigeru、Matsuzawa Yasushi、Tomiyama Hirofumi、Yamaoka‐Tojo Minako、Ueda Shinichiro、Higashi Yukihito、Node Koichi
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 6 Pages: 1551-1563
  • DOI: 10.1111/jdi.13289
  • Peer Reviewed / Open Access
• [Journal Article] Effect of cardiac rehabilitation on cognitive function in elderly patients with cardiovascular diseases (2020)
  • Author(s): Fujiyoshi Kazuhiro、Minami Yoshiyasu、Yamaoka-Tojo Minako、Kutsuna Toshiki、Obara Shinichi、Aoyama Akihiro、Ako Junya
  • Journal Title: PLOS ONE Volume: 15 Issue: 5 Pages: 0233688-0233688
  • DOI: 10.1371/journal.pone.0233688
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial glycocalyx and severity and vulnerability of coronary plaque in patients with coronary artery disease (2020)
  • Author(s): Nemoto Teruyoshi、Minami Yoshiyasu、Yamaoka-Tojo Minako、Kato Ayami、Katsura Aritomo、Sato Toshimitsu、Muramatsu Yusuke、Kakizaki Ryota、Fujiyoshi Kazuhiro、Hashimoto Takuya、Meguro Kentaro、Shimohama Takao、Ako Junya
  • Journal Title: Atherosclerosis Volume: 302 Pages: 1-7
  • DOI: 10.1016/j.atherosclerosis.2020.04.014
  • Peer Reviewed / Open Access
• [Journal Article] Association between sarcopenia and atherosclerosis in elderly patients with ischemic heart disease. (2020)
  • Author(s): Shota Uchida,Kentaro Kamiya,Nobuaki Hamazaki,Ryota Matsuzawa,Kohei Nozaki,Takafumi Ichikawa,Yuta Suzuki,Takeshi Nakamura,Masashi Yamashita,Hidenori Kariya,Emi Maekawa,Minako Yamaoka-Tojo,Atsuhiko Matsunaga,Junya Ako
  • Journal Title: Heart and vessels Volume: - Issue: 6 Pages: 769-775
  • DOI: 10.1007/s00380-020-01554-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence and prognosis of respiratory muscle weakness in heart failure patients with preserved ejection fraction. (2020)
  • Author(s): Nobuaki Hamazaki,Kentaro Kamiya,Ryota Matsuzawa,Kohei Nozaki,Takafumi Ichikawa,Shinya Tanaka,Takeshi Nakamura,Masashi Yamashita,Emi Maekawa,Chiharu Noda,Minako Yamaoka-Tojo,Atsuhiko Matsunaga,Takashi Masuda,Junya Ako
  • Journal Title: Respiratory medicine Volume: 161 Pages: 105834-105834
  • DOI: 10.1016/j.rmed.2019.105834
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acute Effects of Whole-Body Vibration Training on Endothelial Function and Cardiovascular Response in Elderly Patients with Cardiovascular Disease (2019)
  • Author(s): Aoyama Akihiro、Yamaoka-Tojo Minako、Obara Shinichi、Shimizu Erika、Fujiyoshi Kazuhiro、Noda Chiharu、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: International Heart Journal Volume: 60 Issue: 4 Pages: 854-861
  • DOI: 10.1536/ihj.18-592
  • NAID: 130007684167
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-07-30
  • Peer Reviewed
• [Journal Article] Impaired Flow-Mediated Dilation and Severity and Vulnerability of Culprit Plaque in Patients with Coronary Artery Disease (2019)
  • Author(s): Nemoto Teruyoshi、Minami Yoshiyasu、Yamaoka-Tojo Minako、Sato Toshimitsu、Muramatsu Yusuke、Kakizaki Ryota、Fujiyoshi Kazuhiro、Hashimoto Takuya、Meguro Kentaro、Shimohama Takao、Tojo Taiki、Ako Junya
  • Journal Title: International Heart Journal Volume: 60 Issue: 3 Pages: 539-545
  • DOI: 10.1536/ihj.18-531
  • NAID: 130007655741
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-05-30
  • Peer Reviewed
• [Journal Article] Rising time from bed in acute phase after hospitalization predicts frailty at hospital discharge in patients with acute heart failure. (2019)
  • Author(s): Kohei Nozaki,Nobuaki Hamazaki,Kentaro Kamiya,Takafumi Ichikawa,Takeshi Nakamura,Masashi Yamashita,Emi Maekawa,Atsuhiko Matsunaga,Minako Yamaoka-Tojo,Junya Ako
  • Journal Title: Journal of cardiology Volume: 75 Issue: 6 Pages: 587-593
  • DOI: 10.1016/j.jjcc.2019.12.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preoperative skeletal muscle density is associated with postoperative mortality in patients with cardiovascular disease (2019)
  • Author(s): Yamashita Masashi、Kamiya Kentaro、Matsunaga Atsuhiko、Kitamura Tadashi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamamoto Shohei、Kariya Hidenori、Maekawa Emi、Meguro Kentaro、Ogura Misao、Yamaoka-Tojo Minako、Ako Junya、Miyaji Kagami
  • Journal Title: Interactive CardioVascular and Thoracic Surgery Volume: 30 Issue: 4 Pages: 515-522
  • DOI: 10.1093/icvts/ivz307
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Empagliflozin on Endothelial Function in Patients With Type 2 Diabetes and Cardiovascular Disease: Results from the Multicenter, Randomized, Placebo-Controlled, Double-Blind EMBLEM Trial (2019)
  • Author(s): Tanaka Atsushi、Shimabukuro Michio、Machii Noritaka、Teragawa Hiroki、Okada Yosuke、Shima Kosuke R.、Takamura Toshinari、Taguchi Isao、Hisauchi Itaru、Toyoda Shigeru、Matsuzawa Yasushi、Tomiyama Hirofumi、Yamaoka-Tojo Minako、Yoshida Hisako、Sato Yasunori、Ikehara Yumi、Ueda Shinichiro、Higashi Yukihito、Node Koichi
  • Journal Title: Diabetes Care Volume: 42 Issue: 10 Pages: e159-e161
  • DOI: 10.2337/dc19-1177
  • Peer Reviewed
• [Journal Article] Impact of Gait Speed on the Obesity Paradox in Older Patients With Cardiovascular Disease. (2019)
  • Author(s): Takeshi Nakamura,Kentaro Kamiya,Atsuhiko Matsunaga,Nobuaki Hamazaki,Ryota Matsuzawa,Kohei Nozaki,Masashi Yamashita,Emi Maekawa,Chiharu Noda,Minako Yamaoka-Tojo,Junya Ako
  • Journal Title: The American journal of medicine Volume: 132 Issue: 12 Pages: 1458-1465
  • DOI: 10.1016/j.amjmed.2019.06.047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 特別講演：動脈硬化進展リスクとしての血管内皮グリコカリックス障害 (2022)
  • Author(s): 東條美奈子
  • Organizer: 第21回日本血管血流学会学術集会
  • Invited
• [Presentation] FXa阻害薬に期待する作用. LS-1 基礎から学ぶ：心房細動×心不全 (2022)
  • Author(s): 東條美奈子
  • Organizer: 第51回日本心脈管作動物質学会
  • Invited
• [Presentation] 心不全発症・増悪予防のための運動の重要性と注意点 (2022)
  • Author(s): 東條美奈子
  • Organizer: 第10回臨床高血圧学会
  • Invited
• [Presentation] 収縮機能の保たれた心不全患者における左室拡張機能の低下は運動耐容能の低下に関連する (2022)
  • Author(s): 小松拓巳、東條美奈子、北里梨紗、神谷健太郎、松永篤彦、阿古潤哉
  • Organizer: 第58回日本循環器病予防学会学術集会
• [Presentation] 血管不全リスクとしての血管内皮グリコカリックス障害. 会長企画シンポジウム「新しい日常における血管不全学の進歩」 (2022)
  • Author(s): 東條美奈子
  • Organizer: 第７回日本血管不全学会
  • Invited
• [Presentation] Residual risks and vascular endothelial glycocalyx. AHA-JCS Joint Symposium「How do we struggle against residual risk?」 (2022)
  • Author(s): Yamaoka-Tojo M
  • Organizer: 第86回日本循環器学会学術集会
  • Invited
• [Presentation] 心臓リハビリテーションと血管内皮グリコカリックス. 合同シンポジウム３「アンチエイジングのための心血管リハビリテーション」 (2021)
  • Author(s): 東條美奈子
  • Organizer: 脳心血管抗加齢研究会第17回学術大会・日本抗加齢協会第5回学術フォーラム
  • Invited
• [Presentation] Protective roles of rivaroxaban on H2O2-induced oxidative stress injury in vascular endothelial glycocalyx through the PI3K/IQGAP1 pathway (2021)
  • Author(s): Kitasato L, Yamaoka-Tojo M, Ako J
  • Organizer: 第38回国際心臓研究学会日本支部会総会
• [Presentation] 慢性期心不全患者におけるうつ症状傾向と運動機能指標の関連性 (2019)
  • Author(s): 長田健哉、東條美奈子、青山晃大、阿古潤哉
  • Organizer: 第23回日本心不全学会学術集会
• [Presentation] 健常若年者の喫煙が血管内皮グリコカリックスに及ぼす影響 (2019)
  • Author(s): 柚山昇範、青山晃大、長田健哉、加藤洋平、松永篤彦、東條美奈子
  • Organizer: 第４回心血管理学療法学会
• [Presentation] 慢性心不全患者における骨格筋量の減少は１年後の左室心筋重量の増加を予測する (2019)
  • Author(s): 加藤洋平、青山晃大、長田健哉、柚山昇範、遠原真一、苅谷英紀、阿古潤哉、松永篤彦、東條美奈子
  • Organizer: 第４回心血管理学療法学会
• [Presentation] Change in respiratory muscle strength predicts clinical events in patients with chronic heart failure (2019)
  • Author(s): Hamazaki N, Masuda T, Kamiya K, Matsuzawa R, Nozaki K, Ichikawa T, Tabata M, Maekawa E, Noda C, Yamaoka-Tojo M, Matsunaga A, Ako J
  • Organizer: ESC2019
  • Int'l Joint Research
• [Presentation] 単回の運動が健常若年者における血管内皮グリコカリックス層に及ぼす影響 (2019)
  • Author(s): 長田健哉、東條美奈子、青山晃大、加藤洋平、柚山昇範、松永篤彦
  • Organizer: 第25回日本心臓リハビリテーション学会学術集会
• [Book] 新型コロナウイルス感染症と血管内皮 (2020)
  • Author(s): 東條 美奈子
  • Total Pages: 128
  • Publisher: 南山堂
  • ISBN: 4525249811
• [Remarks] Researchmap
  • URL: https://researchmap.jp/read0073726
• [Remarks] ResearchGate
  • URL: https://www.researchgate.net/profile/Minako-Yamaoka-Tojo
• [Remarks] LinkedIn
  • URL: https://www.linkedin.com/in/minakoyamaokatojo/