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Evaluation of muscle oxidative capacity with correction of optical properties

Research Project

Project/Area Number 19K11450
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionTokyo Medical University

Principal Investigator

Kime Ryotaro  東京医科大学, 医学部, 講師 (90366120)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords近赤外線分光法 / 光散乱係数 / 平均光路長 / 筋酸素動態 / 自転車運動 / 骨格筋有酸素能力 / 散乱係数 / 光散乱強度 / 近赤外線時間分解分光法 / 皮下脂肪層 / 前腕掌握運動 / 脂肪ファントム / 骨格筋 / 皮下脂肪 / 光学特性 / 脂肪組織 / 筋有酸素能 / 磁気共鳴分光法 / 皮下脂肪厚
Outline of Research at the Start

近赤外線分光法(NIRS)を用いて筋機能を評価する際には皮下脂肪などの光散乱物質の影響を補正する必要があるにもかかわらず,その補正は大変困難である.そこで本研究では,測定対象領域(皮下脂肪も含めた筋組織)の散乱媒質が個体間で均一化するように,予め設定した散乱係数の基準値とほぼ同値となるように脂肪ファントムを皮膚上に貼付した状態で運動時の組織酸素濃度変化を計測し,筋組織での酸素の取り込み能力の定量的評価を行う.この方法では個体間における光散乱強度の影響を受けないので, 運動時における筋組織酸素濃度の定量的計測が可能になると考えられる.

Outline of Final Research Achievements

The differences in scattering coefficients affect to absolute values evaluated by near infrared spectroscopy (NIRS). Hence, we have normalized the effects of scattering coefficients by gathering the subjects who have almost the same fat layer thickness. The subjects performed cycling exercise at constant work rate for 6 min., and we evaluated the increased Oxy-Hb and Total-Hb during the cycling exercise in endurance trained group (TR) and control group (CON). We found that increased Oxy-Hb was significantly higher in TR group than CON group, and increased Oxy-Hb was significantly positive correlated with peak oxygen uptake.

Academic Significance and Societal Importance of the Research Achievements

近赤外線分光法による筋機能計測はスポーツ医科学の分野で広く利用されている。しかしながら、光学特性に大きな影響を及ぼす皮下脂肪厚(ATT)の影響を補正していない研究も多く、またATTの影響を補正した研究でも補正式の違いによって結果が大きく異なるという問題が生じている。そこで本研究は、ATTが同程度の被験者を集め(CON)、更にCONとATTがほぼ同じで普段から持久的トレーニングを行っている被験者(TR)も集めることで、光学特性に影響を与える散乱係数を標準化した。ATTを揃えた被験者を対象に、散乱係数が計測可能な近赤外線時間分解分光法を用いて筋有酸素能を評価したのは本研究が初めてである。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (11 results)

All 2024 2023 2021 2020

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Muscle oxygen dynamics measured by NIRS2024

    • Author(s)
      Ryotaro Kime, Tasuki Endo, Shun Takagi, Takafumi Hamaoka
    • Journal Title

      Advances experimental biology and medicine

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in Optical Path Length Reveal Significant Potential Errors of Muscle Oxygenation Evaluation during Exercise in Humans.2021

    • Author(s)
      Endo T, Kime R, Fuse S, Murase N, Kurosawa Y, Hamaoka T.
    • Journal Title

      Med. Sci. Sports Exer.

      Volume: 53 (4) Issue: 4 Pages: 853-859

    • DOI

      10.1249/mss.0000000000002530

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced Scattering Coefficient During Incremental Exercise Is Constant Without Being Affected by Changes in Muscle Oxygenation or Hemodynamics.2021

    • Author(s)
      Endo T, Kime R, Fuse S, Murase N, Kurosawa Y, Hamaoka T.
    • Journal Title

      Advances in Experimental Medicine & Biology

      Volume: 1269 Pages: 107-112

    • DOI

      10.1007/978-3-030-48238-1_17

    • ISBN
      9783030482367, 9783030482381
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skeletal Muscle Deoxygenation and Its Relationship to Aerobic Capacity During Early and Late Stages of Aging.2021

    • Author(s)
      Takagi S, Kime R, Murase N, Niwayama M, Sakamoto S, Katsumura T.
    • Journal Title

      Advances in Experimental Medicine & Biology

      Volume: 1269 Pages: 77-82

    • DOI

      10.1007/978-3-030-48238-1_12

    • ISBN
      9783030482367, 9783030482381
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients with Chronic Heart Failure2021

    • Author(s)
      Watanabe Tsubasa、Murase Norio、Kime Ryotaro、Kurosawa Yuko、Fuse Sayuri、Hamaoka Takafumi
    • Journal Title

      Advances in Experimental Medicine & Biology

      Volume: 1269 Pages: 101-105

    • DOI

      10.1007/978-3-030-48238-1_16

    • ISBN
      9783030482367, 9783030482381
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Limited muscle oxygen diffusive transport during exercise in humans2020

    • Author(s)
      Kime, R., T. Endo, R. Tanaka, S. Fuse, M. Kuroiwa, Y. Kurosawa, T. Hamaoka.
    • Journal Title

      Proc. SPIE

      Volume: 11237 Pages: 1-9

    • DOI

      10.1117/12.2550671

    • Related Report
      2020 Research-status Report
  • [Presentation] 運動時における骨格筋機能の評価法と臨床現場への応用2024

    • Author(s)
      木目良太郎、浜岡隆文
    • Organizer
      第14回 日本腎臓リハビリテーション学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Muscle oxygen dynamics measured by NIRS2023

    • Author(s)
      Ryotaro Kime, Tasuki Endo, Shun Takagi, Takafumi Hamaoka
    • Organizer
      The International Society on Oxygen Transport to Tissue
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋酸素消費量の測定法とその限界2021

    • Author(s)
      木目良太郎,遠藤祐輝,田中璃己,布施 沙由理,黒岩 美幸,黒澤 裕子,浜岡 隆文
    • Organizer
      第24回酸素ダイナミクス研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 中強度自転車運動中における筋組織血液量の増加が散乱係数変化に及ぼす影響2021

    • Author(s)
      遠藤祐輝,木目良太郎,庭山雅嗣,布施沙由理,田中璃己,黒岩美幸,村瀬訓生,黒澤裕子,浜岡隆文
    • Organizer
      第24回酸素ダイナミクス研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Limited muscle oxygen diffusive transport during exercise in humans2020

    • Author(s)
      R. Kime, T. Endo, R. Tanaka, S. Fuse, M. Kuroiwa, Y. Kurosawa, T. Hamaoka
    • Organizer
      SPIE Photonics West
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2025-01-30  

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